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Article

1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells

  • Authors:
    • Anyu Bao
    • Yan Li
    • Yongqing Tong
    • Hongyun Zheng
    • Wei Wu
    • Chuandong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Clinical Laboratory, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China
  • Pages: 1177-1184
    |
    Published online on: February 24, 2014
       https://doi.org/10.3892/ijmm.2014.1664
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Abstract

1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] plays an anticancer role in multiple types of cancer and potentiates the cytotoxic effects of several common chemotherapeutic agents. The hypercalcemia caused by 1,25(OH)2D3 alone or resistance to cisplatin weaken the anticancer effects of vitamin D. Thus, in this study, we aimed to investigate the synergistic effects of 1,25(OH)2D3 and cisplatin on the apoptosis and cell cycle progression of gastric cancer cells. BGC-823 human gastric cancer cells were treated with 1,25(OH)2D3 or cisplatin alone, or a combination of both agents. Cell apoptosis was assessed by TUNEL assay and flow cytometry. The expression of the apoptosis-related proteins, poly(ADP-ribose) polymerase (PARP), Bax, Bcl-2, caspase-3 and caspase-8, was examined using immunoblot analysis. ERK and AKT phosphorylation were examined by immunoblot analysis. The cell cycle distribution was determined by propidium iodide staining and flow cytometric analysis. p21 and p27 protein expression was also examined using immunoblot analysis. Our results revealed that co-treatment with 1,25(OH)2D3 enhanced cisplatin-induced apoptosis and upregulated the expression of Bax, and promoted the cleavage of PARP and caspase-3. The phosphorylation levels of ERK and AKT were reduced following combined treatment with 1,25(OH)2D3 and cisplatin. The percentage of cells in the G0/G1 phase was greater in the cells treated with the combined treatment than in those treated with either 1,25(OH)2D3 or cisplatin alone. p21 and p27 expression was upregulated following co-treatment with both agents. The results of this study suggest that 1,25(OH)2D3 potentiates cisplatin-mediated cell growth inhibition and cell apoptosis, which involves the upregulation of Bax, a decrease in ERK and AKT phosphorylation levels, and increased p21 and p27 levels.
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1 

Deeb KK, Trump DL and Johnson CS: Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer. 7:684–700. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Eelen G, Verlinden L, De Clercq P, Vandewalle M, Bouillon R and Verstuyf A: Vitamin D analogs and coactivators. Anticancer Res. 26:2717–2721. 2006.PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

4 

Wadhwa R, Song S, Lee JS, Yao Y, Wei Q and Ajani JA: Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol. 10:643–655. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Abnet CC, Chen Y, Chow WH, et al: Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 172:94–106. 2010. View Article : Google Scholar

6 

Fleet JC: Molecular actions of vitamin D contributing to cancer prevention. Mol Aspects Med. 29:388–396. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Feldman DR, Bosl GJ, Sheinfeld J and Motzer RJ: Medical treatment of advanced testicular cancer. JAMA. 299:672–684. 2008. View Article : Google Scholar

8 

Krishnan AV, Trump DL, Johnson CS and Feldman D: The role of vitamin D in cancer prevention and treatment. Rheum Dis Clin North Am. 38:161–178. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Krege S, Beyer J, Souchon R, et al: European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol. 53:478–496. 2008. View Article : Google Scholar

10 

Tanida S, Mizoshita T, Ozeki K, et al: Mechanisms of cisplatin-induced apoptosis and of cisplatin sensitivity: potential of BIN1 to act as a potent predictor of cisplatin sensitivity in gastric cancer treatment. Int J Surg Oncol. 2012:8628792012.

11 

Moffatt KA, Johannes WU and Miller GJ: 1Alpha, 25dihydroxyvitamin D3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines. Clin Cancer Res. 5:695–703. 1999.PubMed/NCBI

12 

Cho YL, Christensen C, Saunders DE, et al: Combined effects of 1,25-dihydroxyvitamin D3 and platinum drugs on the growth of MCF-7 cells. Cancer Res. 51:2848–2853. 1991.PubMed/NCBI

13 

Ma Y, Yu WD, Trump DL and Johnson CS: 1,25D3 enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models. Cancer. 116:3294–3303. 2010.PubMed/NCBI

14 

Light BW, Yu WD, McElwain MC, Russell DM, Trump DL and Johnson CS: Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res. 57:3759–3764. 1997.

15 

Almhanna K, Strosberg J and Malafa M: Targeting AKT protein kinase in gastric cancer. Anticancer Res. 31:4387–4392. 2011.PubMed/NCBI

16 

Yao J, Qian CJ, Ye B, Zhang X and Liang Y: ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. Life Sci. 91:186–193. 2012.PubMed/NCBI

17 

Chen S, Law CS and Gardner DG: Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 118:135–141. 2010. View Article : Google Scholar

18 

Bao A, Li Y, Tong Y, Zheng H, Wu W and Wei C: Tumor-suppressive effects of 1,25-dihydroxyvitamin D3 in gastric cancer cells. Hepatogastroenterology. 60:943–948. 2013.PubMed/NCBI

