Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
July-2015 Volume 36 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 36 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells

  • Authors:
    • Bang-Jin Kim
    • Yong-An Lee
    • Ki-Jung Kim
    • Yong-Hee Kim
    • Mi-Seon Jung
    • Seung-Jung Ha
    • Hyun-Gu Kang
    • Sang-Eun Jung
    • Byung-Gak Kim
    • Yu-Ri Choi
    • Jeong Tae Do
    • Buom-Yong Ryu
  • View Affiliations / Copyright

    Affiliations: Department of Animal Science and Technology, Chung-Ang University, Anseong, Republic of Korea, Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, MI, USA, Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul, Republic of Korea
  • Pages: 255-262
    |
    Published online on: May 12, 2015
       https://doi.org/10.3892/ijmm.2015.2208
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Spermatogonial stem cells (SSCs) are adult male germ cells that develop after birth. Throughout the lifetime of an organism, SSCs sustain spermatogenesis through self-renewal and produce daughter cells that differentiate into spermatozoa. Several studies have demonstrated that SSCs can acquire pluripotency under appropriate culture conditions, thus becoming multipotent germline stem cells (mGSCs) that express markers of pluripotency in culture and form teratomas following transplantation into immunodeficient mice. In the present study, we generated neural precursor cells expressing CD24, a neural precursor marker, from pluripotent stem cell lines and demonstrated that these cells effectively differentiated along a neural lineage in vitro. In addition, we found that paracrine factors promoted CD24 expression during the neural differentiation of mGSCs. Our results indicated that the expression of CD24, enhanced by a combination of retinoic acid (RA), noggin and fibroblast growth factor 8 (FGF8) under serum-free conditions promoted neural precursor differentiation. Using a simple cell sorting method, we were able to collect neural precursor cells with the potential to differentiate from mGSCs into mature neurons and astrocytes in vitro.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Hu BY, Du ZW, Li XJ, Ayala M and Zhang SC: Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects. Development. 136:1443–1452. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA and Zhang SC: Specification of motoneurons from human embryonic stem cells. Nat Biotechnol. 23:215–221. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL and Studer L: Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA. 101:12543–12548. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Roy NS, Cleren C, Singh SK, Yang L, Beal MF and Goldman SA: Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med. 12:1259–1268. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi JB, Nishikawa S, Nishikawa S, Muguruma K and Sasai Y: A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol. 25:681–686. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, et al: Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 453:524–528. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Nishikawa S, Goldstein RA and Nierras CR: The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol. 9:725–729. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Takahashi K and Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126:663–676. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Spradling A, Drummond-Barbosa D and Kai T: Stem cells find their niche. Nature. 414:98–104. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Conrad S, Renninger M, Hennenlotter J, Wiesner T, Just L, Bonin M, Aicher W, Bühring HJ, Mattheus U, Mack A, et al: Generation of pluripotent stem cells from adult human testis. Nature. 456:344–349. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Guan K, Nayernia K, Maier LS, Wagner S, Dressel R, Lee JH, Nolte J, Wolf F, Li M, Engel W and Hasenfuss G: Pluripotency of spermatogonial stem cells from adult mouse testis. Nature. 440:1199–1203. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Izadyar F, Pau F, Marh J, Slepko N, Wang T, Gonzalez R, Ramos T, Howerton K, Sayre C and Silva F: Generation of multipotent cell lines from a distinct population of male germ line stem cells. Reproduction. 135:771–784. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, et al: Generation of pluripotent stem cells from neonatal mouse testis. Cell. 119:1001–1012. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Kanatsu-Shinohara M, Lee J, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ikawa M, Nakamura T, Ogura A and Shinohara T: Pluripotency of a single spermatogonial stem cell in mice. Biol Reprod. 78:681–687. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Ko K, Tapia N, Wu G, Kim JB, Bravo MJ, Sasse P, Glaser T, Ruau D, Han DW, Greber B, et al: Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell. 5:87–96. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chaval S, Scherr DS, Zhang F, Torres R, Gale NW, et al: Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 449:346–350. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Kim BJ, Lee YA, Kim YH, Kim KJ, Jung MS, Ha SJ, Kang HG, Kim BG, Do JT, Yang HS and Ryu BY: Establishment of adult mouse testis-derived multipotent germ line stem cells and comparison of lineage-specific differentiation potential. Tissue Eng Regen Med. 11:121–130. 2014. View Article : Google Scholar

