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Article

Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke

  • Authors:
    • Zhiguo Pan
    • Yu Shao
    • Wenpeng Dong
    • Chenxi Liu
    • Yi  Chen
    • Hui Jin
    • Liqun Tang
    • Junming Qiu
    • Lei Su
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China, Department of Overseas Chinese, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China, Department of Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China, Information Center, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China
  • Pages: 1699-1705
    |
    Published online on: September 29, 2014
       https://doi.org/10.3892/ijmm.2014.1950
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Abstract

In our previous study, we demonstrated that Xuebijing (XBJ), a traditional Chinese medicine, attenuates hypotension in rats suffering from heatstroke (HS). However, the underlying mechanisms have not yet been fully elucidated. Thus, the current study was carried out to investigate the mechanisms underlying the effects of XBJ on hypotension n rats suffering from HS. For this purpose, 72 anesthetized rats were randomized into 3 groups and intravenously injected twice daily for 3 days with XBJ (4 ml/kg body weight, XBJ group) or phosphate‑buffered saline (PBS) (HS and sham-operated groups). Models of HS were established in the HS and XBJ groups by placing the rats in a simulated climate chamber with a temperature of 40˚C and a humidity of 60%. Rectal temperature, arterial pressure and heart rate were monitored and recorded. Angiotensin Ⅱ (Ang Ⅱ) levels were increased during HS (shown by ELISA), and XBJ had no apparent effect on Ang Ⅱ levels. The levels of Ang Ⅱ type 1 (AT1) receptor surface expression and AT1 receptor‑associated protein 1 (Arap1) were decreased during HS; however, these effects were attenuated by pre-treatment with XBJ (shown by RT-qPCR and western blot analysis). For in vitro experiments, rat macrophages pre-treated with XBJ were stimulated with lipopolysaccharide (LPS). Pre-treatment with XBJ induced a marked inhibitory effect on the release of pro-inflammatory cytokines in the LPS‑stimulated macrophages. Furthermore, XBJ inhibited the activation of nuclear factor κB (NF‑κB) induced by LPS in the macrophages. Taken together, our data demonstrate that XBJ promotes Arap1 expression by inhibiting the activation of the NF‑κB signaling pathway and the release of pro-inflammatory cytokines, which may be the molecular mechanisms through which XBJ alleviates blood pressure reduction in rats suffering from HS.
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1 

Knochel JP: Disorders due to heat and cold. Textbook of Medicine. Wyngaarden JB and Smith LH: Saunders; Philadelphia: pp. 2304–2306. 1985

2 

Semenza JC, Rubin CH, Falter KH, et al: Heat-related deaths during the July 1995 heat wave in Chicago. N Engl J Med. 335:84–90. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Robine JM, Cheung SL, Le Roy S, et al: Death toll exceeded 70,000 in Europe during the summer of 2003. C R Biol. 331:171–178. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Leon LR, Blaha MD and DuBose DA: Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery. J Appl Physiol (1985). 100:1400–1409. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Lu KC, Wang JY, Lin SH, Chu P and Lin YF: Role of circulating cytokines and chemokines in exertional heatstroke. Crit Care Med. 32:399–403. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Bouchama A, Ollivier V, Roberts G, et al: Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock. 24:332–335. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Bouchama A, Hammami MM, Al Shail E and De Vol E: Differential effects of in vitro and in vivo hyperthermia on the production of interleukin-10. Intensive Care Med. 26:1646–1651. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Bouchama A, al-Sedairy S, Siddiqui S, Shail E and Rezeig M: Elevated pyrogenic cytokines in heatstroke. Chest. 104:1498–1502. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Hammami MM, Bouchama A, Al-Sedairy S, et al: Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heatstress. Crit Care Med. 25:1314–1319. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Hashim IA, Al-Zeer A, Al-Shohaib S, Al-Ahwal M and Shenkin A: Cytokine changes in patients with heatstroke during pilgrimage to Makkah. Mediators Inflamm. 6:135–139. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002. View Article : Google Scholar

12 

Bouchama A, Roberts G, Al Mohanna F, et al: Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol (1985). 98:697–705. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Lin MT, Kao TY, Jin YT and Chen CF: Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Res Bull. 37:595–598. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Lin MT, Liu HH and Yang YL: Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke. Am J Physiol. 273:H2072–H2077. 1997.PubMed/NCBI

15 

Cumming AD, Driedger AA, McDonald JW, et al: Vasoactive hormones in the renal response to systemic sepsis. Am J Kidney Dis. 11:23–32. 1988. View Article : Google Scholar : PubMed/NCBI

16 

Hilgenfeldt U, Kienapfel G, Kellermann W, Schott R and Schmidt M: Renin-angiotensin system in sepsis. Clin Exp Hypertens A. 9:1493–1504. 1987. View Article : Google Scholar

17 

Benedict CR and Rose JA: Arterial norepinephrine changes in patients with septic shock. Circ Shock. 38:165–172. 1992.PubMed/NCBI

18 

Castrop H: Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system. Pflugers Arch. 465:111–119. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Kai H, Griendling KK, Lassègue B, et al: Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor. Hypertension. 24:523–527. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Guo DF, Chenier I, Tardif V, Orlov SN and Inagami T: Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Biochem Biophys Res Commun. 310:1254–1265. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Doblinger E, Höcherl K, Mederle K, et al: Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. Am J Physiol Renal Physiol. 302:F1313–F1324. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Mederle K, Schweda F, Kattler V, et al: The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension. Crit Care. 17:R1302013. View Article : Google Scholar : PubMed/NCBI

23 

Chen Y, Tong H, Zhang X, et al: Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats. J Tradit Chin Med. 33:243–249. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Jiang M, Zhou M, Han Y, et al: Identification of NF-κB inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF. J Ethnopharmacol. 147:426–433. 2013.

