Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer

  • Authors:
    • Yang-Jia Zhuo
    • Ming Xi
    • Yue-Ping Wan
    • Wei Hua
    • Yuan-Ling Liu
    • Song Wan
    • Yu-Lin Zhou
    • Hong-Wei Luo
    • Shu-Lin Wu
    • Wei-De Zhong
    • Chin-Lee Wu
  • View Affiliations

  • Published online on: January 30, 2015     https://doi.org/10.3892/ijmm.2015.2086
  • Pages: 966-972
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Centromere protein F (CENPF) is a protein associated with the centromere-kinetochore complex and chromosomal segregation during mitosis. Previous studies have demonstrated that the upregulation of CENPF may be used as a proliferation marker of malignant cell growth in tumors. The overexpression of CENPF has also been reported to be associated with a poor prognosis in human cancers. However, the clinical significance of CENPF in prostate cancer (PCa) has not yet been fully elucidated. Thus, the aim of the present study was to determine the association of CENPF with tumor progression and prognosis in patients with PCa. The expression of CENPF at the protein level in human PCa and non-cancerous prostate tissues was detected by immunohistochemical analysis, which was further validated using a microarray-based dataset (NCBI GEO accession no: GSE21032) at the mRNA level. Subsequently, the association of CENPF expression with the clinicopathological characteristics of the patients with PCa was statistically analyzed. Immunohistochemistry and dataset analysis revealed that CENPF expression was significantly increased in the PCa tissues compared with the non-cancerous prostate tissues [immunoreactivity score (IRS): PCa, 177.98±94.096 vs. benign, 121.30±89.596, P<0.001; mRNA expression in the dataset: PCa, 5.67±0.47 vs. benign, 5.40±0.11; P<0.001]. Additionally, as revealed by the dataset, the upregulation of CENPF mRNA expression in the PCa tissues significantly correlated with a higher Gleason score (GS, P=0.005), an advanced pathological stage (P=0.008), the presence of metastasis (P<0.001), a shorter overall survival (P=0.003) and prostate-specific antigen (PSA) failure (P<0.001). Furthermore, both univariate and multivariate analyses revealed that the upregulation of CENPF was an independent predictor of poor biochemical recurrence (BCR)-free survival (P<0.001 and P=0.012, respectively). Our data suggest that the increased expression of CENPF plays an important role in the progression of PCa. More importantly, the increased expression of CENPF may efficiently predict poor BCR-free survival in patients with PCa.
View Figures
View References

Related Articles

Journal Cover

April-2015
Volume 35 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhuo Y, Xi M, Wan Y, Hua W, Liu Y, Wan S, Zhou Y, Luo H, Wu S, Zhong W, Zhong W, et al: Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer. Int J Mol Med 35: 966-972, 2015
APA
Zhuo, Y., Xi, M., Wan, Y., Hua, W., Liu, Y., Wan, S. ... Wu, C. (2015). Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer. International Journal of Molecular Medicine, 35, 966-972. https://doi.org/10.3892/ijmm.2015.2086
MLA
Zhuo, Y., Xi, M., Wan, Y., Hua, W., Liu, Y., Wan, S., Zhou, Y., Luo, H., Wu, S., Zhong, W., Wu, C."Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer". International Journal of Molecular Medicine 35.4 (2015): 966-972.
Chicago
Zhuo, Y., Xi, M., Wan, Y., Hua, W., Liu, Y., Wan, S., Zhou, Y., Luo, H., Wu, S., Zhong, W., Wu, C."Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer". International Journal of Molecular Medicine 35, no. 4 (2015): 966-972. https://doi.org/10.3892/ijmm.2015.2086