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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2016 Volume 37 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Repositioning of drugs using open-access data portal DTome: A test case with probenecid (Review)

Mohammad U. Ahmed, Dylan J. Bennett, Tze-Chen Hsieh, Barbara B. Doonan, Saba Ahmed, Joseph M. Wu
Pages: 3-10
Published online on: 13 November 2015

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Characteristics of α-Gal epitope, anti-Gal antibody, α1,3 galactosyltransferase and its clinical exploitation (Review)

Guoli Huai, Ping Qi, Hongji Yang, Yi Wang
Pages: 11-20
Published online on: 30 October 2015

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Article Open Access

Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

Vlasta Peržeľová, František Sabol, Tomáš Vasilenko, Martin Novotný, Ivan Kováč, Martin Slezák, Ján Ďurkáč, Martin Hollý, Martina Pilátová, Pavol Szabo, Lenka Varinská, Zuzana Čriepoková, Tomáš Kučera, Herbert Kaltner, Sabine André, Hans‑Joachim Gabius, Pavel Mučaji, Karel Smetana, Peter Gál
Pages: 21-28
Published online on: 21 September 2015

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Article Open Access

Non-thermal dielectric-barrier discharge plasma damages human keratinocytes by inducing oxidative stress

Ki Cheon Kim, Mei Jing Piao, Susara Ruwan Kumara Madduma Hewage, Xia Han, Kyoung Ah Kang, Jin Oh Jo, Young Sun Mok, Jennifer H. Shin, Yeunsoo Park, Suk Jae Yoo, Jin Won Hyun
Pages: 29-38
Published online on: 09 November 2015

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Article Open Access

Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways

Can Wei, Hong-Zhu Li, Yue-Hong Wang, Xue Peng, Hong-Jiang Shao, Hong-Xia Li, Shu-Zhi Bai, Xiao-Xiao Lu, Ling-Yun Wu, Rui Wang, Chang-Qing Xu
Pages: 39-46
Published online on: 11 November 2015

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Article Open Access

MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway

Lihua Wang, Guixian Song, Ming Liu, Bin Chen, Yumei Chen, Yahui Shen, Jingai Zhu, Xiaoyu Zhou
Pages: 47-55
Published online on: 02 November 2015

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Article Open Access

The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress

Shu Tang, Hongbo Chen, Yanfen Cheng, Mohammad Abdel Nasir, Nicole Kemper, Endong Bao
Pages: 56-62
Published online on: 19 November 2015

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Article Open Access

Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling

Wenkai Li, Sheng Wei, Chaoxu Liu, Mingyu Song, Hua Wu, Yong Yang
Pages: 63-73
Published online on: 03 November 2015

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Article Open Access

The activation of p38 MAPK limits the abnormal proliferation of vascular smooth muscle cells induced by high sodium concentrations

Yan Wu, Juan Zhou, Huan Wang, Yue Wu, Qiyue Gao, Lijun Wang, Qiang Zhao, Peining Liu, Shanshan Gao, Wen Wen, Weiping Zhang, Yan Liu, Zuyi Yuan
Pages: 74-82
Published online on: 27 October 2015

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Article Open Access

Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro

Yen Ta Huang, Yi Ya Chen, Yu Hsien Lai, Chuan Chu Cheng, Tzu Chun Lin, Ying Shih Su, Chin Hung Liu, Pei Chun Lai
Pages: 83-91
Published online on: 09 November 2015

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Article Open Access

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Young-Min Kim, Hee-Jin Jung, Jae-Sue Choi, Taek-Jeong Nam
Pages: 92-98
Published online on: 11 November 2015

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Article Open Access

TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis

Gang Li, Xuejun Wu, Le Yang, Yuxiang He, Yang Liu, Xing Jin, Hai Yuan
Pages: 99-107
Published online on: 13 November 2015

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Article Open Access

Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells

Jeong-Mi Kim, Eun-Mi Noh, Ha-Rim Kim, Mi-Seong Kim, Hyun-Kyung Song, Minok Lee, Sei-Hoon Yang, Guem-San Lee, Hyoung-Chul Moon, Kang-Beom Kwon, Young-Rae Lee
Pages: 108-114
Published online on: 19 November 2015

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Article Open Access

Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue

June Seok Heo, Youjeong Choi, Han-Soo Kim, Hyun Ok Kim
Pages: 115-125
Published online on: 19 November 2015

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Article

Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway

Jing Wen, Yuyan Zhao, Lei Guo
Pages: 126-132
Published online on: 13 November 2015

