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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December-2014 Volume 34 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia

  • Authors:
    • Hyeng-Soo Kim
    • Ga Young Lim
    • Junmo Hwang
    • Zae Young Ryoo
    • Tae-Lin Huh
    • Sanggyu Lee
  • View Affiliations / Copyright

    Affiliations: School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 702-701, Republic of Korea
  • Pages: 1675-1680
    |
    Published online on: October 2, 2014
       https://doi.org/10.3892/ijmm.2014.1957
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Abstract

Obovatol, a compound isolated from the bark cortex of Magnolia officinalis (cortex Magnoliae officinalis; M. officinalis), has been studied for use in the treatment of solid cancers. However, the mechanisms of action and the effects of obovatol against acute myeloid leukemia (AML) remain unclear and require further investigation. Therefore, this study was conducted using a human AML cell line (MM6). Obovatol increased pro-apoptotic (Bax) and decreased anti-apoptotic (Bcl-2) protein expression, resulting in caspase-3 and caspase-9 activation measured by caspase-Glo 3/7 assay. Furthermore, obovatol activated the mitogen-activated protein kinase (MAPK) signaling pathway [c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38] and inhibited the activation of the nuclear factor-κB (NF-κB) signaling pathway analyzed by western blot analysis. Taken together, these findings provide evidence that obovatol inhibits cell proliferation in AML and induces apoptosis through the activation of the MAPK pathway in addition to the intrinsic apoptotic pathway. In addition, obovatol suppressed the expression of mixed-lineage leukemia (MLL) target genes by inhibiting the activation of the NF-κB pathway. Therefore, these results suggest that obovatol may have potential for use in the treatment of leukemia.
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Copy and paste a formatted citation
Spandidos Publications style
Kim H, Lim GY, Hwang J, Ryoo ZY, Huh T and Lee S: Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia. Int J Mol Med 34: 1675-1680, 2014.
APA
Kim, H., Lim, G.Y., Hwang, J., Ryoo, Z.Y., Huh, T., & Lee, S. (2014). Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia. International Journal of Molecular Medicine, 34, 1675-1680. https://doi.org/10.3892/ijmm.2014.1957
MLA
Kim, H., Lim, G. Y., Hwang, J., Ryoo, Z. Y., Huh, T., Lee, S."Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia". International Journal of Molecular Medicine 34.6 (2014): 1675-1680.
Chicago
Kim, H., Lim, G. Y., Hwang, J., Ryoo, Z. Y., Huh, T., Lee, S."Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia". International Journal of Molecular Medicine 34, no. 6 (2014): 1675-1680. https://doi.org/10.3892/ijmm.2014.1957
Copy and paste a formatted citation
x
Spandidos Publications style
Kim H, Lim GY, Hwang J, Ryoo ZY, Huh T and Lee S: Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia. Int J Mol Med 34: 1675-1680, 2014.
APA
Kim, H., Lim, G.Y., Hwang, J., Ryoo, Z.Y., Huh, T., & Lee, S. (2014). Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia. International Journal of Molecular Medicine, 34, 1675-1680. https://doi.org/10.3892/ijmm.2014.1957
MLA
Kim, H., Lim, G. Y., Hwang, J., Ryoo, Z. Y., Huh, T., Lee, S."Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia". International Journal of Molecular Medicine 34.6 (2014): 1675-1680.
Chicago
Kim, H., Lim, G. Y., Hwang, J., Ryoo, Z. Y., Huh, T., Lee, S."Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia". International Journal of Molecular Medicine 34, no. 6 (2014): 1675-1680. https://doi.org/10.3892/ijmm.2014.1957
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