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Article

Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway

  • Authors:
    • Dong Hwan Kim
    • Woo‑Sung Jung
    • Mi Eun Kim
    • Hee‑Woo Lee
    • Hwa‑Young Youn
    • Jong Keun Seon
    • Haeng‑Nam Lee
    • Jun Sik Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Immunology Research Lab, BK21‑plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University, Gwangju 501‑759, Republic of Korea, Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151‑742, Republic of Korea, Center for Joint Disease, Chonnam National University Hwasun Hospital, Hwasun‑eup, Hwasun‑gun, Jeollanam‑do 519‑809, Republic of Korea, Department of Mechanical Engineering, College of Engineering, Chosun University, Gwangju 501‑759, Republic of Korea
  • Pages: 1669-1674
    |
    Published online on: October 2, 2014
       https://doi.org/10.3892/ijmm.2014.1956
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Abstract

Anaphylaxis is a rapidly occurring allergic reaction to any foreign substance, including venom from insects, foods and medications, which may cause fatalities. To prevent anaphylaxis, these triggers must be avoided. However, avoidance of numerous triggers is difficult. For this reason, the development of immunotherapeutic adjuvants that suppress the allergic response is important for anaphylaxis control. Mast cells are one of the major inflammatory cells involved in the inflammatory response, which secrete several inflammatory cytokines, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, and IL‑1β, and recruits other immune cells. Mast cells are also involved in a number of diseases, such as sinusitis, rheumatoid arthritis and asthma. Genistein, a phytoestrogen, has been reported to have anti‑oxidative and anti‑inflammatory activities. However, the effects of genistein on the anti‑inflammatory response of mast cells remain unknown. In the present study, the anti‑inflammatory effects of genistein on mast cells were investigated. Genistein significantly decreased IL‑6 and IL‑1β mRNA levels, as well as IL‑6 production in PMA/A23187‑induced mast cells activation. In addition, genistein inhibited the phosphorylation of ERK 1/2 in PMA/A23187‑induced mast cell activation. However, phosphorylation of p38 was not altered. Thus, these findings indicate that genistein inhibited the inflammatory status of mast cells through inhibition of the ERK pathway.
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1 

Metcalfe DD, Peavy RD and Gilfillan AM: Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol. 124:639–646. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Oskeritzian CA, Price MM, Hait NC, et al: Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med. 207:465–474. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Worm M: Epidemiology of anaphylaxis. Chem Immunol Allergy. 95:12–21. 2010. View Article : Google Scholar

4 

Boden SR and Wesley Burks A: Anaphylaxis: a history with emphasis on food allergy. Immunol Rev. 242:247–257. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Lee JK and Vadas P: Anaphylaxis: mechanisms and management. Clin Exp Allergy. 41:923–938. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Simons FE: World Allergy Organization survey on global availability of essentials for the assessment and management of anaphylaxis by allergy-immunology specialists in health care settings. Ann Allergy Asthma Immunol. 104:405–412. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Simons FE: Anaphylaxis: recent advances in assessment and treatment. J Allergy Clin Immunol. 124:625–636. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhang B, Alysandratos KD, Angelidou A, et al: Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis. J Allergy Clin Immunol. 127:1522–1531. 2011. View Article : Google Scholar

9 

Tchougounova E, Pejler G and Abrink M: The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J Exp Med. 198:423–431. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Lee S, Park HH, Son HY, et al: DA-9601 inhibits activation of the human mast cell line HMC-1 through inhibition of NF-κB. Cell Biol Toxicol. 23:105–112. 2007.PubMed/NCBI

11 

Shin J, Pan H and Zhong XP: Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood. 119:3306–3314. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kalesnikoff J and Galli SJ: New developments in mast cell biology. Nat Immunol. 9:1215–1223. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Guma M, Kashiwakura J, Crain B, et al: JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis. Proc Natl Acad Sci USA. 107:22122–22127. 2010.PubMed/NCBI

14 

Lu Y, Piao D, Zhang H, et al: Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcɛRI-mediated mast cells. Food Chem Toxicol. 59:696–702. 2013.PubMed/NCBI

15 

Lee J and Lim KT: Expression of TNF-α and IL-6 in HMC-1 cells treated with bisphenol A is attenuated by plant-originating glycoprotein (75 kDa) by blocking p38 MAPK. Naunyn Schmiedebergs Arch Pharmacol. 382:51–61. 2010.

