1
|
Salk JJ, Bansal A, Lai LA, et al: Clonal
expansions and short telomeres are associated with neoplasia in
early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel
Dis. 19:2593–2602. 2013. View Article : Google Scholar : PubMed/NCBI
|
2
|
Willenbucher RF, Aust DE, Chang CG, et al:
Genomic instability is an early event during the progression
pathway of ulcerative-colitis-related neoplasia. Am J Pathol.
154:1825–1830. 1999. View Article : Google Scholar : PubMed/NCBI
|
3
|
Rubin CE, Haggitt RC, Burmer GC, et al:
DNA aneuploidy in colonic biopsies predicts future development of
dysplasia in ulcerative colitis. Gastroenterology. 103:1611–1620.
1992.PubMed/NCBI
|
4
|
Rabinovitch PS, Dziadon S, Brentnall TA,
et al: Pancolonic chromosomal instability precedes dysplasia and
cancer in ulcerative colitis. Cancer Res. 59:5148–5153.
1999.PubMed/NCBI
|
5
|
Hammarberg C, Slezak P and Tribukait B:
Early detection of malignancy in ulcerative colitis. A
flow-cytometric DNA study. Cancer. 53:291–295. 1984. View Article : Google Scholar : PubMed/NCBI
|
6
|
Fozard JB, Quirke P, Dixon MF, Giles GR
and Bird CC: DNA aneuploidy in ulcerative colitis. Gut.
27:1414–1418. 1986. View Article : Google Scholar : PubMed/NCBI
|
7
|
Meling GI, Clausen OP, Bergan A,
Schjølberg A and Rognum TO: Flow cytometric DNA ploidy pattern in
dysplastic mucosa, and in primary and metastatic carcinomas in
patients with longstanding ulcerative colitis. Br J Cancer.
64:339–344. 1991. View Article : Google Scholar : PubMed/NCBI
|
8
|
Meyer KF, Nause SL, Freitag-Wolf S, et al:
Aneuploidy characterizes adjacent non-malignant mucosa of
ulcerative colitis-associated but not sporadic colorectal
carcinomas: a matched-pair analysis. Scand J Gastroenterol.
48:679–687. 2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Gerling M, Meyer KF, Fuchs K, et al: High
frequency of aneuploidy defines ulcerative colitis-associated
carcinomas: a comparative prognostic study to sporadic colorectal
carcinomas. Ann Surg. 252:74–83. 2010. View Article : Google Scholar
|
10
|
Gerling M, Nousiainen K, Hautaniemi S, et
al: Aneuploidy-associated gene expression signatures characterize
malignant transformation in ulcerative colitis. Inflamm Bowel Dis.
19:691–703. 2013. View Article : Google Scholar : PubMed/NCBI
|
11
|
Lengauer C, Kinzler KW and Vogelstein B:
Genetic instabilities in human cancers. Nature. 396:643–649. 1998.
View Article : Google Scholar
|
12
|
Davoli T and de Lange T: The causes and
consequences of polyploidy in normal development and cancer. Annu
Rev Cell Dev Biol. 27:585–610. 2011. View Article : Google Scholar : PubMed/NCBI
|
13
|
Londoño-Vallejo JA: Telomere instability
and cancer. Biochimie. 90:73–82. 2008. View Article : Google Scholar
|
14
|
Cheung AL and Deng W: Telomere
dysfunction, genome instability and cancer. Front Biosci.
13:2075–2090. 2008. View
Article : Google Scholar
|
15
|
Kong CM, Lee XW and Wang X: Telomere
shortening in human diseases. FEBS J. 280:3180–3193. 2013.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Kops GJ, Weaver BA and Cleveland DW: On
the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev
Cancer. 5:773–785. 2005. View
Article : Google Scholar : PubMed/NCBI
|
17
|
Bharadwaj R and Yu H: The spindle
checkpoint, aneuploidy, and cancer. Oncogene. 23:2016–2027. 2004.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Musacchio A and Salmon ED: The
spindle-assembly checkpoint in space and time. Nat Rev Mol Cell
Biol. 8:379–393. 2007. View
Article : Google Scholar : PubMed/NCBI
|
19
|
Musacchio A and Hardwick KG: The spindle
checkpoint: structural insights into dynamic signalling. Nat Rev
Mol Cell Biol. 3:731–741. 2002. View
Article : Google Scholar : PubMed/NCBI
|
20
|
Kops GJ, Foltz DR and Cleveland DW:
Lethality to human cancer cells through massive chromosome loss by
inhibition of the mitotic checkpoint. Proc Natl Acad Sci USA.
