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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2014 Volume 34 Issue 4

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Review

Atherosclerosis and tumor suppressor molecules (Review)

  • Authors:
    • Miho Suzuki
    • Akari Minami
    • Atsuko Nakanishi
    • Keiko Kobayashi
    • Satoru Matsuda
    • Yasunori Ogura
    • Yasuko Kitagishi
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Nutrition, Nara Women's University, Nishimachi, Nara 630-8506, Japan
  • Pages: 934-940
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    Published online on: July 25, 2014
       https://doi.org/10.3892/ijmm.2014.1866
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Abstract

Atherosclerosis, the major cause of heart attack and stroke, is a chronic inflammatory disease characterized by the formation of atherosclerotic plaque. Oxidized low-density lipoprotein through increased oxidative stress has been identified as one of the primary factors responsible for atherogenesis. Cell proliferation and death are key processes in the progression of atherosclerosis. The oxidative environment in areas of lipid accumulation is mainly created by the production of reactive oxygen species, which are assumed to mediate vascular tissue injury. Oxidative DNA damage and levels of DNA repair are reduced during dietary lipid lowering. The tumor suppressor molecules play a pivotal role in regulating cell proliferation, DNA repair and cell death, which are important processes in regulating the composition of atherosclerotic plaque. Accordingly, in this review, we discuss the fundamental role of tumor suppressor molecules in regulating atherogenesis. In particular, we discuss how tumor suppressor molecules are activated in the complex environment of atherosclerotic plaque, and regulate growth arrest, cell senescence and the apoptosis of vascular smooth muscle cells, which may protect against the progression of atherosclerosis. In addition, we discuss promising alternatives to the use of medications (such as statin) against atherosclerosis, namely diet, with the use of plant-derived supplements to modulate the expression and/or activity of tumor suppressor molecules. We also summarize the progress of research made on herbs with a focus on the modulatory roles of tumor suppressors, and on the molecular mechanisms underlying the prevention if atherosclerosis, supporting designs for further research in this field.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki M, Minami A, Nakanishi A, Kobayashi K, Matsuda S, Ogura Y and Kitagishi Y: Atherosclerosis and tumor suppressor molecules (Review). Int J Mol Med 34: 934-940, 2014.
APA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., & Kitagishi, Y. (2014). Atherosclerosis and tumor suppressor molecules (Review). International Journal of Molecular Medicine, 34, 934-940. https://doi.org/10.3892/ijmm.2014.1866
MLA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34.4 (2014): 934-940.
Chicago
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34, no. 4 (2014): 934-940. https://doi.org/10.3892/ijmm.2014.1866
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki M, Minami A, Nakanishi A, Kobayashi K, Matsuda S, Ogura Y and Kitagishi Y: Atherosclerosis and tumor suppressor molecules (Review). Int J Mol Med 34: 934-940, 2014.
APA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., & Kitagishi, Y. (2014). Atherosclerosis and tumor suppressor molecules (Review). International Journal of Molecular Medicine, 34, 934-940. https://doi.org/10.3892/ijmm.2014.1866
MLA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34.4 (2014): 934-940.
Chicago
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34, no. 4 (2014): 934-940. https://doi.org/10.3892/ijmm.2014.1866
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