Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March-2015 Volume 35 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 35 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis

  • Authors:
    • Marcin Trejter
    • Anna Hochol
    • Marianna Tyczewska
    • Agnieszka Ziolkowska
    • Karol Jopek
    • Marta Szyszka
    • Ludwik K. Malendowicz
    • Marcin Rucinski
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland
    Copyright: © Trejter et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 702-714
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/ijmm.2015.2064
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Notable sex-related differences exist in mammalian adrenal cortex structure and function. In adult rats, the adrenal weight and the average volume of zona fasciculata cells of females are larger and secrete greater amounts of corticosterone than those of males. The molecular bases of these sex-related differences are poorly understood. In this study, to explore the molecular background of these differences, we defined zone- and sex-specific transcripts in adult male and female (estrous cycle phase) rats. Twelve-week-old rats of both genders were used and samples were taken from the zona glomerulosa (ZG) and zona fasciculata/reticularis (ZF/R) zones. Transcriptome identification was carried out using the Affymetrix® Rat Gene 1.1 ST Array. The microarray data were compared by fold change with significance according to moderated t-statistics. Subsequently, we performed functional annotation clustering using the Gene Ontology (GO) and Database for Annotation, Visualization and Integrated Discovery (DAVID). In the first step, we explored differentially expressed transcripts in the adrenal ZG and ZF/R. The number of differentially expressed transcripts was notably higher in the female than in the male rats (702 vs. 571). The differentially expressed genes which were significantly enriched included genes involved in steroid hormone metabolism, and their expression levels in the ZF/R of adult female rats were significantly higher compared with those in the male rats. In the female ZF/R, when compared with that of the males, prevailing numbers of genes linked to cell fraction, oxidation/reduction processes, response to nutrients and to extracellular stimuli or steroid hormone stimuli were downregulated. The microarray data for key genes involved directly in steroidogenesis were confirmed by qPCR. Thus, when compared with that of the males, in the female ZF/R, higher expression levels of genes involved directly in steroid hormone synthesis were accompanied by lower expression levels of genes regulating basal cell functions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Bachmann R: Die Nebenniere. Handbuch der Mikroskopischen Anatomie des Menschen. Bargmann W: 6/5. Springer; Berlin Göttingen Heidelberg: pp. 1–952. 1954, View Article : Google Scholar

2 

Kitay JI: Effects of estrogen and androgen on the adrenal cortex of the rat. Functions of the Adrenal Cortex. 2. McKerns KW: North Holland Publishing Corpany; Amsterdam: pp. 775–811. 1968

3 

Kime D, Vinson GP, Major P and Kilpatrick R: Adrenal-gonad relationship. Functions of the Adrenal Cortex. 3. McKerns KW: Academic Press; London: pp. 183–347. 1979

4 

Malendowicz LK: Cytophysiology of the mammalian adrenal cortex as related to sex, gonadectomy and gonadal hormones. PTPN Press; Poznan: pp. 1–233. 1994

5 

Goel N, Workman JL, Lee TT, et al: Sex differences in the HPA axis. Compr Physiol. 4:1121–1155. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lescoat G, Jego P, Beraud G and Maniey J: Sex influences on the response of the hypothalamo-hypophysio-adrenal axis to emotional and systemic stress in the rat. 164:2106–2113. 1970.(In French).

7 

Le Mevel JC, Abitbol S, Beraud G and Maniey J: Temporal changes in plasma adrenocorticotropin concentration after repeated neurotropic stress in male and female rats. Endocrinology. 105:812–817. 1979. View Article : Google Scholar : PubMed/NCBI

8 

Lesniewska B, Miskowiak B, Nowak M and Malendowicz LK: Sex differences in adrenocortical structure and function. XXVII. The effect of ether stress on ACTH and corticosterone in intact, gonadectomized, and testosterone- or estradiol-replaced rats. Res Exp Med (Berl). 190:95–103. 1990. View Article : Google Scholar

9 

Malendowicz LK: Sex differences in adrenocortical structure and function. I. The effects of postpubertal gonadectomy and gonadal hormone replacement on nuclear volume of adrenocortical cells in the rat. Cell Tissue Res. 151:525–536. 1974. View Article : Google Scholar : PubMed/NCBI

10 

Malendowicz LK: Sex differences in adrenocortical structure and function. II. The effects of postpubertal gonadectomy and gonadal hormone replacement on the rat adrenal cortex evaluated by stereology at the light microscope level. Cell Tissue Res. 151:537–547. 1974. View Article : Google Scholar : PubMed/NCBI

