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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July-2014 Volume 34 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma

  • Authors:
    • Bin Yi
    • You Hu
    • Gongzhao Qin
    • Wen Gu
    • Xinguo Zhu
    • Songbing He
    • Jian Zhou
    • Dechun Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Gynaecology and Obstetrics, Suzhou Municipal Hospital, Suzhou, Jiangsu 215003, P.R. China
  • Pages: 205-212
    |
    Published online on: April 30, 2014
       https://doi.org/10.3892/ijmm.2014.1765
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Abstract

Rho GDP dissociation inhibitor 2 (RhoGDI2) has been identified as a regulator of tumor metastasis, although its role in tumor progression remains controversial. In this study, we examined the expression of RhoGDI2 in PC tissues and cell lines. To investigate the function of RhoGDI2 in PC cells, RhoGDI2 expression was depleted in PANC-1 and Patu8988 cells by small interfering RNA (siRNA). RhoGDI2 was found to be overexpressed in pancreatic carcinoma (PC) tissues and PC cell lines. Additionally, the results showed that depletion of RhoGDI2 significantly inhibited cell motility and invasion in vitro, but did not affect cell proliferation. The clinical study together with the experimental data confirmed that RhoGDI2 modulated the expression of matrix metalloproteinase 2 (MMP2). Taken together, findings of the present study indicated that RhoGDI2 is involved in pancreatic tumor malignancy and metastasis. Thus, RhoGDI2 is a potential target for the gene therapy of PC.
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Copy and paste a formatted citation
Spandidos Publications style
Yi B, Hu Y, Qin G, Gu W, Zhu X, He S, Zhou J and Li D: Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. Int J Mol Med 34: 205-212, 2014.
APA
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S. ... Li, D. (2014). Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. International Journal of Molecular Medicine, 34, 205-212. https://doi.org/10.3892/ijmm.2014.1765
MLA
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S., Zhou, J., Li, D."Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma". International Journal of Molecular Medicine 34.1 (2014): 205-212.
Chicago
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S., Zhou, J., Li, D."Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma". International Journal of Molecular Medicine 34, no. 1 (2014): 205-212. https://doi.org/10.3892/ijmm.2014.1765
Copy and paste a formatted citation
x
Spandidos Publications style
Yi B, Hu Y, Qin G, Gu W, Zhu X, He S, Zhou J and Li D: Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. Int J Mol Med 34: 205-212, 2014.
APA
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S. ... Li, D. (2014). Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. International Journal of Molecular Medicine, 34, 205-212. https://doi.org/10.3892/ijmm.2014.1765
MLA
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S., Zhou, J., Li, D."Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma". International Journal of Molecular Medicine 34.1 (2014): 205-212.
Chicago
Yi, B., Hu, Y., Qin, G., Gu, W., Zhu, X., He, S., Zhou, J., Li, D."Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma". International Journal of Molecular Medicine 34, no. 1 (2014): 205-212. https://doi.org/10.3892/ijmm.2014.1765
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