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Review Open Access

Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)

  • Authors:
    • George B. Stefano
    • Richard M. Kream
  • View Affiliations / Copyright

    Affiliations: MitoGenetics, Farmingdale, NY 11735, USA
    Copyright: © Stefano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 547-555
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    Published online on: January 28, 2016
       https://doi.org/10.3892/ijmm.2016.2471
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Abstract

Mitochondria and chloroplasts represent endosymbiotic models of complex organelle development, driven by intense evolutionary pressure to provide exponentially enhanced ATP-dependent energy production functionally linked to cellular respiration and photosynthesis. Within the realm of translational medicine, it has become compellingly evident that mitochondrial dysfunction, resulting in compromised cellular bioenergetics, represents a key causative factor in the etiology and persistence of major diseases afflicting human populations. As a pathophysiological consequence of enhanced oxygen utilization that is functionally uncoupled from the oxidative phosphorylation of ADP, significant levels of reactive oxygen species (ROS) may be generated within mitochondria and chloroplasts, which may effectively compromise cellular energy production following prolonged stress/inflammatory conditions. Empirically determined homologies in biochemical pathways, and their respective encoding gene sequences between chloroplasts and mitochondria, suggest common origins via entrapped primordial bacterial ancestors. From evolutionary and developmental perspectives, the elucidation of multiple biochemical and molecular relationships responsible for errorless bioenergetics within mitochondrial and plastid complexes will most certainly enhance the depth of translational approaches to ameliorate or even prevent the destructive effects of multiple disease states. The selective choice of discussion points contained within the present review is designed to provide theoretical bases and translational insights into the pathophysiology of human diseases from a perspective of dysregulated mitochondrial bioenergetics with special reference to chloroplast biology.
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1 

Stefano GB and Kream R: Psychiatric disorders involving mitochondrial processes. Psychol Obs. 1:1–6. 2015.

2 

Stefano GB, Mantione KJ, Casares FM and Kream RM: Anaerobically functioning mitochondria: Evolutionary perspective on modulation of energy metabolism in Mytilus edulis. Invertebrate Surviv J. 12:22–28. 2015.

3 

Snyder C and Stefano GB: Mitochondria and chloroplasts shared in animal and plant tissues: Significance of communication. Med Sci Monit. 21:1507–1511. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Mantione K, Kream RM and Stefano GB: Variations in critical morphine biosynthesis genes and their potential to influence human health. Neuro Endocrinol Lett. 31:11–18. 2010.PubMed/NCBI

5 

Esch T and Stefano G: Proinflammation: A common denominator or initiator of different pathophysiological disease processes. Med Sci Monit. 8:HY1–HY9. 2002.PubMed/NCBI

6 

Takahashi E and Sato M: Anaerobic respiration sustains mitochondrial membrane potential in a prolyl hydroxylase pathway-activated cancer cell line in a hypoxic microenvironment. Am J Physiol Cell Physiol. 306:C334–C342. 2014. View Article : Google Scholar

7 

Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH, Ichim T, Quintero-Del-Rio AI and Ortiz N: The bio-energetic theory of carcinogenesis. Med Hypotheses. 79:433–439. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Chen Z and Stamler JS: Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med. 16:259–265. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Müller M, Mentel M, van Hellemond JJ, Henze K, Woehle C, Gould SB, Yu RY, van der Giezen M, Tielens AG and Martin WF: Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev. 76:444–495. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Watt IN, Montgomery MG, Runswick MJ, Leslie AG and Walker JE: Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc Natl Acad Sci USA. 107:16823–16827. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Degli Esposti M: Bioenergetic evolution in proteobacteria and mitochondria. Genome Biol Evol. 6:3238–3251. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Aliev G, Priyadarshini M, Reddy VP, Grieg NH, Kaminsky Y, Cacabelos R, Ashraf GM, Jabir NR, Kamal MA, Nikolenko VN, et al: Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Curr Med Chem. 21:2208–2217. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Carvalho C, Machado N, Mota PC, Correia SC, Cardoso S, Santos RX, Santos MS, Oliveira CR and Moreira PI: Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies. J Alzheimers Dis. 35:623–635. 2013.PubMed/NCBI

14 

Chong ZZ, Li F and Maiese K: Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol. 75:207–246. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Ebadi M, Govitrapong P, Sharma S, Muralikrishnan D, Shavali S, Pellett L, Schafer R, Albano C and Eken J: Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of Parkinson's disease. Biol Signals Recept. 10:224–253. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Kream RM, Mantione KJ, Casares FM and Stefano GB: Impaired expression of ATP-binding cassette transporter genes in diabetic ZDF rat blood. Int J Diabetes Res. 3:49–55. 2014.

