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Article

Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin

  • Authors:
    • Seok Cheol Yoon
    • In-Gyu Je
    • Xun Cui
    • Hae Ran Park
    • Dongwoo Khang
    • Jeong-Suk Park
    • Sang-Hyun Kim
    • Tae-Yong Shin
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea, Department of Molecular Medicine, Gachon University, Incheon 406-840, Republic of Korea, Department of Alternative Medicine, Nambu University, Gwangju 506-706, Republic of Korea
  • Pages: 217-224
    |
    Published online on: November 3, 2015
       https://doi.org/10.3892/ijmm.2015.2401
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Abstract

Allergic disease is caused by exposure to normally innocuous substances that activate mast cells. Mast cell-mediated allergic inflammation is closely related to a number of allergic disorders, such as anaphylaxis, allergic rhinitis, asthma and atopic dermatitis. The discovery of drugs for treating allergic disease is an interesting subject and important to human health. The aim of the present study was to investigate the anti‑allergic and anti-inflammatory effects of the aqueous extract of Pogostemon cablin (Blanco) Benth (AEPC) (a member of the Labiatae family) using mast cells, and also to determine its possible mechanisms of action. An intraperitoneal injection of compound 48/80 or a serial injection of immunoglobulin E and antigen was used to induce anaphylaxis in mice. We found that AEPC inhibited compound 48/80‑induced systemic and immunoglobulin E-mediated cutaneous anaphylaxis in a dose-dependent manner. The release of histamine from mast cells was reduced by AEPC, and this suppressive effect was associated with the regulation of calcium influx. In addition, AEPC attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated expression of pro-inflammatory cytokines in mast cells. The inhibitory effects of AEPC on pro-inflammatory cytokines were dependent on the activation of nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK). AEPC blocked the PMACI-induced translocation of NF-κB into the nucleus by hindering the degradation of IκBα and the phosphorylation of p38 MAPK. Our results thus indicate that AEPC inhibits mast cell‑mediated allergic inflammation by suppressing mast cell degranulation and the expression of pro-inflammatory cytokines caused by reduced intracellular calcium levels and the activation of NF-κB and p38 MAPK.
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Copy and paste a formatted citation
Spandidos Publications style
Yoon SC, Je I, Cui X, Park HR, Khang D, Park J, Kim S and Shin T: Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin. Int J Mol Med 37: 217-224, 2016.
APA
Yoon, S.C., Je, I., Cui, X., Park, H.R., Khang, D., Park, J. ... Shin, T. (2016). Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin. International Journal of Molecular Medicine, 37, 217-224. https://doi.org/10.3892/ijmm.2015.2401
MLA
Yoon, S. C., Je, I., Cui, X., Park, H. R., Khang, D., Park, J., Kim, S., Shin, T."Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin". International Journal of Molecular Medicine 37.1 (2016): 217-224.
Chicago
Yoon, S. C., Je, I., Cui, X., Park, H. R., Khang, D., Park, J., Kim, S., Shin, T."Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin". International Journal of Molecular Medicine 37, no. 1 (2016): 217-224. https://doi.org/10.3892/ijmm.2015.2401
Copy and paste a formatted citation
x
Spandidos Publications style
Yoon SC, Je I, Cui X, Park HR, Khang D, Park J, Kim S and Shin T: Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin. Int J Mol Med 37: 217-224, 2016.
APA
Yoon, S.C., Je, I., Cui, X., Park, H.R., Khang, D., Park, J. ... Shin, T. (2016). Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin. International Journal of Molecular Medicine, 37, 217-224. https://doi.org/10.3892/ijmm.2015.2401
MLA
Yoon, S. C., Je, I., Cui, X., Park, H. R., Khang, D., Park, J., Kim, S., Shin, T."Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin". International Journal of Molecular Medicine 37.1 (2016): 217-224.
Chicago
Yoon, S. C., Je, I., Cui, X., Park, H. R., Khang, D., Park, J., Kim, S., Shin, T."Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin". International Journal of Molecular Medicine 37, no. 1 (2016): 217-224. https://doi.org/10.3892/ijmm.2015.2401
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