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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2014 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Therapeutic suppression of premature termination codons: Mechanisms and clinical considerations (Review)

John Karijolich, Yi-Tao Yu
Pages: 355-362
Published online on: 17 June 2014

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Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (Review)

Magdy El-Salhy, Odd Helge Gilja, Doris Gundersen, Jan G. Hatlebakk, Trygve Hausken
Pages: 363-371
Published online on: 17 June 2014

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Review

Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms (Review)

L. F. Li, R. L.Y. Chan, L. Lu, J. Shen, L. Zhang, W. K.K. Wu, L. Wang, T. Hu, M. X. Li, C. H. Cho
Pages: 372-380
Published online on: 22 May 2014

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Article Open Access

Hepatocyte growth factor regulates the TGF‑β1‑induced proliferation, differentiation and secretory function of cardiac fibroblasts

Xin Yi, Xiaoyan Li, Yanli Zhou, Shan Ren, Weiguo Wan, Gaoke Feng, Xuejun Jiang
Pages: 381-390
Published online on: 16 May 2014

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Article Open Access

Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats

Junli Zhen, Zhenzhen Qu, Haibo Fang, Lan Fu, Yupeng Wu, Hongchao Wang, Hongmin Zang, Weiping Wang
Pages: 391-398
Published online on: 06 June 2014

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Article Open Access

Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells Retraction in /10.3892/ijmm.2025.5688

Bo Meng, Yisong Wang, Bin Li
Pages: 399-408
Published online on: 17 June 2014

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Article Open Access

Alteration of glycine receptor immunoreactivity in the auditory brainstem of mice following three months of exposure to radiofrequency radiation at SAR 4.0 W/kg

Dhiraj Maskey, Hyung Gun Kim, Myung-Whan Suh, Gu Seob Roh, Myeung Ju Kim
Pages: 409-419
Published online on: 22 May 2014

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Article Open Access

MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells

Weiwei Liu, Chuanming Xu, Huifang Wan, Chunju Liu, Can Wen, Hongfei Lu, Fusheng Wan
Pages: 420-428
Published online on: 11 June 2014

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Article Open Access

Bushen‑Yizhi formula ameliorates cognition deficits and attenuates oxidative stress‑related neuronal apoptosis in scopolamine‑induced senescence in mice

Xue‑Qin Hou, Dian‑Wei Wu, Chun‑Xia Zhang, Rong Yan, Cong Yang, Cui‑Ping  Rong, Lei Zhang, Xiang Chang, Ru‑Yu Su, Shi‑Jie Zhang, Wen‑Qing  He, Zhao  Qu, Shi Li, Zi‑Ren Su, Yun‑Bo Chen, Qi Wang, Shu‑Huan Fang
Pages: 429-439
Published online on: 11 June 2014

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Article Open Access

Erythropoietin improves neurobehavior by reducing dopaminergic neuron loss in a 6‑hydroxydopamine‑induced rat model

Chen Qi, Mingxin Xu, Jing Gan, Xinxin Yang, Na Wu, Lu  Song, Weien Yuan, Zhenguo Liu
Pages: 440-450
Published online on: 17 June 2014

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Article Open Access

Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

Lei Jin, Jian Zhao, Wensen Jing, Shiju Yan, Xin Wang, Chun Xiao, Baoan Ma
Pages: 451-463
Published online on: 16 June 2014

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Article

A comparison of epidermal growth factor receptor mutation testing methods in different tissue types in non-small cell lung cancer

Suqin Yi, Yuan Zhuang, Jun Zhou, Haitao Ma, Jianan Huang, Lin  Wang, Weidong Zhu, Suya Kang, Linchuan Guo, Feng Guo
Pages: 464-474
Published online on: 28 May 2014

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Article

Expression of glucagon-like peptide-1 receptor and glucose‑dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells

Emina Aoyama, Ippei Watari, Katarzyna Anna Podyma-Inoue, Masaki Yanagishita, Takashi Ono
Pages: 475-482
Published online on: 27 May 2014

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Article

α-tubulin nuclear overexpression is an indicator of poor prognosis in patients with non-Hodgkin's lymphoma

Shinichi Hayashi, Tetsuo Mikami, Yoshihiro Murai, Yasuo Takano, Johji Imura
Pages: 483-490
Published online on: 04 June 2014

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Article

Characterization of microRNA expression in serous ovarian carcinoma

Yanhong Li, Li Yao, Fei Liu, Jia Hong, Lin Chen, Beilei Zhang, Wei Zhang
Pages: 491-498
Published online on: 17 June 2014

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Article

Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo

Linjie Si, Jing Xu, Chenlong Yi, Xiaohan Xu, Fang Wang, Weijuan Gu, Yuqing Zhang, Xiaowei Wang
Pages: 499-506
Published online on: 14 May 2014

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Article

The large intracellular loop of ptch1 mediates the non-canonical Hedgehog pathway through cyclin B1 in nevoid basal cell carcinoma syndrome

Fei-Yan Yu, Ying-Ying Hong, Jia-Fei Qu, Feng Chen, Tie-Jun Li
Pages: 507-512
Published online on: 16 May 2014

