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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July-2014 Volume 34 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164

  • Authors:
    • Jia-Ang Shi
    • Da-Lin Lu
    • Xuan Huang
    • Wei Tan
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, P.R. China, Medical College, Nanchang University, Jiangxi 330000, P.R. China
  • Pages: 237-243
    |
    Published online on: April 22, 2014
       https://doi.org/10.3892/ijmm.2014.1749
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Abstract

It is known that microRNA-219 (miR-219) expression is downregulated in medulloblastoma. In the present study, we investigated the expression, targets and functional effects of miR-219 in D283-MED medulloblastoma cells. We first demonstrated that miR-219 not only inhibits proliferation, but also suppresses the invasion and migration of D283-MED cells. Moreover, the knockdown of miR-219 promoted the proliferation, migration and invasion of the D283-MED cells. Secondly, we predicted that miR-219 targets the 3' untranslated region (3'UTR) of CD164 and orthodenticle homeobox 2 (OTX2) and then confirmed that it significantly downregulated the protein expression of CD164 and OTX2 in D283-MED cells. Finally, we demonstrated that the proliferation, invasion and migration of D283-MED cells were promoted by theectopic expression of CD164. These results indicate that miR-219 suppresses the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. The results also suggest that miR-219 may serve as a potential therapeutic agent for medulloblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Shi J, Lu D, Huang X and Tan W: miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. Int J Mol Med 34: 237-243, 2014.
APA
Shi, J., Lu, D., Huang, X., & Tan, W. (2014). miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. International Journal of Molecular Medicine, 34, 237-243. https://doi.org/10.3892/ijmm.2014.1749
MLA
Shi, J., Lu, D., Huang, X., Tan, W."miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164". International Journal of Molecular Medicine 34.1 (2014): 237-243.
Chicago
Shi, J., Lu, D., Huang, X., Tan, W."miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164". International Journal of Molecular Medicine 34, no. 1 (2014): 237-243. https://doi.org/10.3892/ijmm.2014.1749
Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Lu D, Huang X and Tan W: miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. Int J Mol Med 34: 237-243, 2014.
APA
Shi, J., Lu, D., Huang, X., & Tan, W. (2014). miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. International Journal of Molecular Medicine, 34, 237-243. https://doi.org/10.3892/ijmm.2014.1749
MLA
Shi, J., Lu, D., Huang, X., Tan, W."miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164". International Journal of Molecular Medicine 34.1 (2014): 237-243.
Chicago
Shi, J., Lu, D., Huang, X., Tan, W."miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164". International Journal of Molecular Medicine 34, no. 1 (2014): 237-243. https://doi.org/10.3892/ijmm.2014.1749
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