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Article

Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways

  • Authors:
    • Hong Jiang
    • Jichang Li
    • Tiezhong Zhou
    • Chunhua Wang
    • Hua Zhang
    • Hongjun Wang
  • View Affiliations / Copyright

    Affiliations: College of Animal Husbandry and Veterinary Medicine, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China, Scientific Research Department, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China
  • Pages: 1298-1304
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/ijmm.2014.1684
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Abstract

Colistin, a cyclic cationic polypeptide antibiotic that is used to treat infections, may cause neurotoxicity. However, whether colistin can induce apoptosis and the precise mechanism of apoptosis involved in PC12 cells remains to be determined. The aim of the present study was to determine reactive oxygen species (ROS) level and DNA damage, as well as apoptotic factors such as p53, cytochrome c, Bax, Bcl‑2, Fas, Fas‑L and caspase family via western blotting in PC12 cells treated with colistin sulfate. The results showed that colistin sulfate increased ROS levels significantly. An increase of ROS levels induces the release of cytochrome c and DNA damage. DNA damage can activate p53, which leads to the upregulation of Bax and downregulation of Bcl-2. The imbalance of Bax/Bcl‑2 promotes additional release of cytochrome c. The release of cytochrome c contributes to the activation of caspase‑9 and the subsequent activation of caspase‑3. An increase of Fas and Fas‑L induced the activation of caspase‑8 leading to the activation of caspases‑3, the latter induces apoptosis. Therefore, these results demonstrate that the apoptotic pathway of colistin-induced apoptosis in PC12 cells is involved in both the mitochondrial and death receptor pathway.
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1 

Falagas ME and Kasiakou SK: Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. Crit Care. 10:R272006. View Article : Google Scholar : PubMed/NCBI

2 

Michalopoulos A and Falagas ME: Colistin and polymyxin B in critical care. Crit Care Clin. 24:377–391. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Michalopoulos A, Kasiakou SK, Mastora Z, Rellos K, Kapaskelis AM and Falagas ME: Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis. Crit Care. 9:R53–R59. 2005. View Article : Google Scholar

4 

Zavascki AP, Goldani LZ, Li J and Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 60:1206–1215. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Conway SP, Brownlee KG, Denton M and Peckham DG: Antibiotic treatment of multidrug-resistant organisms in cystic fibrosis. Am J Respir Med. 2:321–332. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Littlewood JM, Koch C, Lambert PA, et al: A ten year review of colomycin. Respir Med. 94:632–640. 2000.PubMed/NCBI

7 

Betrosian AP, Frantzeskaki F, Xanthaki A and Douzinas EE: Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia. J Infect. 56:432–436. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Furtado GH, d’Azevedo PA, Santos AF, Gales AC, Pignatari AC and Medeiros EA: Intravenous polymyxin B for the treatment of nosocomial pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. Int J Antimicrob Agents. 30:315–319. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Holloway KP, Rouphael NG, Wells JB, King MD and Blumberg HM: Polymyxin B and doxycycline use in patients with multidrug-resistant Acinetobacter baumannii infections in the intensive care unit. Ann Pharmacother. 40:1939–1945. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Oliveira MS, Prado GV, Costa SF, Grinbaum RS and Levin AS: Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp. J Antimicrob Chemother. 61:1369–1375. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Cheng CY, Sheng WH, Wang JT, Chen YC and Chang SC: Safety and efficacy of intravenous colistin (colistin methanesulphonate) for severe multidrug-resistant Gram-negative bacterial infections. Int J Antimicrob Agents. 35:297–300. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257. 1972. View Article : Google Scholar : PubMed/NCBI

13 

Maroto R and Perez-Polo JR: BCL-2-related protein expression in apoptosis: oxidative stress versus serum deprivation in PC12 cells. J Neurochem. 69:514–523. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Aravind L, Dixit VM and Koonin EV: The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci. 24:47–53. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Spanos S, Rice S, Karagiannis P, et al: Caspase activity and expression of cell death genes during development of human preimplantation embryos. Reproduction. 124:353–363. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Meng H, Li C, Feng L, et al: Effects of Ginkgolide B on 6-OHDA-induced apoptosis and calcium over load in cultured PC12. Int J Dev Neurosci. 25:509–514. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Sasaki N, Toda T, Kaneko T, Baba N and Matsuo M: Flavonoids suppress the cytotoxicity of linoleic acid hydroperoxide toward PC12 cells. Biol Pharm Bull. 25:1093–1096. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Hirata Y: Manganese-induced apoptosis in PC12 cells. Neurotoxicol Teratol. 24:639–653. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Ravni A, Bourgault S, Lebon A, et al: The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. J Neurochem. 98:321–329. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Vaudry D, Chen Y, Hsu CM and Eiden LE: PC12 cells as a model to study the neurotrophic activities of PACAP. Ann N Y Acad Sci. 971:491–496. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Hou RR, Chen JZ, Chen H, Kang XG, Li MG and Wang BR: Neuroprotective effects of (−)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells. Cell Biol Int. 32:22–30. 2008.