11 

Malendowicz LK, Robba C and Nussdorfer GG: Sex differences in adrenocortical structure and function. XXII. Light- and electron-microscopic morphometric studies on the effects of gonadectomy and gonadal hormone replacement on the rat adrenal cortex. Cell Tissue Res. 244:141–145. 1986.PubMed/NCBI

12 

Nussdorfer GG: Cytophysiology of the adrenal cortex. Int Rev Cytol. 98:1–405. 1986.PubMed/NCBI

13 

Schimmer BP, Cordova M, Cheng H, et al: Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells. Endocrinology. 147:2357–2367. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Nishimoto K, Rigsby CS, Wang T, et al: Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata. Endocrinology. 153:1755–1763. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Nishimoto K, Rainey WE, Bollag WB and Seki T: Lessons from the gene expression pattern of the rat zona glomerulosa. Mol Cell Endocrinol. 371:107–113. 2013. View Article : Google Scholar : PubMed/NCBI

16 

El Wakil A, Mari B, Barhanin J and Lalli E: Genomic analysis of sexual dimorphism of gene expression in the mouse adrenal gland. Horm Metab Res. 45:870–873. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Dennis G Jr, Sherman BT, Hosack DA, et al: DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

18 

Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar

19 

Rucinski M, Andreis PG, Ziolkowska A, Nussdorfer GG and Malendowicz LK: Differential expression and function of beacon in the rat adrenal cortex and medulla. Int J Mol Med. 16:35–40. 2005.PubMed/NCBI

20 

Spinazzi R, Ziolkowska A, Neri G, et al: Orexins modulate the growth of cultured rat adrenocortical cells, acting through type 1 and type 2 receptors coupled to the MAPK p42/p44- and p38-dependent cascades. Int J Mol Med. 15:847–852. 2005.PubMed/NCBI

21 

Tyczewska M, Rucinski M, Trejter M, et al: Angiogenesis in the course of enucleation-induced adrenal regeneration - expression of selected genes and proteins involved in development of capillaries. Peptides. 38:404–413. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Tyczewska M, Rucinski M, Ziolkowska A, et al: Expression of selected genes involved in steroidogenesis in the course of enucleation-induced rat adrenal regeneration. Int J Mol Med. 33:613–623. 2014.

23 

Tyczewska M, Rucinski M and Ziolkowska A: Enucleation-induced rat adrenal gland regeneration - expression profile of selected genes involved in control of adrenocortical cell proliferation. Int J Endocrinol. 14(130359): 2014

24 

Gentleman RC, Carey VJ, Bates DM, et al: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5:R802004. View Article : Google Scholar : PubMed/NCBI

25 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B. 57:289–300. 1995.

26 

Gene Ontology Consortium: The Gene Ontology project in 2008. Nucleic Acids Res. 36:D440–D444. 2008.

27 

Feng G, Shaw P, Rosen ST, et al: Using the bioconductor GeneAnswers package to interpret gene lists. Methods Mol Biol. 802:101–112. 2012. View Article : Google Scholar

28 

Ashburner M, Ball CA, Blake JA, et al: Gene ontology: tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Bassett MH, Mayhew B, Rehman K, et al: Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab. 90:5446–5455. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Assie G, Auzan C, Gasc JM, et al: Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis. J Clin Endocrinol Metab. 90:6638–6649. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Lenzini L, Seccia TM, Aldighieri E, et al: Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis. Hypertension. 50:1106–1113. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Giordano TJ, Kuick R, Else T, et al: Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res. 15:668–676. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Wang T, Satoh F, Morimoto R, et al: Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands. Eur J Endocrinol. 164:613–619. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Wilmot RH, Vezzosi D, Rizk-Rabin M, et al: Identification of gene expression profiles associated with cortisol secretion in adrenocortical adenomas. J Clin Endocrinol Metab. 98:E1109–E1121. 2013. View Article : Google Scholar

35 

Romero DG, Plonczynski MW, Welsh BL, et al: Gene expression profile in rat adrenal zona glomerulosa cells stimulated with aldosterone secretagogues. Physiol Genomics. 32:117–127. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Romero DG, Gomez-Sanchez EP and Gomez-Sanchez CE: Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis. Physiol Genomics. 42A:259–266. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Oster H, Damerow S, Hut RA and Eichele G: Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes. J Biol Rhythms. 21:350–361. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Ishii T, Mitsui T, Suzuki S, et al: A genome-wide expression profile of adrenocortical cells in knockout mice lacking steroidogenic acute regulatory protein. Endocrinology. 153:2714–2723. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Nishimoto K, Harris RB, Rainey WE and Seki T: Sodium deficiency regulates rat adrenal zona glomerulosa gene expression. Endocrinology. 155:1363–1372. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Tan PK, Downey TJ, Spitznagel EL, et al: Evaluation of gene expression measurements from commercial microarray platforms. Nucleic Acids Res. 31:5676–5684. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Barnes M, Freudenberg J, Thompson S, et al: Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res. 33:5914–5923. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Russ J and Futschik ME: Comparison and consolidation of microarray data sets of human tissue expression. BMC Genomics. 11(305): 2010

