Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2015 Volume 35 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2015 Volume 35 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Composite peptide‑based vaccines for cancer immunotherapy (Review)

  • Authors:
    • Jie Yang
    • Qing Zhang
    • Ke Li
    • Hong Yin
    • Jun‑Nian Zheng
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu 221000, P.R. China
  • Pages: 17-23
    |
    Published online on: November 12, 2014
       https://doi.org/10.3892/ijmm.2014.2000
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The use of peptide‑based vaccines as therapeutics aims to elicit immune responses through antigenic epitopes derived from tumor antigens. Peptide‑based vaccines are easily synthesized and chemically stable entities, and of note, they are absent of oncogenic potential. However, their application is more complicated as the success of an effective peptide‑based vaccine is determined by numerous parameters. The success thus far has been limited by the choice of tumor antigenic peptides, poor immunogenicity and incorporation of strategies to reverse cancer‑mediated immune suppression. In the present review, an overview of the mechanisms of peptide‑based vaccines is provided and antigenic peptides are categorized with respect to their tissue distribution in order to determine their usefulness as targets. Furthermore, certain approaches are proposed that induce and maintain T cells for immunotherapy. The recent progress indicates that peptide‑based vaccines are preferential for targeted therapy in cancer patients.
View Figures

Figure 1

View References

1 

Yong X, Xiao YF, Luo G, et al: Strategies for enhancing vaccine-induced CTl antitumor immune responses. J Biomed Biotechnol. 2012:6050452012. View Article : Google Scholar : PubMed/NCBI

2 

Rosenberg SA, Yang JC and Restifo NP: Cancer immunotherapy: moving beyond current vaccines. Nat Med. 10:909–915. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lazoura E and Apostolopoulos V: Rational peptide-based vaccine design for cancer immunotherapeutic applications. Curr Med Chem. 12:629–639. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Buhrman JD, Jordan KR, Munson DJ, Moore BL, Kappler JW and Slansky JE: Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor. J Biol Chem. 288:33213–33225. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Milani A, Sangiolo D, Montemurro F, Aglietta M and Valabrega G: Active immunotherapy in HER2 overexpressing breast cancer: current status and future perspectives. Ann Oncol. 24:1740–1748. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Tanaka T, Kitamura H, Inoue R, et al: Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer - results from phase I clinical trials. Clin Dev Immunol. 2013:262967l2013. View Article : Google Scholar

7 

Hui EP, Taylor GS, Jia H, et al: Phase I trial of recombinant modified vaccinia ankara encoding epstein-BARR viral tumor antigens in nasopharyngeal carcinoma patients. Cancer Res. 73:1676–1688. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Asahara S, Takeda K, Yamao K, Maguchi H and Yamaue H: Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer. J Transl Med. 11:2912013. View Article : Google Scholar : PubMed/NCBI

9 

Basha G, Lizée G, Reinicke AT, et al: MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells. PLoS One. 3:e32472008. View Article : Google Scholar : PubMed/NCBI

10 

Mellman I, Coukos G and Dranoff G: Cancer immunotherapy comes of age. Nature. 480:480–489. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Flutter B and Gao B: MHC class I antigen presentation-recently trimmed and well presented. Cell Mol Immunol. 1:22–30. 2004.

12 

Neefjes J, Jongsma MLM, Paul P and Bakke O: Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 11:823–836. 2011.PubMed/NCBI

