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Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells

  • Authors:
    • Jeong-Mi Kim
    • Eun-Mi Noh
    • Ha-Rim Kim
    • Mi-Seong Kim
    • Hyun-Kyung Song
    • Minok Lee
    • Sei-Hoon Yang
    • Guem-San Lee
    • Hyoung-Chul Moon
    • Kang-Beom Kwon
    • Young-Rae Lee
  • View Affiliations / Copyright

    Affiliations: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Jeonbuk 570-749, Republic of Korea, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Jeonbuk 570-749, Republic of Korea, Department of Herbology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk 570-749, Republic of Korea, Institute of Customized Physical Therapy, Gwanju Metropolitan City 506-303, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 108-114
    |
    Published online on: November 19, 2015
       https://doi.org/10.3892/ijmm.2015.2417
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Abstract

Metastatic cancers spread from their site of origin (the primary site) to other parts of the body. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is important in metastatic cancers as it plays a major role in cancer cell invasion. The present study examined the inhibitory effect of an ethanol extract of Peucedanum japonicum Thunb. (PJT) on MMP-9 expression and the invasion of MCF-7 breast cancer cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Western blot analysis, gelatin zymography, and reverse transcription-quantitative PCR revealed that PJT significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, PJT attenuated TPA-induced nuclear translocation and the transcriptional activation of nuclear factor (NF)-κB. The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCα/NF-κB pathway in MCF-7 cells. Thus, the inhibition of MMP-9 expression by PJT may have potential value as a therapy for restricting the invasiveness of breast cancer.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst. 89:1260–1270. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Nakajima M, Welch DR, Belloni PN and Nicolson GL: Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials. Cancer Res. 47:4869–4876. 1987.PubMed/NCBI

4 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Woessner JF Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:2145–2154. 1991.PubMed/NCBI

6 

Stetler-Stevenson WG, Hewitt R and Corcoran M: Matrix metal-loproteinases and tumor invasion: from correlation and causality to the clinic. Semin Cancer Biol. 7:147–154. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Itoh Y and Nagase H: Matrix metalloproteinases in cancer. Essays Biochem. 38:21–36. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Brinckerhoff CE and Matrisian LM: Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 3:207–214. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Gum R, Wang H, Lengyel E, Juarez J and Boyd D: Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades. Oncogene. 14:1481–1493. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Newton AC: Regulation of protein kinase C. Curr Opin Cell Biol. 9:161–167. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Zeigler ME, Chi Y, Schmidt T and Varani J: Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol. 180:271–284. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Hozumi A, Nishimura Y, Nishiuma T, Kotani Y and Yokoyama M: Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway. Am J Physiol Lung Cell Mol Physiol. 281:L1444–L1452. 2001.PubMed/NCBI

13 

Weng CJ, Chau CF, Hsieh YS, Yang SF and Yen GC: Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1. Carcinogenesis. 29:147–156. 2008. View Article : Google Scholar

14 

Lin CW, Hou WC, Shen SC, Juan SH, Ko CH, Wang LM and Chen YC: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis. 29:1807–1815. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lee SO, Jeong YJ, Kim M, Kim CH and Lee IS: Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-kappaB-dependent MMP-9 expression. Biochem Biophys Res Commun. 366:1019–1024. 2008. View Article : Google Scholar

16 

Hong S, Park KK, Magae J, Ando K, Lee TS, Kwon TK, Kwak JY, Kim CH and Chang YC: Ascochlorin inhibits matrix metallopro-teinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J Biol Chem. 280:25202–25209. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Woo MS, Jung SH, Kim SY, Hyun JW, Ko KH, Kim WK and Kim HS: Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem Biophys Res Commun. 335:1017–1025. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Eberhardt W, Huwiler A, Beck KF, Walpen S and Pfeilschifter J: Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J Immunol. 165:5788–5797. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Kim HR, Kim JM, Kim MS, Hwang JK, Park YJ, Yang SH, Kim HJ, Ryu DG, Lee DS, Oh H, et al: Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells. BMC Complement Altern Med. 14:1702014. View Article : Google Scholar

20 

Hisamoto M, Kikuzaki H, Ohigashi H and Nakatani N: Antioxidant compounds from the leaves of Peucedanum japonicum thunb. J Agric Food Chem. 51:5255–5261. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Hisamoto M, Kikuzaki H and Nakatani N: Constituents of the leaves of Peucedanum japonicum Thunb. and their biological activity. J Agric Food Chem. 52:445–450. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Nugara RN, Inafuku M, Iwasaki H and Oku H: Partially purified Peucedanum japonicum Thunb extracts exert anti-obesity effects in vitro. Nutrition. 30:575–583. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Chen IS, Chang CT, Sheen WS, Teng CM, Tsai IL, Duh CY and Ko FN: Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum. Phytochemistry. 41:525–530. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Chiu WT, Shen SC, Chow JM, Lin CW, Shia LT and Chen YC: Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 37:118–129. 2010. View Article : Google Scholar

