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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2015 Volume 36 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)

Julian Banerji
Pages: 607-626
Published online on: 15 July 2015

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Article Open Access

Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells

Yingchao Wang, Lina Ma, Chunmei Wang, Guangyao Sheng, Lei Feng, Chuyun Yin
Pages: 627-632
Published online on: 30 June 2015

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Article Open Access

Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice

Peng Zhao, Ru Zhou, Xiao-Yun Zhu, Yin-Ju Hao, Nan Li, Jie Wang, Yang Niu, Tao Sun, Yu-Xiang Li, Jian-Qiang Yu
Pages: 633-644
Published online on: 24 June 2015

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Article Open Access

Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors

Lei Zhao, Shizhou Liu, Xiaofang Che, Kezuo Hou, Yanju Ma, Ce Li, Ti Wen, Yibo Fan, Xuejun Hu, Yunpeng Liu, Xiujuan Qu
Pages: 645-652
Published online on: 30 June 2015

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Article Open Access

Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma

Chengzhi Xie, Zhenhui Lu, Guoxing Liu, Yu Fang, Jiefeng Liu, Zhao Huang, Fusheng Wang, Xiaolong Wu, Xiaohua Lei, Xiaocheng Li, Yueming Zhang, Zecheng Hu, Ke Qian, Jixiong Hu, Shengfu Huang, Dewu Zhong, Xundi Xu
Pages: 653-660
Published online on: 09 July 2015

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Article Open Access

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

Kang Xu, Weijian Chen, Xiaofei Wang, Yan Peng, Anjing Liang, Dongsheng Huang, Chunhai Li, Wei Ye
Pages: 661-668
Published online on: 10 July 2015

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Article Open Access

miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling

Xianggui Yang, Xiaoyan Wang, Fang Nie, Tianming Liu, Xuejing Yu, Honglian Wang, Qianyin Li, Rui Peng, Zhaomin Mao, Qin Zhou, Ge Li
Pages: 669-677
Published online on: 24 June 2015

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Article Open Access

Pathogenesis of glucocorticoid-induced avascular necrosis: A microarray analysis of gene expression in vitro

Yanyan Bian, Wenwei Qian, Hongling Li, Robert Chunhua Zhao, Wang Xing Shan, Xisheng Weng
Pages: 678-684
Published online on: 06 July 2015

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Article Open Access

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway Retraction in /10.3892/ijmm.2023.5241

Zhi Zeng, Wen‑Dong Huang, Qi Gao, Mei‑Ling Su, Yong‑Fei Yang, Zhao‑Chun Liu, Bang‑Hao Zhu
Pages: 685-697
Published online on: 22 July 2015

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Article Open Access

5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma

Wenming Wang, Jing Wang, Min Li, Jianming Ying, Hongmei Jing
Pages: 698-704
Published online on: 01 July 2015

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Article Open Access

FGF-2 induces the proliferation of human periodontal ligament cells and modulates their osteoblastic phenotype by affecting Runx2 expression in the presence and absence of osteogenic inducers

Shaofeng An, Xiangya Huang, Yan Gao, Junqi Ling, Yihua Huang, Yin Xiao
Pages: 705-711
Published online on: 01 July 2015

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Article

Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys

Yuko Watanabe, Momoko Yoshida, Kyosuke Yamanishi, Hideyuki Yamamoto, Daisuke Okuzaki, Hiroshi Nojima, Teruo Yasunaga, Haruki Okamura, Hisato Matsunaga, Hiromichi Yamanishi
Pages: 712-724
Published online on: 10 July 2015

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Article

Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells

Yu Chen, Shengyun Cai, Jingwen Wang, Mingjuan Xu
Pages: 725-732
Published online on: 29 June 2015

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Article

Apelin-13 induces MCF-7 cell proliferation and invasion via phosphorylation of ERK1/2

Xuewei Peng, Fengyu Li, Ping Wang, Shengnan Jia, Lili Sun, Hongliang Huo
Pages: 733-738
Published online on: 30 June 2015

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Article

Chronic ethanol treatment of human hepatocytes inhibits the activation of the insulin signaling pathway by increasing cytosolic free calcium levels

Yi‑Min Chen, Jin‑Fang Zhao, Yong‑Lin Liu, Jie Chen, Rong‑Lin Jiang
Pages: 739-746
Published online on: 13 July 2015

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Article

Identification of novel targets for the diagnosis and treatment of liver fibrosis

Paolo Fagone, Katia Mangano, Santa Mammana, Antonio Pesce, Aurora Pesce, Rosario Caltabiano, Alexandra Giorlandino, Teresa Rosanna Portale, Eugenio Cavalli, Giuseppe A.G. Lombardo, Marinella Coco, Stefano Puleo, Ferdinando Nicoletti
Pages: 747-752
Published online on: 29 June 2015

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Article

Myocardin-related transcription factor-A-overexpressing bone marrow stem cells protect cardiomyocytes and alleviate cardiac damage in a rat model of acute myocardial infarction

Ze Zhong, Jia-Qing Hu, Xin-Dong Wu, Yong Sun, Jun Jiang
Pages: 753-759
Published online on: 25 June 2015

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Article

MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II

Yujing Cao, Qiuxia Lv, Cuitian Lv
Pages: 760-766
Published online on: 07 July 2015

