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Article

Melatonin improves experimental colitis with sleep deprivation

  • Authors:
    • Young-Sook Park
    • Sook-Hee Chung
    • Seong-Kyu Lee
    • Ja-Hyun Kim
    • Jun-Bong Kim
    • Tae-Kyun Kim
    • Dong-Shin Kim
    • Haing-Woon Baik
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea, Department of Gastroenterology, Ajou University School of Medicine, Suwon 443-721, Republic of Korea, Department of Biochemistry and Molecular Biology, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea
  • Pages: 979-986
    |
    Published online on: January 27, 2015
       https://doi.org/10.3892/ijmm.2015.2080
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Abstract

Sleep deprivation (SD) is an epidemic phenomenon in modern countries, and its harmful effects are well known. SD acts as an aggravating factor in inflammatory bowel disease. Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized. Thus, in this study, we assessed the measurable effects of SD on experimental colitis and the protective effects of melatonin. For this purpose, male imprinting control region (ICR) mice (n=24) were used; the mice were divided into 4 experimental groups as follows: the control, colitis, colitis with SD and colitis with SD and melatonin groups. Colitis was induced by the administration of 5% dextran sulfate sodium (DSS) in the drinking water for 6 days. The mice were sleep-deprived for 3 days. Changes in body weight, histological analyses of colon tissues and the expression levels of pro-inflammatory cytokines and genes were evaluated. SD aggravated inflammation and these effects were reversed by melatonin in the mice with colitis. In addition, weight loss in the mice with colitis with SD was significantly reduced by the injection of melatonin. Treatment with melatonin led to high survival rates in the mice, in spite of colitis with SD. The levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-17, interferon-γ and tumor necrosis factor-α, in the serum of mice were significantly increased by SD and reduced by melatonin treatment. The melatonin-treated group showed a histological improvement of inflammation. Upon gene analysis, the expression of the inflammatory genes, protein kinase Cζ (PKCζ) and calmodulin 3 (CALM3), was increased by SD, and the levels decreased following treatment with melatonin. The expression levels of the apoptosis-related inducible nitric oxide synthase (iNOS) and wingless-type MMTV integration site family, member 5A (Wnt5a) genes was decreased by SD, but increased following treatment with melatonin. Treatment with melatonin reduced weight loss and prolonged survival in mice with colitis with SD. Melatonin exerted systemic anti-inflammatory effects. Gene analysis revealed a possible mechanism of action of melatonin in inflammation and sleep disturbance. Thus, melatonin may be clinically applicable for patients with inflammatory bowel disease, particulary those suffering from sleep disturbances.
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1 

Langan RC, Gotsch PB, Krafczyk MA and Skillinge DD: Ulcerative colitis: diagnosis and treatment. Am Fam Physician. 76:1323–1330. 2007.PubMed/NCBI

2 

Bamias G and Cominelli F: Immunopathogenesis of inflammatory bowel disease: current concepts. Curr Opin Gastroenterol. 23:365–369. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Farrell RJ and Peppercorn MA: Ulcerative colitis. Lancet. 359:331–340. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Niess JH, Mönnikes H, Dignass AU, Klapp BF and Arck PC: Review on the influence of stress on immune mediators, neuro-peptides and hormones with relevance for inflammatory bowel disease. Digestion. 65:131–140. 2002. View Article : Google Scholar

5 

Sonnenberg A: Occupational distribution of inflammatory bowel disease among German employees. Gut. 31:1037–1040. 1990. View Article : Google Scholar : PubMed/NCBI

6 

Necefli A, Tulumoğlu B, Giriş M, et al: The effect of melatonin on TNBS-induced colitis. Dig Dis Sci. 51:1538–1545. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Mazzon E, Esposito E, Crisafulli C, et al: Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. J Pineal Res. 41:363–373. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Li JH, Yu JP, Yu HG, et al: Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm. 2005.185–193. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Nosál’ová V1, Zeman M, Cerná S, Navarová J and Zakálová M: Protective effect of melatonin in acetic acid induced colitis in rats. J Pineal Res. 42:364–370. 2007. View Article : Google Scholar

