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The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II

  • Authors:
    • Huixin Guo
    • Baoxin Liu
    • Lei Hou
    • Erlinda The
    • Gang Li
    • Dongzhi Wang
    • Qiqiang Jie
    • Wenliang Che
    • Yidong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1159-1168
    |
    Published online on: March 2, 2015
       https://doi.org/10.3892/ijmm.2015.2119
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Abstract

Angiotensin II (AngII) is the central product of the renin‑angiotensin system (RAS) and this octapeptide contributes to the pathophysiology of cardiac hypertrophy and remodeling. mAKAPβ is an A‑kinase anchoring protein (AKAP) that has the function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. In this study, we aimed to investigate the role of mAKAPβ in AngII‑induced cardiomyocyte hypertrophy and the possible mechanisms involved. Cultured cardiomyocytes from neonatal rats were treated with AngII. Subsequently, the morphology of the cardiomyocytes was observed and the expression of mAKAPβ and cardiomyocyte hypertrophic markers was measured. mAKAPβ‑shRNA was constructed for RNA interference; the expression of mAKAPβ and hypertrophic markers, the cell surface area and the [3H]Leucine incorporation rate in the AngII‑treated rat cardiomyocytes were detected following RNA interference. Simultaneously, changes in the expression levels of phosphorylated extracellular signal-regulated kinase (p‑ERK)2 in the cardiomyocytes were assessed. The cell size of the AngII-treated cardiaomyocytes was significantly larger than that of the untreated cardiomyocytes. The expression of hypertrophic markers and p‑ERK2, the cell surface area and the [3H]Leucine incorporation rate were all significantly increased in the AngII‑treated cells. However, the expression of mAKAPβ remained unaltered in this process. RNA interference simultaneously inhibited the protein expression of mAKAPβ and p‑ERK2, and the hypertrophy of the cardiomyocytes induced by AngII was attenuated. These results demonstrate that AngII induces hypertrophy in cardiomyocytes, and mAKAPβ is possibly involved in this process. The effects of mAKAPβ on AngII‑induced cardiomyocyte hypertrophy may be associated with p‑ERK2 expression.
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1 

Gupta S, Das B and Sen S: Cardiac hypertrophy: mechanisms and therapeutic opportunities. Antioxid Redox Signal. 9:623–652. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Zhang L, Malik S, Kelley GG, Kapiloff MS and Smrcka AV: Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. J Biol Chem. 286:23012–23021. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Aoyagi T, Fujii AM, Flanagan MF, Arnold LW, Brathwaite KW, Colan SD and Mirsky I: Transition from compensated hypertrophy to intrinsic myocardial dysfunction during development of left ventricular pressure-overload hypertrophy in conscious sheep: Systolic dysfunction precedes diastolic dysfunction. Circulation. 88:2415–2425. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Oka T and Komuro I: Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure. Circ J. 72(Suppl A): A13–A16. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Oka T, Akazawa H, Naito AT and Komuro I: Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure. Circ Res. 114:565–571. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Papin JA, Hunter T, Palsson BO and Subramaniam S: Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol. 6:99–111. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Molkentin JD and Dorn GW 2nd: Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol. 63:391–426. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Javadov S, Jang S and Agostini B: Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives. Pharmacol Ther. 144:202–225. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Heineke J and Molkentin JD: Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 7:589–600. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Pawson T and Nash P: Assembly of cell regulatory systems through protein interaction domains. Science. 300:445–452. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Scott JD and Santana LF: A-kinase anchoring proteins: getting to the heart of the matter. Circulation. 121:1264–1271. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Dodge-Kafka KL, Langeberg L and Scott JD: Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res. 98:993–1001. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS and Scott JD: The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 437:574–578. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Kapiloff MS, Piggott LA, Sadana R, Li J, Heredia LA, Henson E, Efendiev R and Dessauer CW: An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes. J Biol Chem. 284:23540–23546. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N and Marks AR: PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 101:365–376. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Pare GC, Bauman AL, McHenry M, Michel JJ, Dodge-Kafka KL and Kapiloff MS: The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci. 118:5637–5646. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Schulze DH, Muqhal M, Lederer WJ and Ruknudin AM: Sodium/calcium exchanger (NCX1) macromolecular complex. J Biol Chem. 278:28849–28855. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Wong W, Goehring AS, Kapiloff MS, Langeberg LK and Scott JD: mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal. 1:ra182008.PubMed/NCBI

19 

Faul C, Dhume A, Schecter AD and Mundel P: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol. 27:8215–8227. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Pare GC, Easlick JL, Mislow JM, McNally EM and Kapiloff MS: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res. 303:388–399. 2005. View Article : Google Scholar : PubMed/NCBI

21 

de Gasparo M, Catt KJ, Inagami T, Wright JW and Unger T: International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 52:415–472. 2000.PubMed/NCBI

22 

Sever PS, Gradman AH and Azizi M: Managing cardiovascular and renal risk: the potential of direct renin inhibition. J Renin Angiotensin Aldosterone Syst. 10:65–76. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Sata M and Fukuda D: Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis. J Med Invest. 57:12–25. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Wang CH, Li F and Takahashi N: The renin angiotensin system and the metabolic syndrome. Open Hypertens J. 3:1–13. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Abadir PM: The frail renin-angiotensin system. Clin Geriatr Med. 27:53–65. 2011. View Article : Google Scholar

26 

Möllmann H, Schmidt-Schweda S, Nef H, Möllmann S, Burstin JV, Klose S, Elsässer A and Holubarsch CJ: Contractile effects of angiotensin and endothelin in failing and non-failing human hearts. Int J Cardiol. 114:34–40. 2007. View Article : Google Scholar

