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Article

Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells

  • Authors:
    • Xiao Ke
    • Guanghong Hu
    • Wenyi Fang
    • Jintuan Chen
    • Xin Zhang
    • Chunbo Yang
    • Jun Peng
    • Youqin Chen
    • Thomas J. Sferra
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350122, P.R. China, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
  • Pages: 1133-1137
    |
    Published online on: January 28, 2015
       https://doi.org/10.3892/ijmm.2015.2083
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Abstract

Increasing evidence indicates that the pathogenesis of ulcerative colitis (UC) is highly regulated by the interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) pathway and its negative feedback regulator, suppressor of cytokine signaling 3 (SOCS3). Therefore, modulating the signaling feedback loop of IL-6/STAT3/SOCS3 may prove to be a novel therapeutic approach for the treatment of UC. Qing Hua Chang Yin (QHCY) is a traditional Chinese formulation that has long been used in clinic for the treatment of UC. We have previously reported that QHCY ameliorates acute intestinal inflammation in vivo and in vitro through the suppression of the nuclear factor‑κB (NF-κB) pathway. In the present study, in order to further elucidate the mechanisms responsible for the anti‑inflammatory activities of QHCY, we stimulated human intestinal Caco-2 cells with lipopolysaccharide (LPS) to create an in vitro model of an inflamed human intestinal epithelium, and evaluated the effects of QHCY on the IL-6/STAT3/SOCS3 signaling network in inflamed Caco-2 cells. The levels of IL-6 were measured by ELISA and the levels of STAT3 and SOCS3 were measured by western blot analysis. We found that QHCY significantly inhibited the LPS-induced secretion of pro-inflammatory IL-6 in the Caco-2 cells in a dose-dependent manner. Moreover, QHCY profoundly suppressed the LPS-induced phosphorylation of Janus-activated kinase 1 (JAK1), JAK2 and STAT3. Furthermore, treatment with QHCY markedly augmented the expression of SOCS3. Taken together, the findings of the present study suggest that the modulation of the IL-6/STAT3/SOCS3 signaling network may be one of the mechanisms through which QHCY exerts its anti‑inflammatory effects.
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1 

Eaden JA, Abrams KR and Mayberry JF: The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 48:526–535. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Eaden J: Review article: colorectal carcinoma and inflammatory bowel disease. Aliment Pharmacol Ther. 20(Suppl 4): 24–30. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Ekbom A, Helmick C, Zack M and Adami HO: Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 323:1228–1233. 1990. View Article : Google Scholar : PubMed/NCBI

4 

Canavan C, Abrams KR and Mayberry J: Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther. 23:1097–1104. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Gillen CD, Walmsley RS, Prior P, et al: Ulcerative colitis and crohn’s disease: a comparison of the colorectal cancer risk in extensive colitis. Gut. 35:1590–1592. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Isaacs KL, Lewis JD, Sandborn WJ, et al: State of the art: IBD therapy and clinical trials in IBD. Inflamm Bowel Dis. 11(Suppl l): S3–S12. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Kaser A and Tilg H: Novel therapeutic targets in the treatmentof IBD. Expert Opin Ther Targets. 12:553–563. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Hanauer SB: Inflammatory bowel disease. N Engl J Med. 334:841–848. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Bensoussan M, Jovenin N, Garcia B, et al: Complementary and alternative medicine use by patients with inflammatory bowel disease: results from a postal survey. Gastroenterol Clin Biol. 30:14–23. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Stickel F and Schuppan D: Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 39:293–304. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Treasure J: Herbal medicine and cancer: an introductory overview. Semin Oncol Nurs. 21:177–183. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Langmead L and Rampton DS: Review article: complementary and alternative therapies for inflammatory bowel disease. Aliment Pharmacol Ther. 23:341–349. 2006. View Article : Google Scholar : PubMed/NCBI

13 

MacDonald TT, Hutchings P, Choy MY, et al: Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol. 81:301–305. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Gross V, Andus T, Caesar I, et al: Evidence for continous stimulation of interleukin-6 production in Crohn’s disease. Gastroenterology. 102:514–519. 1992.PubMed/NCBI

15 

Holub MC, Makó E, Dévay T, et al: Increased interleukin-6 levels, interleukin-6 receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory bowel disease. Scand J Gastroenterol Suppl. 228:47–50. 1998.PubMed/NCBI

16 

Reinecker HC, Steffen M, Witthoeft T, et al: Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin Exp Immunol. 94:174–181. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Mitsuyama K, Sasaki E, Toyonaga A, et al: Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion. 50:104–111. 1991. View Article : Google Scholar : PubMed/NCBI

18 

Carey R, Jurickova I, Ballard E, et al: Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease. Inflamm Bowel Dis. 14:446–457. 2008. View Article : Google Scholar :

19 

Ishiguro Y: Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol. 34:66–74. 1999. View Article : Google Scholar : PubMed/NCBI

20 

ter Steege JC, van de Ven MW, Forget PP, et al: The role of endogenous IFN-gamma, TNF-alpha and IL-10 in LPS-induced nitric oxide release in a mouse model. Cytokine. 10:115–123. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Lawrence T, Willoughby DA and Gilroy DW: Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol. 2:787–795. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Turini ME and DuBois RN: Cyclooxygenase-2: a therapeutic target. Annu Rev Med. 53:35–57. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Moncada S: Nitric oxide: discovery and impact on clinical medicine. J R Soc Med. 92:164–169. 1999.PubMed/NCBI

