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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2015 Volume 35 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

The role of hypoxia in inflammatory disease (Review)

John Biddlestone, Daniel Bandarra, Sonia Rocha
Pages: 859-869
Published online on: 27 January 2015

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Article Open Access

Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant

Bo-Yun Jang, Hyung Don Ryoo, Jaekyoung Son, Kyung-Chul Choi, Dong-Myoung Shin, Sang-Wook Kang, Min-Ji Kang
Pages: 870-876
Published online on: 25 February 2015

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Article Open Access

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis

Akiko Katsura, Asahiro Morishita, Hisakazu Iwama, Joji Tani, Teppei Sakamoto, Miwa Tatsuta, Yuka Toyota, Koji Fujita, Kiyohito Kato, Emiko Maeda, Takako Nomura, Hisaaki Miyoshi, Hirohito Yoneyama, Takashi Himoto, Shintaro Fujiwara, Hideki Kobara, Hirohito Mori, Toshiro Niki, Masafumi Ono, Mitsuomi Hirashima, Tsutomu Masaki
Pages: 877-884
Published online on: 06 February 2015

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Article Open Access

Lentivirus-mediated RNAi knockdown of the gap junction protein, Cx43, attenuates the development of vascular restenosis following balloon injury

Xiao-Jian Han, Min Chen, Tao Hong, Ling-Yu Zhu, Dan  He, Jiu-Geng Feng, Li-Ping Jiang
Pages: 885-892
Published online on: 23 January 2015

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Article Open Access

Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Pages: 893-900
Published online on: 18 February 2015

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Article Open Access

Effects of baicalin on collagen Ι and collagen ΙΙΙ expression in pulmonary arteries of rats with hypoxic pulmonary hypertension

Panpan Liu, Shuangquan Yan, Mayun Chen, Ali Chen, Dan Yao, Xiaomei Xu, Xueding Cai, Liangxing Wang, Xiaoying Huang
Pages: 901-908
Published online on: 25 February 2015

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Article Open Access

The proliferative effects of Pyropia yezoensis peptide on IEC-6 cells are mediated through the epidermal growth factor receptor signaling pathway

Min-Kyeong Lee, In-Hye Kim, Youn-Hee Choi, Jeong-Wook Choi, Young-Min Kim, Taek-Jeong Nam
Pages: 909-914
Published online on: 26 February 2015

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Article Open Access

An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway

Hyun Jung Koo, Eun-Hwa Sohn, Suhkneung Pyo, Han Goo Woo, Dae Won Park, Young-Min Ham, Seon-A Jang, Soo-Yeong Park, Se Chan Kang
Pages: 915-924
Published online on: 26 February 2015

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Article Open Access

Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes

Nieves González, Antonio Martín-Duce, Félix Martínez-Arrieta, Zaida Moreno-Villegas, Sergio Portal-Núñez, Raúl Sanz, Jesús Egido
Pages: 925-931
Published online on: 04 February 2015

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Article Open Access

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

Jiajing Yin, Yufan Wang, Liping Gu, Nengguang Fan, Yuhang Ma, Yongde Peng
Pages: 932-940
Published online on: 30 January 2015

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Article Open Access

CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation

Minhui Hua, Sujuan Yan, Yan Deng, Qinghua Xi, Rong Liu, Shuyun Yang, Jian Liu, Chunhui Tang, Yingying Wang, Jianxin Zhong
Pages: 941-949
Published online on: 04 February 2015

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Article Open Access

Characterization of three alternative transcripts of the BRCA1 gene in patients with breast cancer and a family history of breast and/or ovarian cancer who tested negative for pathogenic mutations

Gaetana Gambino, Mariella Tancredi, Elisabetta Falaschi, Paolo Aretini, Maria Adelaide Caligo
Pages: 950-956
Published online on: 16 February 2015

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Article Open Access

Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages

Sin-Hye Park, Ji Hun Paek, Daekeun Shin, Jae-Yong Lee, Soon Sung Lim, Young-Hee Kang
Pages: 957-965
Published online on: 12 February 2015