18 

Glaser T, Opitz T, Kischlat T, Konang R, Sasse P, Fleischmann BK, Engel W, Nayernia K and Brüstle O: Adult germ line stem cells as a source of functional neurons and glia. Stem Cells. 26:2434–2443. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Baumgarth N and Roederer M: A practical approach to multi-color flow cytometry for immunophenotyping. J Immunol Methods. 243:77–97. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Kantor AB and Roederer M: FACS analysis of leukocytes. Handbook of Experimental Immunology. Herzenberg LA, Weir DM and Blackwell C: Blackwell Science; Boston: pp. 43–49. 1996

21 

Morrison SJ, Uchida N and Weissman IL: The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol. 11:35–71. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Zola H: Medical applications of leukocyte surface molecules-the CD molecules. Mol Med. 12:312–316. 2006.

23 

Iversen SD and Iversen LL: Dopamine: 50 years in perspective. Trends Neurosci. 30:188–193. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Fraichard A, Chassande O, Bilbaut G, Dehay C, Savatier P and Samarut J: In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J Cell Sci. 108:3181–3188. 1995.PubMed/NCBI

25 

Megiorni F, Mora B, Indovina P and Mazzilli MC: Expression of neuronal markers during NTera2/cloneD1 differentiation by cell aggregation method. Neurosci Lett. 373:105–109. 2005. View Article : Google Scholar

26 

Caceres A, Mautino J and Kosik KS: Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron. 9:607–618. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Dehmelt L, Smart FM, Ozer RS and Halpain S: The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation. J Neurosci. 23:9479–9490. 2003.PubMed/NCBI

28 

Harada A, Teng J, Takei Y, Oguchi K and Hirokawa N: MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol. 158:541–549. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL and McKay RD: New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature. 448:196–199. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Zhang SC: Defining glial cells during CNS development. Nat Rev Neurosci. 2:840–843. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Bouhon IA, Kato H, Chandran S and Allen ND: Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Res Bull. 68:62–75. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Finley MF, Devata S and Huettner JE: BMP-4 inhibits neural differentiation of murine embryonic stem cells. J Neurobiol. 40:271–287. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Okabe S, Forsberg-Nilsson K, Spiro AC, Segal M and McKay RD: Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev. 59:89–102. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Tropepe V, Hitoshi S, Sirard C, Mak TW, Rossant J and van der Kooy D: Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron. 30:65–78. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, Kawasaki H, Watanabe Y, Mizuseki K and Sasai Y: Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci. 8:288–296. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Wiles MV and Johansson BM: Embryonic stem cell development in a chemically defined medium. Exp Cell Res. 247:241–248. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Ying QL, Stavridis M, Griffiths D, Li M and Smith A: Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol. 21:183–186. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI and Sasai Y: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron. 28:31–40. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Lee SH, Lumelsky N, Studer L, Auerbach JM and McKay RD: Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol. 18:675–679. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Wichterle H, Lieberam I, Porter JA and Jessell TM: Directed differentiation of embryonic stem cells into motor neurons. Cell. 110:385–397. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Cai C and Grabel L: Directing the differentiation of embryonic stem cells to neural stem cells. Dev Dyn. 236:3255–3266. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Kay R, Rosten PM and Humphries RK: CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J Immunol. 147:1412–1416. 1991.PubMed/NCBI

