Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2015 Volume 36 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2015 Volume 36 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress

  • Authors:
    • Yi-Chun Wang
    • Jing-Shi Liu
    • Jun-Yi Chen
    • Sheng-Qi Wu
    • Gui-Rong Wang
    • Jing Nie
    • Shu-Kun Zhang
    • Qu-Lian Guo
    • Jun-Ming Luo
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Critical Care Medicine, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China, Central Laboratory, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China, Department of Surgery, SUNY Upstate Medical University College of Medicine, Syracuse, NY 13210, USA, Department of Pathology, Qinghai People's Provincial Hospital, Xining, Qinghai 810007, P.R. China
  • Pages: 1648-1656
    |
    Published online on: October 15, 2015
       https://doi.org/10.3892/ijmm.2015.2377
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mutations in matrilin-3 are associated with common skeletal diseases, such as hand osteoarthritis (HOA), as well as rare chondrodysplasias, such as multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). In the present study, we constructed the mutations R116W [at the von Willebrand factor, type A (vWFA) domain], T298M [at the first epidermal growth factor (EGF) domain] and C299S (at the first EGF domain), according to the mouse sequence, which are associated with human MED, HOA and SEMD, respectively, by overlap extension PCR and inserted them into an expression vector (pcDNA3.1/v5-His). We transfected these contructs into the COS-1 or MCT cells, and the results revealed that the HOA-related matrilin-3 mutation (T298M) leads to a high expression level of growth arrest DNA damage-inducible gene 153 (GADD153, also known as CHOP; an endoplasmic reticulum stress marker), as shown by western blot analysis and does not significantly affect protein secretion, as shown by immunofluorescence staining; however, osteochondroplasia, i.e., MED-related (R116W) and SEMD-related (C299S) mutations lead to both high levels of GADD153 expression and protein trafficking into the cytoplasm and form multiple vacuoles in cells, which in turn leads to insufficient protein secretion.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Li L, Zhang L, Shao Y, Wang G, Gong R, Wang Z, Peng J, Wang S, Genochio D, Zhao B and Luo J: Distinct roles of two alternative splice variants of matrilin-2 in protein oligomerization and proteolysis. Mol Med Rep. 6:1204–1210. 2012.PubMed/NCBI

2 

Krieg T and LeRoy EC: Diseases of the extracellular matrix. J Mol Med Berl. 76:224–225. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Mateos J, De la Fuente A, Lesende-Rodriguez I, Fernández-Pernas P, Arufe MC and Blanco FJ: Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress. Stem Cell Res (Amst). 11:1137–1148. 2013. View Article : Google Scholar

4 

Ankam S, Teo BK, Kukumberg M and Yim EK: High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment. Organogenesis. 9:128–142. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Chen Q, Zhang Y, Johnson DM and Goetinck PF: Assembly of a novel cartilage matrix protein filamentous network: molecular basis of differential requirement of von Willebrand factor A domains. Mol Biol Cell. 10:2149–2162. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Frank S, Schulthess T, Landwehr R, Lustig A, Mini T, Jenö P, Engel J and Kammerer RA: Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. J Biol Chem. 277:19071–19079. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Klatt AR, Becker AK, Neacsu CD, Paulsson M and Wagener R: The matrilins: modulators of extracellular matrix assembly. Int J Biochem Cell Biol. 43:320–330. 2011. View Article : Google Scholar

8 

Paulsson M, Piecha D, Segat D, Smyth N and Wagener R: The matrilins: a growing family of A-domain-containing proteins. Biochem Soc Trans. 27:824–826. 1999. View Article : Google Scholar

9 

Piecha D, Muratoglu S, Mörgelin M, Hauser N, Studer D, Kiss I, Paulsson M and Deák F: Matrilin-2, a large, oligomeric matrix protein, is expressed by a great variety of cells and forms fibrillar networks. J Biol Chem. 274:13353–13361. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Whittaker CA and Hynes RO: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol Biol Cell. 13:3369–3387. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Luo J and Wan Y: Tightly regulated distribution of family members of proteins is related to social property in the open body system (Review). Int J Mol Med. 17:411–418. 2006.PubMed/NCBI

12 

Belluoccio D, Schenker T, Baici A and Trueb B: Characterization of human matrilin-3 (MATN3). Genomics. 53:391–394. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Y and Chen Q: Changes of matrilin forms during endochondral ossification. Molecular basis of oligomeric assembly. J Biol Chem. 275:32628–32634. 2000. View Article : Google Scholar : PubMed/NCBI

14 

van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A and Chen Q: Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J Pathol. 169:515–527. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Wang ZK, Luo JM, Kanbe K and Chen Q: Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis. J Orthop Surg. 3:212008. View Article : Google Scholar :