24 

Mudter J, Weigmann B, Bartsch B, et al: Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am J Gastroenterol. 100:64–72. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Musso A, Dentelli P, Carlino A, et al: Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation. Inflamm Bowel Dis. 11:91–98. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Kubo M, Hanada T and Yoshimura A: Suppressors of cytokine signaling and immunity. Nat Immunol. 4:1169–1176. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Alexander WS and Hilton DJ: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol. 22:503–529. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Grutkoski PS, Chen Y, Chung CS and Ayala A: Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes. J Leukoc Biol. 74:916–922. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Corvinus FM, Orth C, Moriggl R, et al: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia. 7:545–555. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Mitsuyama K, Matsumoto S, Rose-John S, et al: STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut. 55:1263–1269. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Isomoto H, Mott JL, Kobayashi S, et al: Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. Gastroenterology. 132:384–396. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Wang XY and Tian DL: Etiological and pathological characteristics of ulcerative colitis and TCM differentiation and treatment. Beijing Zhong Yi Yao Da Xue Xue Bao. 30:554–559. 2007.In Chinese.

33 

Gong YP, Liu W, Ma GT, et al: Randomized control study of ‘Qingchang Suppository’ on ulcerative colitis. Shanghai Zhong Yi Yao Da Xue Xue Bao. 21:33–36. 2007.In Chinese.

34 

Fu NL and Huang JY: Progress of clinical research of traditional Chinese medicine for the treatment of ulcerative colitis. J Tradit Chin Med. 40:501–503. 1999.In Chinese.

35 

Li QG: An idea about treatment of ulcerative colitis by TCM methods. Beijing Zhong Yi. 23:149–150. 2004.In Chinese.

36 

Wang CH, Gao WY, Li YF, et al: Study of Fufangkushen colon-release capsule on ulcerative colitis of endo-retention of damp heat type. Xian Dai Zhong Xi Yi Jie He Za Zhi. 18:13–15. 2009.In Chinese.

37 

Chen JT, Ke X, Fu XY, et al: The clinical study of heat-clearing and damp-drying on the treatment of damp-heat ulcerative colitis. Zhongguo Zhong Xi Yi Jie He Xiao Hua Za Zhi. 17:256–257. 2009.In Chinese.

38 

Ke X, Zhou F, Gao Y, Xie B, et al: Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis through the inhibition of the TLR4/NF-κB pathway. Int J Mol Med. 32:926–930. 2013.PubMed/NCBI

39 

Ke X, Chen J, Zhang X, et al: Qing Hua Chang Yin attenuates lipopolysaccharide-induced inflammatory response in human intestinal cells by inhibiting NF-κB activation. Exp Ther Med. 6:189–193. 2013.PubMed/NCBI

40 

Levy DE and Darnell J: Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 3:651–662. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Murray PJ: The JAK-STAT signaling pathway: input and output integration. J Immunol. 178:2623–2629. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Pfitzner E, Kliem S, Baus D and Litterst M: The role of STATs in inflammation and inflammatory diseases. Curr Pharm Des. 10:2839–2850. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Okugawa S, Ota Y, Kitazawa T, et al: Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages. Am J Physiol Cell Physiol. 285:C399–C408. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Zhu Z, Jin H, Yu P, et al: Mollugin inhibits the inflammatory response in LPS-stimulated RAW264.7 macrophages by blocking the Janus kinase (JAK)-signal transducers and activators of transcription. Biol Pharm Bull. 36:399–406. 2013. View Article : Google Scholar

45 

Greenhalgh CJ, Miller ME, Hilton DJ, et al: Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease. Gastroenterology. 123:2064–2081. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ke X, Hu G, Fang W, Chen J, Zhang X, Yang C, Peng J, Chen Y and Sferra TJ: Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells. Int J Mol Med 35: 1133-1137, 2015.
APA
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C. ... Sferra, T.J. (2015). Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells. International Journal of Molecular Medicine, 35, 1133-1137. https://doi.org/10.3892/ijmm.2015.2083
MLA
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C., Peng, J., Chen, Y., Sferra, T. J."Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells". International Journal of Molecular Medicine 35.4 (2015): 1133-1137.
Chicago
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C., Peng, J., Chen, Y., Sferra, T. J."Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells". International Journal of Molecular Medicine 35, no. 4 (2015): 1133-1137. https://doi.org/10.3892/ijmm.2015.2083
Copy and paste a formatted citation
x
Spandidos Publications style
Ke X, Hu G, Fang W, Chen J, Zhang X, Yang C, Peng J, Chen Y and Sferra TJ: Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells. Int J Mol Med 35: 1133-1137, 2015.
APA
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C. ... Sferra, T.J. (2015). Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells. International Journal of Molecular Medicine, 35, 1133-1137. https://doi.org/10.3892/ijmm.2015.2083
MLA
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C., Peng, J., Chen, Y., Sferra, T. J."Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells". International Journal of Molecular Medicine 35.4 (2015): 1133-1137.
Chicago
Ke, X., Hu, G., Fang, W., Chen, J., Zhang, X., Yang, C., Peng, J., Chen, Y., Sferra, T. J."Qing Hua Chang Yin inhibits the LPS-induced activation of the IL-6/STAT3 signaling pathway in human intestinal Caco-2 cells". International Journal of Molecular Medicine 35, no. 4 (2015): 1133-1137. https://doi.org/10.3892/ijmm.2015.2083
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