43 

Malendowicz LK: Sex differences in adrenocortical structure and function. XXIV. Comparative morphometric studies on adrenal cortex of intact mature male and female rats of different strains. Cell Tissue Res. 249:443–449. 1987.PubMed/NCBI

44 

Ramachandran J and Suyama AT: Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin. Proc Natl Acad Sci USA. 72:113–117. 1975. View Article : Google Scholar : PubMed/NCBI

45 

Rybak SM and Ramachandran J: Primary culture of normal rat adrenocortical cells. I. Culture conditions for optimal growth and function. In Vitro. 17:599–604. 1981. View Article : Google Scholar : PubMed/NCBI

46 

Dallman MF: Control of adrenocortical growth in vivo. Endocr Res. 10:213–242. 1984. View Article : Google Scholar : PubMed/NCBI

47 

Hu J, Zhang Z, Shen WJ and Azhar S: Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab. 7(47): 2010

48 

Gallo-Payet N and Battista MC: Steroidogenesis-adrenal cell signal transduction. Compr Physiol. 4:889–964. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Malendowicz LK and Mlynarczyk W: Sex differences in adrenocortical structure and function. X. Lipid and corticosterone in the rat adrenal as affected by gonadectomy and testosterone or estradiol replacement. Endokrinologie. 79:292–300. 1982.PubMed/NCBI

50 

Boyd GS and Trzeciak WH: Cholesterol metabolism in the adrenal cortex: studies on the mode of action of ACTH. Ann NY Acad Sci. 212:361–377. 1973. View Article : Google Scholar : PubMed/NCBI

51 

Kraemer FB, Shen WJ, Harada K, et al: Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol Endocrinol. 18:549–557. 2004. View Article : Google Scholar

52 

Trzeciak WH and Malendowicz LK: Sex differences in adrenocortical structure and function. VII. Adrenal sterol ester hydrolase activity in the rat and its dependence on gonadal hormones. Horm Metab Res. 13:519–522. 1981. View Article : Google Scholar : PubMed/NCBI

53 

Stocco DM: StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol. 63:193–213. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Kim YC, Ariyoshi N, Artemenko I, et al: Control of cholesterol access to cytochrome P450scc in rat adrenal cells mediated by regulation of the steroidogenic acute regulatory protein. Steroids. 62:10–20. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Lo YC, Brett L, Kenyon CJ, et al: StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland. Endocr Res. 24:559–563. 1998. View Article : Google Scholar

56 

Lehoux JG, Hales DB, Fleury A, et al: The in vivo effects of adrenocorticotropin and sodium restriction on the formation of the different species of steroidogenic acute regulatory protein in rat adrenal. Endocrinology. 140:5154–5164. 1999.PubMed/NCBI

57 

Rucinski M, Tortorella C, Ziolkowska A, et al: Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: in vivo studies on the regenerating rat adrenal cortex. Int J Mol Med. 21:593–597. 2008.PubMed/NCBI

58 

Bastida CM, Cremades A, Castells MT, et al: Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. Am J Physiol. 292:E1010–E1017. 2007.

59 

Simpson ER, Mason JI, John ME, et al: Regulation of the biosynthesis of steroidogenic enzymes. J Steroid Biochem. 27:801–805. 1987. View Article : Google Scholar : PubMed/NCBI

60 

Miller WL: Role of mitochondria in steroidogenesis. Endocr Dev. 20:1–19. 2011.

61 

Ishimura K and Fujita H: Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes. Microsc Res Tech. 36:445–453. 1997. View Article : Google Scholar : PubMed/NCBI

62 

Colby HD and Kitay JI: Effects of gonadal hormones on adrenal steroid metabolism in vitro. Steroids. 20:143–157. 1972. View Article : Google Scholar : PubMed/NCBI

63 

Malendowicz LK: Sex differences in adrenocortical structure and function. III. The effects of postpubertal gonadectomy and gonadal hormone replacement on adrenal cholesterol side chain cleavage activity and on steroids biosynthesis by rat adrenal homogenates. Endokrinologie. 75:311–323. 1976.

