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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2015 Volume 36 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Signaling through RIG-I and type I interferon receptor: Immune activation by Newcastle disease virus in man versus immune evasion by Ebola virus (Review)

Volker Schirrmacher
Pages: 3-10
Published online on: 18 May 2015

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Review Open Access

Isolation of extracellular vesicles: Determining the correct approach (Review)

Rafal Szatanek, Jarek Baran, Maciej Siedlar, Monika Baj-Krzyworzeka
Pages: 11-17
Published online on: 22 April 2015

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Article Open Access

MFG-E8 inhibits neutrophil migration through αvβ3-integrin-dependent MAP kinase activation

Monowar Aziz, Weng‑Lang Yang, Lana M. Corbo, Wayne W. Chaung, Shingo Matsuo, Ping Wang
Pages: 18-28
Published online on: 23 April 2015

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Article Open Access

The administration of Fructus Schisandrae attenuates dexamethasone-induced muscle atrophy in mice

Joo Wan Kim, Sae-Kwang Ku, Min Ho Han, Ki Young Kim, Sung Goo Kim, Gi-Young Kim, Hye Jin Hwang, Byung Woo Kim, Cheol Min Kim, Yung Hyun Choi
Pages: 29-42
Published online on: 04 May 2015

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Article Open Access

Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide

Yunchuan Zhou, Yang Zhou, Shanshan Yu, Jingxian Wu, Yanlin Chen, Yong Zhao
Pages: 43-52
Published online on: 08 May 2015

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Article Open Access

Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells

Bo Li, Do Sung Kim, Raj Kumar Yadav, Hyung Ryong Kim, Han Jung Chae
Pages: 53-64
Published online on: 28 April 2015

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Article Open Access

Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines

Alena Nunukova, Jakub Neradil, Jan Skoda, Josef Jaros, Ales Hampl, Jaroslav Sterba, Renata Veselska
Pages: 65-72
Published online on: 14 May 2015

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Article Open Access

Cellular response of chondrocytes to magnesium alloys for orthopedic applications

Yi Liao, Qingli Xu, Jian Zhang, Jialing Niu, Guangyin Yuan, Yao Jiang, Yaohua He, Xinling Wang
Pages: 73-82
Published online on: 14 May 2015

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Article Open Access

Interleukin-17A contributes to the development of post-operative atrial fibrillation by regulating inflammation and fibrosis in rats with sterile pericarditis

Xiao-Xing Fu, Ning Zhao, Qian Dong, Li-Li Du, Xiao-Jun Chen, Qiong‑Feng Wu, Xiang Cheng, Yi-Mei Du, Yu-Hua Liao
Pages: 83-92
Published online on: 08 May 2015

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Article Open Access

MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1 Corrigendum in /10.3892/ijmm.2023.5269

Ting Wang, Tengfei Chen, Hua Niu, Chang Li, Chun Xu, Yuanyuan Li, Rui Huang, Jun Zhao, Shuyan Wu
Pages: 93-102
Published online on: 21 May 2015

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Article Open Access

Gene set enrichment analysis of pathways and transcription factors associated with diabetic retinopathy using a microarray dataset

Kan He, Wenwen Lv, Qing Zhang, Yuqing Wang, Liming Tao, Dahai Liu
Pages: 103-112
Published online on: 22 May 2015

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Article Open Access

Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells

Lingmei Li, Lisha Qi, Zhijie Liang, Wangzhao Song, Yanxue Liu, Yalei Wang, Baocun Sun, Bin Zhang, Wenfeng Cao
Pages: 113-122
Published online on: 25 May 2015

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Article Open Access

CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural fibrosis

Honghai Xu, Cong Liu, Zhengming Sun, Xiong Guo, Yuelin Zhang, Mengting Liu, Peng Li
Pages: 123-129
Published online on: 21 April 2015

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Article Open Access

The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells

Jianyan Hu, Tingting Li, Shanshan Du, Yongdong Chen, Shuai Wang, Fen Xiong, Qiang Wu
Pages: 130-138
Published online on: 23 April 2015

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Article Open Access

Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant

Ningxia Song, Lei Gao, Huiying Qiu, Chongmei Huang, Hui Cheng, Hong Zhou, Shuqing Lv, Li Chen, Jianmin Wang
Pages: 139-149
Published online on: 21 April 2015

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Article Open Access

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling Expression of Concern in /10.3892/ijmm.2025.5600

Xueling Guo, Jin Shang, Yan Deng, Xiao Yuan, Die Zhu, Huiguo Liu
Pages: 150-158
Published online on: 24 April 2015

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Article Open Access

Effects of etidronate on the Enpp1-/- mouse model of generalized arterial calcification of infancy

Carmen Huesa, Katherine A. Staines, Jose Luis Millán, Vicky E. MacRae
Pages: 159-165
Published online on: 15 May 2015

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Article Open Access

The ectopic expression of Snail in MDBK cells does not induce epithelial-mesenchymal transition

Genya Izawa, Wakako Kobayashi, Misako Haraguchi, Akiharu Sudo, Masayuki Ozawa
Pages: 166-172
Published online on: 19 May 2015

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Article Open Access

Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets

Chenghu Huang, Li Yuan, Shuyi Cao
Pages: 173-185
Published online on: 12 May 2015

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Article Open Access

Effect of lentivirus-mediated survivin transfection on the morphology and apoptosis of nucleus pulposus cells derived from degenerative human disc in vitro

