Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model

  • Authors:
    • Hyun-Jin An
    • Woo-Ram Lee
    • Kyung-Hyun Kim
    • Jung-Yeon Kim
    • Sun-Jae Lee
    • Sang-Mi Han
    • Kwang-Gill Lee
    • Chong-Kee Lee
    • Kwan-Kyu Park
  • View Affiliations

  • Published online on: September 12, 2014     https://doi.org/10.3892/ijmm.2014.1933
  • Pages: 1341-1348
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Abstract

Propionibacterium acnes (P. acnes) is a major contributing factor to the inflammatory component of acne. The many prescription medications for acne allow for a large number of potential combination treatments. However, several antibiotics, apart from their antibacterial effects, exert side‑effects, such as the suppression of host inflammatory responses. Purified bee venom (BV) is a natural toxin produced by honeybees (Apis mellifera L.). BV has been widely used as a traditional medicine for various diseases. In the present study, to investigate the therapeutic effects of BV against P. acnes-induced inflammatory skin disease, P. acnes was intradermally injected into the ears of mice. After the injection, BV was applied to the skin surface of the right ear. Histological observation revealed that P. acnes induced a considerable increase in the number of infiltrated inflammatory cells. However, treatment with BV markedly reduced these reactions compared with the P. acnes-injected mice not treated with BV. Moreover, the expression levels of tumor necrosis factor (TNF)-α, and interleukin (IL)-1β were significantly reduced in the BV-treated mice compared with the untreated P. acnes-injected mice. In addition, treatment with BV significantly inhibited Toll-like receptor (TLR)2 and CD14 expression in P. acnes-injected tissue. The binding activity of nuclear factor-κB (NF-κB) and activator protein (AP)-1 was markedly suppressed following treatment with BV. The results from our study, using an animal model, indicate that BV exerts an inhibitory effect on inflammatory skin diseases. In conclusion, our data indicate that BV has potential for use as an anti-acne agent and may be useful in the pharmaceutical and cosmetics industries.
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November-2014
Volume 34 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
An H, Lee W, Kim K, Kim J, Lee S, Han S, Lee K, Lee C and Park K: Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model. Int J Mol Med 34: 1341-1348, 2014
APA
An, H., Lee, W., Kim, K., Kim, J., Lee, S., Han, S. ... Park, K. (2014). Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model. International Journal of Molecular Medicine, 34, 1341-1348. https://doi.org/10.3892/ijmm.2014.1933
MLA
An, H., Lee, W., Kim, K., Kim, J., Lee, S., Han, S., Lee, K., Lee, C., Park, K."Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model". International Journal of Molecular Medicine 34.5 (2014): 1341-1348.
Chicago
An, H., Lee, W., Kim, K., Kim, J., Lee, S., Han, S., Lee, K., Lee, C., Park, K."Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model". International Journal of Molecular Medicine 34, no. 5 (2014): 1341-1348. https://doi.org/10.3892/ijmm.2014.1933