|
1
|
Forbes JM, Coughlan MT and Cooper ME:
Oxidative stress as a major culprit in kidney disease in diabetes.
Diabetes. 57:1446–1454. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Brownlee M: Biochemistry and molecular
cell biology of diabetic complications. Nature. 414:813–820. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Brownlee M: The pathobiology of diabetic
complications: a unifying mechanism. Diabetes. 54:1615–1625. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zheng Z, Chen H, Ke G, Fan Y, Zou H, et
al: Protective effect of perindopril on diabetic retinopathy is
associated with decreased vascular endothelial growth
factor-to-pigment epithelium-derived factor ratio: involvement of a
mitochondria-reactive oxygen species pathway. Diabetes. 58:954–964.
2009. View Article : Google Scholar
|
|
5
|
Mattson MP and Kroemer G: Mitochondria in
cell death: novel targets for neuroprotection and cardioprotection.
Trends Mol Med. 9:196–205. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mattson MP and Liu D: Mitochondrial
potassium channels and uncoupling proteins in synaptic plasticity
and neuronal cell death. Biochem Biophys Res Commun. 304:539–549.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Cui Y, Xu X, Bi H, Wu J, et al: Expression
modification of uncoupling proteins and MnSOD in retinal
endothelial cells and pericytes induced by high glucose: the role
of reactive oxygen species in diabetic retinopathy. Exp Eye Res.
83:807–816. 2001. View Article : Google Scholar
|
|
8
|
Fleury C, Neverova M, Collins S, Raimbault
S, et al: Uncoupling protein-2: a novel gene linked to obesity and
hyperinsulinemia. Nat Genet. 15:269–272. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pecqueur C, Couplan E, Bouillaud F and
Ricquier D: Genetic and physiological analysis of the role of
uncoupling proteins in human energy homeostasis. J Mol Med.
79:48–56. 2001. View Article : Google Scholar
|
|
10
|
Pecqueur C, Alves-Guerra MC, Gelly C,
Levi-Meyrueis C, Couplan E, et al: Uncoupling protein 2, in vivo
distribution, induction upon oxidative stress, and evidence for
translational regulation. J Biol Chem. 276:8705–8712. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Couplan E, del Mar Gonzalez-Barroso M,
Alves-Guerra MC, Ricquier D, Goubern M and Bouillaud F: No evidence
for a basal, retinoic, or superoxide-induced uncoupling activity of
the uncoupling protein 2 present in spleen or lung mitochondria. J
Biol Chem. 277:26268–26275. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang CY, Baffy G, Perret P, Krauss S,
Peroni O, et al: Uncoupling protein-2 negatively regulates insulin
secretion and is a major link between obesity, beta cell
dysfunction, and type 2 diabetes. Cell. 105:745–755. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Krauss S, Brand MD and Buttgereit F:
Signaling takes a breath - new quantitative perspectives on
bioenergetics and signal transduction. Immunity. 15:497–502. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Krauss S, Zhang CY, Scorrano L, Dalgaard
LT, St-Pierre J, et al: Superoxide-mediated activation of
uncoupling protein 2 causes pancreatic beta cell dysfunction. J
Clin Invest. 112:1831–1842. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Turner JD, Gaspers LD, Wang G and Thomas
AP: Uncoupling protein-2 modulates myocardial
excitation-contraction coupling. Circ Res. 106:730–738. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Horvath TL, Warden CH, Hajos M, Lombardi
A, Goglia F, et al: Brain uncoupling protein 2: uncoupled neuronal
mitochondria predict thermal synapses in homeostatic centers. J
Neurosci. 19:10417–10427. 1999.PubMed/NCBI
|
|
17
|
Liu Y, Chen L, Xu X, Vicaut E and Sercombe
R: Both ischemic preconditioning and ghrelin administration protect
hippocampus from ischemia/reperfusion and upregulate uncoupling
protein-2. BMC Physiol. 9:172009. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Della-Morte D, Dave KR, DeFazio RA, Bao
YC, Raval AP, et al: Resveratrol pretreatment protects rat brain
from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2
pathway. Neuroscience. 159:993–1002. 2009. View Article : Google Scholar
|
|
19
|
Arsenijevic D, Onuma H, Pecqueur C,
Ricquier D, et al: Disruption of the uncoupling protein-2 gene in
mice reveals a role in immunity and reactive oxygen species
production. Nat Genet. 26:435–439. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Nègre-Salvayre A, Hirtz C, Carrera G,
Casteilla L, et al: A role for uncoupling protein-2 as a regulator
of mitochondrial hydrogen peroxide generation. FASEB J. 11:809–815.