101:8699–8704. 2004. View Article : Google Scholar : PubMed/NCBI
|
21
|
Weaver BA and Cleveland DW: Decoding the
links between mitosis, cancer, and chemotherapy: The mitotic
checkpoint, adaptation, and cell death. Cancer Cell. 8:7–12. 2005.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Aylon Y and Oren M: p53: guardian of
ploidy. Mol Oncol. 5:315–323. 2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Sato A and MacHinami R: p53
immunohistochemistry of ulcerative colitis-associated with
dysplasia and carcinoma. Pathol Int. 49:858–868. 1999. View Article : Google Scholar : PubMed/NCBI
|
24
|
Klump B, Holzmann K, Kühn A, et al:
Distribution of cell populations with DNA aneuploidy and p53
protein expression in ulcerative colitis. Eur J Gastroenterol
Hepatol. 9:789–794. 1997. View Article : Google Scholar : PubMed/NCBI
|
25
|
Baker SJ, Preisinger AC, Jessup JM, et al:
p53 gene mutations occur in combination with 17p allelic deletions
as late events in colorectal tumorigenesis. Cancer Res.
50:7717–7722. 1990.PubMed/NCBI
|
26
|
Mao JH, Wu D, Perez-Losada J, et al:
Crosstalk between Aurora-A and p53: Frequent deletion or
downregulation of Aurora-A in tumors from p53 null mice. Cancer
Cell. 11:161–173. 2007. View Article : Google Scholar : PubMed/NCBI
|
27
|
Ha GH and Breuer EK: Mitotic kinases and
p53 signaling. Biochem Res Int. 2012:1959032012. View Article : Google Scholar : PubMed/NCBI
|
28
|
Katayama H, Wang J, Treekitkarnmongkol W,
et al: Aurora kinase-A inactivates DNA damage-induced apoptosis and
spindle assembly checkpoint response functions of p73. Cancer Cell.
21:196–211. 2012. View Article : Google Scholar : PubMed/NCBI
|
29
|
Wu CC, Yang TY, Yu CT, et al: p53
negatively regulates Aurora A via both transcriptional and
posttranslational regulation. Cell Cycle. 11:3433–3442. 2012.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Forrester K, Ambs S, Lupold SE, et al:
Nitric oxide-induced p53 accumulation and regulation of inducible
nitric oxide synthase expression by wild-type p53. Proc Natl Acad
Sci USA. 93:2442–2447. 1996. View Article : Google Scholar : PubMed/NCBI
|
31
|
Nikonova AS, Astsaturov I, Serebriiskii
IG, Dunbrack RL Jr and Golemis EA: Aurora A kinase (AURKA) in
normal and pathological cell division. Cell Mol Life Sci.
70:661–687. 2013. View Article : Google Scholar :
|
32
|
De Angelis PM, Clausen OP, Schjølberg A
and Stokke T: Chromosomal gains and losses in primary colorectal
carcinomas detected by CGH and their associations with tumour DNA
ploidy, genotypes and phenotypes. Br J Cancer. 80:526–535. 1999.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Zhou H, Kuang J, Zhong L, et al: Tumour
amplified kinase STK15/BTAK induces centrosome amplification,
aneuploidy and transformation. Nat Genet. 20:189–193. 1998.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Marumoto T, Zhang D and Saya H: Aurora-A-a
guardian of poles. Nat Rev Cancer. 5:42–50. 2005. View Article : Google Scholar : PubMed/NCBI
|
35
|
Burum-Auensen E, De Angelis PM, Schjølberg
AR, Røislien J, Andersen SN and Clausen OP: Spindle proteins Aurora
A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic
mucosa of patients with longstanding ulcerative colitis. J Clin
Pathol. 60:1403–1408. 2007. View Article : Google Scholar : PubMed/NCBI
|
36
|
Friis-Ottessen M, Bendix L, Kølvraa S,
Norheim-Andersen S, De Angelis PM and Clausen OP: Telomere
shortening correlates to dysplasia but not to DNA aneuploidy in
longstanding ulcerative colitis. BMC Gastroenterol. 14:82014.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Friis-Ottessen M, De Angelis PM,
Schjølberg AR, Andersen SN and Clausen OP: Reduced hTERT protein
levels are associated with DNA aneuploidy in the colonic mucosa of
patients suffering from longstanding ulcerative colitis. Int J Mol
Med. 33:1477–1483. 2014.PubMed/NCBI
|
38
|
Schjølberg AR, Clausen OPF, Burum-Auensen
E and De Angelis PM: Aneuploidy is associated with TP53 expression
but not with BRCA1 or TERT expression in sporadic colorectal
cancer. Anticancer Res. 29:4381–4387. 2009.PubMed/NCBI
|
39
|
Burum-Auensen E, De Angelis PM, Schjølberg
AR, Kravik KL, Aure M and Clausen OP: Subcellular localization of
the spindle proteins Aurora A, Mad2, and BUBR1 assessed by
immunohistochemistry. J Histochem Cytochem. 55:477–486. 2007.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Clausen OP, Lothe RA, Børresen-Dale AL, et
al: Association of p53 accumulation with TP53 mutations, loss of
heterozygosity at 17p13, and DNA ploidy status in 273 colorectal
carcinomas. Diagn Mol Pathol. 7:215–223. 1998. View Article : Google Scholar
|
41
|
Ekstrøm PO, Warren DJ and Thilly WG:
Separation principles of cycling temperature capillary
electrophoresis. Electrophoresis. 33:1162–1168. 2012. View Article : Google Scholar : PubMed/NCBI
|
42
|
Ekstrøm PO, Khrapko K, Li-Sucholeiki XC,
Hunter IW and Thilly WG: Analysis of mutational spectra by
denaturing capillary electrophoresis. Nat Protoc. 3:1153–1166.
