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Article Open Access

Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits

  • Authors:
    • Chen Li
    • Yan Tu
    • Ting-Rong Liu
    • Zhi-Gang Guo
    • Di Xie
    • Jian-Kai Zhong
    • Yong-Zhen Fan
    • Wen-Yan Lai
  • View Affiliations / Copyright

    Affiliations: Division of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 715-723
    |
    Published online on: January 19, 2015
       https://doi.org/10.3892/ijmm.2015.2072
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Abstract

Rosiglitazone has been found to have anti-atherogenic effects and to increase serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels. However, in vivo studies investigating the regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) by rosiglitazone are limited. Moreover, the effects of rosiglitazone on the function and levels of HDL are unclear. In the present study, we investigated the effects of rosiglitazone on HDL function and its mechanisms of action in atherosclerotic rabbits. Our results revealed that rosiglitazone induced a significant increase in serum HDL-C levels, paraoxonase 1 (PON1) activity, [3H]cholesterol efflux rates, and the expression of ABCA1 and SR-BI in hepatocytes and peritoneal macrophages. The expression of ABCA1 was also increased in aortic lesions. Rosiglitazone markedly reduced serum myeloperoxidase (MPO) activity, aortic intima-media thickness (IMT) and the percentage of plaque area in the aorta. It can thus be concluded that in atherosclerotic rabbits, rosigitazone increases the levels of HDL-C and hinders atherosclerosis. Thus, it improves HDL quality and function, as well as the HDL-induced cholesterol efflux, exerting anti-inflammatory and antioxidant effects.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Tu Y, Liu T, Guo Z, Xie D, Zhong J, Fan Y and Lai W: Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits. Int J Mol Med 35: 715-723, 2015.
APA
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J. ... Lai, W. (2015). Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits. International Journal of Molecular Medicine, 35, 715-723. https://doi.org/10.3892/ijmm.2015.2072
MLA
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J., Fan, Y., Lai, W."Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits". International Journal of Molecular Medicine 35.3 (2015): 715-723.
Chicago
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J., Fan, Y., Lai, W."Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits". International Journal of Molecular Medicine 35, no. 3 (2015): 715-723. https://doi.org/10.3892/ijmm.2015.2072
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Tu Y, Liu T, Guo Z, Xie D, Zhong J, Fan Y and Lai W: Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits. Int J Mol Med 35: 715-723, 2015.
APA
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J. ... Lai, W. (2015). Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits. International Journal of Molecular Medicine, 35, 715-723. https://doi.org/10.3892/ijmm.2015.2072
MLA
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J., Fan, Y., Lai, W."Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits". International Journal of Molecular Medicine 35.3 (2015): 715-723.
Chicago
Li, C., Tu, Y., Liu, T., Guo, Z., Xie, D., Zhong, J., Fan, Y., Lai, W."Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits". International Journal of Molecular Medicine 35, no. 3 (2015): 715-723. https://doi.org/10.3892/ijmm.2015.2072
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