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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2015 Volume 36 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

Jun Li, Lin Ye, Sioned Owen, Hoi Ping Weeks, Zhongtao Zhang, Wen G. Jiang
Pages: 1451-1463
Published online on: 23 October 2015

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Pre-stimulation of CD81 expression by resting BΒ cells increases proliferation following EBV infection, but the overexpression of CD81 induces the apoptosis of EBV-transformed B cells

Ga Bin Park, Daejin Kim, Sung Jae Park, Hyun-Kyung Lee, Ji Hyun Kim, Yeong Seok Kim, Sae-Gwang Park, In-Hak Choi, Sung Ho Yoon, Youn Jae Lee, Sunghwa Paeng, Dae Young Hur
Pages: 1464-1478
Published online on: 13 October 2015

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Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy

Yue Zhao, Yue Feng, Yun-Mei Zhang, Xiao-Xue Ding, Yu-Zhu Song, A-Mei Zhang, Li Liu, Hong Zhang, Jia-Huan Ding, Xue-Shan Xia
Pages: 1479-1486
Published online on: 07 October 2015

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Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro

Yan Wang, Jizong Lin, Qing-Zhuang Chen, Ning Zhu, De-Qi Jiang, Ming-Xing Li, Yong Wang
Pages: 1487-1496
Published online on: 19 October 2015

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Article Open Access

miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells

Qiling Song, Liang Zhong, Chu Chen, Zuchuan Tang, Hongxia Liu, Yiqin Zhou, Min Tang, Lan Zhou, Guowei Zuo, Jinyong Luo, Yan Zhang, Qiong Shi, Yaguang Weng
Pages: 1497-1506
Published online on: 09 October 2015

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Article Open Access

CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy

Yu Di, Yiou Zhang, Qingzhu Nie, Xiaolong Chen
Pages: 1507-1518
Published online on: 12 October 2015

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Bushen Zhuangjin decoction inhibits TM-induced chondrocyte apoptosis mediated by endoplasmic reticulum stress

Pingdong Lin, Xiaping Weng, Fayuan Liu, Yuhuan Ma, Houhuang Chen, Xiang Shao, Wenwei Zheng, Xianxiang Liu, Hongzhi Ye, Xihai Li
Pages: 1519-1528
Published online on: 22 October 2015

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Sevoflurane post-conditioning reduces rat myocardial ischemia reperfusion injury through an increase in NOS and a decrease in phopshorylated NHE1 levels Corrigendum in /10.3892/ijmm.2021.4843

Jianfang Cao, Hong Xie, Ying Sun, Jiang Zhu, Ming Ying, Shigang Qiao, Qin Shao, Haorong Wu, Chen Wang
Pages: 1529-1537
Published online on: 12 October 2015

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Total saponins from Aralia taibaiensis protect against myocardial ischemia/reperfusion injury through AMPK pathway

Jiajia Yan, Jialin Duan, Xiaoxiao Wu, Chao Guo, Ying Yin, Yanrong Zhu, Tianxin Hu, Guo Wei, Aidong Wen, Miaomiao Xi
Pages: 1538-1546
Published online on: 23 October 2015

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The orphan nuclear receptor Nur77 inhibits low shear stress-induced carotid artery remodeling in mice

Ying Yu, Zhaohua Cai, Mingli Cui, Peng Nie, Zhe Sun, Shiqun Sun, Shichun Chu, Xiaolei Wang, Liuhua Hu, Jing Yi, Linghong Shen, Ben He
Pages: 1547-1555
Published online on: 14 October 2015

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Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells

Ke-Feng Wang, Hang Yang, Wen-Qi Jiang, Su Li, Yu-Chen Cai
Pages: 1556-1562
Published online on: 16 October 2015

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Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy

Dongdong Chen, Xiaoyang Tao, Yang Wang, Fengxuan Tian, Yongxin Wei, Guilin Chen, Haitao Shen, Zhong Wang, Zhengquan Yu, Haiying Li, Gang Chen
Pages: 1563-1571
Published online on: 09 October 2015

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Ξ²-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Pages: 1572-1582
Published online on: 20 October 2015

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Article

Induction of dissociated cytokine profiles by ISRAA with selective critical involvement of ERK1/2 in its signaling functions

Sahar Elhannan, Safa Taha, Noureddine Ben Khalaf, Halla Bakheit, M. Dahmani Fathallah, Moiz Bakhiet
Pages: 1583-1592
Published online on: 15 October 2015

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Article

Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods

Jiaxuan He, Rongliang Xue, Siyuan Li, Jianrui Lv, Yong Zhang, Liying Fan, Yunpeng Teng, Haidong Wei
Pages: 1593-1600
Published online on: 22 October 2015

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Article

Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells

Darong Hong, Soon Young Jang, Eun Hyang Jang, Bom Jung, In-Hye Cho, Min-Ju Park, Seo Young Jeong, Jong-Ho Kim
Pages: 1601-1606
Published online on: 13 October 2015