10 

Akcan A, Kucuk C, Sozuer E, et al: Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats. World J Gastroenterol. 14:918–924. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Stebelová K, Herichová I and Zeman M: Diabetes induces changes in melatonin concentrations in peripheral tissues of rat. Neuro Endocrinol Lett. 28:159–165. 2007.PubMed/NCBI

12 

Cuzzocrea S, Mazzon E, Serraino I, et al: Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J Pineal Res. 30:1–12. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Dong WG, Mei Q, Yu JP, et al: Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol. 9:1307–1311. 2003.PubMed/NCBI

14 

Tahan G, Gramignoli R, Marongiu F, et al: Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci. 56:715–720. 2011. View Article : Google Scholar

15 

van Hulzen ZJ and Coenen AM: Effects of paradoxical sleep deprivation on two-way avoidance acquisition. Physiol Behav. 29:581–587. 1982. View Article : Google Scholar : PubMed/NCBI

16 

Lee YD, Kim JY, Lee KH, et al: Melatonin attenuates lipopoly-saccharide-induced acute lung inflammation in sleep-deprived mice. J Pineal Res. 46:53–57. 2009. View Article : Google Scholar

17 

Levenstein S, Prantera C, Varvo V, et al: Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am J Gastroenterol. 95:1213–1220. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Tang Y, Preuss F, Turek FW, Jakate S and Keshavarzian A: Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis. Sleep Med. 10:597–603. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Swanson GR, Burgess HJ and Keshavarzian A: Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev Clin Immunol. 7:29–36. 2011. View Article : Google Scholar :

20 

Boye B, Lundin KE, Jantschek G, et al: INSPIRE study: does stress management improve the course of inflammatory bowel disease and disease-specific quality of life in distressed patients with ulcerative colitis or Crohn’s disease? A randomized controlled trial. Inflamm Bowel Dis. 17:1863–1873. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lerner AB, Case JD, Lee TH and Mori W: Isolation of melatonin, the pineal factor that lightens melanocytes. J Am Chem Soc. 80:25871958. View Article : Google Scholar

22 

Bubenik GA: Thirty four years since the discovery of gastrointestinal melatonin. J Physiol Pharmacol. 59(Suppl 2): S33–S51. 2008.

23 

Thor PJ, Krolczyk G, Gil K, Zurowski D and Nowak L: Melatonin and serotonin effects on gastrointestinal motility. J Physiol Pharmacol. 58(Suppl 6): S97–S103. 2007.

24 

Chen CQ, Fichna J, Bashashati M, Li YY and Storr M: Distribution, function and physiological role of melatonin in the lower gut. World J Gastroenterol. 17:3888–3898. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Esposito E, Mazzon E, Riccardi L, et al: Matrix metallopro-teinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. J Pineal Res. 45:166–173. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Winiarska K, Fraczyk T, Malinska D, Drozak J and Bryla J: Melatonin attenuates diabetes-induced oxidative stress in rabbits. J Pineal Res. 40:168–176. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Mei Q, Yu JP, Xu JM, et al: Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. Acta Pharmacol Sin. 23:882–886. 2002.PubMed/NCBI

28 

Ranjbaran Z, Keefer L, Farhadi A, et al: Impact of sleep disturbances in inflammatory bowel disease. J Gastroenterol Hepatol. 22:1748–1753. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Keefer L, Stepanski EJ, Ranjbaran Z, Benson LM and Keshavarzian A: An initial report of sleep disturbance in inactive inflammatory bowel disease. J Gastroenterol Hepatol. 2:409–416. 2006.

30 

Bergmann BM, Gilliland MA, Balzano S, Refetoff S and Rechtschaffen A: Sleep deprivation in the rat: XIX. Effects of thyroxine administration Sleep. 18:317–324. 1995.