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Article

Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer

Yang-Jia Zhuo, Ming Xi, Yue-Ping Wan, Wei Hua, Yuan-Ling Liu, Song Wan, Yu-Lin Zhou, Hong-Wei Luo, Shu-Lin Wu, Wei-De Zhong, Chin-Lee Wu
Pages: 966-972
Published online on: 30 January 2015

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Article

Chromatin immunoprecipitation-sequencing predicts p300 binding sites in the MCF7 human breast cancer cell line Corrigendum in /10.3892/ijmm.2016.2642

Xiemei Wang, Shaolin Li
Pages: 973-978
Published online on: 27 January 2015

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Article

Melatonin improves experimental colitis with sleep deprivation

Young-Sook Park, Sook-Hee Chung, Seong-Kyu Lee, Ja-Hyun Kim, Jun-Bong Kim, Tae-Kyun Kim, Dong-Shin Kim, Haing-Woon Baik
Pages: 979-986
Published online on: 27 January 2015

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Article

Rhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-κB signaling

Ji-Won Park, Ok-Kyoung Kwon, Jung-Hee Kim, Sei-Ryang Oh, Jae-Hong Kim, Jin-Hyub Paik, Bambang Marwoto, Rifatul Widjhati, Fifit Juniarti, Doddy Irawan, Kyung-Seop Ahn
Pages: 987-994
Published online on: 25 February 2015

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Article

PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo Retraction in /10.3892/ijmm.2024.5459

Xinting Pan, Qingyun Zhu, Yunbo Sun, Liandi Li, Yunpeng Zhu, Zhihui Zhao, Jianxin Zuo, Wei Fang, Kun Li
Pages: 995-1002
Published online on: 11 February 2015

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Article

The role of Toll-like receptor 3 and 4 in regulating the function of mesenchymal stem cells isolated from umbilical cord

Li Zhang, Dan Liu, Dan Pu, Yanwen Wang, Li Li, Yanqi He, Yalun Li, Lei Li, Zhixin Qiu, Shuang Zhao, Weimin Li
Pages: 1003-1010
Published online on: 19 February 2015

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Article

Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells

Young Chan Song, Yonghee Lee, Hyeong Mi Kim, Moo Yeol Hyun, Yun Young Lim, Kye Yong Song, Beom Joon Kim
Pages: 1011-1016
Published online on: 26 February 2015

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Article

Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices

Daehwan Kim, So Young Kim, Seog Kyun Mun, Sangmyung Rhee, Beom Joon Kim
Pages: 1017-1025
Published online on: 03 February 2015

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Article

Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-β1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro

Le Yang, Jin Hu, Hong-Zhen Hao, Zhao Yin, Gang Liu, Xiao-Jing Zou
Pages: 1026-1032
Published online on: 02 February 2015

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Article

Downregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion

Li Yao, Yi Zhang, Qiao Zhu, Xinyi Li, Shaojun Zhu, Li Gong, Xiujuan Han, Miao Lan, Shanqu Li, Wei Zhang, Yanhong Li
Pages: 1033-1041
Published online on: 09 February 2015

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Article

Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway

So Young Kim, Moo Yeol Hyun, Kyung Chan Go, Christos C. Zouboulis, Beom Joon Kim
Pages: 1042-1050
Published online on: 12 February 2015

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Article

Transplantation of human umbilical cord-derived mesenchymal stems cells for the treatment of Becker muscular dystrophy in affected pedigree members

Pang Li, Kai Cui, Bo Zhang, Zhendan Wang, Yangyang Shen, Xiangyu Wang, Jianbo Zhang, Feng Tong, Sheng Li
Pages: 1051-1057
Published online on: 30 January 2015

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Article

TBX20 loss-of-function mutation contributes to double outlet right ventricle

Yun Pan, Rui Geng, Ning Zhou, Gui-Fen Zheng, Hong Zhao, Juan Wang, Cui-Mei Zhao, Xing-Biao Qiu, Yi-Qing Yang, Xing-Yuan Liu
Pages: 1058-1066
Published online on: 22 January 2015