13 

Van Kaer L: Major histocompatibility complex class I-restricted antigen processing and presentation. Tissue Antigens. 60:1–9. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Vyas JM, Van der Veen AG and Ploegh HL: The known unknowns of antigen processing and presentation. Nat Rev Immunol. 8:607–618. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Pieters J: MHC class II-restricted antigen processing and presentation. Adv Immunol. 75:159–208. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Callan MF, Fazou C, Yang H, et al: CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest. 106:1251–1261. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Vanneman M and Dranoff G: Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer. 12:237–251. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, Meganathan J and Selvaraj P: Immunotherapeutic strategies for cancer treatment: a novel protein transfer approach for cancer vaccine development. Med Res Rev. 32:1197–1219. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Vesely MD, Kershaw MH, Schreiber RD and Smyth MJ: Natural innate and adaptive immunity to cancer. Annu Rev Immunol. 29:235–271. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kennedy R and Celis E: Multiple roles for CD4+ T cells in anti-tumor immune responses. Immunol Rev. 222:129–144. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Bos R and Sherman LA: CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res. 70:8368–8377. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Dosset M, Godet Y, Vauchy C, et al: Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor. Clin Cancer Res. 18:6284–6295. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Wei HJ, Wu AT, Hsu CH, et al: The development of a novel cancer immunotherapeutic platform using tumor-targeting mesenchymal stem cells and a protein vaccine. Mol Ther. 19:2249–2257. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Liao SJ, Deng DR, Zeng D, et al: HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo. J Huazhong Univ Sci Technolog Med Sci. 33:735–742. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Palucka K, Banchereau J and Mellman I: Designing vaccines based on biology of human dendritic cell subsets. Immunity. 33:464–478. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Walker EB, Miller W, Haley D, Floyd K, Curti B and Urba WJ: Characterization of the class I-restricted gp100 melanoma peptide-stimulated primary immune response in tumor-free vaccine-draining lymph nodes and peripheral blood. Clin Cancer Res. 15:2541–2551. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Schwartzentruber DJ, Lawson DH, Richards JM, et al: gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 364:2119–2127. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Knuth A, Wölfel T, Klehmann E, Boon T and Meyer zum Buschenfelde KH: Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection. Proc Natl Acad Sci USA. 86:2804–2808. 1989. View Article : Google Scholar : PubMed/NCBI

29 

Fujie T, Tahara K, Tanaka F, Mori M, Takesako K and Akiyoshi T: A MAGE-1-encoded HLA-A24-binding synthetic peptide induces specific anti-tumor cytotoxic T lymphocytes. Int J Cancer. 80:169–172. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Simpson AJ, Caballero OL, Jungbluth A, Chen YT and Old LJ: Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer. 5:615–625. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Karbach J, Gnjatic S, Bender A, et al: Tumor-reactive CD8+ T-cell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and montanide ISA-51: association with survival. Int J Cancer. 126:909–918. 2010.

32 

Disis ML, Gooley TA, Rinn K, et al: Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol. 20:2624–2632. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Sangha R and Butts C: L-BLP25: a peptide vaccine strategy in non small cell lung cancer. Clin Cancer Res. 13:s4652–s4654. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Barratt-Boyes SM, Vlad A and Finn OJ: Immunization of chimpanzees with tumor antigen MUC1 mucin tandem repeat peptide elicits both helper and cytotoxic T-cell responses. Clin Cancer Res. 5:1918–1924. 1999.PubMed/NCBI

35 

Bernhardt SL, Gjertsen MK, Trachsel S, et al: Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br J Cancer. 95:1474–1482. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Kim NW, Piatyszek MA, Prowse KR, et al: Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011–2015. 1994. View Article : Google Scholar : PubMed/NCBI

37 

Brunsvig PF, Aamdal S, Gjertsen MK, et al: Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer. Cancer Immunol Immunother. 55:1553–1564. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Brunsvig PF, Kyte JA, Kersten C, et al: Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin Cancer Res. 17:6847–6857. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Ding Z, Ou R, Ni B, Tang J and Xu Y: Cytolytic activity of the human papillomavirus type 16 E711-20 epitope-specific cytotoxic t lymphocyte is enhanced by heat shock protein 110 in HLA-A*0201 transgenic mice. Clin Vaccine Immunol. 20:1027–1033. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Yang J, Zhang Y, Wang H, et al: Vaccination with the repeat β-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects. Tumor Biol. 33:1777–1784. 2012. View Article : Google Scholar

41 

Koido S, Homma S, Okamoto M, et al: Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes. PLoS One. 8:e592802013. View Article : Google Scholar : PubMed/NCBI