31 

Trivedi PP and Jena GB: Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci. 58:3460–3474. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Westbrook AM, Wei B, Hacke K, et al: The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity. Mutagenesis. 27:77–86. 2012. View Article : Google Scholar

33 

Arthur JC, Perez-Chanona E, Mühlbauer M, et al: Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 338:120–123. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Reyland ME: Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front Biosci (Landmark Ed). 14:2386–2399. 2009. View Article : Google Scholar

35 

Means AR, VanBerkum MF, Bagchi I, Lu KP and Rasmussen CD: Regulatory functions of calmodulin. Pharmacol Ther. 50:255–270. 1991. View Article : Google Scholar : PubMed/NCBI

36 

Kankuri E, Asmawi MZ, Korpela R, Vapaatalo H and Moilanen E: Induction of iNOS in a rat model of acute colitis. Inflammation. 23:141–152. 1999. View Article : Google Scholar : PubMed/NCBI

37 

You J, Nguyen AV, Albers CG, Lin F and Holcombe RF: Wnt pathway-related gene expression in inflammatory bowel disease. Dig Dis Sci. 53:1013–1019. 2008. View Article : Google Scholar

38 

Du Q, Park KS, Guo Z, et al: Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res. 66:7024–7031. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Pereira CP, Bachli EB and Schoedon G: The wnt pathway: a macrophage effector molecule that triggers inflammation. Curr Atheroscler Rep. 11:236–242. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Baert F, Vermeire S, Noman M, et al: Management of ulcerative colitis and Crohn’s disease. Acta Clin Belg. 59:304–314. 2004. View Article : Google Scholar

41 

Malhotra S, Bhasin D, Shafiq N and Pandhi P: Drug treatment of ulcerative colitis: unfractionated heparin, low molecular weight heparins and beyond. Expert Opin Pharmacother. 5:329–334. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Chojnacki C, Wisniewska-Jarosinska M, Walecka-Kapica E, et al: Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J Physiol Pharmacol. 62:327–334. 2011.PubMed/NCBI

43 

Rakhimova O: Use of melatonin in combined treatment for inflammatory bowel diseases. Ter Arkh. 82:64–68. 2010.In Russian.

44 

Motilva V, Garcia-Maurino S, Talero E and Illanes M: New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin. J Pineal Res. 51:44–60. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park Y, Chung S, Lee S, Kim J, Kim J, Kim T, Kim D and Baik H: Melatonin improves experimental colitis with sleep deprivation. Int J Mol Med 35: 979-986, 2015.
APA
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T. ... Baik, H. (2015). Melatonin improves experimental colitis with sleep deprivation. International Journal of Molecular Medicine, 35, 979-986. https://doi.org/10.3892/ijmm.2015.2080
MLA
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T., Kim, D., Baik, H."Melatonin improves experimental colitis with sleep deprivation". International Journal of Molecular Medicine 35.4 (2015): 979-986.
Chicago
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T., Kim, D., Baik, H."Melatonin improves experimental colitis with sleep deprivation". International Journal of Molecular Medicine 35, no. 4 (2015): 979-986. https://doi.org/10.3892/ijmm.2015.2080
Copy and paste a formatted citation
x
Spandidos Publications style
Park Y, Chung S, Lee S, Kim J, Kim J, Kim T, Kim D and Baik H: Melatonin improves experimental colitis with sleep deprivation. Int J Mol Med 35: 979-986, 2015.
APA
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T. ... Baik, H. (2015). Melatonin improves experimental colitis with sleep deprivation. International Journal of Molecular Medicine, 35, 979-986. https://doi.org/10.3892/ijmm.2015.2080
MLA
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T., Kim, D., Baik, H."Melatonin improves experimental colitis with sleep deprivation". International Journal of Molecular Medicine 35.4 (2015): 979-986.
Chicago
Park, Y., Chung, S., Lee, S., Kim, J., Kim, J., Kim, T., Kim, D., Baik, H."Melatonin improves experimental colitis with sleep deprivation". International Journal of Molecular Medicine 35, no. 4 (2015): 979-986. https://doi.org/10.3892/ijmm.2015.2080
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