Open Access

Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy

  • Authors:
    • Hong-Min Zhou
    • Ming-Li Zhong
    • Yan-Fang Zhang
    • Wen-Yu Cui
    • Chao-Liang Long
    • Hai Wang
  • View Affiliations

  • Published online on: September 12, 2014     https://doi.org/10.3892/ijmm.2014.1931
  • Pages: 1209-1218
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Endothelial dysfunction can lead to congestive heart failure and the activation of endothelial ATP-sensitive potassium (KATP) channels may contribute to endothelial protection. Therefore, the present study was carried out to investigate the hypothesis that natakalim, a novel KATP channel opener, ameliorates post-infarction left ventricular remodeling and failure by correcting endothelial dysfunction. The effects of myocardial infarction were assessed 8 weeks following left anterior descending coronary artery occlusion in male Wistar rats. Depressed blood pressure, cardiac dysfunction, evidence of left ventricular remodeling and congestive heart failure were observed in the rats with myocardial infarction. Treatment with natakalim at daily oral doses of 1, 3 or 9 mg/kg/day for 8 weeks prevented these changes. Natakalim also prevented the progression to cardiac failure, which was demonstrated by the increase in right ventricular weight/body weight (RVW/BW) and relative lung weight, signs of cardiac dysfunction, as well as the overexpression of atrial and brain natriuretic peptide mRNAs. Our results also demonstrated that natakalim enhanced the downregulation of endothelium-derived nitric oxide, attenuated the upregulation of inducible nitric oxide synthase-derived nitric oxide (NO), inhibited the upregulated endothelin system and corrected the imbalance between prostacyclin and thromboxane A2. Overall, our findings suggest that natakalim prevents post-infarction hypertrophy and cardiac failure by restoring the coordinated balance between endothelial function and cardiac hypertrophy.
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November-2014
Volume 34 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhou H, Zhong M, Zhang Y, Cui W, Long C and Wang H: Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. Int J Mol Med 34: 1209-1218, 2014
APA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., & Wang, H. (2014). Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. International Journal of Molecular Medicine, 34, 1209-1218. https://doi.org/10.3892/ijmm.2014.1931
MLA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34.5 (2014): 1209-1218.
Chicago
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34, no. 5 (2014): 1209-1218. https://doi.org/10.3892/ijmm.2014.1931