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Review Open Access

Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

  • Authors:
    • Jun Li
    • Lin Ye
    • Sioned Owen
    • Hoi Ping Weeks
    • Zhongtao Zhang
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Cardiff China Medical Research Collaborative, Institute of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1451-1463
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    Published online on: October 23, 2015
       https://doi.org/10.3892/ijmm.2015.2390
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Abstract

The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Ye L, Owen S, Weeks HP, Zhang Z and Jiang WG: Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med 36: 1451-1463, 2015.
APA
Li, J., Ye, L., Owen, S., Weeks, H.P., Zhang, Z., & Jiang, W.G. (2015). Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). International Journal of Molecular Medicine, 36, 1451-1463. https://doi.org/10.3892/ijmm.2015.2390
MLA
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36.6 (2015): 1451-1463.
Chicago
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36, no. 6 (2015): 1451-1463. https://doi.org/10.3892/ijmm.2015.2390
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Ye L, Owen S, Weeks HP, Zhang Z and Jiang WG: Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med 36: 1451-1463, 2015.
APA
Li, J., Ye, L., Owen, S., Weeks, H.P., Zhang, Z., & Jiang, W.G. (2015). Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). International Journal of Molecular Medicine, 36, 1451-1463. https://doi.org/10.3892/ijmm.2015.2390
MLA
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36.6 (2015): 1451-1463.
Chicago
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36, no. 6 (2015): 1451-1463. https://doi.org/10.3892/ijmm.2015.2390
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