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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2016 Volume 37 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Repositioning of drugs using open-access data portal DTome: A test case with probenecid (Review)

Mohammad U. Ahmed, Dylan J. Bennett, Tze-Chen Hsieh, Barbara B. Doonan, Saba Ahmed, Joseph M. Wu
Pages: 3-10
Published online on: 13 November 2015

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Review Open Access

Characteristics of α-Gal epitope, anti-Gal antibody, α1,3 galactosyltransferase and its clinical exploitation (Review)

Guoli Huai, Ping Qi, Hongji Yang, Yi Wang
Pages: 11-20
Published online on: 30 October 2015

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Article Open Access

Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

Vlasta Peržeľová, František Sabol, Tomáš Vasilenko, Martin Novotný, Ivan Kováč, Martin Slezák, Ján Ďurkáč, Martin Hollý, Martina Pilátová, Pavol Szabo, Lenka Varinská, Zuzana Čriepoková, Tomáš Kučera, Herbert Kaltner, Sabine André, Hans‑Joachim Gabius, Pavel Mučaji, Karel Smetana, Peter Gál
Pages: 21-28
Published online on: 21 September 2015

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Article Open Access

Non-thermal dielectric-barrier discharge plasma damages human keratinocytes by inducing oxidative stress

Ki Cheon Kim, Mei Jing Piao, Susara Ruwan Kumara Madduma Hewage, Xia Han, Kyoung Ah Kang, Jin Oh Jo, Young Sun Mok, Jennifer H. Shin, Yeunsoo Park, Suk Jae Yoo, Jin Won Hyun
Pages: 29-38
Published online on: 09 November 2015

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Article Open Access

Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways

Can Wei, Hong-Zhu Li, Yue-Hong Wang, Xue Peng, Hong-Jiang Shao, Hong-Xia Li, Shu-Zhi Bai, Xiao-Xiao Lu, Ling-Yun Wu, Rui Wang, Chang-Qing Xu
Pages: 39-46
Published online on: 11 November 2015

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Article Open Access

MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway

Lihua Wang, Guixian Song, Ming Liu, Bin Chen, Yumei Chen, Yahui Shen, Jingai Zhu, Xiaoyu Zhou
Pages: 47-55
Published online on: 02 November 2015

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Article Open Access

The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress

Shu Tang, Hongbo Chen, Yanfen Cheng, Mohammad Abdel Nasir, Nicole Kemper, Endong Bao
Pages: 56-62
Published online on: 19 November 2015

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Article Open Access

Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling

Wenkai Li, Sheng Wei, Chaoxu Liu, Mingyu Song, Hua Wu, Yong Yang
Pages: 63-73
Published online on: 03 November 2015

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Article Open Access

The activation of p38 MAPK limits the abnormal proliferation of vascular smooth muscle cells induced by high sodium concentrations

Yan Wu, Juan Zhou, Huan Wang, Yue Wu, Qiyue Gao, Lijun Wang, Qiang Zhao, Peining Liu, Shanshan Gao, Wen Wen, Weiping Zhang, Yan Liu, Zuyi Yuan
Pages: 74-82
Published online on: 27 October 2015

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Article Open Access

Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro

Yen Ta Huang, Yi Ya Chen, Yu Hsien Lai, Chuan Chu Cheng, Tzu Chun Lin, Ying Shih Su, Chin Hung Liu, Pei Chun Lai
Pages: 83-91
Published online on: 09 November 2015

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Article Open Access

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Young-Min Kim, Hee-Jin Jung, Jae-Sue Choi, Taek-Jeong Nam
Pages: 92-98
Published online on: 11 November 2015

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Article Open Access

TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis

Gang Li, Xuejun Wu, Le Yang, Yuxiang He, Yang Liu, Xing Jin, Hai Yuan
Pages: 99-107
Published online on: 13 November 2015

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Article Open Access

Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells

Jeong-Mi Kim, Eun-Mi Noh, Ha-Rim Kim, Mi-Seong Kim, Hyun-Kyung Song, Minok Lee, Sei-Hoon Yang, Guem-San Lee, Hyoung-Chul Moon, Kang-Beom Kwon, Young-Rae Lee
Pages: 108-114
Published online on: 19 November 2015

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Article Open Access

Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue

June Seok Heo, Youjeong Choi, Han-Soo Kim, Hyun Ok Kim
Pages: 115-125
Published online on: 19 November 2015

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Article

Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway

Jing Wen, Yuyan Zhao, Lei Guo
Pages: 126-132
Published online on: 13 November 2015

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Article

Adipocyte and leptin accumulation in tumor-induced thymic involution

Alejandro Lamas, Elena Lopez, Roberto Carrio, Diana M. Lopez
Pages: 133-138
Published online on: 27 October 2015

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Article

Integrated analyses of a major histocompatibility complex, methylation and transcribed ultra-conserved regions in systemic lupus erythematosus

Hua Lin, Weiguo Sui, Qiupei Tan, Jiejing Chen, Yue Zhang, Minglin Ou, Wen Xue, Fengyan Li, Cuihui Cao, Yufeng Sun, Yong Dai
Pages: 139-148
Published online on: 19 November 2015

