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International Journal of Molecular Medicine
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Article

Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells

  • Authors:
    • Darong Hong
    • Soon Young Jang
    • Eun Hyang Jang
    • Bom Jung
    • In-Hye Cho
    • Min-Ju Park
    • Seo Young Jeong
    • Jong-Ho Kim
  • View Affiliations / Copyright

    Affiliations: Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea, Department of Pharmacy, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea
  • Pages: 1601-1606
    |
    Published online on: October 13, 2015
       https://doi.org/10.3892/ijmm.2015.2373
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Abstract

Shikonin (SK), a natural naphthoquinone isolated from the Chinese medicinal herb, has been known to suppress the proliferation of several cancer cells. However, its role in the epithelial mesenchymal transition (EMT) has yet to be demonstrated. The aim of the present study was to examine the effects of SK on EMT. Lipopolysaccharide (LPS) induced EMT-like phenotypic changes, enhancing cell migration and invasion. SK markedly reduced the expression of the LPS-induced EMT markers, including N-cadherin in MDA-MB‑231 cells, and increased the expression of E-cadherin in MCF-7 cells. SK also inhibited cell migration and invasion in vitro. The effects of SK on the LPS-induced EMT were mediated by the inactivation of the NF-κB-Snail signaling pathway. The results provided new evidence that SK suppresses breast cancer cell invasion and migration by inhibiting the EMT. Therefore, SK is a potentially effective anticancer agent for breast tumors, by inhibiting metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Hong D, Jang SY, Jang EH, Jung B, Cho I, Park M, Jeong SY and Kim J: Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells. Int J Mol Med 36: 1601-1606, 2015.
APA
Hong, D., Jang, S.Y., Jang, E.H., Jung, B., Cho, I., Park, M. ... Kim, J. (2015). Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells. International Journal of Molecular Medicine, 36, 1601-1606. https://doi.org/10.3892/ijmm.2015.2373
MLA
Hong, D., Jang, S. Y., Jang, E. H., Jung, B., Cho, I., Park, M., Jeong, S. Y., Kim, J."Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells". International Journal of Molecular Medicine 36.6 (2015): 1601-1606.
Chicago
Hong, D., Jang, S. Y., Jang, E. H., Jung, B., Cho, I., Park, M., Jeong, S. Y., Kim, J."Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells". International Journal of Molecular Medicine 36, no. 6 (2015): 1601-1606. https://doi.org/10.3892/ijmm.2015.2373
Copy and paste a formatted citation
x
Spandidos Publications style
Hong D, Jang SY, Jang EH, Jung B, Cho I, Park M, Jeong SY and Kim J: Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells. Int J Mol Med 36: 1601-1606, 2015.
APA
Hong, D., Jang, S.Y., Jang, E.H., Jung, B., Cho, I., Park, M. ... Kim, J. (2015). Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells. International Journal of Molecular Medicine, 36, 1601-1606. https://doi.org/10.3892/ijmm.2015.2373
MLA
Hong, D., Jang, S. Y., Jang, E. H., Jung, B., Cho, I., Park, M., Jeong, S. Y., Kim, J."Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells". International Journal of Molecular Medicine 36.6 (2015): 1601-1606.
Chicago
Hong, D., Jang, S. Y., Jang, E. H., Jung, B., Cho, I., Park, M., Jeong, S. Y., Kim, J."Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells". International Journal of Molecular Medicine 36, no. 6 (2015): 1601-1606. https://doi.org/10.3892/ijmm.2015.2373
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