1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
2
|
Xu X, Yamamoto H, Liu G, Ito Y, Ngan CY,
Kondo M, Nagano H, Dono K, Sekimoto M and Monden M: CDC25A
inhibition suppresses the growth and invasion of human
hepatocellular carcinoma cells. Int J Mol Med. 21:145–152.
2008.PubMed/NCBI
|
3
|
Martínez-López N, Varela-Rey M,
Fernández-Ramos D, Woodhoo A, Vázquez-Chantada M, Embade N,
Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, et al:
Activation of LKB1-Akt pathway independent of phosphoinositide
3-kinase plays a critical role in the proliferation of
hepatocellular carcinoma from nonalcoholic steatohepatitis.
Hepatology. 52:1621–1631. 2010. View Article : Google Scholar : PubMed/NCBI
|
4
|
Xu J, Yun X, Jiang J, Wei Y, Wu Y, Zhang
W, Liu Y, Wang W, Wen Y and Gu J: Hepatitis B virus X protein
blunts senescence-like growth arrest of human hepatocellular
carcinoma by reducing Notch1 cleavage. Hepatology. 52:142–154.
2010. View Article : Google Scholar : PubMed/NCBI
|
5
|
Rhyu MS, Jan LY and Jan YN: Asymmetric
distribution of numb protein during division of the sensory organ
precursor cell confers distinct fates to daughter cells. Cell.
76:477–491. 1994. View Article : Google Scholar : PubMed/NCBI
|
6
|
Spana EP, Kopczynski C, Goodman CS and Doe
CQ: Asymmetric localization of numb autonomously determines sibling
neuron identity in the Drosophila CNS. Development. 121:3489–3494.
1995.PubMed/NCBI
|
7
|
Vervoort M, Dambly-Chaudière C and Ghysen
A: Cell fate determination in Drosophila. Curr Opin Neurobiol.
7:21–28. 1997. View Article : Google Scholar : PubMed/NCBI
|
8
|
Park M, Yaich LE and Bodmer R: Mesodermal
cell fate decisions in Drosophila are under the control of the
lineage genes numb, Notch, and sanpodo. Mech Dev. 75:117–126. 1998.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Spana EP and Doe CQ: Numb antagonizes
Notch signaling to specify sibling neuron cell fates. Neuron.
17:21–26. 1996. View Article : Google Scholar : PubMed/NCBI
|
10
|
Guo M, Jan LY and Jan YN: Control of
daughter cell fates during asymmetric division: Interaction of Numb
and Notch. Neuron. 17:27–41. 1996. View Article : Google Scholar : PubMed/NCBI
|
11
|
Chien CT, Wang S, Rothenberg M, Jan LY and
Jan YN: Numb-associated kinase interacts with the phosphotyrosine
binding domain of Numb and antagonizes the function of Numb in
vivo. Mol Cell Biol. 18:598–607. 1998.PubMed/NCBI
|
12
|
Bric A, Miething C, Bialucha CU, Scuoppo
C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, et al:
Functional identification of tumor-suppressor genes through an in
vivo RNA interference screen in a mouse lymphoma model. Cancer
Cell. 16:324–335. 2009. View Article : Google Scholar : PubMed/NCBI
|
13
|
Pece S, Serresi M, Santolini E, Capra M,
Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G and Di
Fiore PP: Loss of negative regulation by Numb over Notch is
relevant to human breast carcinogenesis. J Cell Biol. 167:215–221.
2004. View Article : Google Scholar : PubMed/NCBI
|
14
|
Colaluca IN, Tosoni D, Nuciforo P,
Senic-Matuglia F, Galimberti V, Viale G, Pece S and Di Fiore PP:
NUMB controls p53 tumour suppressor activity. Nature. 451:76–80.
2008. View Article : Google Scholar : PubMed/NCBI
|
15
|
Liu G, Xie C, Sun F, Xu X, Yang Y, Zhang
T, Deng Y, Wang D, Huang Z, Yang L, et al: Clinical significance of
transient receptor potential vanilloid 2 expression in human
hepatocellular carcinoma. Cancer Genet Cytogenet. 197:54–59. 2010.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Xie C, Liu G, Liu J, Huang Z, Wang F, Lei
X, Wu X, Huang S, Zhong D and Xu X: Anti-proliferative effects of
anandamide in human hepatocellular carcinoma cells. Oncol Lett.
4:403–407. 2012.PubMed/NCBI
|
17
|
Miao X, Liu G, Xu X, Xie C, Sun F, Yang Y,
Zhang T, Hua S, Fan W, Li Q, et al: High expression of vanilloid
receptor-1 is associated with better prognosis of patients with
hepatocellular carcinoma. Cancer Genet Cytogenet. 186:25–32. 2008.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Fu L, Qin YR, Xie D, Hu L, Kwong DL,
Srivastava G, Tsao SW and Guan XY: Characterization of a novel
tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous
cell carcinoma. Cancer Res. 67:10720–10726. 2007. View Article : Google Scholar : PubMed/NCBI
|
19
|
Xu X, Liu Y, Huang S, Liu G, Xie C, Zhou
J, Fan W, Li Q, Wang Q, Zhong D, et al: Overexpression of
cannabinoid receptors CB1 and CB2 correlates with improved
prognosis of patients with hepatocellular carcinoma. Cancer Genet
Cytogenet. 171:31–38. 2006. View Article : Google Scholar : PubMed/NCBI
|
20
|
Neumüller RA and Knoblich JA: Dividing
cellular asymmetry: Asymmetric cell division and its implications
for stem cells and cancer. Genes Dev. 23:2675–2699. 2009.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Zhao C, Chen A, Jamieson CH, Fereshteh M,
Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, et al:
Hedgehog signalling is essential for maintenance of cancer stem
cells in myeloid leukaemia. Nature. 458:776–779. 2009. View Article : Google Scholar : PubMed/NCBI
|
22
|
Ito T, Kwon HY, Zimdahl B, Congdon KL,
Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, et al:
Regulation of myeloid leukaemia by the cell-fate determinant
Musashi. Nature. 466:765–768. 2010. View Article : Google Scholar : PubMed/NCBI
|
23
|
Westhoff B, Colaluca IN, D'Ario G,
Donzelli M, Tosoni D, Volorio S, Pelosi G, Spaggiari L, Mazzarol G,
Viale G, et al: Alterations of the Notch pathway in lung cancer.
