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Article

Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes

  • Authors:
    • Jin-Woo Jeong
    • Hye Hyeon Lee
    • Ki Won Lee
    • Ki Young Kim
    • Sung Goo Kim
    • Su Hyun Hong
    • Gi-Young Kim
    • Cheol Park
    • Ho Kyoung Kim
    • Young Whan Choi
    • Yung Hyun Choi
  • View Affiliations / Copyright

    Affiliations: Anti-Aging Research Center, Dongeui University, Busan 614-714, Republic of Korea, Research Institute, Bio-Port Korea Inc., MarineBio-industry Development Center, Busan 619-912, Republic of Korea, Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 614-052, Republic of Korea, Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea, Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dongeui University, Busan 614-714, Republic of Korea, Herbal Medicine Resources Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea, Department of Horticultural Bioscience, College of Natural Resource and Life Sciences, Pusan National University, Miryang 627-706, Republic of Korea
  • Pages: 452-460
    |
    Published online on: December 23, 2015
       https://doi.org/10.3892/ijmm.2015.2443
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Abstract

The pro-inflammatory cytokine interleukin-1β (IL-1β) is known to play a crucial role in the pathogenesis of osteoarthritis (OA) by stimulating several mediators that contribute to cartilage degradation. Mori folium, the leaves of Morus alba L., has long been used in traditional medicine to treat diabetes, protect the liver, and lower blood pressure; however, the role of Mori folium in OA is not yet fully understood. Therefore, in the present study, we investigated whether Mori folium water extract (MF) inhibited the catabolic effects of IL-1β in vitro, and also whether it inhibited the matrix metalloproteinases (MMPs), inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) through the attenuation of nuclear factor-κB (NF-κB) and mitogen activated protein kinase (MAPK) pathways in SW1353 human chondrocytes. MMP proteins in culture medium were determined using a cytokine‑specific enzyme-linked immunosorbent assay (ELISA). The production of NO and prostaglandin E2 (PGE2) were evaluated using Griess reagent and ELISA. Subsequently, the mRNA and protein levels of MMPs, iNOS, COX-2, NF-κB and MAPKs were examined by RT-qPCR and/or western blot analysis. The results indicate that MF significantly reduced the IL-1β‑induced release of MMP-1 and -13 in SW1353 cells, which was associated with the inhibition of MMP-1 and -13 mRNA and protein expression in a concentration‑dependent manner at concentrations with no cytotoxicity. MF also attenuated the IL-1β-induced production of NO and PGE2, and reduced iNOS and COX-2 expression. Furthermore, we noted that MF markedly suppressed the IL-1β‑induced nuclear translocation of NF-κB, which correlated with the inhibitory effects of MF on inhibitor-κB (IκB) degradation, and the phosphorylation of p38 MAPK was selectively restored by MF upon IL-1β stimulation. These results indicate that MF inhibited the production and expression of MMP-1 and -13 and inflammatory mediators, at least in part, through suppressing the activation of either NF-κB or p38 MAPK in IL-1β-treated SW1353 chondrocytes. Therefore, the novel findings of the present study suggest that MF is a potential therapeutic choice for chondroprotection against the collagen matrix breakdown in the cartilage of diseased tissues, such as those found in patients with arthritic disorders.
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View References

1 

Hardingham T: Extracellular matrix and pathogenic mechanisms in osteoarthritis. Curr Rheumatol Rep. 10:30–36. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Wilusz RE, Sanchez-Adams J and Guilak F: The structure and function of the pericellular matrix of articular cartilage. Matrix Biol. 39:25–32. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Bian Q, Wang YJ, Liu SF and Li YP: Osteoarthritis: genetic factors, animal models, mechanisms, and therapies. Front Biosci (Elite Ed). 4:74–100. 2012. View Article : Google Scholar

4 

Daheshia M and Yao JQ: The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol. 35:2306–2312. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Hwang HS, Park IY, Kim DW, Choi SY, Jung YO and Kim HA: PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model. BMB Rep. 48:407–412. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Burrage PS, Mix KS and Brinckerhoff CE: Matrix metalloproteinases: role in arthritis. Front Biosci. 11:529–543. 2006. View Article : Google Scholar

7 

Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L and Winberg JO: Regulation of matrix metalloproteinase activity in health and disease. FEBS J. 278:28–45. 2011. View Article : Google Scholar

8 

Berenbaum F: Signaling transduction: target in osteoarthritis. Curr Opin Rheumatol. 16:616–622. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Vincenti MP and Brinckerhoff CE: Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 4:157–164. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M and Karsdal MA: MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation - divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage. 18:279–288. 2010. View Article : Google Scholar

