Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge

  • Authors:
    • Mee-Young Lee
    • In-Sik Shin
    • Woo-Young Jeon
    • Nara Shin
    • Hyeun-Kyoo Shin
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  • Published online on: February 10, 2014     https://doi.org/10.3892/ijmm.2014.1654
  • Pages: 978-986
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Abstract

Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this stuyd, the effects of Bangpungtongseong-san water extract (BPTS) on airway remodeling were examined using a murine model of bronchial asthma induced by ovalbumin (OVA) challenge. We focused on the effects of BPTS on the regulation of chronic asthma. BALB/c mice were randomly assigned to 5 groups, some of which were sensitized and challenged with OVA for 4 weeks. After the final ovalbumin challenge, typical asthma-like morphological changes were observed in the lung tissue with hematoxylin and eosin staining, periodic acid‑Schiff, as well as with Masson's trichrome staining. The levels of transforming growth factor‑β1 (TGF-β1) and Smad3 were assessed by immunohistochemistry and western blot analysis. The expression levels of vascular endothelial growth factor (VEGF) and adhesion molecules, such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were also detected by western blot analysis. Our results revealed that BPTS reduced the OVA-induced increase in the infiltration of leukocytes, mucus hyperplasia and collagen deposition. Compared with the OVA-challenged group, the BPTS group had lower expression levels of adhesion molecules, TGF-β1, Smad3 and VEGF proteins in the lung tissues. The results of the current study suggest that BPTS prevents asthma airway remodeling in chronic asthma by inhibiting the activation of the TGF-β1‑Smad3-signaling pathway, as well as the expression of VEGF and adhesion molecules. BPTS may thus be a potential drug for the treatment of patients with changes that occur in the airways due to severe asthma.
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2014-April
Volume 33 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lee M, Shin I, Jeon W, Shin N and Shin H: Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. Int J Mol Med 33: 978-986, 2014
APA
Lee, M., Shin, I., Jeon, W., Shin, N., & Shin, H. (2014). Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. International Journal of Molecular Medicine, 33, 978-986. https://doi.org/10.3892/ijmm.2014.1654
MLA
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33.4 (2014): 978-986.
Chicago
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33, no. 4 (2014): 978-986. https://doi.org/10.3892/ijmm.2014.1654