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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2015 Volume 35 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

The role of hypoxia in inflammatory disease (Review)

John Biddlestone, Daniel Bandarra, Sonia Rocha
Pages: 859-869
Published online on: 27 January 2015

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Article Open Access

Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant

Bo-Yun Jang, Hyung Don Ryoo, Jaekyoung Son, Kyung-Chul Choi, Dong-Myoung Shin, Sang-Wook Kang, Min-Ji Kang
Pages: 870-876
Published online on: 25 February 2015

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Article Open Access

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis

Akiko Katsura, Asahiro Morishita, Hisakazu Iwama, Joji Tani, Teppei Sakamoto, Miwa Tatsuta, Yuka Toyota, Koji Fujita, Kiyohito Kato, Emiko Maeda, Takako Nomura, Hisaaki Miyoshi, Hirohito Yoneyama, Takashi Himoto, Shintaro Fujiwara, Hideki Kobara, Hirohito Mori, Toshiro Niki, Masafumi Ono, Mitsuomi Hirashima, Tsutomu Masaki
Pages: 877-884
Published online on: 06 February 2015

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Article Open Access

Lentivirus-mediated RNAi knockdown of the gap junction protein, Cx43, attenuates the development of vascular restenosis following balloon injury

Xiao-Jian Han, Min Chen, Tao Hong, Ling-Yu Zhu, Dan  He, Jiu-Geng Feng, Li-Ping Jiang
Pages: 885-892
Published online on: 23 January 2015

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Article Open Access

Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Pages: 893-900
Published online on: 18 February 2015

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Article Open Access

Effects of baicalin on collagen Ι and collagen ΙΙΙ expression in pulmonary arteries of rats with hypoxic pulmonary hypertension

Panpan Liu, Shuangquan Yan, Mayun Chen, Ali Chen, Dan Yao, Xiaomei Xu, Xueding Cai, Liangxing Wang, Xiaoying Huang
Pages: 901-908
Published online on: 25 February 2015

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Article Open Access

The proliferative effects of Pyropia yezoensis peptide on IEC-6 cells are mediated through the epidermal growth factor receptor signaling pathway

Min-Kyeong Lee, In-Hye Kim, Youn-Hee Choi, Jeong-Wook Choi, Young-Min Kim, Taek-Jeong Nam
Pages: 909-914
Published online on: 26 February 2015

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Article Open Access

An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway

Hyun Jung Koo, Eun-Hwa Sohn, Suhkneung Pyo, Han Goo Woo, Dae Won Park, Young-Min Ham, Seon-A Jang, Soo-Yeong Park, Se Chan Kang
Pages: 915-924
Published online on: 26 February 2015

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Article Open Access

Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes

Nieves González, Antonio Martín-Duce, Félix Martínez-Arrieta, Zaida Moreno-Villegas, Sergio Portal-Núñez, Raúl Sanz, Jesús Egido
Pages: 925-931
Published online on: 04 February 2015

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Article Open Access

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

Jiajing Yin, Yufan Wang, Liping Gu, Nengguang Fan, Yuhang Ma, Yongde Peng
Pages: 932-940
Published online on: 30 January 2015

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Article Open Access

CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation

Minhui Hua, Sujuan Yan, Yan Deng, Qinghua Xi, Rong Liu, Shuyun Yang, Jian Liu, Chunhui Tang, Yingying Wang, Jianxin Zhong
Pages: 941-949
Published online on: 04 February 2015

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Article Open Access

Characterization of three alternative transcripts of the BRCA1 gene in patients with breast cancer and a family history of breast and/or ovarian cancer who tested negative for pathogenic mutations

Gaetana Gambino, Mariella Tancredi, Elisabetta Falaschi, Paolo Aretini, Maria Adelaide Caligo
Pages: 950-956
Published online on: 16 February 2015

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Article Open Access

Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages

Sin-Hye Park, Ji Hun Paek, Daekeun Shin, Jae-Yong Lee, Soon Sung Lim, Young-Hee Kang
Pages: 957-965
Published online on: 12 February 2015