16 

Chapman KL, Mortier GR, Chapman K, Loughlin J, Grant ME and Briggs MD: Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia. Nat Genet. 28:393–396. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Jackson GC, Barker FS, Jakkula E, Czarny-Ratajczak M, Mäkitie O, Cole WG, Wright MJ, Smithson SF, Suri M, Rogala P, et al: Missense mutations in the beta strands of the single A-domain of matrilin-3 result in multiple epiphyseal dysplasia. J Med Genet. 41:52–59. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Mäkitie O, Mortier GR, Czarny-Ratajczak M, Wright MJ, Suri M, Rogala P, Freund M, Jackson GC, Jakkula E, Ala-Kokko L, et al: Clinical and radiographic findings in multiple epiphyseal dysplasia caused by MATN3 mutations: description of 12 patients. Am J Med Genet A. 125A:278–284. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Mabuchi A, Haga N, Maeda K, Nakashima E, Manabe N, Hiraoka H, Kitoh H, Kosaki R, Nishimura G, Ohashi H and Ikegawa S: Novel and recurrent mutations clustered in the von Willebrand factor A domain of MATN3 in multiple epiphyseal dysplasia. Hum Mutat. 24:439–440. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Cotterill SL, Jackson GC, Leighton MP, Wagener R, Mäkitie O, Cole WG and Briggs MD: Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3. Hum Mutat. 26:557–565. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB and Dunwoodie SL: Evolution of distinct EGF domains with specific functions. Protein Sci. 14:1091–1103. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG and Stuart D: The structure of a Ca2+-binding epidermal growth factor-like domain: its role in protein-protein interactions. Cell. 82:131–141. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Borochowitz ZU, Scheffer D, Adir V, Dagoneau N, Munnich A and Cormier-Daire V: Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: homozygote matrilin 3 mutation in a novel form of SEMD. J Med Genet. 41:366–372. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Stefánsson SE, Jónsson H, Ingvarsson T, Manolescu I, Jónsson HH, Olafsdóttir G, Pálsdóttir E, Stefánsdóttir G, Sveinbjörnsdóttir G, Frigge ML, et al: Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3. Am J Hum Genet. 72:1448–1459. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhang S, Peng J, Guo Y, Javidiparsijani S, Wang G, Wang Y, Liu H, Liu J and Luo J: Matrilin-2 is a widely distributed extracellular matrix protein and a potential biomarker in the early stage of osteoarthritis in articular cartilage. Biomed Res Int. 2014:9861272014.PubMed/NCBI

26 

Wei F, Moore DC, Wei L, Li Y, Zhang G, Wei X, Lee JK and Chen Q: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther. 14:R1772012. View Article : Google Scholar : PubMed/NCBI

27 

Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, et al National Arthritis Data Workgroup: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58:26–35. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Otten C, Wagener R, Paulsson M and Zaucke F: Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not. J Med Genet. 42:774–779. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Liu H, Qian J, Wang F, Sun X, Xu X, Xu W and Zhang X and Zhang X: Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication. Eye (Lond). 24:137–144. 2010. View Article : Google Scholar

30 

Feng LJ, Jiang TC, Zhou CY, Yu CL, Shen YJ, Li J and Shen YX: Activated macrophage-like synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis. Inflamm Res. 63:335–346. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Carlisle RE, Brimble E, Werner KE, Cruz GL, Ask K, Ingram AJ and Dickhout JG: 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. PLoS One. 9:e846632014. View Article : Google Scholar : PubMed/NCBI

32 

Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID and Handford PA: Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell. 85:597–605. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Bork P, Downing AK, Kieffer B and Campbell ID: Structure and distribution of modules in extracellular proteins. Q Rev Biophys. 29:119–167. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Vranka J, Mokashi A, Keene DR, Tufa S, Corson G, Sussman M, Horton WA, Maddox K, Sakai L and Bächinger HP: Selective intracellular retention of extracellular matrix proteins and chaperones associated with pseudoachondroplasia. Matrix Biol. 20:439–450. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Hecht JT, Makitie O, Hayes E, Haynes R, Susic M, Montufar-Solis D, Duke PJ and Cole WG: Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate. J Orthop Res. 22:759–767. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Mann HH, Ozbek S, Engel J, Paulsson M and Wagener R: Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. J Biol Chem. 279:25294–25298. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11:381–389. 2004. View Article : Google Scholar

38 

Prasanthi JRP, Larson T, Schommer J and Ghribi O: Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PLoS One. 6:e264202011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu J, Chen J, Wu S, Wang G, Nie J, Zhang S, Guo Q and Luo J: Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress. Int J Mol Med 36: 1648-1656, 2015.
APA
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J. ... Luo, J. (2015). Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress. International Journal of Molecular Medicine, 36, 1648-1656. https://doi.org/10.3892/ijmm.2015.2377
MLA
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J., Zhang, S., Guo, Q., Luo, J."Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress". International Journal of Molecular Medicine 36.6 (2015): 1648-1656.
Chicago
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J., Zhang, S., Guo, Q., Luo, J."Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress". International Journal of Molecular Medicine 36, no. 6 (2015): 1648-1656. https://doi.org/10.3892/ijmm.2015.2377
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu J, Chen J, Wu S, Wang G, Nie J, Zhang S, Guo Q and Luo J: Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress. Int J Mol Med 36: 1648-1656, 2015.
APA
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J. ... Luo, J. (2015). Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress. International Journal of Molecular Medicine, 36, 1648-1656. https://doi.org/10.3892/ijmm.2015.2377
MLA
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J., Zhang, S., Guo, Q., Luo, J."Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress". International Journal of Molecular Medicine 36.6 (2015): 1648-1656.
Chicago
Wang, Y., Liu, J., Chen, J., Wu, S., Wang, G., Nie, J., Zhang, S., Guo, Q., Luo, J."Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress". International Journal of Molecular Medicine 36, no. 6 (2015): 1648-1656. https://doi.org/10.3892/ijmm.2015.2377
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team