11 

Mengshol JA, Vincenti MP, Coon CI, Barchowsky A and Brinckerhoff CE: Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 43:801–811. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Studer R, Jaffurs D, Stefanovic-Racic M, Robbins PD and Evans CH: Nitric oxide in osteoarthritis. Osteoarthritis Cartilage. 7:377–379. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Farkouh ME, Greenberg JD, Jeger RV, Ramanathan K, Verheugt FW, Chesebro JH, Kirshner H, Hochman JS, Lay CL, Ruland S, et al: Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. Ann Rheum Dis. 66:764–770. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Herndon CM: Topical delivery of nonsteroidal anti-inflammatory drugs for osteoarthritis. J Pain Palliat Care Pharmacother. 26:18–23. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Mobasheri A: Intersection of inflammation and herbal medicine in the treatment of osteoarthritis. Curr Rheumatol Rep. 14:604–616. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Wang X, Wei S, Liu T, Pang J, Gao N, Ding D, Duan T, Cao Y, Zheng Y and Zhan H: Effectiveness, medication patterns, and adverse events of traditional chinese herbal patches for osteoarthritis: a systematic review. Evid Based Complement Alternat Med. 2014:3431762014. View Article : Google Scholar : PubMed/NCBI

17 

Ann JY, Eo H and Lim Y: Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice. Genes Nutr. 10:462015. View Article : Google Scholar : PubMed/NCBI

18 

Jo SP, Kim JK and Lim YH: Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet. Food Chem Toxicol. 65:213–218. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim HG, Jeong HU, Park G, Kim H, Lim Y and Oh MS: Mori folium and mori fructus mixture attenuates high-fat diet-induced cognitive deficits in mice. Based Complement Alternat Med. 2015:3794182015.

20 

Tirupathi RG, Suresh BK, Ujwal KJ, Sujana P, Raoa AV and Sreedhar AS: Anti-microbial principles of selected remedial plants from Southern India. Asian Pac J Trop Biomed. 1:298–305. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Qin J, Fan M, He J, Wu XD, Peng LY, Su J, Cheng X, Li Y, Kong LM, Li RT and Zhao Q: New cytotoxic and anti-inflammatory compounds isolated from Morus alba L. Nat Prod Res. 29:1711–1718. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, Hossain M, Rashid M, Sadik G, Nasrin S, et al: A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes. 6:242013. View Article : Google Scholar : PubMed/NCBI

23 

Deepa M, Sureshkumar T, Satheeshkumar PK and Priya S: Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase. Nutr Cancer. 65:305–310. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Deepa M and Priya S: Purification and characterization of a novel anti-proliferative lectin from Morus alba L. leaves. Protein Pept Lett. 19:839–845. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M and Yamane Y: Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr. 135:729–734. 2005.PubMed/NCBI

26 

Sugimoto M, Arai H, Tamura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, et al: Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. Atherosclerosis. 204:388–394. 2009. View Article : Google Scholar

27 

Lee YJ, Choi DH, Kim EJ, Kim HY, Kwon TO, Kang DG and Lee HS: Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet. Am J Chin Med. 39:39–52. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Lee H, Pyo MJ, Bae SK, Heo Y, Kim CG, Kang C and Kim E: Improved Therapeutic Profiles of PLA2-Free Bee Venom Prepared by Ultrafiltration Method. Toxicol Res. 31:33–40. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J and Kim TY: Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin. Exp Mol Med. 46:e872014. View Article : Google Scholar : PubMed/NCBI

30 

Gebauer M, Saas J, Sohler F, Haag J, Söder S, Pieper M, Bartnik E, Beninga J, Zimmer R and Aigner T: Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta. Osteoarthritis Cartilage. 13:697–708. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Toegel S, Wu SQ, Otero M, Goldring MB, Leelapornpisid P, Chiari C, Kolb A, Unger FM, Windhager R and Viernstein H: Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes Nutr. 7:307–318. 2012. View Article : Google Scholar :