2008. View Article : Google Scholar : PubMed/NCBI
|
43
|
Bjørheim J, Gaudernack G and Ekstrøm PO:
Mutation analysis of TP53 exons 5–8 by automated constant
denaturant capillary electrophoresis. Tumour Biol. 22:323–327.
2001. View Article : Google Scholar
|
44
|
Bischoff JR, Anderson L, Zhu Y, et al: A
homologue of Drosophila aurora kinase is oncogenic and amplified in
human colorectal cancers. EMBO J. 17:3052–3065. 1998. View Article : Google Scholar : PubMed/NCBI
|
45
|
Baba Y, Nosho K, Shima K, et al: Aurora-A
expression is independently associated with chromosomal instability
in colorectal cancer. Neoplasia. 11:418–425. 2009.PubMed/NCBI
|
46
|
Goos JA, Coupe VM, Diosdado B, et al:
Aurora kinase A (AURKA) expression in colorectal cancer liver
metastasis is associated with poor prognosis. Br J Cancer.
109:2445–2452. 2013. View Article : Google Scholar : PubMed/NCBI
|
47
|
Greco V, Lauro G, Fabbrini A and Torsoli
A: Histochemistry of the colonic epithelial mucins in normal
subjects and in patients with ulcerative colitis. A qualitative and
histophotometric investigation. Gut. 8:491–496. 1967. View Article : Google Scholar : PubMed/NCBI
|
48
|
Roessner A, Kuester D, Malfertheiner P and
Schneider-Stock R: Oxidative stress in ulcerative
colitis-associated carcinogenesis. Pathol Res Pract. 204:511–524.
2008. View Article : Google Scholar : PubMed/NCBI
|
49
|
D’Angiolella V, Santarpia C and Grieco D:
Oxidative stress overrides the spindle checkpoint. Cell Cycle.
6:576–579. 2007. View Article : Google Scholar
|
50
|
Floyd S, Pines J and Lindon C: APC/C Cdh1
targets aurora kinase to control reorganization of the mitotic
spindle at anaphase. Curr Biol. 18:1649–1658. 2008. View Article : Google Scholar : PubMed/NCBI
|
51
|
Risques RA, Lai LA, Brentnall TA, et al:
Ulcerative colitis is a disease of accelerated colon aging:
evidence from telomere attrition and DNA damage. Gastroenterology.
135:410–418. 2008. View Article : Google Scholar : PubMed/NCBI
|
52
|
Lang SM, Stratakis DF, Heinzlmann M,
Heldwein W, Wiebecke B and Loeschke K: Molecular screening of
patients with long standing extensive ulcerative colitis: detection
of p53 and Ki-ras mutations by single strand conformation
polymorphism analysis and differential hybridisation in colonic
lavage fluid. Gut. 44:822–825. 1999. View Article : Google Scholar : PubMed/NCBI
|
53
|
Hussain SP, Amstad P, Raja K, et al:
Increased p53 mutation load in noncancerous colon tissue from
ulcerative colitis: a cancer-prone chronic inflammatory disease.
Cancer Res. 60:3333–3337. 2000.PubMed/NCBI
|
54
|
Yoshida T, Mikami T, Mitomi H and Okayasu
I: Diverse p53 alterations in ulcerative colitis-associated
low-grade dysplasia: full-length gene sequencing in microdissected
single crypts. J Pathol. 199:166–175. 2003. View Article : Google Scholar : PubMed/NCBI
|
55
|
van Schaik FD, Oldenburg B, Offerhaus GJ,
et al: Role of immunohistochemical markers in predicting
progression of dysplasia to advanced neoplasia in patients with
ulcerative colitis. Inflamm Bowel Dis. 18:480–488. 2012. View Article : Google Scholar
|
56
|
Harris CC and Hollstein M: Clinical
implications of the p53 tumor-suppressor gene. N Engl J Med.