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GC-MS-based metabolomic analysis of human papillary thyroid carcinoma tissue

Minjian Chen, Meiping Shen, Yanyun Li, Cuiping Liu, Kun Zhou, Weiyue Hu, Bo Xu, Yankai Xia, Wei Tang
Pages: 1607-1614
Published online on: 12 October 2015

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Article

Suppression of Evi1 promotes the osteogenic differentiation and inhibits the adipogenic differentiation of bone marrow-derived mesenchymal stem cells inΒ vitro

Qijun An, Dou Wu, Yuehong Ma, Biao Zhou, Qiang Liu
Pages: 1615-1622
Published online on: 21 October 2015

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Article

Identification of differentially expressed genes associated with burn sepsis using microarray

Xiaoli Xu, Zhaorong Shi, Jiale Hu, Bo Yuan, Huimin Huang, Hongmei Fang, Xiangyi Yin, Niuyan Nie, Xiaoyue Sheng
Pages: 1623-1629
Published online on: 14 October 2015

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Article

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

Xuehu Xu, Xiaobing Wu, Qingping Jiang, Yan Sun, Haibo Liu, Rong Chen, Shangbiao Wu
Pages: 1630-1638
Published online on: 09 October 2015

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Article

Potential microRNA biomarkers for acute ischemic stroke

Ye Zeng, Jing‑Xia Liu, Zhi‑Ping Yan, Xing‑Hong Yao, Xiao‑Heng Liu
Pages: 1639-1647
Published online on: 12 October 2015

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Article

Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress

Yi-Chun Wang, Jing-Shi Liu, Jun-Yi Chen, Sheng-Qi Wu, Gui-Rong Wang, Jing Nie, Shu-Kun Zhang, Qu-Lian Guo, Jun-Ming Luo
Pages: 1648-1656
Published online on: 15 October 2015

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Article

Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells

Zhenzhen Wen, Shujiong Feng, Lijuan Wei, Zhimin Wang, Defei Hong, Qiang Wang
Pages: 1657-1663
Published online on: 21 October 2015

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Article

Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells

Anjali Sharma-Bhandari, Sun-Hyang Park, Ju-Young Kim, Jaemin Oh, Youngho Kim
Pages: 1664-1670
Published online on: 21 October 2015

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Article

Melatonin affects the dynamic steady-state equilibrium of estrogen sulfates in human umbilical vein endothelial cells by regulating the balance between estrogen sulfatase and sulfotransferase

Alicia GonzΓ‘lez, Carlos MartΓ­nez-Campa, Carolina Alonso-GonzΓ‘lez, Samuel Cos
Pages: 1671-1676
Published online on: 07 October 2015

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Article

Apoptosis-related gene expression in tumor tissue samples obtained from patients diagnosed with glioblastoma multiforme

Eva Blahovcova, Romana Richterova, Branislav Kolarovszki, Dusan Dobrota, Peter Racay, Jozef Hatok
Pages: 1677-1684
Published online on: 12 October 2015

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Article

Loss of ancestral N-glycosylation sites in conserved proteins during human evolution

Dong Seon Kim, Dongjin Choi, Yoonsoo Hahn
Pages: 1685-1692
Published online on: 07 October 2015

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Article

Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

Miran Kim, Mi Seon Park, Jungeun Son, Inji Park, Hyun-Kyung Lee, Chowon Kim, Byung-Hwa Min, Jaewoong Ryoo, Kwang Shik Choi, Dong-Seok Lee, Hyun-Shik Lee
Pages: 1693-1700
Published online on: 12 October 2015

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Article

Bioactive peptide from Pyropia yezoensis and its anti-inflammatory activities

Hyun‑Ah Lee, In‑Hye Kim, Taek‑Jeong Nam
Pages: 1701-1706
Published online on: 21 October 2015

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Article

Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-Ξ±-stimulated interleukin-6 synthesis in osteoblasts

Naohiro Yamamoto, Haruhiko Tokuda, Gen Kuroyanagi, Shingo Kainuma, Reou Ohguchi, Kazuhiko Fujita, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Pages: 1707-1712
Published online on: 20 October 2015

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Article

Suppressive effects of microRNA-16 on the proliferation, invasion and metastasis of hepatocellular carcinoma cells

Wei-Lu Wu, Wei-Ya Wang, Wen-Qing Yao, Gan-Di Li
Pages: 1713-1719
Published online on: 16 October 2015

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Article

Decreased expression of miR-204 in plasma is associated with a poor prognosis in patients with non-small cell lung cancer

Weigang Guo, Yongxing Zhang, Yi Zhang, Yu Shi, Junjie Xi, Hong Fan, Songtao Xu
Pages: 1720-1726
Published online on: 22 October 2015

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam MartΓ­nez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Published online on: 30 December 2025

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Article Number: 53
Published online on: 30 December 2025

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Published online on: 30 December 2025

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