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Article

Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer

Yang-Jia Zhuo, Ming Xi, Yue-Ping Wan, Wei Hua, Yuan-Ling Liu, Song Wan, Yu-Lin Zhou, Hong-Wei Luo, Shu-Lin Wu, Wei-De Zhong, Chin-Lee Wu
Pages: 966-972
Published online on: 30 January 2015

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Article

Chromatin immunoprecipitation-sequencing predicts p300 binding sites in the MCF7 human breast cancer cell line Corrigendum in /10.3892/ijmm.2016.2642

Xiemei Wang, Shaolin Li
Pages: 973-978
Published online on: 27 January 2015

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Article

Melatonin improves experimental colitis with sleep deprivation

Young-Sook Park, Sook-Hee Chung, Seong-Kyu Lee, Ja-Hyun Kim, Jun-Bong Kim, Tae-Kyun Kim, Dong-Shin Kim, Haing-Woon Baik
Pages: 979-986
Published online on: 27 January 2015

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Article

Rhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-κB signaling

Ji-Won Park, Ok-Kyoung Kwon, Jung-Hee Kim, Sei-Ryang Oh, Jae-Hong Kim, Jin-Hyub Paik, Bambang Marwoto, Rifatul Widjhati, Fifit Juniarti, Doddy Irawan, Kyung-Seop Ahn
Pages: 987-994
Published online on: 25 February 2015

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Article

PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo Retraction in /10.3892/ijmm.2024.5459

Xinting Pan, Qingyun Zhu, Yunbo Sun, Liandi Li, Yunpeng Zhu, Zhihui Zhao, Jianxin Zuo, Wei Fang, Kun Li
Pages: 995-1002
Published online on: 11 February 2015

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Article

The role of Toll-like receptor 3 and 4 in regulating the function of mesenchymal stem cells isolated from umbilical cord

Li Zhang, Dan Liu, Dan Pu, Yanwen Wang, Li Li, Yanqi He, Yalun Li, Lei Li, Zhixin Qiu, Shuang Zhao, Weimin Li
Pages: 1003-1010
Published online on: 19 February 2015

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Article

Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells

Young Chan Song, Yonghee Lee, Hyeong Mi Kim, Moo Yeol Hyun, Yun Young Lim, Kye Yong Song, Beom Joon Kim
Pages: 1011-1016
Published online on: 26 February 2015

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Article

Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices

Daehwan Kim, So Young Kim, Seog Kyun Mun, Sangmyung Rhee, Beom Joon Kim
Pages: 1017-1025
Published online on: 03 February 2015

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Article

Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-β1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro

Le Yang, Jin Hu, Hong-Zhen Hao, Zhao Yin, Gang Liu, Xiao-Jing Zou
Pages: 1026-1032
Published online on: 02 February 2015

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Article

Downregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion

Li Yao, Yi Zhang, Qiao Zhu, Xinyi Li, Shaojun Zhu, Li Gong, Xiujuan Han, Miao Lan, Shanqu Li, Wei Zhang, Yanhong Li
Pages: 1033-1041
Published online on: 09 February 2015

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Article

Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway

So Young Kim, Moo Yeol Hyun, Kyung Chan Go, Christos C. Zouboulis, Beom Joon Kim
Pages: 1042-1050
Published online on: 12 February 2015

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Article

Transplantation of human umbilical cord-derived mesenchymal stems cells for the treatment of Becker muscular dystrophy in affected pedigree members

Pang Li, Kai Cui, Bo Zhang, Zhendan Wang, Yangyang Shen, Xiangyu Wang, Jianbo Zhang, Feng Tong, Sheng Li
Pages: 1051-1057
Published online on: 30 January 2015

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Article

TBX20 loss-of-function mutation contributes to double outlet right ventricle

Yun Pan, Rui Geng, Ning Zhou, Gui-Fen Zheng, Hong Zhao, Juan Wang, Cui-Mei Zhao, Xing-Biao Qiu, Yi-Qing Yang, Xing-Yuan Liu
Pages: 1058-1066
Published online on: 22 January 2015

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Article

Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-κB signaling pathway in vivo and in vitro