25 

Chen SH, Chang FM, Niu KC, Lin MY and Lin MT: Resuscitation from experimental heatstroke by estrogen therapy. Crit Care Med. 34:1113–1118. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Chen CM, Hou CC, Cheng KC, et al: Activated protein C therapy in a rat heat stroke model. Crit Care Med. 34:1960–1966. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta (CT)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Ohtani R, Ohashi Y, Muranaga K, Itoh N and Okamoto H: Changes in activity of the renin-angiotensin system of the rat by induction of acute inflammation. Life Sci. 44:237–241. 1989. View Article : Google Scholar : PubMed/NCBI

29 

Rodriguez-Fernandez M, Grosman B, Yuraszeck TM, et al: Modeling the intra- and extracellular cytokine signaling pathway under heat stroke in the liver. PLoS One. 8:e733932013. View Article : Google Scholar : PubMed/NCBI

30 

Gilmore TD: Introduction to NF-kappaB: players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Watanabe T, Miyoshi M and Imoto T: Angiotensin II: its effects on fever and hypothermia in systemic inflammation. Front Biosci. 9:438–447. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Paradis P, Dali-Youcef N, Paradis FW, Thibault G and Nemer M: Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci USA. 97:931–936. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Hall JE: Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation. Am J Physiol. 250:R960–R972. 1986.PubMed/NCBI

34 

Hall JE and Granger JP: Adenosine alters glomerular filtration control by angiotensin II. Am J Physiol. 250:F917–F923. 1986.PubMed/NCBI

35 

Hunyady L, Catt KJ, Clark AJ and Gáborik Z: Mechanisms and functions of AT(1) angiotensin receptor internalization. Regul Pept. 91:29–44. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Gaborik Z, Szaszák M, Szidonya L, et al: Beta-arrestin- and dynamin-dependent endocytosis of the AT1 angiotensin receptor. Mol Pharmacol. 59:239–247. 2001.PubMed/NCBI

37 

Perry SJ and Lefkowitz RJ: Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol. 12:130–138. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ and Luttrell LM: beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem. 277:9429–9436. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Smith RD, Baukal AJ, Zolyomi A, et al: Agonist-induced phosphorylation of the endogenous AT1 angiotensin receptor in bovine adrenal glomerulosa cells. Mol Endocrinol. 12:634–644. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Smith RD, Hunyady L, Olivares-Reyes JA, et al: Agonist-induced phosphorylation of the angiotensin AT1a receptor is localized to a serine/threonine-rich region of its cytoplasmic tail. Mol Pharmacol. 54:935–941. 1998.PubMed/NCBI

41 

Conchon S, Peltier N, Corvol P and Clauser E: A noninternalized nondesensitized truncated AT1A receptor transduces an amplified ANG II signal. Am J Physiol. 274:E336–E345. 1998.PubMed/NCBI

42 

Hunyady L, Bor M, Balla T and Catt KJ: Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor. J Biol Chem. 269:31378–31382. 1994.PubMed/NCBI

43 

Tang H, Guo DF, Porter JP, Wanaka Y and Inagami T: Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. Circ Res. 82:523–531. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Hagiwara S, Iwasaka H, Matumoto S, Hidaka S and Noguchi T: Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models. Crit Care Med. 37:626–633. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Ghosh S and Hayden MS: New regulators of NF-kappaB in inflammation. Nat Rev Immunol. 8:837–848. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Watters TM, Kenny EF and O’Neill LA: Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol. 85:411–419. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Li T: Avoiding adverse drug reactions to Chinese medicine injections. J Evid Based Med. 3:44–49. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Pan Z, Shao Y, Dong W, Liu C, Chen Y, Jin H, Tang L, Qiu J and Su L: Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke. Int J Mol Med 34: 1699-1705, 2014.
APA
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H. ... Su, L. (2014). Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke. International Journal of Molecular Medicine, 34, 1699-1705. https://doi.org/10.3892/ijmm.2014.1950
MLA
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H., Tang, L., Qiu, J., Su, L."Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke". International Journal of Molecular Medicine 34.6 (2014): 1699-1705.
Chicago
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H., Tang, L., Qiu, J., Su, L."Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke". International Journal of Molecular Medicine 34, no. 6 (2014): 1699-1705. https://doi.org/10.3892/ijmm.2014.1950
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Shao Y, Dong W, Liu C, Chen Y, Jin H, Tang L, Qiu J and Su L: Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke. Int J Mol Med 34: 1699-1705, 2014.
APA
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H. ... Su, L. (2014). Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke. International Journal of Molecular Medicine, 34, 1699-1705. https://doi.org/10.3892/ijmm.2014.1950
MLA
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H., Tang, L., Qiu, J., Su, L."Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke". International Journal of Molecular Medicine 34.6 (2014): 1699-1705.
Chicago
Pan, Z., Shao, Y., Dong, W., Liu, C., Chen, Y., Jin, H., Tang, L., Qiu, J., Su, L."Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor‑associated protein 1 in rats suffering from heat stroke". International Journal of Molecular Medicine 34, no. 6 (2014): 1699-1705. https://doi.org/10.3892/ijmm.2014.1950
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