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Article

Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model

Xiuli Li, Jin Li, Xiaolan Lu, Huihui Ma, Haitao Shi, Hong Li, Danhong Xie, Lei Dong, Chunlian Liang
Pages: 767-775
Published online on: 01 July 2015

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Article

Aplasia Ras homologue member Ⅰ overexpression inhibits tumor growth and induces apoptosis through inhibition of PI3K/Akt survival pathways in human osteosarcoma MG-63 cells in culture

Kaishan Ye, Shuanke Wang, Yong Yang, Xuewen Kang, Jing Wang, Hua Han
Pages: 776-782
Published online on: 08 July 2015

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Article

Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma

Kun Liu, Baocun Sun, Xiulan Zhao, Xudong Wang, Yanlei Li, Zhiqiang Qiu, Tieju Liu, Qiang Gu, Xueyi Dong, Yanhui Zhang, Yong Wang, Nan Zhao
Pages: 783-791
Published online on: 22 July 2015

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Article

Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats

Bokyung Sung, Seong Yeon Hwang, Min Jo Kim, Minjung Kim, Ji Won Jeong, Cheol Min Kim, Hae Young Chung, Nam Deuk Kim
Pages: 792-800
Published online on: 15 July 2015

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Article

Estradiol attenuates the TGF-β1-induced conversion of primary TAFs into myofibroblasts and inhibits collagen production and myofibroblast contraction by modulating the Smad and Rho/ROCK signaling pathways

He‑Song Jiang, Lei‑Lei Zhu, Zheng Zhang, Hai Chen, Yun Chen, Yu‑Tian Dai
Pages: 801-807
Published online on: 16 July 2015

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Article

YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

Sung Hwa Paeng, Won Sun Park, Won-Kyo Jung, Dae-Sung Lee, Gi-Young Kim, Yung Hyun Choi, Su-Kil Seo, Won Hee Jang, Jung Sik Choi, Young-Min Lee, Saegwang Park, Il-Whan Choi
Pages: 808-816
Published online on: 30 June 2015

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Article

MicroRNA-1 regulates the proliferation of vascular smooth muscle cells by targeting insulin-like growth factor 1

Kun Liu, Zhang Ying, Xia Qi, Ying Shi, Qiang Tang
Pages: 817-824
Published online on: 08 July 2015

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Article

Overexpression of heparan sulfate 6-O-sulfotransferase-2 enhances fibroblast growth factor-mediated chondrocyte growth and differentiation

Wei Wang, Xichi Ju, Zhengming Sun, Weikun Hou, Lifang Yang, Rui Zhang
Pages: 825-832
Published online on: 01 July 2015

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Article

Interaction of AIM with insulin-like growth factor-binding protein-4

Qiang You, Yan Wu, Nannan Yao, Guannan Shen, Ying Zhang, Liangguo Xu, Guiying Li, Cynthia Ju
Pages: 833-838
Published online on: 26 June 2015

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Article

PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome

Kyung‑Ah Cho, Peter B. Kang
Pages: 839-844
Published online on: 08 July 2015

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Article

Bcl10 crucially nucleates the pro-apoptotic complexes comprising PDK1, PKCζ and caspase-3 at the nuclear envelope of etoposide-treated human cervical carcinoma C4-I cells

Anna Chiarini, Daisong Liu, Ubaldo Armato, Ilaria Dal Prà
Pages: 845-856
Published online on: 20 July 2015

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Article

Expression of human telomerase reverse transcriptase mediates the senescence of mesenchymal stem cells through the PI3K/AKT signaling pathway

Qiang Zhao, Xue-Yao Wang, Xiao-Xia Yu, Ying-Xian Zhai, Xu He, Shan Wu, Ying-Ai Shi
Pages: 857-864
Published online on: 15 July 2015

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Article

Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons

Yuwen Zhang, Yian Huang, Xu Liu, Guoxiang Wang, Xin Wang, Yun Wang
Pages: 865-872
Published online on: 16 July 2015

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Article

Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway

Yu Lou, Zhen Wang, Yi Xu, Ping Zhou, Junxian Cao, Yuanshi Li, Yeping Chen, Junfeng Sun, Lu Fu
Pages: 873-880
Published online on: 20 July 2015

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Article

Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts

Gen Kuroyanagi, Haruhiko Tokuda, Naohiro Yamamoto, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Pages: 881-889
Published online on: 07 July 2015

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Article

PBEF promotes the apoptosis of pulmonary microvascular endothelial cells and regulates the expression of inflammatory factors and AQP1 through the MAPK pathways

Guang‑Feng Ming, Xin‑Hua Ma, Dao‑Miao Xu, Zhi‑Yong Liu, Yu‑Hang Ai, Hui‑Xia Liu, Zan‑Hua Shi
Pages: 890-896
Published online on: 13 July 2015

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Article

Protective effects of Notch1 signaling activation against high glucose-induced myocardial cell injury: Analysis of its mechanisms of action

Jian Zhang, Bingong Li, Zeqi Zheng, Ting Kang, Minghui Zeng, Yanhua Liu, Baohua Xia
Pages: 897-903
Published online on: 22 July 2015

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Article

Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro

Zengmei Lan, Zhaoyang Chong, Cong Liu, Danyang Feng, Dihai Fang, Weijin Zang, Jun Zhou
Pages: 904-910
Published online on: 20 July 2015

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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