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Article

Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells

  • Authors:
    • Weihai Liu
    • Songzhi Kong
    • Qingfeng Xie
    • Jiyan Su
    • Wenjie Li
    • Huizhen Guo
    • Shanshan Li
    • Xuexuan Feng
    • Ziren Su
    • Yang Xu
    • Xiaoping Lai
  • View Affiliations / Copyright

    Affiliations: Guangdong Food and Drug Vocational College, Guangzhou, Guangdong 510520, P.R. China, College of Science, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China
  • Pages: 739-746
    |
    Published online on: December 30, 2014
       https://doi.org/10.3892/ijmm.2014.2056
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Abstract

Parkinson's disease is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, characterized by the loss of dopominergic neurons in the substantia nigra pars compacta and can be experimentally mimicked by the use of the neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (MPP+), in in vitro models. In this study, we investigated the potential protective effects of apigenin (AP), galangin and genkwanin, naturally occurring plant flavonoids, on the MPP+‑induced cytotoxicity in cultured rat adrenal pheochromocytoma cells (PC12 cells). The PC12 cells were pre-treated with various concentrations of the test compounds for 4 h, followed by the challenge with 1,000 µM MPP+ for 48 h. We found that only pre-treatment with AP (3, 6 and 12 µM) before injury significantly increased cell viability, decreased the release of lactate dehydrogenase, reduced the level of intracellular reactive oxygen species and elevated mitochondrial membrane potential in the MPP+‑treated PC12 cells. In addition, AP markedly suppressed the increased rate of apoptosis and the reduced Bcl‑2/Bax ratio induced by MPP+ in the PC12 cells. Taken together, the findings of this study demonstrate that AP exerts neuroprotective effects against MPP+‑induced neurotoxicity in PC12 cells, at least in part, through the inhibition of oxidative damage and the suppression of apoptosis through the mitochondrial pathway.
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1 

de Lau LM and Breteler MM: Epidemiology of Parkinson’s disease. Lancet Neurol. 5:525–535. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Henchcliffe C and Beal MF: Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol. 4:600–609. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Kanthasamy A, Jin H, Mehrotra S, Mishra R, Kanthasamy A and Rana A: Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson’s disease. Neurotoxicology. 31:555–561. 2010. View Article : Google Scholar :

4 

Winklhofer KF and Haass C: Mitochondrial dysfunction in Parkinson’s disease. Biochim Biophys Acta. 1802:29–44. 2010. View Article : Google Scholar

5 

Yan MH, Wang X and Zhu X: Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med. 62:90–101. 2013. View Article : Google Scholar :

6 

Zorov DB, Filburn CR, Klotz LO, Zweier JL and Sollott SJ: Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med. 192:1001–1014. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Roucou X and Martinou JC: Conformational change of Bax: a question of life or death. Cell Death Differ. 8:875–877. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Tipton KF and Singer TP: Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem. 61:1191–1206. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Langston JW and Ballard PA Jr: Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N Engl J Med. 309:3101983. View Article : Google Scholar

10 

Tetrud JW, Langston JW, Garbe PL and Ruttenber AJ: Mild parkinsonism in persons exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neurology. 39:1483–1487. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Greene LA and Tischler AS: Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA. 73:2424–2428. 1976. View Article : Google Scholar : PubMed/NCBI

12 

Mao QQ, Ip SP, Ko KM, Tsai SH, Zhao M and Che CT: Peony glycosides protect against corticosterone-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol. 29:643–647. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Jiang B, Zhang H, Bi J and Zhang XL: Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity. Neurol Res. 30:639–644. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Zhou J, Sun Y, Zhao X, Deng Z and Pu X: 3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells. Brain Res. 1508:53–62. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Schroeter H, Spencer JP, Rice-Evans C and Williams RJ: Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochem J. 358:547–557. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Li S, Chou G, Hseu Y, Yang H, Kwan H and Yu Z: Isolation of anticancer constituents from flos genkwa (Daphne genkwa Sieb et Zucc) through bioassay-guided procedures. Chem Cent J. 7:1592013. View Article : Google Scholar

17 

Jacobson KA, Moro S, Manthey JA, West PL and Ji XD: Interactions of flavones and other phytochemicals with adenosine receptors. Adv Exp Med Biol. 505:163–171. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Jaganathan SK and Mandal MJ: Antiproliferative effects of honey and of its polyphenols: a review. J Biomed Biotechnol. 2009:8306162009. View Article : Google Scholar : PubMed/NCBI

19 

Shukla S and Gupta S: Apigenin: a promising molecule for cancer prevention. Pharm Res. 27:962–978. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Liu R, Zhang T, Yang H, Lan X, Ying J and Du G: The flavonoid apigenin protects brain neurovascular coupling against amyloid-β25–35-induced toxicity in mice. J Alzheimers Dis. 24:85–100. 2011.