32 

Torzilli PA, Tehrany AM, Grigiene R and Young E: Effects of misoprostol and prostaglandin E2 on proteoglycan biosynthesis and loss in unloaded and loaded articular cartilage explants. Prostaglandins. 52:157–173. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Amin AR, Attur M and Abramson SB: Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis. Curr Opin Rheumatol. 11:202–209. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Wada Y, Shimada K, Sugimoto K, Kimura T and Ushiyama S: Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by downregulating matrix metal-loproteinase-1,-13 and prostaglandin E2 production in human chondrocytes. Int Immunopharmacol. 6:144–155. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Park SJ, Cheon EJ and Kim HA: MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartilage. 21:981–989. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Lu YC, Jayakumar T, Duann YF, Chou YC, Hsieh CY, Yu SY, Sheu JR and Hsiao G: Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. J Agric Food Chem. 59:4969–4978. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Rigoglou S and Papavassiliou AG: The NF-κB signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 45:2580–2584. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res. 288:208–217. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Salvatierra J, Escames G, Hernandez P, Cantero J, Crespo E, Leon J, Salvatierra D, Acuña-Castroviejo D and Vives F: Cartilage and serum levels of nitric oxide in patients with hip osteoarthritis. J Rheumatol. 26:2015–2017. 1999.PubMed/NCBI

40 

Miyaura C, Inada M, Suzawa T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S and Suda T: Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J Biol Chem. 275:19819–19823. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Chen WP, Wang YL, Tang JL, Hu PF, Bao JP and Wu LD: Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Int Immunopharmacol. 12:447–452. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Graham S, Gamie Z, Polyzois I, Narvani AA, Tzafetta K and Tsiridis E, Helioti M, Mantalaris A and Tsiridis E: Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: in vivo and in vitro evidence. Expert Opin Investig Drugs. 18:746–766. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H and Takigawa M: Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem. 123:431–439. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Tung JT, Arnold CE, Alexander LH, Yuzbasiyan-Gurkan V, Venta PJ, Richardson DW and Caron JP: Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures. Am J Vet Res. 63:987–993. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Barchowsky A, Frleta D and Vincenti MP: Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine. 12:1469–1479. 2000. View Article : Google Scholar : PubMed/NCBI

46 

White LA and Brinckerhoff CE: Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind Jun D, c-Fos, and Fra-2. Matrix Biol. 14:715–725. 1995. View Article : Google Scholar : PubMed/NCBI

47 

Roman-Blas JA and Jimenez SA: NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage. 14:839–848. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Itthiarbha A, Phitak T, Sanyacharernkul S, Pothacharoen P, Pompimon W and Kongtawelert P: Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1β-induced expression of matrix metalloproteinase via activation of NF-κB in human chondrocytes. In Vitro Cell Dev Biol Anim. 48:43–53. 2012. View Article : Google Scholar

49 

Sunaga T, Oh N, Hosoya K, Takagi S and Okumura M: Inhibitory effects of pentosan polysulfate sodium on MAP-kinase pathway and NF-κB nuclear translocation in canine chondrocytes in vitro. J Vet Med Sci. 74:707–711. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jeong J, Lee HH, Lee KW, Kim KY, Kim SG, Hong SH, Kim G, Park C, Kim HK, Choi YW, Choi YW, et al: Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. Int J Mol Med 37: 452-460, 2016.
APA
Jeong, J., Lee, H.H., Lee, K.W., Kim, K.Y., Kim, S.G., Hong, S.H. ... Choi, Y.H. (2016). Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. International Journal of Molecular Medicine, 37, 452-460. https://doi.org/10.3892/ijmm.2015.2443
MLA
Jeong, J., Lee, H. H., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., Kim, H. K., Choi, Y. W., Choi, Y. H."Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes". International Journal of Molecular Medicine 37.2 (2016): 452-460.
Chicago
Jeong, J., Lee, H. H., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., Kim, H. K., Choi, Y. W., Choi, Y. H."Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes". International Journal of Molecular Medicine 37, no. 2 (2016): 452-460. https://doi.org/10.3892/ijmm.2015.2443
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong J, Lee HH, Lee KW, Kim KY, Kim SG, Hong SH, Kim G, Park C, Kim HK, Choi YW, Choi YW, et al: Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. Int J Mol Med 37: 452-460, 2016.
APA
Jeong, J., Lee, H.H., Lee, K.W., Kim, K.Y., Kim, S.G., Hong, S.H. ... Choi, Y.H. (2016). Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. International Journal of Molecular Medicine, 37, 452-460. https://doi.org/10.3892/ijmm.2015.2443
MLA
Jeong, J., Lee, H. H., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., Kim, H. K., Choi, Y. W., Choi, Y. H."Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes". International Journal of Molecular Medicine 37.2 (2016): 452-460.
Chicago
Jeong, J., Lee, H. H., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., Kim, H. K., Choi, Y. W., Choi, Y. H."Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes". International Journal of Molecular Medicine 37, no. 2 (2016): 452-460. https://doi.org/10.3892/ijmm.2015.2443
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