25 

Noh EM, Park YJ, Kim JM, Kim MS, Kim HR, Song HK, Hong OY, So HS, Yang SH, Kim JS, et al: Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways. Eur J Pharmacol. 764:79–86. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

27 

Lee YR, Noh EM, Oh HJ, Hur H, Kim JM, Han JH, Hwang JK, Park BH, Park JW, Youn HJ, et al: Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression. Biochem Biophys Res Commun. 405:552–557. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Zwiefel K and Janni W: Current standards in the treatment of breast cancer. Med Monatsschr Pharm. 34:280–288. 2011.In German.

29 

Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25:9–34. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Scorilas A, Karameris A, Arnogiannaki N, Ardavanis A, Bassilopoulos P, Trangas T and Talieri M: Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients. Br J Cancer. 84:1488–1496. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Cho HJ, Kang JH, Kwak JY, Lee TS, Lee IS, Park NG, Nakajima H, Magae J and Chang YC: Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. Carcinogenesis. 28:1104–1110. 2007. View Article : Google Scholar

32 

Mo N, Li ZQ, Li J and Cao YD: Curcumin inhibits TGF-β1-induced MMP-9 and invasion through ERK and Smad signaling in breast cancer MDA- MB-231 cells. Asian Pac J Cancer Prev. 13:5709–5714. 2012. View Article : Google Scholar

33 

Lungu G, Covaleda L, Mendes O, Martini-Stoica H and Stoica G: FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1. Mol Carcinog. 47:424–435. 2008. View Article : Google Scholar

34 

Stoll BA: Biological mechanisms in breast cancer invasiveness: relevance to preventive interventions. Eur J Cancer Prev. 9:73–79. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Fortino V, Torricelli C, Capurro E, Sacchi G, Valacchi G and Maioli E: Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell. Cancer Invest. 26:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Kim JM, Noh EM, Kwon KB, Kim JS, You YO, Hwang JK, Hwang BM, Kim BS, Lee SH, Lee SJ, et al: Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells. Phytomedicine. 19:1085–1092. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Lallena MJ, Diaz-Meco MT, Bren G, Payá CV and Moscat J: Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol. 19:2180–2188. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Sun CM, Syu WJ, Don MJ, Lu JJ and Lee GH: Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. J Nat Prod. 66:1175–1180. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Thanos D and Maniatis T: NF-kappa B: a lesson in family values. Cell. 80:529–532. 1995. View Article : Google Scholar : PubMed/NCBI

40 

Oh JH, Chung AS, Steinbrenner H, Sies H and Brenneisen P: Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts. Arch Biochem Biophys. 423:218–226. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim J, Noh E, Kim H, Kim M, Song H, Lee M, Yang S, Lee G, Moon H, Kwon K, Kwon K, et al: Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells. Int J Mol Med 37: 108-114, 2016.
APA
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M. ... Lee, Y. (2016). Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells. International Journal of Molecular Medicine, 37, 108-114. https://doi.org/10.3892/ijmm.2015.2417
MLA
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M., Yang, S., Lee, G., Moon, H., Kwon, K., Lee, Y."Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells". International Journal of Molecular Medicine 37.1 (2016): 108-114.
Chicago
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M., Yang, S., Lee, G., Moon, H., Kwon, K., Lee, Y."Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells". International Journal of Molecular Medicine 37, no. 1 (2016): 108-114. https://doi.org/10.3892/ijmm.2015.2417
Copy and paste a formatted citation
x
Spandidos Publications style
Kim J, Noh E, Kim H, Kim M, Song H, Lee M, Yang S, Lee G, Moon H, Kwon K, Kwon K, et al: Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells. Int J Mol Med 37: 108-114, 2016.
APA
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M. ... Lee, Y. (2016). Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells. International Journal of Molecular Medicine, 37, 108-114. https://doi.org/10.3892/ijmm.2015.2417
MLA
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M., Yang, S., Lee, G., Moon, H., Kwon, K., Lee, Y."Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells". International Journal of Molecular Medicine 37.1 (2016): 108-114.
Chicago
Kim, J., Noh, E., Kim, H., Kim, M., Song, H., Lee, M., Yang, S., Lee, G., Moon, H., Kwon, K., Lee, Y."Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells". International Journal of Molecular Medicine 37, no. 1 (2016): 108-114. https://doi.org/10.3892/ijmm.2015.2417
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