42 

Muraoka D, Kato T, Wang L, et al: Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells. J Immunol. 185:3768–3776. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Speiser DE, Liénard D, Rufer N, et al: Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest. 115:739–746. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Cho BK, Palliser D, Guillen E, et al: A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity. 12:263–272. 2000. View Article : Google Scholar

45 

Khan S, Bijker MS, Weterings JJ, et al: Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem. 282:21145–21159. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Weber J, Sondak VK, Scotland R, et al: Granulocyte- macrophage-colony-stimulating factor added to a multipeptide vaccine for resected stage II melanoma. Cancer. 97:186–200. 2003. View Article : Google Scholar

47 

Hamid O, Solomon JC, Scotland R, et al: Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease. Clin Cancer Res. 13:215–222. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Lee P, Wang F, Kuniyoshi J, et al: Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma. J Clin Oncol. 19:3836–3847. 2001.PubMed/NCBI

49 

Izumoto S: Peptide vaccine. Adv Exp Med Biol. 746:166–177. 2012. View Article : Google Scholar : PubMed/NCBI

50 

May RJ, Dao T, Pinilla-Ibarz J, et al: Peptide epitopes from the wilms’ tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 13:4547–4555. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Fujiki F, Oka Y, Tsuboi A, et al: Identification and characterization of a WT1 (Wilms Tumor Gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes. J Immunother. 30:282–293. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ and Rao A: Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity. 32:79–90. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Nakanishi Y, Lu B, Gerard C and Iwasaki A: CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help. Nature. 462:510–513. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Williams MA, Tyznik AJ and Bevan MJ: Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature. 441:890–893. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Knutson KL, Schiffman K and Disis ML: Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J Clin Invest. 107:477–484. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Gritzapis AD, Voutsas IF, Lekka E, Papamichail M and Baxevanis CN: Peptide vaccination breaks tolerance to HER-2/neu by generating vaccine-specific FasL(+) CD4(+) T cells: first evidence for intratumor apoptotic regulatory T cells. Cancer Res. 70:2686–2696. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Wang Y, Wang XY, Subjeck JR, Shrikant PA and Kim HL: Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br J Cancer. 104:643–652. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Arens R, van Hall T, van der Burg SH, Ossendorp F and Melief CJM: Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer. Semin Immunol. 25:182–190. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Gray JC, French RR, James S, Al-Shamkhani A, Johnson PW and Glennie MJ: Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies. Eur J Immunol. 38:2499–2511. 2008. View Article : Google Scholar : PubMed/NCBI

60 

Fransen MF, Sluijter M, Morreau H, Arens R and Melief CJ: Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody. Clin Cancer Res. 17:2270–2280. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Ascierto PA, Simeone E, Sznol M, Fu YX and Melero I: Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol. 37:508–516. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Croft M: The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol. 9:271–285. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Croft M: Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol. 3:609–620. 2003. View Article : Google Scholar : PubMed/NCBI

64 

Topalian SL, Weiner GJ and Pardoll DM: Cancer immunotherapy comes of age. J Clin Oncol. 29:4828–4836. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Sin JI, Kim H, Ahn E, et al: Combined stimulation of TLR9 and 4.1BB augments Trp2 peptide vaccine-mediated melanoma rejection by increasing Ag-specific CTl activity and infiltration into tumor sites. Cancer Lett. 330:190–199. 2013. View Article : Google Scholar

66 

Curran MA, Montalvo W, Yagita H and Allison JP: PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci USA. 107:4275–4280. 2010. View Article : Google Scholar : PubMed/NCBI

67 

Apostolopoulos V: Peptide-based vaccines for cancer: are we choosing the right peptides? Expert Rev Vaccines. 8:259–260. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Disis ML, Smith JW, Murphy AE, Chen W and Cheever MA: In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein. Cancer Res. 54:1071–1076. 1994.PubMed/NCBI

69 

Robbins PF, El-Gamil M, Li YF, et al: A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med. 183:1185–1192. 1996. View Article : Google Scholar : PubMed/NCBI

