Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge

  • Authors:
    • Mee-Young Lee
    • In-Sik Shin
    • Woo-Young Jeon
    • Nara Shin
    • Hyeun-Kyoo Shin
  • View Affiliations / Copyright

    Affiliations: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
  • Pages: 978-986
    |
    Published online on: February 10, 2014
       https://doi.org/10.3892/ijmm.2014.1654
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this stuyd, the effects of Bangpungtongseong-san water extract (BPTS) on airway remodeling were examined using a murine model of bronchial asthma induced by ovalbumin (OVA) challenge. We focused on the effects of BPTS on the regulation of chronic asthma. BALB/c mice were randomly assigned to 5 groups, some of which were sensitized and challenged with OVA for 4 weeks. After the final ovalbumin challenge, typical asthma-like morphological changes were observed in the lung tissue with hematoxylin and eosin staining, periodic acid‑Schiff, as well as with Masson's trichrome staining. The levels of transforming growth factor‑β1 (TGF-β1) and Smad3 were assessed by immunohistochemistry and western blot analysis. The expression levels of vascular endothelial growth factor (VEGF) and adhesion molecules, such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were also detected by western blot analysis. Our results revealed that BPTS reduced the OVA-induced increase in the infiltration of leukocytes, mucus hyperplasia and collagen deposition. Compared with the OVA-challenged group, the BPTS group had lower expression levels of adhesion molecules, TGF-β1, Smad3 and VEGF proteins in the lung tissues. The results of the current study suggest that BPTS prevents asthma airway remodeling in chronic asthma by inhibiting the activation of the TGF-β1‑Smad3-signaling pathway, as well as the expression of VEGF and adhesion molecules. BPTS may thus be a potential drug for the treatment of patients with changes that occur in the airways due to severe asthma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Busse WW and Lemanske RF Jr: Asthma. N Engl J Med. 344:350–362. 2001. View Article : Google Scholar

2 

Rincon M and Irvin CG: Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci. 8:1281–1290. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Finkelman FD, Holmes J, Urban JF Jr, Paul WE and Katona IM: T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production. J Immunol. 142:403–408. 1989.PubMed/NCBI

4 

Adachi T, Motojima S, Hirata A, Fukuda T and Makino S: Eosinophil viability-enhancing activity in sputum from patients with bronchial asthma, Contributions of interleukin-5 and granulocyte/macrophage colony-stimulating factor. Am J Respir Crit Care Med. 151:618–623. 1995.

5 

Sur S, Kita H, Gleich GJ, Chenier TC and Hunt LW: Eosinophil recruitment is associated with IL-5, but not with RANTES, twenty-four hours after allergen challenge. J Allergy Clin Immunol. 97:1272–1278. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Oettgen HC and Geha RS: IgE in asthma and atopy: cellular and molecular connections. J Clin Invest. 104:829–835. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Nelms K, Keegan AD, Zamorano J, Ryan JJ and Paul WE: The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol. 17:701–738. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Zurita-Salinas CS, Palacios-Boix A, Yáñez A, González F and Alcocer-Varela J: Contamination with Mycoplasma spp. induces interleukin-13 expression by human skin fibroblasts in culture. FEMS Immunol Med Microbiol. 15:123–128. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Botero JE, Contreras A and Parra B: Profiling of inflammatory cytokines produced by gingival fibroblasts after human cytomegalovirus infection. Oral Microbiol Immunol. 23:291–298. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Wilson MS and Wynn TA: Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol. 2:103–121. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Mauviel A: Transforming growth factor beta: a key mediator of fibrosis. Meth Mol Med. 117:69–80. 2005.PubMed/NCBI

12 

Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P and Hamid Q: Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol. 17:326–333. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Vasquez-Pinto LM, Nantel F, Sirois P and Jancar S: Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma. Neuropeptides. 44:107–113. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Lee KS, Park SJ, Kim SR, Min KH, Lee KY, Choe YH, Hong SH, Lee YR, Kim JS, Hong SJ and Lee YC: Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signaling pathway. Eur Respir J. 31:523–531. 2008.

15 

Foster CA: VCAM-1/α 4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. J Allergy Clin Immunol. 98:S270–S277. 1996.

16 

Zhu X, Subbaraman R, Sano H, Jacobs B, Sano A, Boetticher E, Muñoz NM and Leff AR: A surrogate method for assessment of β2-integrin-dependent adhesion of human eosinophils to ICAM-1. J Immunol Methods. 240:157–164. 2000.

