Open Access

Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model

  • Authors:
    • Mahendra Pal Singh
    • Rekha Jakhar
    • Sun Chul Kang
  • View Affiliations

  • Published online on: August 7, 2015     https://doi.org/10.3892/ijmm.2015.2306
  • Pages: 992-1000
  • Copyright: © Singh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver diseases are among the most serious health issues nowadays. Hepatocellular carcinoma, one of the most lethal types of cancer worldwide, can be caused by chemically-induced oxidative stress. In the present study, we aimed to evaluate the protective effects of morin hydrate (MH) against acrylamide (AA)-induced hepatotoxicity in male ICR mice. The mice were randomly allocated into 4 groups [the control, the group subcutaneously injected with AA alone (50 mg/kg body weight), the group subcutaneously injected with AA (50 mg/kg body weight) and MH (5 mg/kg body weight) and the group subcutaneously injected with AA (50 mg/kg body weight) and MH (15 mg/kg body weight) for 5 consecutive days]. Histopathological evaluations were performed and the levels of serum hepatic enzymes were analyzed to determine initial liver injury, and the mice in the AA-treated groups were compared with the mice receiving no treatment and with the mice administered MH in combination with AA. Furthermore, oxidative stress, hepatic inflammation and the levels of DNA damage-related markers were evaluated to determine the extent of liver damage induced by AA within a short-term period. The subcutaneous administration of AA induced severe hepatic injury, and combined treatment with AA and MH resulted in a significant improvement in all evaluated parameters. This recovery was most obvious in the group receiving AA and 15 mg/kg body weight dose of MH. The findings of our study demonstrated that MH protected mice from severe hepatic injury induced by AA. Moreover, MH is a natural polyphenolic compound, and thus it has potential for use in the treatment of severe liver diseases, in place of many synthetic drugs.
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October-2015
Volume 36 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Singh MP, Jakhar R and Kang SC: Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model. Int J Mol Med 36: 992-1000, 2015
APA
Singh, M.P., Jakhar, R., & Kang, S.C. (2015). Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model. International Journal of Molecular Medicine, 36, 992-1000. https://doi.org/10.3892/ijmm.2015.2306
MLA
Singh, M. P., Jakhar, R., Kang, S. C."Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model". International Journal of Molecular Medicine 36.4 (2015): 992-1000.
Chicago
Singh, M. P., Jakhar, R., Kang, S. C."Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model". International Journal of Molecular Medicine 36, no. 4 (2015): 992-1000. https://doi.org/10.3892/ijmm.2015.2306