1997.PubMed/NCBI
|
|
21
|
Li LX, Skorpen F, Egeberg K, Jørgensen IH
and Grill V: Uncoupling protein-2 participates in cellular defense
against oxidative stress in clonal beta-cells. Biochem Biophys Res
Commun. 282:273–277. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Bai Y, Onuma H, Bai X, Medvedev AV,
Collins S, et al: Persistent nuclear factor-kappa B activation in
Ucp2−/− mice leads to enhanced nitric oxide and inflammatory
cytokine production. J Biol Chem. 280:19062–19069. 2005.
|
|
23
|
Nishio K, Qiao S and Yamashita H:
Characterization of the differential expression of uncoupling
protein 2 and ROS production in differentiated mouse
macrophage-cells (Mm1) and the progenitor cells (M1). J Mol Histol.
36:35–44. 2005. View Article : Google Scholar
|
|
24
|
Brand MD, Affourtit C, Esteves TC, Parker
N, et al: Mitochondrial superoxide: production, biological effects,
and activation of uncoupling proteins. Free Radic Biol Med.
37:755–767. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Conti B, Sugama S, Lucero J, Bartfai T, et
al: Uncoupling protein 2 protects dopaminergic neurons from acute
1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J Neurochem.
93:493–501. 2005. View Article : Google Scholar
|
|
26
|
Mattiasson G, Shamloo M, Gido G, Wieloch
T, et al: Uncoupling protein-2 prevents neuronal death and
diminishes brain dysfunction after stroke and brain trauma. Nat
Med. 9:1062–1068. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
27
|
Paradis E, Clavel S, Bouillaud F, Ricquier
D and Richard D: Uncoupling protein 2: a novel player in
neuroprotection. Trends Mol Med. 9:522–525. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Richard D, Clavel S, Huang Q, Sanchis D
and Ricquier D: Uncoupling protein 2 in the brain: distribution and
function. Biochem Soc Trans. 29:812–817. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Blanc J, Alves-Guerra MC, Esposito B,
Rousset S, Mallat Z, et al: Protective role of uncoupling protein 2
in atherosclerosis. Circulation. 107:388–390. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Teshima Y, Akao M, Jones SP and Marbán E:
Uncoupling protein-2 overexpression inhibits mitochondrial death
pathway in cardiomyocytes. Circ Res. 93:192–200. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Polonsky KS and Semenkovich CF: The
pancreatic beta cell heats up: UCP2 and insulin secretion in
diabetes. Cell. 105:705–707. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Suh YH, Kim SY, Lee HY, Song DK, et al:
Overexpression of short heterodimer partner recovers impaired
glucose-stimulated insulin secretion of pancreatic beta-cells
overexpressing UCP2. J Endocrinol. 183:133–144. 2004. View Article : Google Scholar
|
|
33
|
Sayeed A, Meng Z, Luciani G, Dairkee SH,
et al: Negative regulation of UCP2 by TGFβ signaling characterizes
low and intermediate-grade primary breast cancer. Cell Death Dis.
1:e532010.
|
|
34
|
Beltramo E, Berrone E, Buttiglieri S and
Porta M: Thiamine and benfotiamine prevent increased apoptosis in
endothelial cells and pericytes cultured in high glucose. Diabetes
Metab Res Rev. 20:330–336. 2004. View
Article : Google Scholar : PubMed/NCBI
|
|
35
|
Li W, Liu X, He Z, Yanoff M, Jian B and Ye
X: Expression of apoptosis regulatory genes by retinal pericytes
after rapid glucose reduction. Invest Ophthalmol Vis Sci.
39:1535–1543. 1998.PubMed/NCBI
|
|
36
|
Naruse K, Nakamura J, Hamada Y, Nakayama
M, Chava S, Komori T, Kato K, Kasuya Y, Miwa K and Hotta N: Aldose
reductase inhibition prevents glucose-induced apoptosis in cultured
bovine retinal microvascular pericytes. Exp Eye Res. 71:309–315.
2000. View Article : Google Scholar
|
|
37
|
Romeo G, Liu WH, Asnaghi V, Kern TS and
Lorenzi M: Activation of nuclear factor-kappaB induced by diabetes
and high glucose regulates a proapoptotic program in retinal
pericytes. Diabetes. 51:2241–2248. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Elorza A, Hyde B, Mikkola HK, Collins S
and Shirihai OS: UCP2 modulates cell proliferation through the
MAPK/ERK pathway during erythropoiesis and has no effect on heme
biosynthesis. J Biol Chem. 283:30461–30470. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Pecqueur C, Bui T, Gelly C, Tompson CB, et
al: Uncoupling protein-2 controls proliferation by promoting fatty
acid oxidation and limiting glycolysis-derived pyruvate
utilization. FASEB J. 22:9–18. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Sears RC and Nevins JR: Signaling networks
that link cell proliferation and cell fate. J Biol Chem.
277:11617–11620. 2002. View Article : Google Scholar : PubMed/NCBI
|