Proc Natl Acad Sci USA. 106:22293–22298. 2009. View Article : Google Scholar : PubMed/NCBI
|
24
|
Maiorano E, Favia G, Pece S, Resta L,
Maisonneuve P, Di Fiore PP, Capodiferro S, Urbani U and Viale G:
Prognostic implications of NUMB immunoreactivity in salivary gland
carcinomas. Int J Immunopathol Pharmacol. 20:779–789. 2007.
|
25
|
Rennstam K, McMichael N, Berglund P,
Honeth G, Hegardt C, Rydén L, Luts L, Bendahl PO and Hedenfalk I:
Numb protein expression correlates with a basal-like phenotype and
cancer stem cell markers in primary breast cancer. Breast Cancer
Res Treat. 122:315–324. 2010. View Article : Google Scholar
|
26
|
Sakai T, Toguchida J, Ohtani N, Yandell
DW, Rapaport JM and Dryja TP: Allele-specific hypermethylation of
the retinoblastoma tumor-suppressor gene. Am J Hum Genet.
48:880–888. 1991.PubMed/NCBI
|
27
|
Merlo A, Herman JG, Mao L, Lee DJ,
Gabrielson E, Burger PC, Baylin SB and Sidransky D: 5′CpG island
methylation is associated with transcriptional silencing of the
tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med.
1:686–692. 1995. View Article : Google Scholar : PubMed/NCBI
|
28
|
Matsuda Y, Ichida T, Matsuzawa J, Sugimura
K and Asakura H: p16(INK4) is inactivated by extensive CpG
methylation in human hepatocellular carcinoma. Gastroenterology.
116:394–400. 1999. View Article : Google Scholar : PubMed/NCBI
|
29
|
Li X, Hui AM, Sun L, Hasegawa K, Torzilli
G, Minagawa M, Takayama T and Makuuchi M: p16INK4A hypermethylation
is associated with hepatitis virus infection, age, and gender in
hepatocellular carcinoma. Clin Cancer Res. 10:7484–7489. 2004.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Chapman G, Liu L, Sahlgren C, Dahlqvist C
and Lendahl U: High levels of Notch signaling down-regulate Numb
and Numblike. J Cell Biol. 175:535–540. 2006. View Article : Google Scholar : PubMed/NCBI
|
31
|
McGill MA, Dho SE, Weinmaster G and
McGlade CJ: Numb regulates post-endocytic trafficking and
degradation of Notch1. J Biol Chem. 284:26427–26438. 2009.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Di Marcotullio L, Ferretti E, Greco A, De
Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M,
Screpanti I, et al: Numb is a suppressor of Hedgehog signalling and
targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol.
8:1415–1423. 2006. View Article : Google Scholar : PubMed/NCBI
|
33
|
Greenbaum LE: Cell cycle regulation and
hepatocarcinogenesis. Cancer Biol Ther. 3:1200–1207. 2004.
View Article : Google Scholar
|
34
|
Hui AM, Makuuchi M and Li X: Cell cycle
regulators and human hepatocarcinogenesis. Hepatogastroenterology.
45:1635–1642. 1998.PubMed/NCBI
|
35
|
Calvisi DF, Ladu S, Pinna F, Frau M,
Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, et
al: SKP2 and CKS1 promote degradation of cell cycle regulators and
are associated with hepatocellular carcinoma prognosis.
Gastroenterology. 137:1816–26.e10. 2009. View Article : Google Scholar : PubMed/NCBI
|
36
|
Ho C, Wang C, Mattu S, Destefanis G, Ladu
S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, et al: AKT
(v-akt murine thymoma viral oncogene homolog 1) and N-Ras
(neuroblastoma ras viral oncogene homolog) coactivation in the
mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian
target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and
c-Myc pathways. Hepatology. 55:833–845. 2012. View Article : Google Scholar :
|
37
|
Cory S and Adams JM: The Bcl2 family:
Regulators of the cellular life-or-death switch. Nat Rev Cancer.
2:647–656. 2002. View
Article : Google Scholar : PubMed/NCBI
|
38
|
Griffiths GJ, Dubrez L, Morgan CP, Jones
NA, Whitehouse J, Corfe BM, Dive C and Hickman JA: Cell
damage-induced conformational changes of the pro-apoptotic protein
Bak in vivo precede the onset of apoptosis. J Cell Biol.
144:903–914. 1999. View Article : Google Scholar : PubMed/NCBI
|
39
|
Hu R, Zhai Q, Liu W and Liu X: An insight
into the mechanism of cytotoxicity of ricin to hepatoma cell: Roles
of Bcl-2 family proteins, caspases, Ca(2+)-dependent proteases and
protein kinase C. J Cell Biochem. 81:583–593. 2001. View Article : Google Scholar : PubMed/NCBI
|
40
|
Wang QF, Chen JC, Hsieh SJ, Cheng CC and
Hsu SL: Regulation of Bcl-2 family molecules and activation of
caspase cascade involved in gypenosides-induced apoptosis in human
hepatoma cells. Cancer Lett. 183:169–178. 2002. View Article : Google Scholar : PubMed/NCBI
|