Xuexiao Ma, Yazhou Lin, Kun Yang, Bin Yue, Hongfei Xiang, Bohua Chen
Pages: 186-194
Published online on: 26 May 2015

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Article Open Access

Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathy

Zhihui Rong, Rui Pan, Liwen Chang, Weihua Lee
Pages: 195-203
Published online on: 22 May 2015

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Article Open Access

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer Retraction in /10.3892/ijmm.2023.5227

Cong Fan, Yunshan Wang, Ziming Liu, Ying Sun, Xiuwen Wang, Guangwei Wei, Junmin Wei
Pages: 204-214
Published online on: 21 May 2015

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Article Open Access

Short-term effects of calcium ions on the apoptosis and onset of mineralization of human dental pulp cells in vitro and in vivo

Shaofeng An, Yan Gao, Yihua Huang, Xiaoqiong Jiang, Ke Ma, Junqi Ling
Pages: 215-221
Published online on: 22 May 2015

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Article

Comparative analysis of type 2 diabetes-associated SNP alleles identifies allele-specific DNA-binding proteins for the KCNQ1 locus

Masaki Hiramoto, Haruhide Udagawa, Atsushi Watanabe, Keisuke Miyazawa, Naoko Ishibashi, Miho Kawaguchi, Takashi Uebanso, Wataru Nishimura, Takao Nammo, Kazuki Yasuda
Pages: 222-230
Published online on: 08 May 2015

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Article

The immunomodulator, ammonium trichloro[1,2-ethanediolato-O,O']-tellurate, suppresses the propagation of herpes simplex virus 2 by reducing the infectivity of the virus progeny

D. Sheinboim, M. Hindiyeh, E. Mendelson, M. Albeck, B. Sredni, S. Dovrat
Pages: 231-238
Published online on: 24 April 2015

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Article

Arg972 insulin receptor substrate-1 inhibits endothelial nitric oxide synthase expression in human endothelial cells by upregulating microRNA-155

Cheng Huang, Guang Li, Haojian Dong, Shuo Sun, Haimin Chen, Demou Luo, Ling Sun, Xida Li, Zhujun Chen, Huijian Yang, Shuisheng Wei, Yingling Zhou
Pages: 239-248
Published online on: 21 April 2015

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Article

Development and characterization of drug-loaded biodegradable PLA microcarriers prepared by the electrospraying technique

Jian Lu, Ren Hou, Zhenlei Yang, Zhihong Tang
Pages: 249-254
Published online on: 04 May 2015

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Article

Effects of paracrine factors on CD24 expression and neural differentiation of male germline stem cells

Bang-Jin Kim, Yong-An Lee, Ki-Jung Kim, Yong-Hee Kim, Mi-Seon Jung, Seung-Jung Ha, Hyun-Gu Kang, Sang-Eun Jung, Byung-Gak Kim, Yu-Ri Choi, Jeong Tae Do, Buom-Yong Ryu
Pages: 255-262
Published online on: 12 May 2015

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Article

1,25-Dihydroxyvitamin D3 prevents toluene diisocyanate-induced airway epithelial barrier disruption

Wenjia Li, Hangming Dong, Haijin Zhao, Jiafu Song, Haixiong Tang, Lihong Yao, Laiyu Liu, Wancheng Tong, Mengchen Zou, Fei Zou, Shaoxi Cai
Pages: 263-270
Published online on: 19 May 2015

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Article

Increased SUMO-1 expression in response to hypoxia: Interaction with HIF-1α in hypoxic pulmonary hypertension

Yongliang Jiang, Jing Wang, Hua Tian, Guang Li, Hao Zhu, Lei Liu, Ruicheng Hu, Aiguo Dai
Pages: 271-281
Published online on: 14 May 2015

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Article

A novel TBX5 loss-of-function mutation associated with sporadic dilated cardiomyopathy

Wei Zhou, Lan Zhao, Jin‑Qi Jiang, Wei‑Feng Jiang, Yi‑Qing Yang, Xing‑Biao Qiu
Pages: 282-288
Published online on: 11 May 2015

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Article

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Nancy P. Kren, Ian S. Zagon, Patricia J. McLaughlin
Pages: 289-293
Published online on: 25 May 2015

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Article

The Notch pathway mediates the angiotensin II-induced synthesis of extracellular matrix components in podocytes

Min Yao, Xiaomei Wang, Xiaomeng Wang, Tao Zhang, Yanqing Chi, Feng Gao
Pages: 294-300
Published online on: 22 April 2015

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Article

3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions

Hongzoo Park, Dae-Sung Lee, Mi-Jin Yim, Yung Hyun Choi, Saegwang Park, Su-Kil Seo, Jung Sik Choi, Won Hee Jang, Sung Su Yea, Won Sun Park, Chang-Min Lee, Won-Kyo Jung, Il-Whan Choi
Pages: 301-308
Published online on: 05 May 2015

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Article

Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function

Tao You, Weike Mao, Benzhi Cai, Faqian Li, Haodong Xu
Pages: 309-315
Published online on: 26 May 2015

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Article

Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway

Lingxia Li, Xiaochuang Wang, Lina Wang, Li Qu, Xinye Zhu, Manxiang Li, Xiaoyan Dang, Ping Li, Yanxia Gao, Zhuo Peng, Longfei Pan, Li Wan
Pages: 316-322
Published online on: 26 May 2015

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Review Open Access

Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Review Open Access

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Article Open Access

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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Review Open Access

A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Review Open Access

Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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