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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May-2015 Volume 35 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer

Retraction in: /10.3892/ijmm.2016.2693
  • Authors:
    • Baisong Lou
    • Xin Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Hospital of Qiqihaer City of Heilongjiang, Qiqihaer, Heilongjiang 161005, P.R. China
  • Pages: 1369-1373
    |
    Published online on: March 18, 2015
       https://doi.org/10.3892/ijmm.2015.2147
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Abstract

MicroRNAs (miRNAs) can function as tumor suppressors and may provide an efficient strategy for the eradication of cancer. Specific miRNAs can be reintroduced into tumor cells to complement loss of tumor suppression activities. The aim of the present study was to develop miRNA delivery formulation using synthesized miR-451. miR-451 was detected using RT-PCR and tissues were analyzed using immunohistochemical analysis. miRNA delivery formulation proved to be effective either locally or systemically. miR-451 accumulation became evident in tumor cells and exerted an anti-proliferative function. The intravenous delivery of formulated miR-451 did not induce any deregulation in the cytokine levels and liver enzymes. Taken together, the results provide insight into the concept of the systemic delivery of synthetic mimics for tumor suppressor miR-451 and provide potential implications for miRNA therapy in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Lou B and Zhou X: Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. Int J Mol Med 35: 1369-1373, 2015.
APA
Lou, B., & Zhou, X. (2015). Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. International Journal of Molecular Medicine, 35, 1369-1373. https://doi.org/10.3892/ijmm.2015.2147
MLA
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35.5 (2015): 1369-1373.
Chicago
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35, no. 5 (2015): 1369-1373. https://doi.org/10.3892/ijmm.2015.2147
Copy and paste a formatted citation
x
Spandidos Publications style
Lou B and Zhou X: Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. Int J Mol Med 35: 1369-1373, 2015.
APA
Lou, B., & Zhou, X. (2015). Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. International Journal of Molecular Medicine, 35, 1369-1373. https://doi.org/10.3892/ijmm.2015.2147
MLA
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35.5 (2015): 1369-1373.
Chicago
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35, no. 5 (2015): 1369-1373. https://doi.org/10.3892/ijmm.2015.2147
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