Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October 2014 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2014 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Stomach antral endocrine cells in patients with irritable bowel syndrome

  • Authors:
    • Magdy El-Salhy
    • Odd Helge Gilja
    • Jan Gunnar Hatlebakk
    • Trygve Hausken
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Stord, Norway, Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Copyright: © El-Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 967-974
    |
    Published online on: August 8, 2014
       https://doi.org/10.3892/ijmm.2014.1887
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

To the best of our knowledge, stomach antral endocrine cells have not previously been investigated in patients with irritable bowel syndrome (IBS). Thus, in the present study, 76 patients with IBS were examined (designated as IBS-total). Diarrhoea was the predominant symptom in 26 of these patients (IBS-D), while in 21 patients, the predominant symptoms were both diarrhoea and constipation (IBS-M) and in 29 patients the predominant symptom was constipation (IBS-C). Forty-three healthy subjects were enrolled as the controls. Stomach antral biopsy samples obtained from all of the subjects were immunostained using the avidin-biotin-complex method for serotonin, gastrin, somatostatin and serotonin transporter (SERT). The immunopositive cell densities and immunoreactivity intensities were determined by computer-aided image analysis. The density of the serotonin-immunoreactive cells was significantly decreased in the IBS-M patients and increased in the IBS-C patients relative to the controls. The immunoreactivity intensity did not differ significantly between the controls and IBS-total. The density of the gastrin-immunoreactive cells was significantly greater in the IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensity of gastrin was significantly greater in the IBS-D patients than in the controls. The density of the somatostatin-immunoreactive cells cells was significantly lower in the IBS-total, IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensities of both somatostatin and SERT did not differ significantly between the controls and IBS-total. The increase in gastrin cell density and the decrease in somatostatin cell density in all IBS subtypes may cause high levels of gastric secretion, which may in turn contribute to the high incidence of dyspepsia and gastro-oesophageal reflux observed in patients with IBS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Moran GW, Leslie FC, Levison SE, Worthington J and McLaughlin JT: Enteroendocrine cells: neglected players in gastrointestinal disorders? Therap Adv Gastroenterol. 1:51–60. 2008. View Article : Google Scholar : PubMed/NCBI

2 

El-Salhy M, Seim I, Chopin L, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: the role of gut neuroendocrine peptides. Front Biosci (Elite Ed). 4:2783–2800. 2012. View Article : Google Scholar : PubMed/NCBI

3 

El-Salhy M, Ostgaard H, Gundersen D, Hatlebakk JG and Hausken T: The role of diet in the pathogenesis and management of irritable bowel syndrome (Review). Int J Mol Med. 29:723–731. 2012.PubMed/NCBI

4 

El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: diagnosis, pathogenesis and treatment options. Nova Science Publishers Inc; New York: 2012

5 

Sternini C, Anselmi L and Rozengurt E: Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes. 15:73–78. 2008.

6 

Sternini C: Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol. 292:G457–G461. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Raybould HE: Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci. 153:41–46. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Raybould HE: Nutrient sensing in the gastrointestinal tract: possible role for nutrient transporters. J Physiol Biochem. 64:349–356. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Bertrand PP and Bertrand RL: Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci. 153:47–57. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Akiba Y and Kaunitz JD: Luminal chemosensing in the duodenal mucosa. Acta Physiol (Oxf). 201:77–84. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Steinert RE and Beglinger C: Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides. Physiol Behav. 105:62–70. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Nakamura E, Hasumura M, Uneyama H and Torii K: Luminal amino acid-sensing cells in gastric mucosa. Digestion. 83(Suppl 1): 13–18. 2011. View Article : Google Scholar

13 

Tolhurst G, Reimann F and Gribble FM: Intestinal sensing of nutrients. Handb Exp Pharmacol. 309–335. 2012. View Article : Google Scholar

14 

Mace OJ, Schindler M and Patel S: The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. J Physiol. 590:2917–2936. 2012. View Article : Google Scholar : PubMed/NCBI

15 

El-Salhy M, Lillebo E, Reinemo A and Salmelid L: Ghrelin in patients with irritable bowel syndrome. Int J Mol Med. 23:703–707. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Dizdar V, Spiller R, Singh G, et al: Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther. 31:883–891. 2010.PubMed/NCBI

17 

El-Salhy M, Vaali K, Dizdar V and Hausken T: Abnormal small-intestinal endocrine cells in patients with irritable bowel syndrome. Dig Dis Sci. 55:3508–3513. 2010. View Article : Google Scholar : PubMed/NCBI

