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Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis

  • Authors:
    • Ming-Wei Liu
    • Yun-Hui Wang
    • Chuan-Yun Qian
    • Hui Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650000, P.R. China, Surgical Intensive Care Unit, The Second Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1492-1504
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    Published online on: September 23, 2014
       https://doi.org/10.3892/ijmm.2014.1943
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Abstract

Xuebijing (XBJ) is a type of traditional Tibetan medicine, and previous pharmacological studies have shown that the ethanol extract is derived from Chuanxiong, Chishao, Danshen and Honghua. Chuanxiong, Chishao, Danshen and Honghua possesses potent anti-inflammatory activity, and has been used in the treatment of inflammatory infectious diseases. In the present study, we investigated the effects of XBJ on pulmonary permeability and lung injury in cecal ligation and puncture (CLP)‑induced sepsis in rats. A CLP sepsis model was established for the control and treatment groups, respectively. Approximately 2 h prior to surgery, an amount of 100 mg/kg XBJ injection was administered to the treatment group. Reverse transcription polymerase chain reaction (PT-PCR) and western blot analysis were used to examine the expression of Toll‑interacting protein (Tollip), interleukin-1 receptor-associated kinase 1 (IRAK1), Toll-like receptor 4 (TLR4), nuclear factor-κB65 (NF-κB65) and TNF receptor‑associated factor 6 (TRAF6) in lung tissue. ELISA was applied to detect changes of tumor necrosis factor-α (TNF‑α), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-4 (IL-4) and interleukin-10 (IL-10) levels in bronchoalveolar lavage (BAL) fluid, and intercellular adhesion molecule 1 (ICAM-1) and von wille­brand factor (vWF) in serum. The number of neutrophils, albumin and total cells in the BAL fluid were measured. For histological analysis, hematoxylin and eosin (H&E) stains were evaluated. Lung permeability, the wet/dry weight ratio (W/D) and the lung pathology score were determined following the induction of ALI by CLP for 24 h. The results demonstrated that XBJ upregulated Tollip expression and blocked the activity of IRAK1, TLR4, NF-κβ65 and TRAF6. Additionally, the number of neutrophils and total cells were significantly decreased in the XBJ group compared to that in the control group. Lung permeability, the wet/dry weight ratio (W/D) and the lung pathology score were significantly decreased in the XBJ group. The histological results also demonstrated the attenuation effect of XBJ on CLP-induced lung inflammation. The results of the present study indicated that XBJ has a significantly reduced CLP-induced lung permeability by upregulating Tollip expression. The protective effects of XBJ suggest its therapeutic potential in CLP‑induced acute lung injury treatment.
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View References

1 

Ware LB and Matthay MA: The acute respiratory distress syndrome. N Engl J Med. 342:1334–1349. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ and Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med. 353:1685–1693. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Berthiaume Y, Folkesson HG and Matthay MA: Lung edema clearance: 20 years of progress invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol. 93:2207–2213. 2002.PubMed/NCBI

4 

Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J and Volpe F: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2:346–351. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Yamakami M and Yokosawa H: Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways. Biol Pharm Bull. 27:564–566. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Yamakami M, Yoshimori T and Yokosawa H: Tom1, a VHS domain containing protein, interacts with Tollip, ubiquitin, and clathrin. J Biol Chem. 278:52865–52872. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H and Nakayama K: Tollip and Tom1 form a complex and recruit ubiquitin conjugated proteins onto early endosomes. J Biol Chem. 279:24435–24443. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Brissoni B, Agostini L, Kropf M, Martinon F, Swoboda Vl, et al: Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol. 16:2265–2270. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Zhang G and Ghosh S: Negative regulation of Toll-like receptor mediated signaling by Tollip. J Biol Chem. 277:7059–7065. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Capelluto DG: Tollip: a multitasking protein in innate immunity and protein trafficking. Microbes Infect. 14:140–147. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Sugi Y, Takahashi K, Nakano K, Hosono A and Kaminogawa S: Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1. Biochem Biophys Res Commun. 412:704–709. 2011. View Article : Google Scholar

12 

Sun ML, Ma DH, Liu M, Yu YX, Cao DB, Ma C, Wang X and Liu XL: Successful treatment of paraquat poisoning by Xuebijing, an injection concocted from multiple Chinese medicinal herbs: a case report. J Altern Complement Med. 15:1375–1378. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Celik S, Erdogan S and Tuzcu M: Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats. Pharmacol Res. 60:270–276. 2009. View Article : Google Scholar