22 

Li Y, Shi W, Zhou Y, et al: Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environ Toxicol Pharmacol. 26:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Shibata S, Maeda M, Furuta K, et al: Neuroprotective effects of (arylthio)cyclopentenone derivatives on manganese-induced apoptosis in PC12 cells. Brain Res. 1294:218–225. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Ahmadian S, Barar J, Saei AA, Fakhree MA and Omidi Y: Cellular toxicity of nanogenomedicine in MCF-7 cell line: MTT assay. J Vis Exp. 11912009.PubMed/NCBI

25 

Peng Q, Wei Z and Lau BH: Fructus corni attenuates oxidative stress in macrophages and endothelial cells. Am J Chin Med. 26:291–300. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Lee YM, Park SH, Shin DI, et al: Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease. J Biol Chem. 283:9986–9998. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Cheng AC, Lee MF, Tsai ML, et al: Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol. 49:485–493. 2011. View Article : Google Scholar

28 

Pan MH, Chang WL, Lin-Shiau SY, Ho CT and Lin JK: Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J Agric Food Chem. 49:1464–1474. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Kawakami M, Inagawa R, Hosokawa T, Saito T and Kurasaki M: Mechanism of apoptosis induced by copper in PC12 cells. Food Chem Toxicol. 46:2157–2164. 2008. View Article : Google Scholar

30 

Woodgate A, MacGibbon G, Walton M and Dragunow M: The toxicity of 6-hydroxydopamine on PC12 and P19 cells. Brain Res Mol Brain Res. 69:84–92. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Martin SJ and Green DR: Protease activation during apoptosis: death by a thousand cuts? Cell. 82:349–352. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Breckenridge DG and Xue D: Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr Opin Cell Biol. 16:647–652. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 275:1132–1136. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Yang X, Wang Y, Luo J, Liu S and Yang Z: Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol. 31:303–311. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Basanez G, Sharpe JC, Galanis J, Brandt TB, Hardwick JM and Zimmerberg J: Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature. J Biol Chem. 277:49360–49365. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:481–490. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Goping IS, Gross A, Lavoie JN, et al: Regulated targeting of BAX to mitochondria. J Cell Biol. 143:207–215. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Gross A, Jockel J, Wei MC and Korsmeyer SJ: Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17:3878–3885. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Eskes R, Desagher S, Antonsson B and Martinou JC: Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol. 20:929–935. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Narita M, Shimizu S, Ito T, et al: Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA. 95:14681–14686. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Candé C, Cecconi F, Dessen P and Kroemer G: Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci. 115:4727–4734. 2002.PubMed/NCBI

42 

Candé C, Cohen I, Daugas E, et al: Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. 84:215–222. 2002.PubMed/NCBI

43 

Wei MC, Lindsten T, Mootha VK, et al: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14:2060–2071. 2000.PubMed/NCBI

44 

Csokay B, Prajda N, Weber G and Olah E: Molecular mechanisms in the antiproliferative action of quercetin. Life Sci. 60:2157–2163. 1997. View Article : Google Scholar : PubMed/NCBI

45 

Zimmermann KC and Green DR: How cells die: apoptosis pathways. J Allergy Clin Immunol. 108:S99–S103. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Li J, Zhou T, Wang C, Zhang H and Wang H: Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways. Int J Mol Med 33: 1298-1304, 2014.
APA
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., & Wang, H. (2014). Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways. International Journal of Molecular Medicine, 33, 1298-1304. https://doi.org/10.3892/ijmm.2014.1684
MLA
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., Wang, H."Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways". International Journal of Molecular Medicine 33.5 (2014): 1298-1304.
Chicago
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., Wang, H."Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways". International Journal of Molecular Medicine 33, no. 5 (2014): 1298-1304. https://doi.org/10.3892/ijmm.2014.1684
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Li J, Zhou T, Wang C, Zhang H and Wang H: Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways. Int J Mol Med 33: 1298-1304, 2014.
APA
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., & Wang, H. (2014). Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways. International Journal of Molecular Medicine, 33, 1298-1304. https://doi.org/10.3892/ijmm.2014.1684
MLA
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., Wang, H."Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways". International Journal of Molecular Medicine 33.5 (2014): 1298-1304.
Chicago
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., Wang, H."Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways". International Journal of Molecular Medicine 33, no. 5 (2014): 1298-1304. https://doi.org/10.3892/ijmm.2014.1684
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