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International Journal of Molecular Medicine
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May-2015 Volume 35 Issue 5

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Article

microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53

  • Authors:
    • Fang Wang
    • Pengwei Lv
    • Xinwei Liu
    • Mingzhi Zhu
    • Xinguang Qiu
  • View Affiliations / Copyright

    Affiliations: Second Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1395-1402
    |
    Published online on: March 3, 2015
       https://doi.org/10.3892/ijmm.2015.2123
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Abstract

Breast cancer (BC) is the foremost cause of cancer-related mortality in women worldwide. An increasing number of studies has confirmed that microRNAs (miRNAs or miRs) play an important role in the development and progression of BC. microRNA-214 (miR‑214), a member of the miRNA family, has been demonstrated to function as both a tumor suppressor and oncogene in various types of human cancer. However, the biological function of miR-214 in BC remains unclear. The present study was designed to investigate the potential role of miR-214 in the development and progression of BC. Our results revealed that miR-214 expression was significantly increased in the BC tissues compared with the adjacent benign tissues, and that the upregulation of miR-214 was significantly associated with the invasion ability of the BC cells. Furthermore, p53, which has been reported to be downregulated in BC, was predicted to be the target gene of miR-214 using bioinformatics software programs. Moreover, luciferase reporter vectors were constructed and it was confirmed that p53 is a target of miR-214. Following the transfection of miR-214 into BC cells, we found that the overexpression of miR-214 markedly enhanced cell invasion through the downregulation of p53 expression. By contrast, the overexpression of p53 abrogated the effects of miR-214. In conclusion, this study demonstrates that miR-214 functions as an oncogene in BC, at least partly by promoting cell invasion through the downregulation of p53. Therefore, miR-214 may be a potential therapeutic target for the treatment of BC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Lv P, Liu X, Zhu M and Qiu X: microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53. Int J Mol Med 35: 1395-1402, 2015.
APA
Wang, F., Lv, P., Liu, X., Zhu, M., & Qiu, X. (2015). microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53. International Journal of Molecular Medicine, 35, 1395-1402. https://doi.org/10.3892/ijmm.2015.2123
MLA
Wang, F., Lv, P., Liu, X., Zhu, M., Qiu, X."microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53". International Journal of Molecular Medicine 35.5 (2015): 1395-1402.
Chicago
Wang, F., Lv, P., Liu, X., Zhu, M., Qiu, X."microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53". International Journal of Molecular Medicine 35, no. 5 (2015): 1395-1402. https://doi.org/10.3892/ijmm.2015.2123
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Lv P, Liu X, Zhu M and Qiu X: microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53. Int J Mol Med 35: 1395-1402, 2015.
APA
Wang, F., Lv, P., Liu, X., Zhu, M., & Qiu, X. (2015). microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53. International Journal of Molecular Medicine, 35, 1395-1402. https://doi.org/10.3892/ijmm.2015.2123
MLA
Wang, F., Lv, P., Liu, X., Zhu, M., Qiu, X."microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53". International Journal of Molecular Medicine 35.5 (2015): 1395-1402.
Chicago
Wang, F., Lv, P., Liu, X., Zhu, M., Qiu, X."microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53". International Journal of Molecular Medicine 35, no. 5 (2015): 1395-1402. https://doi.org/10.3892/ijmm.2015.2123
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