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Article

An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts

Ji Sook Kang, Sung Ok Kim, Gi-Young Kim, Hye Jin Hwang, Byung Woo Kim, Young-Chae Chang, Wun-Jae Kim, Cheol Min Kim, Young Hyun Yoo, Yung Hyun Choi
Pages: 149-156
Published online on: 30 October 2015

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Article

The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes

Yu-Kyoung Park, Victor Sukbong Hong, Tae-Yoon Lee, Jinho Lee, Jong-Soon Choi, Dong-Soon Park, Gi-Young Park, Byeong-Churl Jang
Pages: 157-164
Published online on: 19 November 2015

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Article

3,5,4'-Tri-O-acetylresveratrol decreases seawater inhalation-induced acute lung injury by interfering with the NF-κB and i-NOS pathways

Lijie Ma, Xiangjun Chen, Ruixuan Wang, Hongtao Duan, Libin Wang, Li Liang, Yandong Nan, Xueying Liu, Ao Liu, Faguang Jin
Pages: 165-172
Published online on: 09 November 2015

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Article

Uncarboxylated osteocalcin inhibits high glucose-induced ROS production and stimulates osteoblastic differentiation by preventing the activation of PI3K/Akt in MC3T3-E1 cells

Jingli Liu, Jianhong Yang
Pages: 173-181
Published online on: 17 November 2015

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Article

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

Tianjie Qi, Fei Xu, Xixin Yan, Shuai Li, Haitao Li
Pages: 182-188
Published online on: 27 October 2015

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Article

IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins

Qi Hu, Jing Chen, Jing Zhang, Changwu Xu, Shuo Yang, Hong Jiang
Pages: 189-196
Published online on: 27 October 2015

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Article

Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples

Xin Wang, Xiang Li, Ying-Nan Zeng, Fa He, Xiao-Min Yang, Feng Guan
Pages: 197-206
Published online on: 27 October 2015

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Article

Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK

Juan Duan, Yu Yang, Hong Liu, Peng-Cheng Dou, Sheng-Yu Tan
Pages: 207-216
Published online on: 04 November 2015

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Article

Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin

Seok Cheol Yoon, In-Gyu Je, Xun Cui, Hae Ran Park, Dongwoo Khang, Jeong-Suk Park, Sang-Hyun Kim, Tae-Yong Shin
Pages: 217-224
Published online on: 03 November 2015

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Article

Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-κB

Bochang Lv, Tao Chen, Zhiguo Xu, Fuquan Huo, Yanyan Wei, Xinguang Yang
Pages: 225-232
Published online on: 23 November 2015

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Article

Gain-of-function p53 mutant with 21-bp deletion confers susceptibility to multidrug resistance in MCF-7 cells

Shang-Hsun Tsou, Ming-Hung Hou, Lih-Ching Hsu, Tzer-Ming Chen, Yen-Hui Chen
Pages: 233-242
Published online on: 11 November 2015

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Article

Anti-allergic effects of a nonameric peptide isolated from the intestine gastrointestinal digests of abalone (Haliotis discus hannai) in activated HMC-1 human mast cells

Seok-Chun Ko, Dae-Sung Lee, Won Sun Park, Jong Su Yoo, Mi-Jin Yim, Zhong-Ji Qian, Chang-Min Lee, Junghwan Oh, Won-Kyo Jung, Il-Whan Choi
Pages: 243-250
Published online on: 27 November 2015

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Article

RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway

Yu Yan, Yugang Jiang
Pages: 251-257
Published online on: 30 November 2015

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Article

Danshensu protects against ischemia/reperfusion injury and inhibits the apoptosis of H9c2 cells by reducing the calcium overload through the p-JNK-NF-κB-TRPC6 pathway

Ying Meng, Wei-Zhu Li, You-Wei Shi, Bing-Feng Zhou, Rong Ma, Wei-Ping Li
Pages: 258-266
Published online on: 25 November 2015

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of adipocytes and their derived extracellular vesicles in the progression, diagnosis and treatment of liver diseases (Review)

Kangrong Li, Muhammad Zubair, Yongmin Yan, Jiahao Xu
Article Number: 293
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma

In Sik Shin, Mee Young Lee, Woo Young Jeon, Na Ra Shin, Chang Seob Seo, Hyekyung Ha
Article Number: 292
Published online on: 20 August 2026

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Review Open Access

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review)

Denita Charoenthanakitkul, Chaiyaboot Ariyachet
Article Number: 291
Published online on: 20 August 2026

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Review Open Access

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review)

Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang, Feihong Shu, Ya Deng, Ting Zhang, Jingyu Xu, Rui Xie
Article Number: 290
Published online on: 18 August 2026

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Review Open Access

Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review)

Yuena Qiu, Xiaojing Guo, Jie An
Article Number: 289
Published online on: 18 August 2026

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Review Open Access

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

Shengyao Peng, Zhuo Yao, Junzhe Guo, Chi Zhang, Keda Yang, Lin Tao
Article Number: 288
Published online on: 17 August 2026

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Retraction Open Access

[Retracted] Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Article Number: 287
Published online on: 17 August 2026

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Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Article Open Access

Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Review Open Access

Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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Article Open Access

G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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Review Open Access

XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Review Open Access

Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Review Open Access

Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Review Open Access

Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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