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Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy

  • Authors:
    • Hong-Min Zhou
    • Ming-Li Zhong
    • Yan-Fang Zhang
    • Wen-Yu Cui
    • Chao-Liang Long
    • Hai Wang
  • View Affiliations / Copyright

    Affiliations: Cardiovascular Drug Research Center, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Beijing 100850, P.R. China, Cardiovascular Drug Research Center, Thadweik Academy of Medicine, Beijing 100039, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1209-1218
    |
    Published online on: September 12, 2014
       https://doi.org/10.3892/ijmm.2014.1931
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Abstract

Endothelial dysfunction can lead to congestive heart failure and the activation of endothelial ATP-sensitive potassium (KATP) channels may contribute to endothelial protection. Therefore, the present study was carried out to investigate the hypothesis that natakalim, a novel KATP channel opener, ameliorates post-infarction left ventricular remodeling and failure by correcting endothelial dysfunction. The effects of myocardial infarction were assessed 8 weeks following left anterior descending coronary artery occlusion in male Wistar rats. Depressed blood pressure, cardiac dysfunction, evidence of left ventricular remodeling and congestive heart failure were observed in the rats with myocardial infarction. Treatment with natakalim at daily oral doses of 1, 3 or 9 mg/kg/day for 8 weeks prevented these changes. Natakalim also prevented the progression to cardiac failure, which was demonstrated by the increase in right ventricular weight/body weight (RVW/BW) and relative lung weight, signs of cardiac dysfunction, as well as the overexpression of atrial and brain natriuretic peptide mRNAs. Our results also demonstrated that natakalim enhanced the downregulation of endothelium-derived nitric oxide, attenuated the upregulation of inducible nitric oxide synthase-derived nitric oxide (NO), inhibited the upregulated endothelin system and corrected the imbalance between prostacyclin and thromboxane A2. Overall, our findings suggest that natakalim prevents post-infarction hypertrophy and cardiac failure by restoring the coordinated balance between endothelial function and cardiac hypertrophy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Zhong M, Zhang Y, Cui W, Long C and Wang H: Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. Int J Mol Med 34: 1209-1218, 2014.
APA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., & Wang, H. (2014). Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. International Journal of Molecular Medicine, 34, 1209-1218. https://doi.org/10.3892/ijmm.2014.1931
MLA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34.5 (2014): 1209-1218.
Chicago
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34, no. 5 (2014): 1209-1218. https://doi.org/10.3892/ijmm.2014.1931
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Zhong M, Zhang Y, Cui W, Long C and Wang H: Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. Int J Mol Med 34: 1209-1218, 2014.
APA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., & Wang, H. (2014). Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy. International Journal of Molecular Medicine, 34, 1209-1218. https://doi.org/10.3892/ijmm.2014.1931
MLA
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34.5 (2014): 1209-1218.
Chicago
Zhou, H., Zhong, M., Zhang, Y., Cui, W., Long, C., Wang, H."Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy". International Journal of Molecular Medicine 34, no. 5 (2014): 1209-1218. https://doi.org/10.3892/ijmm.2014.1931
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