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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August-2014 Volume 34 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Transgelin overexpression in lung adenocarcinoma is associated with tumor progression

  • Authors:
    • Xiaohong Wu
    • Liangliang Dong
    • Ruifeng Zhang
    • Kejing Ying
    • Huahao Shen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China, Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 585-591
    |
    Published online on: June 16, 2014
       https://doi.org/10.3892/ijmm.2014.1805
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Abstract

Hypoxia is a common feature of solid tumors and is associated with an increased likelihood of local recurrence and distant metastasis. Transgelin (TAGLN) is an actin cross-linking/polymerization protein that belongs to the family of actin-associated proteins, and there is evidence that TAGLN may be involved in the migration of epithelial cells by interacting with actin or promoting podosome formation. Cell migration is a key step of cancer metastatis. Thus, the aim of this study was to investigate the potential link between TAGLN protein levels and hypoxia in lung adenocarcinoma cells and to explore the possible functions and expression patterns of TAGLN in lung adenocarcinoma. We first examined the effects of altered TAGLN expression on cell migration under both normoxic and hypoxic conditions. Immunohistochemical (IHC) staining was also performed to examine TAGLN protein expression patterns in lung adenocarcinoma samples. Our results revealed that TAGLN was upregulated in the hypoxic lung adenocarcinoma cells. The inhibition of TAGLN expression in the cells using small interfering RNA (siRNA) led to a decreased migration ability. TAGLN was significantly overexpressed in the lung adenocarcinoma tissues compared to the adjacent tumor-free tissues. A high TAGLN expression correlated with an advanced TNM stage, lymph node metastasis and greater differentiation. TAGLN was upregulated in the human lung adenocarcinoma cell lines under hypoxic conditions, which contributed to the migration ability of the cells. Thus, our data suggest that TAGLN may be a viable therapeutic target and a potential biomarker for predicting the prognosis of patients with lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wu X, Dong L, Zhang R, Ying K and Shen H: Transgelin overexpression in lung adenocarcinoma is associated with tumor progression. Int J Mol Med 34: 585-591, 2014.
APA
Wu, X., Dong, L., Zhang, R., Ying, K., & Shen, H. (2014). Transgelin overexpression in lung adenocarcinoma is associated with tumor progression. International Journal of Molecular Medicine, 34, 585-591. https://doi.org/10.3892/ijmm.2014.1805
MLA
Wu, X., Dong, L., Zhang, R., Ying, K., Shen, H."Transgelin overexpression in lung adenocarcinoma is associated with tumor progression". International Journal of Molecular Medicine 34.2 (2014): 585-591.
Chicago
Wu, X., Dong, L., Zhang, R., Ying, K., Shen, H."Transgelin overexpression in lung adenocarcinoma is associated with tumor progression". International Journal of Molecular Medicine 34, no. 2 (2014): 585-591. https://doi.org/10.3892/ijmm.2014.1805
Copy and paste a formatted citation
x
Spandidos Publications style
Wu X, Dong L, Zhang R, Ying K and Shen H: Transgelin overexpression in lung adenocarcinoma is associated with tumor progression. Int J Mol Med 34: 585-591, 2014.
APA
Wu, X., Dong, L., Zhang, R., Ying, K., & Shen, H. (2014). Transgelin overexpression in lung adenocarcinoma is associated with tumor progression. International Journal of Molecular Medicine, 34, 585-591. https://doi.org/10.3892/ijmm.2014.1805
MLA
Wu, X., Dong, L., Zhang, R., Ying, K., Shen, H."Transgelin overexpression in lung adenocarcinoma is associated with tumor progression". International Journal of Molecular Medicine 34.2 (2014): 585-591.
Chicago
Wu, X., Dong, L., Zhang, R., Ying, K., Shen, H."Transgelin overexpression in lung adenocarcinoma is associated with tumor progression". International Journal of Molecular Medicine 34, no. 2 (2014): 585-591. https://doi.org/10.3892/ijmm.2014.1805
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