Yan Wang, Minghao Nie, Yanhong Lu, Rui Wang, Jin Li, Bin Yang, Mingyang Xia, Haiyang Zhang, Xiurong Li
Pages: 1067-1073
Published online on: 09 February 2015

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Article

Integrin-β1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression

Long-Qiang Zhang, Guang-Zong Zhao, Xiao-Yan Xu, Jun Fang, Jing-Ming Chen, Ji-Wen Li, Xue-Jian Gao, Li-Juan Hao, Yun-Zhen Chen
Pages: 1074-1080
Published online on: 26 February 2015

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Article

BAD-mediated apoptotic pathway is associated with human cancer development

Xiaomang B. Stickles, Douglas C. Marchion, Elona Bicaku, Entidhar Al Sawah, Forough Abbasi, Yin Xiong, Nadim Bou Zgheib, Bernadette M. Boac, Brian C. Orr, Patricia L. Judson, Amy Berry, Ardeshir Hakam, Robert M. Wenham, Sachin M. Apte, Anders E. Berglund, Johnathan M. Lancaster
Pages: 1081-1087
Published online on: 05 February 2015

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Article

Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells

S. Rice, L. Pellat, A. Ahmetaga, G. Bano, H. D. Mason, S. A. Whitehead
Pages: 1088-1094
Published online on: 25 February 2015

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Review

Mitogen-activated protein kinase phosphatase-1: A critical phosphatase manipulating mitogen-activated protein kinase signaling in cardiovascular disease (Review)

Chang-Yi Li, Ling-Chao Yang, Kai Guo, Yue-Peng Wang, Yi-Gang Li
Pages: 1095-1102
Published online on: 18 February 2015

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Article

Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction

Shuhua Chen, Jie Yang, Hong Xiang, Wei Chen, Hua Zhong, Guoping Yang, Ting Fang, Hao Deng, Hong Yuan, Alex F. Chen, Hongwei Lu
Pages: 1103-1108
Published online on: 12 February 2015

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Article

Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease

Soo-Yeon Park, Mi-Jeong Kim, Young Jun Kim, Yoo-Hyun Lee, Donghyuk Bae, Sunoh Kim, Younghwa Na, Ho-Geun Yoon
Pages: 1109-1118
Published online on: 12 February 2015

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Article

miR-29c is downregulated in the ectopic endometrium and exerts its effects on endometrial cell proliferation, apoptosis and invasion by targeting c-Jun

Mei Long, Xiaohui Wan, Xiaolin La, Xiaoyun Gong, Xia Cai
Pages: 1119-1125
Published online on: 27 January 2015

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Article

Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways

Sung Ok Kim, Ji Yeoung Park, Seo Young Jeon, Chea Ha Yang, Mi Ryeo Kim
Pages: 1126-1132
Published online on: 06 February 2015

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Article

Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells

Xiao Ke, Guanghong Hu, Wenyi Fang, Jintuan Chen, Xin Zhang, Chunbo Yang, Jun Peng, Youqin Chen, Thomas J. Sferra
Pages: 1133-1137
Published online on: 28 January 2015

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Article

Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties

Qi Shi, Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Li-Na Chen, Cao Chen, Chen Gao, Xiao-Ping Dong
Pages: 1138-1146
Published online on: 13 February 2015

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Correction Open Access

[Corrigendum] Alterations in gene expression during sexual differentiation in androgen receptor knockout mice induced by environmental endocrine disruptors

Dehong Liu, Liping Shen, Yonglin Tao, Ying Kuang, Lei Cai, Dan Wang, Meiduo He, Xuebo Tong, Shuguang Zhou, Jie Sun, Chenchen Shi, Chunxiao Wang, Yi Wu
Pages: 1147-1147
Published online on: 11 February 2015

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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Retraction Open Access

[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Article Open Access

Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Article Open Access

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Article Open Access

Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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Article Open Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Article Open Access

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Article Open Access

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Review Open Access

Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Review Open Access

Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Review Open Access

Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Review Open Access

Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Review Open Access

Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Article Open Access

Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Review Open Access

Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Article Open Access

Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Review Open Access

Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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Article Open Access

IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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Article Open Access

CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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Correction Open Access

[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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Article Open Access

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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