21 

Zhao L, Wang JL, Wang YR and Fa XZ: Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model. Brain Res. 1492:33–45. 2013. View Article : Google Scholar

22 

Wruck CJ, Claussen M, Fuhrmann G, Römer L, Schulz A, Pufe T, Waetzig V, Peipp M, Herdegen T and Götz ME: Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J Neural Transm. (Suppl): 57–67. 2007. View Article : Google Scholar

23 

Zhang ZT, Cao XB, Xiong N, Wang HC, Huang JS, Sun SG and Wang T: Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 31:900–906. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Zhang K, Ma Z, Wang J, Xie A and Xie J: Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells. Neuropharmacology. 61:329–335. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Kong SZ, Xian YF, Ip SP, Lai XP, Shi XG, Lin ZX and Su ZR: Protective effects of hydroxysafflor yellow A on β-amyloid-induced neurotoxicity in PC12 cells. Neurochem Res. 38:951–960. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Wang D, Wong HK, Feng YB and Zhang ZJ: Paeoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and pro-apoptotic pathways in differentiated PC12 cells. Cell Mol Neurobiol. 33:521–529. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Liu XH, Pan LL, Chen PF and Zhu YZ: Leonurine improves ischemia-induced myocardial injury through antioxidative activity. Phytomedicine. 17:753–759. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Toulouse A and Sullivan AM: Progress in Parkinson’s disease-where do we stand? Prog Neurobiol. 85:376–392. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Kwon IH, Choi HS, Shin KS, Lee BK, Lee CK, Hwang BY, Lim SC and Lee MK: Effects of berberine on 6-hydroxydo-pamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson’s disease. Neurosci Lett. 486:29–33. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN and Radi E: Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci. 322:254–262. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Uttara B, Singh AV, Zamboni P and Mahajan RT: Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 7:65–74. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lu XL, Yao XL, Liu Z, Zhang H, Li W, Li Z, Wang GL, Pang J, Lin Y, Xu Z, et al: Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res. 1332:110–119. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Cassarino DS, Parks JK, Parker WD Jr and Bennett JP Jr: The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta. 1453:49–62. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Ling YH, Liebes L, Zou Y and Perez-Soler R: Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem. 278:33714–33723. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Muñoz-Pinedo C: Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense. Adv Exp Med Biol. 738:124–143. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Ghibelli L and Diederich M: Multistep and multitask Bax activation. Mitochondrion. 10:604–613. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Martinou JC and Youle RJ: Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 21:92–101. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Chen Q and Lesnefsky EJ: Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore. FEBS Lett. 585:921–926. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Schelman WR, Andres RD, Sipe KJ, Kang E and Weyhenmeyer JA: Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line. Brain Res Mol Brain Res. 128:160–169. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Selvaraj S, Watt JA and Singh BB: TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+. Cell Calcium. 46:209–218. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Kong S, Xie Q, Su J, Li W, Guo H, Li S, Feng X, Su Z, Xu Y, Xu Y, et al: Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. Int J Mol Med 35: 739-746, 2015.
APA
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H. ... Lai, X. (2015). Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. International Journal of Molecular Medicine, 35, 739-746. https://doi.org/10.3892/ijmm.2014.2056
MLA
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H., Li, S., Feng, X., Su, Z., Xu, Y., Lai, X."Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells". International Journal of Molecular Medicine 35.3 (2015): 739-746.
Chicago
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H., Li, S., Feng, X., Su, Z., Xu, Y., Lai, X."Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells". International Journal of Molecular Medicine 35, no. 3 (2015): 739-746. https://doi.org/10.3892/ijmm.2014.2056
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Kong S, Xie Q, Su J, Li W, Guo H, Li S, Feng X, Su Z, Xu Y, Xu Y, et al: Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. Int J Mol Med 35: 739-746, 2015.
APA
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H. ... Lai, X. (2015). Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. International Journal of Molecular Medicine, 35, 739-746. https://doi.org/10.3892/ijmm.2014.2056
MLA
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H., Li, S., Feng, X., Su, Z., Xu, Y., Lai, X."Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells". International Journal of Molecular Medicine 35.3 (2015): 739-746.
Chicago
Liu, W., Kong, S., Xie, Q., Su, J., Li, W., Guo, H., Li, S., Feng, X., Su, Z., Xu, Y., Lai, X."Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells". International Journal of Molecular Medicine 35, no. 3 (2015): 739-746. https://doi.org/10.3892/ijmm.2014.2056
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