70 

Wölfel T, Hauer M, Schneider J, et al: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science. 269:1281–1284. 1995. View Article : Google Scholar : PubMed/NCBI

71 

Kawakami Y, Wang X, Shofuda T, et al: Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes. J Immunol. 166:2871–2877. 2001. View Article : Google Scholar : PubMed/NCBI

72 

Coulie PG, Lehmann F, Lethé B, et al: A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc Natl Acad Sci USA. 92:7976–7980. 1995. View Article : Google Scholar : PubMed/NCBI

73 

Baurain JF, Colau D, van Baren N, et al: High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene. J Immunol. 164:6057–6066. 2000. View Article : Google Scholar : PubMed/NCBI

74 

Gaudin C, Kremer F, Angevin E, Scott V and Triebel F: A hsp70-2 mutation recognized by CTl on a human renal cell carcinoma. J Immunol. 162:1730–1738. 1999.PubMed/NCBI

75 

Mandruzzato S, Brasseur F, Andry G, Boon T and van der Bruggen P: A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J Exp Med. 186:785–793. 1997. View Article : Google Scholar : PubMed/NCBI

76 

Bristol JA, Schlom J and Abrams SI: Development of a murine mutant ras CD8+ CTL peptide epitope variant that possesses enhanced MHC class I binding and immunogenic properties. J Immunol. 160:2433–2441. 1998.PubMed/NCBI

77 

Couch ME, Ferris RL, Brennan JA, et al: Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clin Cancer Res. 13:7199–7206. 2007. View Article : Google Scholar : PubMed/NCBI

78 

Pieper R, Christian RE, Gonzales MI, et al: Biochemical identification of a mutated human melanoma antigen recognized by CD4(+) T cells. J Exp Med. 189:757–766. 1999. View Article : Google Scholar : PubMed/NCBI

79 

Wang RF, Wang X, Atwood AC, Topalian SL and Rosenberg SA: Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Science. 284:1351–1354. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang J, Zhang Q, Li K, Yin H and Zheng JN: Composite peptide‑based vaccines for cancer immunotherapy (Review). Int J Mol Med 35: 17-23, 2015.
APA
Yang, J., Zhang, Q., Li, K., Yin, H., & Zheng, J. (2015). Composite peptide‑based vaccines for cancer immunotherapy (Review). International Journal of Molecular Medicine, 35, 17-23. https://doi.org/10.3892/ijmm.2014.2000
MLA
Yang, J., Zhang, Q., Li, K., Yin, H., Zheng, J."Composite peptide‑based vaccines for cancer immunotherapy (Review)". International Journal of Molecular Medicine 35.1 (2015): 17-23.
Chicago
Yang, J., Zhang, Q., Li, K., Yin, H., Zheng, J."Composite peptide‑based vaccines for cancer immunotherapy (Review)". International Journal of Molecular Medicine 35, no. 1 (2015): 17-23. https://doi.org/10.3892/ijmm.2014.2000
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Zhang Q, Li K, Yin H and Zheng JN: Composite peptide‑based vaccines for cancer immunotherapy (Review). Int J Mol Med 35: 17-23, 2015.
APA
Yang, J., Zhang, Q., Li, K., Yin, H., & Zheng, J. (2015). Composite peptide‑based vaccines for cancer immunotherapy (Review). International Journal of Molecular Medicine, 35, 17-23. https://doi.org/10.3892/ijmm.2014.2000
MLA
Yang, J., Zhang, Q., Li, K., Yin, H., Zheng, J."Composite peptide‑based vaccines for cancer immunotherapy (Review)". International Journal of Molecular Medicine 35.1 (2015): 17-23.
Chicago
Yang, J., Zhang, Q., Li, K., Yin, H., Zheng, J."Composite peptide‑based vaccines for cancer immunotherapy (Review)". International Journal of Molecular Medicine 35, no. 1 (2015): 17-23. https://doi.org/10.3892/ijmm.2014.2000
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team