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Article

Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-κB signaling pathway in vivo and in vitro

Yan Wang, Minghao Nie, Yanhong Lu, Rui Wang, Jin Li, Bin Yang, Mingyang Xia, Haiyang Zhang, Xiurong Li
Pages: 1067-1073
Published online on: 09 February 2015

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Article

Integrin-β1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression

Long-Qiang Zhang, Guang-Zong Zhao, Xiao-Yan Xu, Jun Fang, Jing-Ming Chen, Ji-Wen Li, Xue-Jian Gao, Li-Juan Hao, Yun-Zhen Chen
Pages: 1074-1080
Published online on: 26 February 2015

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Article

BAD-mediated apoptotic pathway is associated with human cancer development

Xiaomang B. Stickles, Douglas C. Marchion, Elona Bicaku, Entidhar Al Sawah, Forough Abbasi, Yin Xiong, Nadim Bou Zgheib, Bernadette M. Boac, Brian C. Orr, Patricia L. Judson, Amy Berry, Ardeshir Hakam, Robert M. Wenham, Sachin M. Apte, Anders E. Berglund, Johnathan M. Lancaster
Pages: 1081-1087
Published online on: 05 February 2015

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Article

Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells

S. Rice, L. Pellat, A. Ahmetaga, G. Bano, H. D. Mason, S. A. Whitehead
Pages: 1088-1094
Published online on: 25 February 2015

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Review

Mitogen-activated protein kinase phosphatase-1: A critical phosphatase manipulating mitogen-activated protein kinase signaling in cardiovascular disease (Review)

Chang-Yi Li, Ling-Chao Yang, Kai Guo, Yue-Peng Wang, Yi-Gang Li
Pages: 1095-1102
Published online on: 18 February 2015

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Article

Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction

Shuhua Chen, Jie Yang, Hong Xiang, Wei Chen, Hua Zhong, Guoping Yang, Ting Fang, Hao Deng, Hong Yuan, Alex F. Chen, Hongwei Lu
Pages: 1103-1108
Published online on: 12 February 2015

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Article

Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease

Soo-Yeon Park, Mi-Jeong Kim, Young Jun Kim, Yoo-Hyun Lee, Donghyuk Bae, Sunoh Kim, Younghwa Na, Ho-Geun Yoon
Pages: 1109-1118
Published online on: 12 February 2015

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Article

miR-29c is downregulated in the ectopic endometrium and exerts its effects on endometrial cell proliferation, apoptosis and invasion by targeting c-Jun

Mei Long, Xiaohui Wan, Xiaolin La, Xiaoyun Gong, Xia Cai
Pages: 1119-1125
Published online on: 27 January 2015

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Article

Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways

Sung Ok Kim, Ji Yeoung Park, Seo Young Jeon, Chea Ha Yang, Mi Ryeo Kim
Pages: 1126-1132
Published online on: 06 February 2015

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Article

Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells

Xiao Ke, Guanghong Hu, Wenyi Fang, Jintuan Chen, Xin Zhang, Chunbo Yang, Jun Peng, Youqin Chen, Thomas J. Sferra
Pages: 1133-1137
Published online on: 28 January 2015

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Article

Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties

Qi Shi, Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Li-Na Chen, Cao Chen, Chen Gao, Xiao-Ping Dong
Pages: 1138-1146
Published online on: 13 February 2015

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Correction Open Access

[Corrigendum] Alterations in gene expression during sexual differentiation in androgen receptor knockout mice induced by environmental endocrine disruptors

Dehong Liu, Liping Shen, Yonglin Tao, Ying Kuang, Lei Cai, Dan Wang, Meiduo He, Xuebo Tong, Shuguang Zhou, Jie Sun, Chenchen Shi, Chunxiao Wang, Yi Wu
Pages: 1147-1147
Published online on: 11 February 2015

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Review Open Access

Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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Article Open Access

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Article Open Access

Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Article Open Access

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Review Open Access

Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Article Open Access

Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Review Open Access

Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Review Open Access

Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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