64 

Brownie AC, Bhasker CR and Waterman MR: Levels of adrenodoxin, NADPH-cytochrome P-450 reductase and cytochromes P-45011 beta, P-45021, P-450scc, in adrenal zona fasciculata-reticularis tissue from androgen-treated rats. Mol Cell Endocrinol. 55:15–20. 1988. View Article : Google Scholar : PubMed/NCBI

65 

Malee MP and Mellon SH: Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats. Proc Natl Acad Sci USA. 88:4731–4735. 1991. View Article : Google Scholar : PubMed/NCBI

66 

Oaks MK and Raff H: Differentiation of the expression of aldosterone synthase and 11 beta-hydroxylase mRNA in the rat adrenal cortex by reverse transcriptase-polymerase chain reaction. J Steroid Biochem Mol Biol. 54:193–199. 1995. View Article : Google Scholar : PubMed/NCBI

67 

Solyom J, Ludwig E, Regoly-Merei J and Vajda A: The effect of potassium ions in vitro upon steroid biosynthesis by rat adrenals. A study on the effect of different salt intake and sex difference. Endokrinologie. 59:249–259. 1972.PubMed/NCBI

68 

Ruhmann-Wennhold A and Nelson DH: Testosterone inhibition of estradiol-induced stimulation of adrenal 11-beta- and 18-hydroxylation. Proc Soc Exp Biol Med. 133:493–496. 1970. View Article : Google Scholar : PubMed/NCBI

69 

Goldman AS, Gustafsson JA and Stenberg A: Neonatal imprinting of enzyme levels in rat adrenals. Acta Endocrinol (Copenh). 76:719–728. 1974.

70 

Beuschlein F, Keegan CE, Bavers DL, et al: SF-1, DAX-1, and acd: molecular determinants of adrenocortical growth and steroidogenesis. Endocr Res. 28:597–607. 2002. View Article : Google Scholar

71 

Iyer AK and McCabe ER: Molecular mechanisms of DAX1 action. Mol Genet Metab. 83:60–73. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Manna PR, Dyson MT, Jo Y and Stocco DM: Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. Endocrinology. 150:187–199. 2009. View Article : Google Scholar :

73 

Mukai T, Kusaka M, Kawabe K, et al: Sexually dimorphic expression of Dax-1 in the adrenal cortex. Genes Cells. 7:717–729. 2002. View Article : Google Scholar : PubMed/NCBI

74 

Jöhren O, Neidert SJ, Kummer M, Dendorfer A and Dominiak P: Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology. 142:3324–3331. 2001. View Article : Google Scholar : PubMed/NCBI

75 

Jöhren O, Bruggemann N, Dendorfer A and Dominiak P: Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology. 144:1219–1225. 2003. View Article : Google Scholar : PubMed/NCBI

76 

Jöhren O, Bruggemann N and Dominiak P: Orexins (hypocretins) and adrenal function. Horm Metab Res. 36:370–375. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Trejter M, Hochol A, Tyczewska M, Ziolkowska A, Jopek K, Szyszka M, Malendowicz LK and Rucinski M: Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis. Int J Mol Med 35: 702-714, 2015.
APA
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M. ... Rucinski, M. (2015). Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis. International Journal of Molecular Medicine, 35, 702-714. https://doi.org/10.3892/ijmm.2015.2064
MLA
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M., Malendowicz, L. K., Rucinski, M."Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis". International Journal of Molecular Medicine 35.3 (2015): 702-714.
Chicago
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M., Malendowicz, L. K., Rucinski, M."Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis". International Journal of Molecular Medicine 35, no. 3 (2015): 702-714. https://doi.org/10.3892/ijmm.2015.2064
Copy and paste a formatted citation
x
Spandidos Publications style
Trejter M, Hochol A, Tyczewska M, Ziolkowska A, Jopek K, Szyszka M, Malendowicz LK and Rucinski M: Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis. Int J Mol Med 35: 702-714, 2015.
APA
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M. ... Rucinski, M. (2015). Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis. International Journal of Molecular Medicine, 35, 702-714. https://doi.org/10.3892/ijmm.2015.2064
MLA
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M., Malendowicz, L. K., Rucinski, M."Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis". International Journal of Molecular Medicine 35.3 (2015): 702-714.
Chicago
Trejter, M., Hochol, A., Tyczewska, M., Ziolkowska, A., Jopek, K., Szyszka, M., Malendowicz, L. K., Rucinski, M."Sex-related gene expression profiles in the adrenal cortex in the mature rat: Microarray analysis with emphasis on genes involved in steroidogenesis". International Journal of Molecular Medicine 35, no. 3 (2015): 702-714. https://doi.org/10.3892/ijmm.2015.2064
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team