16 

Masilamani M, Wei J, Bhatt S, Paul M, Yakir S and Sampson HA: Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut. J Allergy Clin Immunol. 128:1242–1250. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Dixon RA and Ferreira D: Genistein. Phytochemistry. 60:205–211. 2002. View Article : Google Scholar

18 

Kitaura J, Asai K, Maeda-Yamamoto M, Kawakami Y, Kikkawa U and Kawakami T: Akt-dependent cytokine production in mast cells. J Exp Med. 192:729–740. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Frey RS and Singletary KW: Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells. J Nutr. 133:226–231. 2003.

20 

Zhao JH, Arao Y, Sun SJ, Kikuchi A and Kayama F: Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. Life Sci. 78:812–819. 2006. View Article : Google Scholar

21 

Palanisamy N, Kannappan S and Anuradha CV: Genistein modulates NF-κB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats. Eur J Pharmacol. 667:355–364. 2011.

22 

Woolley DE and Tetlow LC: Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion. Arthritis Res. 2:65–74. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Conti P, Kempuraj D, Di Gioacchino M, et al: Interleukin-6 and mast cells. Allergy Asthma Proc. 23:331–335. 2002.

24 

de Bittencourt Pasquali MA, Gelain DP, Zeidan-Chulia F, et al: Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-κB in human lung cancer A549 cells. Cell Signal. 25:939–954. 2013.PubMed/NCBI

25 

Pullen NA, Barnstein BO, Falanga YT, et al: Novel mechanism for FcɛRI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. J Biol Chem. 287:2045–2054. 2012.

26 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Resendez E Jr, Ting J, Kim KS, Wooden SK and Lee AS: Calcium ionophore A23187 as a regulator of gene expression in mammalian cells. J Cell Biol. 103:2145–2152. 1986. View Article : Google Scholar : PubMed/NCBI

28 

Kim SJ, Kim YJ, Lee JH, et al: Genistein-4′-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside from Sophora japonica (Leguminosae) ameliorates mast cell-mediated allergic inflammation in vivo and in vitro. Orient Pharm Exp Med. 11:207–213. 2011.

29 

Gao F, Wei D, Bian T, et al: Genistein attenuated allergic airway inflammation by modulating the transcription factors T-bet, GATA-3 and STAT-6 in a murine model of asthma. Pharmacology. 89:229–236. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Yu SC and Li XY: Effect of ginsenoside on IL-1β and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. Acta Pharmacol Sin. 21:915–918. 2000.

31 

Ganeshan K, Johnston LK and Bryce PJ: TGF-β1 limits the onset of innate lung inflammation by promoting mast cell-derived IL-6. J Immunol. 190:5731–5738. 2013.

32 

Ganeshan K and Bryce PJ: Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-β. J Immunol. 188:594–603. 2012.PubMed/NCBI

33 

Blackwell TS, Blackwell TR and Christman JW: Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J Immunol. 158:5934–5940. 1997.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim DH, Jung WS, Kim ME, Lee HW, Youn HY, Seon JK, Lee HN and Lee JS: Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. Int J Mol Med 34: 1669-1674, 2014.
APA
Kim, D.H., Jung, W., Kim, M.E., Lee, H., Youn, H., Seon, J.K. ... Lee, J.S. (2014). Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. International Journal of Molecular Medicine, 34, 1669-1674. https://doi.org/10.3892/ijmm.2014.1956
MLA
Kim, D. H., Jung, W., Kim, M. E., Lee, H., Youn, H., Seon, J. K., Lee, H., Lee, J. S."Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway". International Journal of Molecular Medicine 34.6 (2014): 1669-1674.
Chicago
Kim, D. H., Jung, W., Kim, M. E., Lee, H., Youn, H., Seon, J. K., Lee, H., Lee, J. S."Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway". International Journal of Molecular Medicine 34, no. 6 (2014): 1669-1674. https://doi.org/10.3892/ijmm.2014.1956
Copy and paste a formatted citation
x
Spandidos Publications style
Kim DH, Jung WS, Kim ME, Lee HW, Youn HY, Seon JK, Lee HN and Lee JS: Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. Int J Mol Med 34: 1669-1674, 2014.
APA
Kim, D.H., Jung, W., Kim, M.E., Lee, H., Youn, H., Seon, J.K. ... Lee, J.S. (2014). Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. International Journal of Molecular Medicine, 34, 1669-1674. https://doi.org/10.3892/ijmm.2014.1956
MLA
Kim, D. H., Jung, W., Kim, M. E., Lee, H., Youn, H., Seon, J. K., Lee, H., Lee, J. S."Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway". International Journal of Molecular Medicine 34.6 (2014): 1669-1674.
Chicago
Kim, D. H., Jung, W., Kim, M. E., Lee, H., Youn, H., Seon, J. K., Lee, H., Lee, J. S."Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway". International Journal of Molecular Medicine 34, no. 6 (2014): 1669-1674. https://doi.org/10.3892/ijmm.2014.1956
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