27 

Fabris B, Candido R, Bortoletto M, Zentilin L, Sandri M, Fior F, Toffoli B, Stebel M, Bardelli M, Belgrado D, Giacca M and Carretta R: Dose and time-dependent apoptotic effects by angiotensin II infusion on left ventricular cardiomyocytes. J Hypertens. 25:1481–1490. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Schroder E, Magyar J, Burgess D, Andres D and Satin J: Chronic verapamil treatment remodels ICa,L in mouse ventricle. Am J Physiol Heart Circ Physiol. 292:H1906–H1916. 2007. View Article : Google Scholar

29 

Kapiloff MS, Jackson N and Airhart N: mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 114:3167–3176. 2001.PubMed/NCBI

30 

Ruf S, Piper M and Schlüter KD: Specific role for the extracellular signal-regulated kinase pathway in angiotensin II- but not phenylephrine-induced cardiac hypertrophy in vitro. Pflugers Arch. 443:483–490. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Niizeki T, Takeishi Y, Arimoto T, Takahashi H, Shishido T, Koyama Y, Goto K, Walsh RA and Kubota I: Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction. Am J Physiol Heart Circ Physiol. 292:H1105–H1112. 2007. View Article : Google Scholar

32 

Tsutamoto T, Asai S, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Ohnishi M, Wada A, Saito Y and Horie M: Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure. Eur J Heart Fail. 9:1032–1037. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Lu H, Fedak PW, Dai X, Du C, Zhou YQ, Henkelman M, Mongroo PS, Lau A, Yamabi H, Hinek A, Husain M, Hannigan G and Coles JG: Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation. 114:2271–2279. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Dorn GW 2nd and Force T: Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest. 115:527–537. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Oka T, Xu J and Molkentin JD: Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 18:117–131. 2007. View Article : Google Scholar

36 

Michel JJ, Townley IK, Dodge-Kafka KL, Zhang F, Kapiloff MS and Scott JD: Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell. 20:661–672. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Suzuki J, Matsubara H, Urakami M and Inada M: Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circ Res. 73:439–447. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Baker KM, Booz GW and Dostal DE: Cardiac actions of angiotensin II: Role of an intracardiac renin-angiotensin system. Annu Rev Physiol. 54:227–241. 1992. View Article : Google Scholar : PubMed/NCBI

39 

Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS and Lorell BH: Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effect on coronary resistance, contractility, and relaxation. J Clin Invest. 86:1913–1920. 1990. View Article : Google Scholar : PubMed/NCBI

40 

Yamazaki T, Shiojima I, Komuro I, Nagai R and Yazaki Y: Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. J Hypertens Suppl. 12:S153–S157. 1994.PubMed/NCBI

41 

Pratt RE: Angiotensin II and the control of cardiovascular structure. J Am Soc Nephrol. 10(Suppl 11): S120–S128. 1999.PubMed/NCBI

42 

Balakumar P and Jagadeesh G: A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology. Cell Signal. 26:2147–2160. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Mehta PK and Griendling KK: Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 292:C82–C97. 2007. View Article : Google Scholar

44 

Hunyady L and Catt KJ: Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol. 20:953–970. 2006. View Article : Google Scholar

45 

Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S and Delafontaine P: Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 45:2322–2332. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Mizuno T, Takano H, Hiroi Y, Ueki K, Tobe K, Kadowaki T, Nagai R and Yazaki Y: Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circ Res. 77:258–265. 1995. View Article : Google Scholar : PubMed/NCBI

47 

Sadoshima J, Xu Y, Slayter HS and Izumo S: Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:977–984. 1993. View Article : Google Scholar : PubMed/NCBI

48 

Schorb W, Booz GW, Dostal DE, Conrad KM, Chang KC and Baker KM: Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ Res. 72:1245–1254. 1993. View Article : Google Scholar : PubMed/NCBI

49 

Zou Y, Komuro I, Yamazaki T, Kudoh S, Aikawa R, Zhu W, Shiojima I, Hiroi Y, Tobe K and Kadowaki T: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. Circ Res. 82:337–345. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo H, Liu B, Hou L, The E, Li G, Wang D, Jie Q, Che W and Wei Y: The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II. Int J Mol Med 35: 1159-1168, 2015.
APA
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D. ... Wei, Y. (2015). The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II. International Journal of Molecular Medicine, 35, 1159-1168. https://doi.org/10.3892/ijmm.2015.2119
MLA
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D., Jie, Q., Che, W., Wei, Y."The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II". International Journal of Molecular Medicine 35.5 (2015): 1159-1168.
Chicago
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D., Jie, Q., Che, W., Wei, Y."The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II". International Journal of Molecular Medicine 35, no. 5 (2015): 1159-1168. https://doi.org/10.3892/ijmm.2015.2119
Copy and paste a formatted citation
x
Spandidos Publications style
Guo H, Liu B, Hou L, The E, Li G, Wang D, Jie Q, Che W and Wei Y: The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II. Int J Mol Med 35: 1159-1168, 2015.
APA
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D. ... Wei, Y. (2015). The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II. International Journal of Molecular Medicine, 35, 1159-1168. https://doi.org/10.3892/ijmm.2015.2119
MLA
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D., Jie, Q., Che, W., Wei, Y."The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II". International Journal of Molecular Medicine 35.5 (2015): 1159-1168.
Chicago
Guo, H., Liu, B., Hou, L., The, E., Li, G., Wang, D., Jie, Q., Che, W., Wei, Y."The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II". International Journal of Molecular Medicine 35, no. 5 (2015): 1159-1168. https://doi.org/10.3892/ijmm.2015.2119
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