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International Journal of Molecular Medicine
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Article

Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma

  • Authors:
    • Haiyan Jiang
    • Lei Qi
    • Feiran Wang
    • Zhichao Sun
    • Zhongwei Huang
    • Qinghua Xi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Medical College, Nantong University, Nantong, Jiangsu 226019, P.R. China
  • Pages: 1374-1380
    |
    Published online on: March 17, 2015
       https://doi.org/10.3892/ijmm.2015.2142
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Abstract

Semaphorin 3A (SEMA3A) was initially identified to play an important role in axonal guidance. Recently, SEMA3A has also been considered as a candidate tumor suppressor, since it is often downregulated in numerous types of cancer, including prostate cancer, breast cancer and glioma. However, the biological role of SEMA3A in ovarian cancer is not clear. In the present study, the expression of SEMA3A in ovarian cancer and normal ovarian epithelial tissues was detected by immunofluorescence, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting, and the associations between the expression of SEMA3A with the development of ovarian cancer, clinicopathological characteristics and survival were also analyzed. Results from immunofluorescence, RT‑qPCR and western blotting showed that SEMA3A is significantly downregulated in epithelial ovarian carcinoma compared to normal ovarian epithelial specimens (P<0.05). The expression levels of SEMA3A were lower in the cancer tissues with III/IV stage [the International Federation of Gynecology and Obstetrics (FIGO) stage], poor histological grade, lymph node metastasis and distant metastasis compared to that in the cancer tissues with I/II stage (FIGO), well histological grade, or without lymph node metastasis and distant metastasis (P<0.05). A decreased expression of SEMA3A is associated with a poor prognosis (P<0.001). The present findings suggest that decreased SEMA3A expression may be associated with the development of epithelial ovarian carcinoma, and therefore, SEMA3A may be a valuable prognostic marker, as well as a potential molecular therapy target for ovarian cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Qi L, Wang F, Sun Z, Huang Z and Xi Q: Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma. Int J Mol Med 35: 1374-1380, 2015.
APA
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., & Xi, Q. (2015). Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma. International Journal of Molecular Medicine, 35, 1374-1380. https://doi.org/10.3892/ijmm.2015.2142
MLA
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., Xi, Q."Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma". International Journal of Molecular Medicine 35.5 (2015): 1374-1380.
Chicago
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., Xi, Q."Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma". International Journal of Molecular Medicine 35, no. 5 (2015): 1374-1380. https://doi.org/10.3892/ijmm.2015.2142
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Qi L, Wang F, Sun Z, Huang Z and Xi Q: Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma. Int J Mol Med 35: 1374-1380, 2015.
APA
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., & Xi, Q. (2015). Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma. International Journal of Molecular Medicine, 35, 1374-1380. https://doi.org/10.3892/ijmm.2015.2142
MLA
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., Xi, Q."Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma". International Journal of Molecular Medicine 35.5 (2015): 1374-1380.
Chicago
Jiang, H., Qi, L., Wang, F., Sun, Z., Huang, Z., Xi, Q."Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma". International Journal of Molecular Medicine 35, no. 5 (2015): 1374-1380. https://doi.org/10.3892/ijmm.2015.2142
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