18 

El-Salhy M, Gundersen D, Ostgaard H, Lomholt-Beck B, Hatlebakk JG and Hausken T: Low densities of serotonin and peptide YY cells in the colon of patients with irritable bowel syndrome. Dig Dis Sci. 57:873–878. 2012. View Article : Google Scholar : PubMed/NCBI

19 

El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Abnormal rectal endocrine cells in patients with irritable bowel syndrome. Regul Pept. 188:60–65. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Coates MD, Mahoney CR, Linden DR, et al: Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 126:1657–1664. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Wang SH, Dong L, Luo JY, et al: Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome. World J Gastroenterol. 13:6041–6047. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Lee KJ, Kim YB, Kim JH, Kwon HC, Kim DK and Cho SW: The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors. J Gastroenterol Hepatol. 23:1689–1694. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Park JH, Rhee PL, Kim G, et al: Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 18:539–546. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Kim HS, Lim JH, Park H and Lee SI: Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection: an observation in a small case control study. Yonsei Med J. 51:45–51. 2010.PubMed/NCBI

25 

Dunlop SP, Coleman NS, Blackshaw E, et al: Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol. 3:349–357. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Spiller RC, Jenkins D, Thornley JP, et al: Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 47:804–811. 2000. View Article : Google Scholar : PubMed/NCBI

27 

El-Salhy M, Lomholt-Beck B and Hausken T: Chromogranin A as a possible tool in the diagnosis of irritable bowel syndrome. Scand J Gastroenterol. 45:1435–1439. 2010. View Article : Google Scholar : PubMed/NCBI

28 

El-Salhy M, Mazzawi T, Gundersen D and Hausken T: Chromogranin A cell density in the rectum of patients with irritable bowel syndrome. Mol Med Rep. 6:1223–1225. 2012.PubMed/NCBI

29 

Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F and Spiller RC: Functional bowel disorders. Gastroenterology. 130:1480–1491. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Spiller R, Aziz Q, Creed F, et al: Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut. 56:1770–1798. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Roalfe AK, Roberts LM and Wilson S: Evaluation of the Birmingham IBS symptom questionnaire. BMC Gastroenterol. 8:302008. View Article : Google Scholar : PubMed/NCBI

32 

Talley NJ, Verlinden M and Jones M: Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Aliment Pharmacol Ther. 15:207–216. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Arslan G, Lind R, Olafsson S, Florvaag E and Berstad A: Quality of life in patients with subjective food hypersensitivity: applicability of the 10-item short form of the Nepean Dyspepsia Index. Dig Dis Sci. 49:680–687. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Patrick DL, Drossman DA, Frederick IO, DiCesare J and Puder KL: Quality of life in persons with irritable bowel syndrome: development and validation of a new measure. Dig Dis Sci. 43:400–411. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Drossman DA, Patrick DL, Whitehead WE, et al: Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire. Am J Gastroenterol. 95:999–1007. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Gershon MD and Tack J: The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 132:397–414. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Gershon MD: Plasticity in serotonin control mechanisms in the gut. Curr Opin Pharmacol. 3:600–607. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Gershon MD: 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes. 20:14–21. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Gershon MD: Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc. 123:268–280. 2012.PubMed/NCBI

40 

Camilleri M, Andrews CN, Bharucha AE, et al: Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. 132:17–25. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Camilleri M, Busciglio I, Carlson P, et al: Candidate genes and sensory functions in health and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 295:G219–G225. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Kumar S, Ranjan P, Mittal B and Ghoshal UC: Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls. J Gastrointestin Liver Dis. 21:31–38. 2012.PubMed/NCBI

43 

Park JM, Choi MG, Park JA, et al: Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil. 18:995–1000. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Saito YA, Locke GR III, Zimmerman JM, et al: A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil. 19:465–470. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Wendelbo I, Mazzawi T and El-Salhy M: Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Mol Med Rep. 9:180–184. 2013.PubMed/NCBI

46 

El-Salhy M, Wendelbo I and Gundersen D: Serotonin and serotonin transporter in the rectum of patients with irritable bowel disease. Mol Med Rep. 8:451–455. 2013.PubMed/NCBI

47 

Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 27:536–542. 2011. View Article : Google Scholar

48 

Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 26:598–603. 2010. View Article : Google Scholar

49 

Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 23:595–601. 2007. View Article : Google Scholar

50 

Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 18:639–649. 2002. View Article : Google Scholar

51 

Chu S and Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 28:587–593. 2012. View Article : Google Scholar

52 

Van Citters GW and Lin HC: Ileal brake: neuropeptidergic control of intestinal transit. Curr Gastroenterol Rep. 8:367–373. 2006.PubMed/NCBI

53 

Pourhoseingholi A, Vahedi M, Pourhoseingholi MA, et al: Irritable bowel syndrome, gastro-oesophageal reflux disease and dyspepsia: overlap analysis using loglinear models. Arab J Gastroenterol. 13:20–23. 2012. View Article : Google Scholar