17 

Shimada T, Kudo T, Akase T and Aburada M: Preventive effects of Bofutsushosan on obesity and various metabolic disorders. Biol Pharm Bull. 31:1362–1367. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Ohno K, Chung HJ, Maruyama I and Tani T: Bofutsushosan, a traditional Chinese formulation, prevents intimal thickening and vascular smooth muscle cell proliferation induced by balloon endothelial denudation in rats. Biol Pharm Bull. 28:2162–2165. 2005. View Article : Google Scholar

19 

Morimoto Y, Sakata M, Ohno A, Maegawa T and Tajima S: Effects of Byakko-ka-ninjin-to, Bofu-tsusho-san and Gorei-san on blood glucose level, water intake and urine volume in KKAy mice. Yakugaku Zasshi. 122:163–168. 2002.(In Japanese).

20 

Kim HJ, Yoon KM, Im EY, Byun JS, Kim DJ and Kwak MA: Three case report of Bangpungtongsung-san effect on improvement of hypertension patients. KJOPP. 23:740–743. 2009.

21 

Kim HJ, Park OS, Kim KS, Cha JH and Kim YB: The effect of Bangpungtongsung-San on model of allergic rhinitis. JKOOD. 19:21–30. 2006.

22 

Lee MY, Shin IS, Lim HS, Seo CS, Ha H and Shin HK: Kochia scoparia fruit attenuates allergic airway inflammation in ovalbumin (OVA)-induced murine asthma model. Inhal Toxicol. 23:938–946. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Yuk JE, Lee MY, Kwon OK, Cai XF, Jang HY, Oh SR, Lee HK and Ahn KS: Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 11:266–273. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lee G, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM and Elias JA: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 10:1095–1103. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Chaudhary NI, Roth GJ, Hilberg F, Müller-Quernheim J, Prasse A, Zissel G, Schnapp A and Park JE: Inhibition of PDGF, VEGF and FGF signaling attenuates fibrosis. Eur Respir J. 29:976–985. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST and Davies DE: The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol. 25:385–391. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Sumi Y and Hamid Q: Airway remodeling in asthma. Allergol Int. 56:341–348. 2007. View Article : Google Scholar

28 

Westergren-Thorsson G, Larsen K, Nihlberg K, Andersson-Sjöland A, Hallgren O, Marko-Varga G and Bjermer L: Pathological airway remodelling in inflammation. Clin Respir J. 4:1–8. 2010. View Article : Google Scholar

29 

Howell JE and McAnulty RJ: TGF-β: its role in asthma and therapeutic potential. Current Drug Targets. 7:547–565. 2006.

30 

Halwani R, Al-Muhsen S, Al-Jahdali H and Hamid Q: Role of transforming growth factor-β in airway remodeling in asthma. Am J Respir Cell Mol Biol. 44:127–133. 2011.

31 

Salib RJ and Howarth PH: Transforming growth factor-β in allergic inflammatory disease of the upper airways: friend or foe? Clin Exp Allergy. 39:1128–1135. 2009.

32 

Baek KJ, Cho JY, Rosenthal P, Alexander LE, Nizet V and Broide DH: Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model. Clin Immunol. 147:27–37. 2013.PubMed/NCBI

33 

Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsukda K, Oguma T, Takeda T, Ito I, Chin K and Mishima M: Sputum levels of transforming growth factor-β1 in asthma: relation to clinical and computed tomography findings. J Investig Allergol Clin Immunol. 18:202–206. 2008.

34 

Hoshino M, Takahashi M and Aoike N: Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol. 107:295–301. 2001. View Article : Google Scholar

35 

Chavakis E and Dimmeler S: Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler Thromb Vasc Biol. 22:887–893. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Ferrara N, Gerber HP and Le Couter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee M, Shin I, Jeon W, Shin N and Shin H: Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. Int J Mol Med 33: 978-986, 2014.
APA
Lee, M., Shin, I., Jeon, W., Shin, N., & Shin, H. (2014). Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. International Journal of Molecular Medicine, 33, 978-986. https://doi.org/10.3892/ijmm.2014.1654
MLA
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33.4 (2014): 978-986.
Chicago
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33, no. 4 (2014): 978-986. https://doi.org/10.3892/ijmm.2014.1654
Copy and paste a formatted citation
x
Spandidos Publications style
Lee M, Shin I, Jeon W, Shin N and Shin H: Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. Int J Mol Med 33: 978-986, 2014.
APA
Lee, M., Shin, I., Jeon, W., Shin, N., & Shin, H. (2014). Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. International Journal of Molecular Medicine, 33, 978-986. https://doi.org/10.3892/ijmm.2014.1654
MLA
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33.4 (2014): 978-986.
Chicago
Lee, M., Shin, I., Jeon, W., Shin, N., Shin, H."Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge". International Journal of Molecular Medicine 33, no. 4 (2014): 978-986. https://doi.org/10.3892/ijmm.2014.1654
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team