14 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

15 

Kakkar P, Das B and Viswanathan PN: A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys. 21:130–132. 1984.PubMed/NCBI

16 

Rokicki W, Zalejska-Fiolka J, Mrukwa-Kominek E, Majewski W and Birkner E: Effect of selected dietary compounds on extracellular superoxide dismutase in the vitreous of chinchillas. Ophthalmic Res. 50:54–58. 2013. View Article : Google Scholar : PubMed/NCBI

17 

von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D’Alecy LG, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S and Sydow K: Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. Circulation. 124:2735–2745. 2011.

18 

Zhang B, Liu ZY, Li YY, Luo Y, Liu ML, Dong HY, Wang YX, Liu Y, Zhao PT, Jin FG and Li ZC: Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci. 44:573–579. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhang L, Luo N, Liu J, Duan Z, Du G, Cheng J, Lin H and Li Z: Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock. J Surg Res. 171:783–790. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Szapiel SV, Elson NA, Fulmer JD, Hunninghake GW and Crystal RG: Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis. 120:893–899. 1979.PubMed/NCBI

21 

Risøe PK, Ryg U, Wang YY, Rutkovskiy A, Smedsrød B, Valen G and Dahle MK: Cecal ligation and puncture sepsis is associated with attenuated expression of adenylyl cyclase 9 and increased miR142–3p. Shock. 36:390–395. 2011.PubMed/NCBI

22 

Li HF, Sun MG, Yu YX and Liu XL: Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation. Neural Regen Res. 6:2573–2576. 2011.

23 

Chen Y, Tong HS, Zhang XQ, Tang LQ, Pan ZG, Liu ZF, Duan PK and Su L: Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats. J Tradit Chin Med. 33:243–249. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Qi F, Liang ZX, She DY, Yan GT and Chen LA: A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients. J Tradit Chin Med. 31:46–49. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Shao M, Liu B, Wang JQ, Tao XG, Zhou SS, Jin K and Zhang CP: Effect of Xuebijing injection on T helper 17 and CD4+ CD25+ regulatory T cells in patients with sepsis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 23:430–434. 2011.(In Chinese).

26 

Sun J, Xue Q, Guo L, Cui L and Wang J: Xuebijing protects against lipopolysaccharide-induced lung injury in rabbits. Exp Lung Res. 36:211–218. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Zhou G, Kamenos G, Pendem S, Wilson JX and Wu F: Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis. Am J Physiol Regul Integr Comp Physiol. 302:R409–R416. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Nan YH, Park IS, Hahm KS and Shin SY: Antimicrobial activity, bactericidal mechanism and LPS-neutralizing activity of the cell-penetrating peptide pVEC and its analogs. J Pept Sci. 17:812–817. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Hukkanen RR, Liggitt HD, Murnane RD and Frevert CW: Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation. Toxicol Pathol. 37:799–804. 2009. View Article : Google Scholar

30 

Moncada-Pazos A, Obaya AJ, Llamazares M, Heljasvaara R, Suárez MF, Colado E, Noël A, Cal S and López-Otín C: ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem. 287:39554–39563. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ghosh S and Hayden MS: Newregulators of NF-κB in inflammation. Nat Rev Immunol. 8:837–848. 2008.

32 

Zhao D, Ding R, Mao Y, Wang L, Zhang Z and Ma X: Heparin rescues sepsis-associated acute lung injury and lethality through the suppression of inflammatory responses. Inflammation. 35:1825–1832. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ji MH, Zhu XL, Liu FF, Li GM, Tian M, Wu J, Fan YX, Li N and Yang JJ: Alpha 2A-adrenoreceptor blockade improves sepsis-induced acute lung injury accompanied with depressed high mobility group box-1 levels in rats. Cytokine. 60:639–645. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Li X, Zheng Z, Li X and Ma X: Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-κB activation on endothelial cell. Cytokine. 60:114–121. 2012.PubMed/NCBI