54 

Kim HG, Lee KJ, Lim SG, Jung JY and Cho SW: G-protein beta3 subunit C825T polymorphism in patients with overlap syndrome of functional dyspepsia and irritable Bowel syndrome. J Neurogastroenterol Motil. 18:205–210. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Suzuki H and Hibi T: Overlap syndrome of functional dyspepsia and irritable bowel syndrome - are both diseases mutually exclusive? J Neurogastroenterol Motil. 17:360–365. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Nakajima S, Takahashi K, Sato J, et al: Spectra of functional gastrointestinal disorders diagnosed by Rome III integrative questionnaire in a Japanese outpatient office and the impact of overlapping. J Gastroenterol Hepatol. 25(Suppl 1): S138–S143. 2010. View Article : Google Scholar

57 

Olafsdottir LB, Gudjonsson H, Jonsdottir HH and Thjodleifsson B: Stability of the irritable bowel syndrome and subgroups as measured by three diagnostic criteria - a 10-year follow-up study. Aliment Pharmacol Ther. 32:670–680. 2010.PubMed/NCBI

58 

Kaji M, Fujiwara Y, Shiba M, et al: Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol. 25:1151–1156. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Noh YW, Jung HK, Kim SE and Jung SA: Overlap of erosive and non-erosive reflux diseases with functional gastrointestinal disorders according to rome III criteria. J Neurogastroenterol Motil. 16:148–156. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Hori K, Matsumoto T and Miwa H: Analysis of the gastrointestinal symptoms of uninvestigated dyspepsia and irritable bowel syndrome. Gut Liver. 3:192–196. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Ford AC, Marwaha A, Lim A and Moayyedi P: Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia. Clin Gastroenterol Hepatol. 8:401–409. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Wang LH, Fang XC and Pan GZ: Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut. 53:1096–1101. 2004. View Article : Google Scholar : PubMed/NCBI

63 

Dunlop SP, Jenkins D, Neal KR and Spiller RC: Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology. 125:1651–1659. 2003. View Article : Google Scholar : PubMed/NCBI

64 

El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG and Hausken T: Is irritable bowel syndrome an organic disorder? World J Gastroenterol. 2:384–400. 2014. View Article : Google Scholar

65 

El-Salhy M, Hatlebakk JG, Gilja OH and Hausken T: Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment. Expert Rev Gastroenterol Hepatol. 8:435–443. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
El-Salhy M, Gilja OH, Hatlebakk JG and Hausken T: Stomach antral endocrine cells in patients with irritable bowel syndrome. Int J Mol Med 34: 967-974, 2014.
APA
El-Salhy, M., Gilja, O.H., Hatlebakk, J.G., & Hausken, T. (2014). Stomach antral endocrine cells in patients with irritable bowel syndrome. International Journal of Molecular Medicine, 34, 967-974. https://doi.org/10.3892/ijmm.2014.1887
MLA
El-Salhy, M., Gilja, O. H., Hatlebakk, J. G., Hausken, T."Stomach antral endocrine cells in patients with irritable bowel syndrome". International Journal of Molecular Medicine 34.4 (2014): 967-974.
Chicago
El-Salhy, M., Gilja, O. H., Hatlebakk, J. G., Hausken, T."Stomach antral endocrine cells in patients with irritable bowel syndrome". International Journal of Molecular Medicine 34, no. 4 (2014): 967-974. https://doi.org/10.3892/ijmm.2014.1887
Copy and paste a formatted citation
x
Spandidos Publications style
El-Salhy M, Gilja OH, Hatlebakk JG and Hausken T: Stomach antral endocrine cells in patients with irritable bowel syndrome. Int J Mol Med 34: 967-974, 2014.
APA
El-Salhy, M., Gilja, O.H., Hatlebakk, J.G., & Hausken, T. (2014). Stomach antral endocrine cells in patients with irritable bowel syndrome. International Journal of Molecular Medicine, 34, 967-974. https://doi.org/10.3892/ijmm.2014.1887
MLA
El-Salhy, M., Gilja, O. H., Hatlebakk, J. G., Hausken, T."Stomach antral endocrine cells in patients with irritable bowel syndrome". International Journal of Molecular Medicine 34.4 (2014): 967-974.
Chicago
El-Salhy, M., Gilja, O. H., Hatlebakk, J. G., Hausken, T."Stomach antral endocrine cells in patients with irritable bowel syndrome". International Journal of Molecular Medicine 34, no. 4 (2014): 967-974. https://doi.org/10.3892/ijmm.2014.1887
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team