19 

Mitrea DM, Yoon MK, Ou L and Kriwacki RW: Disorder-function relationships for the cell cycle regulatory proteins p21 and p27. Biol Chem. 393:259–274. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Leung WK, Wu MS, Kakugawa Y, et al: Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 9:279–287. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Macdonald JS: Treatment of localized gastric cancer. Semin Oncol. 31:566–573. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Carrato A, Gallego-Plazas J and Guillen-Ponce C: Adjuvant therapy of resected gastric cancer is necessary. Semin Oncol. 32(Suppl 9): S105–S108. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Topuz E, Basaran M, Saip P, et al: Adjuvant intraperitoneal chemotherapy with cisplatinum, mitoxantrone, 5-fluorouracil, and calcium folinate in patients with gastric cancer: a phase II study. Am J Clin Oncol. 25:619–624. 2002. View Article : Google Scholar

24 

Cavanna L, Artioli F, Codignola C, et al: Oxaliplatin in combination with 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic gastric cancer (MGC). Am J Clin Oncol. 29:371–375. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Louvet C, Andre T, Tigaud JM, et al: Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol. 20:4543–4548. 2002. View Article : Google Scholar

26 

Mocellin S: Vitamin D and cancer: deciphering the truth. Biochim Biophys Actas. 1816:172–178. 2011.PubMed/NCBI

27 

Picotto G, Liaudat AC, Bohl L and Tolosa de Talamoni N: Molecular aspects of vitamin D anticancer activity. Cancer Invest. 30:604–614. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Reichrath J, Friedrich M and Vogt T: Vitamin D and its analogs in cancer prevention and therapy. Anticancer Res. 32:209–210. 2012.PubMed/NCBI

29 

Rahman N: Realizing the promise of cancer predisposition genes. Nature. 505:302–308. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Fingas CD, Altinbas A, Schlattjan M, et al: Expression of apoptosis- and vitamin D pathway-related genes in hepatocellular carcinoma. Digestion. 87:176–181. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Fulda S and Debatin KM: Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 25:4798–4811. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Wang W, Zhao CH, Zhang N and Wang J: Vitamin D analog EB1089 induces apoptosis in a subpopulation of SGC-7901 gastric cancer cells through a mitochondrial-dependent apoptotic pathway. Nutr Cancer. 65:1067–1075. 2013. View Article : Google Scholar

33 

Narvaez CJ and Welsh J: Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem. 276:9101–9107. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Koshizuka K, Koike M, Kubota T, Said J, Binderup L and Koeffler HP: Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo. Int J Oncol. 13:421–428. 1998.

35 

Wagner N, Wagner KD, Schley G, Badiali L, Theres H and Scholz H: 1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax. Exp Eye Res. 77:1–9. 2003.

36 

Basu A and Krishnamurthy S: Cellular responses to cisplatin-induced DNA damage. J Nucleic Acids. 2010:2013672010. View Article : Google Scholar

37 

Wang S, Li W, Xue Z, et al: Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin. Mol Carcinog. 52:900–907. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Ma Y, Yu WD, Kong RX, Trump DL and Johnson CS: Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carcinoma cells. Cancer Res. 66:8131–8138. 2006.

39 

Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2:489–501. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Xiao H, Shi W, Liu S, et al: 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway. Am J Nephrol. 30:34–43. 2009. View Article : Google Scholar

41 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Shen XJ, Wang HB, Ma XQ and Chen JH: β,β-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastric cancer SGC-7901 cells. PLoS One. 7:e417732012.

43 

Lee HJ, So JY, DeCastro A, et al: Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling. J Steroid Biochem Mol Biol. 121:408–412. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Wu S, Lao XY, Sun TT, et al: Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway. Cancer Lett. 337:293–300. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Artaza JN, Sirad F, Ferrini MG and Norris KC: 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol. 119:73–83. 2010.

46 

Luo W, Chen Y, Liu M, et al: EB1089 induces Skp2-dependent p27 accumulation, leading to cell growth inhibition and cell cycle G1 phase arrest in human hepatoma cells. Cancer Invest. 27:29–37. 2009. View Article : Google Scholar

47 

Banerjee P and Chatterjee M: Antiproliferative role of vitamin D and its analogs - a brief overview. Mol Cell Biochem. 253:247–254. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bao A, Li Y, Tong Y, Zheng H, Wu W and Wei C: 1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. Int J Mol Med 33: 1177-1184, 2014.
APA
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., & Wei, C. (2014). 1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. International Journal of Molecular Medicine, 33, 1177-1184. https://doi.org/10.3892/ijmm.2014.1664
MLA
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., Wei, C."1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells". International Journal of Molecular Medicine 33.5 (2014): 1177-1184.
Chicago
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., Wei, C."1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells". International Journal of Molecular Medicine 33, no. 5 (2014): 1177-1184. https://doi.org/10.3892/ijmm.2014.1664
Copy and paste a formatted citation
x
Spandidos Publications style
Bao A, Li Y, Tong Y, Zheng H, Wu W and Wei C: 1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. Int J Mol Med 33: 1177-1184, 2014.
APA
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., & Wei, C. (2014). 1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. International Journal of Molecular Medicine, 33, 1177-1184. https://doi.org/10.3892/ijmm.2014.1664
MLA
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., Wei, C."1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells". International Journal of Molecular Medicine 33.5 (2014): 1177-1184.
Chicago
Bao, A., Li, Y., Tong, Y., Zheng, H., Wu, W., Wei, C."1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells". International Journal of Molecular Medicine 33, no. 5 (2014): 1177-1184. https://doi.org/10.3892/ijmm.2014.1664
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