43 

Williams LA, McLellan AD, Summers KL, Sorg RV, Fearnley DB and Hart DN: Identification of a novel dendritic cell surface antigen defined by carbohydrate specific CD24 antibody cross-reactivity. Immunology. 89:120–125. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Calaora V, Chazal G, Nielsen PJ, Rougon G and Moreau H: mCD24 expression in the developing mouse brain and in zones of secondary neurogenesis in the adult. Neuroscience. 73:581–594. 1996. View Article : Google Scholar : PubMed/NCBI

45 

Axell MZ, Zlateva S and Curtis M: A method for rapid derivation and propagation of neural progenitors from human embryonic stem cells. J Neurosci Methods. 184:275–284. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Do JT, Joo JY, Han DW, Araúzo-Bravo MJ, Kim MJ, Greber B, Zaehres H, Sobek-Klocke I, Chung HM and Schöler HR: Generation of parthenogenetic induced pluripotent stem cells from parthenogenetic neural stem cells. Stem Cells. 27:2962–2968. 2009.PubMed/NCBI

47 

Gerrard L, Rodgers L and Cui W: Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. Stem Cells. 23:1234–1241. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Hicks AU, Lappalainen RS, Narkilahti S, Suuronen R, Corbett D, Sivenius J, Hovatta O and Jolkkonen J: Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: Cell survival and functional recovery. Eur J Neurosci. 29:562–574. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Koch P, Opitz T, Steinbeck JA, Ladewig J and Brüstle O: A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci USA. 106:3225–3230. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Maden M: Retinoid signalling in the development of the central nervous system. Nat Rev Neurosci. 3:843–853. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Pierani A, Brenner-Morton S, Chiang C and Jessell TM: A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell. 97:903–915. 1999. View Article : Google Scholar : PubMed/NCBI

52 

Hirsinger E, Duprez D, Jouve C, Malapert P, Cooke J and Pourquié O: Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning. Development. 124:4605–4614. 1997.PubMed/NCBI

53 

Marcelino J, Sciortino CM, Romero MF, Ulatowski LM, Ballock RT, Economides AN, Eimon PM, Harland RM and Warman ML: Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc Natl Acad Sci USA. 98:11353–11358. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Sasai Y, Lu B, Steinbeisser H and De Robertis EM: Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 376:333–336. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim B, Lee Y, Kim K, Kim Y, Jung M, Ha S, Kang H, Jung S, Kim B, Choi Y, Choi Y, et al: Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells. Int J Mol Med 36: 255-262, 2015.
APA
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S. ... Ryu, B. (2015). Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells. International Journal of Molecular Medicine, 36, 255-262. https://doi.org/10.3892/ijmm.2015.2208
MLA
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S., Kang, H., Jung, S., Kim, B., Choi, Y., Do, J. T., Ryu, B."Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells". International Journal of Molecular Medicine 36.1 (2015): 255-262.
Chicago
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S., Kang, H., Jung, S., Kim, B., Choi, Y., Do, J. T., Ryu, B."Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells". International Journal of Molecular Medicine 36, no. 1 (2015): 255-262. https://doi.org/10.3892/ijmm.2015.2208
Copy and paste a formatted citation
x
Spandidos Publications style
Kim B, Lee Y, Kim K, Kim Y, Jung M, Ha S, Kang H, Jung S, Kim B, Choi Y, Choi Y, et al: Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells. Int J Mol Med 36: 255-262, 2015.
APA
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S. ... Ryu, B. (2015). Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells. International Journal of Molecular Medicine, 36, 255-262. https://doi.org/10.3892/ijmm.2015.2208
MLA
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S., Kang, H., Jung, S., Kim, B., Choi, Y., Do, J. T., Ryu, B."Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells". International Journal of Molecular Medicine 36.1 (2015): 255-262.
Chicago
Kim, B., Lee, Y., Kim, K., Kim, Y., Jung, M., Ha, S., Kang, H., Jung, S., Kim, B., Choi, Y., Do, J. T., Ryu, B."Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells". International Journal of Molecular Medicine 36, no. 1 (2015): 255-262. https://doi.org/10.3892/ijmm.2015.2208
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team