329:1318–1327. 1993. View Article : Google Scholar : PubMed/NCBI
|
57
|
Brentnall TA, Crispin DA, Rabinovitch PS,
et al: Mutations in the p53 gene: an early marker of neoplastic
progression in ulcerative colitis. Gastroenterology. 107:369–378.
1994.PubMed/NCBI
|
58
|
Wong NA, Mayer NJ, MacKell S, Gilmour HM
and Harrison DJ: Immunohistochemical assessment of Ki67 and p53
expression assists the diagnosis and grading of ulcerative
colitis-related dysplasia. Histopathology. 37:108–114. 2000.
View Article : Google Scholar : PubMed/NCBI
|
59
|
Shigaki K, Mitomi H, Fujimori T, et al:
Immunohistochemical analysis of chromogranin A and p53 expressions
in ulcerative colitis-associated neoplasia: neuroendocrine
differentiation as an early event in the colitis-neoplasia
sequence. Hum Pathol. 44:2393–2399. 2013. View Article : Google Scholar : PubMed/NCBI
|
60
|
Harpaz N, Peck AL, Yin J, et al: p53
protein expression in ulcerative colitis-associated colorectal
dysplasia and carcinoma. Hum Pathol. 25:1069–1074. 1994. View Article : Google Scholar : PubMed/NCBI
|
61
|
Katsha A, Soutto M, Sehdev V, et al:
Aurora kinase A promotes inflammation and tumorigenesis in mice and
human gastric neoplasia. Gastroenterology. 145:1312–1322.e-8. 2013.
View Article : Google Scholar : PubMed/NCBI
|
62
|
Katayama H, Sasai K, Kawai H, et al:
Phosphorylation by aurora kinase A induces Mdm2-mediated
destabilization and inhibition of p53. Nat Genet. 36:55–62. 2004.
View Article : Google Scholar : PubMed/NCBI
|
63
|
Vader G and Lens SM: The Aurora kinase
family in cell division and cancer. Biochim Biophys Acta.
1786:60–72. 2008.PubMed/NCBI
|
64
|
Bartkova J, Rezaei N, Liontos M, et al:
Oncogene-induced senescence is part of the tumorigenesis barrier
imposed by DNA damage checkpoints. Nature. 444:633–637. 2006.
View Article : Google Scholar : PubMed/NCBI
|
65
|
Suram A, Kaplunov J, Patel PL, et al:
Oncogene-induced telomere dysfunction enforces cellular senescence
in human cancer precursor lesions. EMBO J. 31:2839–2851. 2012.
View Article : Google Scholar : PubMed/NCBI
|
66
|
Zhang D, Shimizu T, Araki N, et al: Aurora
A overexpression induces cellular senescence in mammary gland
hyperplastic tumors developed in p53-deficient mice. Oncogene.
27:4305–4314. 2008. View Article : Google Scholar : PubMed/NCBI
|
67
|
Ashcroft M and Vousden KH: Regulation of
p53 stability. Oncogene. 18:7637–7643. 1999. View Article : Google Scholar
|
68
|
Milyavsky M, Mimran A, Senderovich S, et
al: Activation of p53 protein by telomeric (TTAGGG)n repeats.
Nucleic Acids Res. 29:5207–5215. 2001. View Article : Google Scholar
|
69
|
d’Adda di Fagagna F, Reaper PM,
Clay-Farrace L, et al: A DNA damage checkpoint response in
telomere-initiated senescence. Nature. 426:194–198. 2003.
View Article : Google Scholar
|
70
|
Risques RA, Lai LA, Himmetoglu C, et al:
Ulcerative colitis-associated colorectal cancer arises in a field
of short telomeres, senescence, and inflammation. Cancer Res.
71:1669–1679. 2011. View Article : Google Scholar : PubMed/NCBI
|
71
|
Gorfine SR, Bauer JJ, Harris MT and Kreel
I: Dysplasia complicating chronic ulcerative colitis: is immediate
colectomy warranted? Dis Colon Rectum. 43:1575–1581. 2000.
View Article : Google Scholar : PubMed/NCBI
|
72
|
Ullman TA, Loftus EV Jr, Kakar S, Burgart
LJ, Sandborn WJ and Tremaine WJ: The fate of low grade dysplasia in
ulcerative colitis. Am J Gastroenterol. 97:922–927. 2002.
View Article : Google Scholar : PubMed/NCBI
|