35 

Biswas A, Wilmanski J, Forsman H, Hrncir T, Hao L, Tlaskalova-Hogenova H and Kobayashi KS: Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur J Immunol. 41:182–194. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Ostuni R, Zanoni I and Granucci F: Deciphering the complexity of Toll-like receptor signaling. Cell Mol Life Sci. 67:4109–4134. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Liew FY, Xu D, Brint EK and O’Neill LA: Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol. 5:446–458. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Oshima N, Ishihara S, Rumi MAK, Aziz MM, Mishima Y, Kadota C, Moriyama I, Ishimura N, Amano Y and Kinoshita Y: A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol. 159:185–198. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR and Li X: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4:920–927. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R and Flavell RA: IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:191–202. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Bulut Y, Faure E, Thomas L, Equils O and Arditi M: Cooperation of toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein a lipoprotein: role of toll interacting protein and IL-1 receptor signaling molecules in toll-like receptor 2 signaling. J Immunol. 167:987–994. 2001.PubMed/NCBI

42 

Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R and Tschopp J: Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 197:263–268. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Neumann D, Lienenklaus S, Rosati O and Martin MU: IL-1β-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1. Eur J Immunol. 32:3689–3698. 2002.

44 

Shimizu K, Taniyama Y, Sanada F, Azuma J, Iwabayashi M, Iekushi K, Rakugi H and Morishita R: Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation. Arterioscler Thromb Vasc Biol. 32:2687–2693. 2012. View Article : Google Scholar

45 

Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N and Ware LB: Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax. 67:1032–1039. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Bedirli N, Demirtas CY, Akkaya T, Salman B, Alper M, Bedirli A and Pasaoglu H: Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation. J Surg Res. 178:e17–e23. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Yageta Y, Ishii Y, Morishima Y, Masuko H, Ano S, Yamadori T, Itoh K, Takeuchi K, Yamamoto M and Hizawa N: Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice. J Virol. 85:4679–4690. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Boutten A, Goven D, Boczkowski J and Bonay M: Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway. Expert Opin Ther Targets. 14:329–346. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Polack FP and Kleeberger SR: Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med. 179:138–150. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Jeong SJ, Han SH, Kim CO, Choi JY and Kim JM: Anti-vascular endothelial growth factor antibody attenuates inflammation and decreases mortality in an experimental model of severe sepsis. Crit Care. 17:R97–R98. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Qiu Y, Ferguson J, Oltean S, Neal CR, Kaura A, Bevan H, Wood E, Sage LM, Lanati S, Nowak DG, Salmon AH, Bates D and Harper SJ: Overexpression of VEGF165b in podocytes reduces glomerular permeability. J Am Soc Nephrol. 21:1498–1509. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Jezovnik MK and Poredos P: Idiopathic venous thrombosis is related to systemic inflammatory response and to increased levels of circulating markers of endothelial dysfunction. Int Angiol. 29:226–231. 2010.PubMed/NCBI

53 

Hack CE and Zeerleder S: The endothelium in sepsis: source of and a target for inflammation. Crit Care Med. 29:S21–S27. 2001.PubMed/NCBI

54 

Reinhart K, Bayer O, Brunkhorst F and Meisner M: Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med. 30:S302–S312. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL and Schally AV: Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. Am J Physiol Renal Physiol. 303:F1026–F1036. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu M, Wang Y, Qian C and Li H: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. Int J Mol Med 34: 1492-1504, 2014.
APA
Liu, M., Wang, Y., Qian, C., & Li, H. (2014). Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. International Journal of Molecular Medicine, 34, 1492-1504. https://doi.org/10.3892/ijmm.2014.1943
MLA
Liu, M., Wang, Y., Qian, C., Li, H."Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis". International Journal of Molecular Medicine 34.6 (2014): 1492-1504.
Chicago
Liu, M., Wang, Y., Qian, C., Li, H."Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis". International Journal of Molecular Medicine 34, no. 6 (2014): 1492-1504. https://doi.org/10.3892/ijmm.2014.1943
Copy and paste a formatted citation
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Spandidos Publications style
Liu M, Wang Y, Qian C and Li H: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. Int J Mol Med 34: 1492-1504, 2014.
APA
Liu, M., Wang, Y., Qian, C., & Li, H. (2014). Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. International Journal of Molecular Medicine, 34, 1492-1504. https://doi.org/10.3892/ijmm.2014.1943
MLA
Liu, M., Wang, Y., Qian, C., Li, H."Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis". International Journal of Molecular Medicine 34.6 (2014): 1492-1504.
Chicago
Liu, M., Wang, Y., Qian, C., Li, H."Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis". International Journal of Molecular Medicine 34, no. 6 (2014): 1492-1504. https://doi.org/10.3892/ijmm.2014.1943
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