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Article

Adipocyte and leptin accumulation in tumor-induced thymic involution

Alejandro Lamas, Elena Lopez, Roberto Carrio, Diana M. Lopez
Pages: 133-138
Published online on: 27 October 2015

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Article

Integrated analyses of a major histocompatibility complex, methylation and transcribed ultra-conserved regions in systemic lupus erythematosus

Hua Lin, Weiguo Sui, Qiupei Tan, Jiejing Chen, Yue Zhang, Minglin Ou, Wen Xue, Fengyan Li, Cuihui Cao, Yufeng Sun, Yong Dai
Pages: 139-148
Published online on: 19 November 2015

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Article

An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts

Ji Sook Kang, Sung Ok Kim, Gi-Young Kim, Hye Jin Hwang, Byung Woo Kim, Young-Chae Chang, Wun-Jae Kim, Cheol Min Kim, Young Hyun Yoo, Yung Hyun Choi
Pages: 149-156
Published online on: 30 October 2015

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Article

The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes

Yu-Kyoung Park, Victor Sukbong Hong, Tae-Yoon Lee, Jinho Lee, Jong-Soon Choi, Dong-Soon Park, Gi-Young Park, Byeong-Churl Jang
Pages: 157-164
Published online on: 19 November 2015

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Article

3,5,4'-Tri-O-acetylresveratrol decreases seawater inhalation-induced acute lung injury by interfering with the NF-κB and i-NOS pathways

Lijie Ma, Xiangjun Chen, Ruixuan Wang, Hongtao Duan, Libin Wang, Li Liang, Yandong Nan, Xueying Liu, Ao Liu, Faguang Jin
Pages: 165-172
Published online on: 09 November 2015

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Article

Uncarboxylated osteocalcin inhibits high glucose-induced ROS production and stimulates osteoblastic differentiation by preventing the activation of PI3K/Akt in MC3T3-E1 cells

Jingli Liu, Jianhong Yang
Pages: 173-181
Published online on: 17 November 2015

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Article

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

Tianjie Qi, Fei Xu, Xixin Yan, Shuai Li, Haitao Li
Pages: 182-188
Published online on: 27 October 2015

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Article

IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins

Qi Hu, Jing Chen, Jing Zhang, Changwu Xu, Shuo Yang, Hong Jiang
Pages: 189-196
Published online on: 27 October 2015

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Article

Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples

Xin Wang, Xiang Li, Ying-Nan Zeng, Fa He, Xiao-Min Yang, Feng Guan
Pages: 197-206
Published online on: 27 October 2015

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Article

Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK

Juan Duan, Yu Yang, Hong Liu, Peng-Cheng Dou, Sheng-Yu Tan
Pages: 207-216
Published online on: 04 November 2015

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Article

Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin

Seok Cheol Yoon, In-Gyu Je, Xun Cui, Hae Ran Park, Dongwoo Khang, Jeong-Suk Park, Sang-Hyun Kim, Tae-Yong Shin
Pages: 217-224
Published online on: 03 November 2015

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Article

Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-κB

Bochang Lv, Tao Chen, Zhiguo Xu, Fuquan Huo, Yanyan Wei, Xinguang Yang
Pages: 225-232
Published online on: 23 November 2015

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Article

Gain-of-function p53 mutant with 21-bp deletion confers susceptibility to multidrug resistance in MCF-7 cells

Shang-Hsun Tsou, Ming-Hung Hou, Lih-Ching Hsu, Tzer-Ming Chen, Yen-Hui Chen
Pages: 233-242
Published online on: 11 November 2015

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Article

Anti-allergic effects of a nonameric peptide isolated from the intestine gastrointestinal digests of abalone (Haliotis discus hannai) in activated HMC-1 human mast cells

Seok-Chun Ko, Dae-Sung Lee, Won Sun Park, Jong Su Yoo, Mi-Jin Yim, Zhong-Ji Qian, Chang-Min Lee, Junghwan Oh, Won-Kyo Jung, Il-Whan Choi
Pages: 243-250
Published online on: 27 November 2015

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Article

RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway

Yu Yan, Yugang Jiang
Pages: 251-257
Published online on: 30 November 2015

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Article

Danshensu protects against ischemia/reperfusion injury and inhibits the apoptosis of H9c2 cells by reducing the calcium overload through the p-JNK-NF-κB-TRPC6 pathway

Ying Meng, Wei-Zhu Li, You-Wei Shi, Bing-Feng Zhou, Rong Ma, Wei-Ping Li
Pages: 258-266
Published online on: 25 November 2015

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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