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Article

Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms

Mohamed-Salah I. Abaza, Abdul-Majeed Bahman, Raja'a J. Al-Attiyah
Pages: 513-532
Published online on: 04 June 2014

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Article

Osmotic stress decreases aquaporin-4 expression in the human retinal pigment epithelial cell line, ARPE-19

François Willermain, Sarah Janssens, Tatjana Arsenijevic, Isabelle Piens, Nargis Bolaky, Laure Caspers, Jason Perret, Christine Delporte
Pages: 533-538
Published online on: 29 May 2014

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Article

Functional analysis of the nuclear localization signal of the POU transcription factor Skn‑1a in epidermal keratinocytes

Ryuta Moritsugu, Katsuto Tamai, Hajime Nakano, Takayuki Aizu, Koji Nakajima, Takehiro Yamazaki, Daisuke Sawamura
Pages: 539-544
Published online on: 13 June 2014

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Article

Tougu Xiaotong capsule promotes chondrocyte autophagy by regulating the Atg12/LC3 conjugation systems

Xihai Li, Fayuan Liu, Wenna Liang, Hongzhi Ye, Huiting Li, Fangrong Yu, Jiashou Chen, Wenlie Chen, Ruhui Lin, Chunsong Zheng, Guangwen Wu, Huifeng Xu, Xianxiang Liu
Pages: 545-552
Published online on: 04 June 2014

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Article

Caffeine prevents human prion protein-mediated neurotoxicity through the induction of autophagy

Ji-Hong Moon, Ju-Hee Lee, Jin-Young Park, Sung-Wook Kim, You-Jin Lee, Seog‑Jin Kang, Jae-Won Seol, Dong-Choon Ahn, Sang-Youel Park
Pages: 553-558
Published online on: 18 June 2014

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Article

Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue

Susan Bae, Shuting Sun, Tara Aghaloo, Ju-Eun Oh, Charles E. McKenna, Mo K. Kang, Ki-Hyuk Shin, Sotirios Tetradis, No-Hee Park, Reuben H. Kim
Pages: 559-563
Published online on: 11 June 2014

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Article

Oxidized high-density lipoprotein impairs the function of human renal proximal tubule epithelial cells through CD36

Xiang Gao, Jianxiang Wu, Yixin Qian, Lili Fu, Guiqun  Wu, Chenggang Xu, Changlin Mei
Pages: 564-572
Published online on: 10 June 2014

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Article

Exome sequencing reveals CHM mutations in six families with atypical choroideremia initially diagnosed as retinitis pigmentosa

Shiqiang Li, Liping Guan, Shaohua Fang, Hui Jiang, Xueshan Xiao, Jianhua Yang, Panfeng Wang, Ye Yin, Xiangming Guo, Jun Wang, Jianguo Zhang, Qingjiong Zhang
Pages: 573-577
Published online on: 06 June 2014

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Article

Brain death induces the alteration of liver protein expression profiles in rabbits

Bing Du, Ling Li, Zhibiao Zhong, Xiaoli Fan, Bingbing Qiao, Chongxiang He, Zhen Fu, Yanfeng Wang, Qifa Ye
Pages: 578-584
Published online on: 16 June 2014

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Article

Transgelin overexpression in lung adenocarcinoma is associated with tumor progression

Xiaohong Wu, Liangliang Dong, Ruifeng Zhang, Kejing Ying, Huahao Shen
Pages: 585-591
Published online on: 16 June 2014

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Article

Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation

Kyung-Chan Kim, Eun-Ha Choi, Chuhee Lee
Pages: 592-598
Published online on: 13 June 2014

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Article

Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination

Yazhou Wang, Xingjun Wu, Yueping Zhong, Jianhong  Shen, Xinhua Wu, Shaoqing Ju, Xiaofei Wang
Pages: 599-605
Published online on: 02 June 2014

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Article

Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts

Michaël Beck, Marjan Moreels, Roel Quintens, Khalil Abou-El-Ardat, Hussein  El-Saghire, Kevin Tabury, Arlette Michaux, Ann Janssen, Mieke  Neefs, Patrick Van Oostveldt, Winnok H. De Vos, Sarah Baatout
Pages: 606-615
Published online on: 22 May 2014

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Article

shRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib

Shun-Quan Wu, Zhen-Zhen Xu, Wen-Yan Niu, Hao-Bo Huang, Rong Zhan
Pages: 616-623
Published online on: 06 June 2014

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Article

Mixtures of recombinant growth factors inhibit the production of pro-inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 cells by inactivating the ERK and NF-κB pathways

Yonghee Lee, Dohyun Lee, Kyotan Koo, Jay Lee, Yi Seop Song, Ho Sang Yoon, Yoo Mi Choi, Beom Joon Kim
Pages: 624-631
Published online on: 28 May 2014

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Article

β-catenin regulates NF-κB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide

Jaewoong Jang, Jong-Hyeok Ha, Sang-In Chung, Yoosik Yoon
Pages: 632-638
Published online on: 16 June 2014

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Article

The binding site for the transcription factor, NF-κB, on the cystathionine γ-lyase promoter is critical for LPS‑induced cystathionine γ-lyase expression

Maoxian Wang, Zhanyun Guo, Shilong Wang
Pages: 639-645
Published online on: 27 May 2014

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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