17 

Kream RM, Mantione KJ, Casares FM and Stefano GB: Concerted dysregulation of 5 major classes of blood leukocyte genes in diabetic ZDF rats: A working translational profile of comorbid rheumatoid arthritis progression. Int J Prev Treat. 3:17–25. 2014.

18 

Wang F, Guo X, Shen X, Kream RM, Mantione KJ and Stefano GB: Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: A potential etiological linkage. Med Sci Monit Basic Res. 20:118–129. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wang F, Stefano GB and Kream RM: Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: Etiological contribution to complex regional pain syndromes (Part I). Med Sci Monit. 20:1067–1077. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Wang F, Stefano GB and Kream RM: Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: Etiological contribution to complex regional pain syndromes (Part II). Med Sci Monit. 20:1188–1200. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Panksepp J, Herman B, Conner R, Bishop P and Scott JP: The biology of social attachments: Opiates alleviate separation distress. Biol Psychiatry. 13:607–618. 1978.PubMed/NCBI

22 

Pierce RC and Kumaresan V: The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev. 30:215–238. 2006. View Article : Google Scholar

23 

Schmauss C and Emrich HM: Dopamine and the action of opiates: A reevaluation of the dopamine hypothesis of schizophrenia. With special consideration of the role of endogenous opioids in the pathogenesis of schizophrenia. Biol Psychiatry. 20:1211–1231. 1985. View Article : Google Scholar : PubMed/NCBI

24 

Stępień A, Stępień M, Wlazeł RN, Paradowski M, Banach M and Rysz J: Assessment of the relationship between lipid parameters and obesity indices in non-diabetic obese patients: A preliminary report. Med Sci Monit. 20:2683–2688. 2014. View Article : Google Scholar

25 

Göhring I, Sharoyko VV, Malmgren S, Andersson LE, Spégel P, Nicholls DG and Mulder H: Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J Biol Chem. 289:3786–3798. 2014. View Article : Google Scholar :

26 

Mantione KJ, Kream RM, Kuzelova H, Ptacek R, Raboch J, Samuel JM and Stefano GB: Comparing bioinformatic gene expression profiling methods: Microarray and RNA-Seq. Med Sci Monit Basic Res. 20:138–142. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kram KE and Finkel SE: Culture volume and vessel affect long-term survival, mutation frequency, and oxidative stress of Escherichia coli. Appl Environ Microbiol. 80:1732–1738. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Stefano GB and Kream RM: Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes. Med Sci Monit. 21:1478–1484. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Guo R, Li W, Liu B, Li S, Zhang B and Xu Y: Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro. Med Sci Monit Basic Res. 20:82–92. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yildirim V, Doganci S, Yesildal F, Kaya E, Ince ME, Ozkan G, Gumusel B, Avcu F and Ozgurtas T: Sodium nitrite provides angiogenic and proliferative effects in vivo and in vitro. Med Sci Monit Basic Res. 21:41–46. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Davila AF and Zamorano P: Mitochondria and the evolutionary roots of cancer. Phys Biol. 10:0260082013. View Article : Google Scholar : PubMed/NCBI

32 

Doeller JE, Grieshaber MK and Kraus DW: Chemolithoheterotrophy in a metazoan tissue: Thiosulfate production matches ATP demand in ciliated mussel gills. J Exp Biol. 204:3755–3764. 2001.PubMed/NCBI

33 

Doeller JE, Kraus DW, Shick JM and Gnaiger E: Heat flux, oxygen flux, and mitochondrial redox state as a function of oxygen availability and ciliary activity in excised gills of Mytilus edulis. J Exp Zool. 265:1–8. 1993. View Article : Google Scholar : PubMed/NCBI

34 

Tan DX, Manchester LC, Liu X, Rosales-Corral SA, Acuna-Castroviejo D and Reiter RJ: Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eukaryotes. J Pineal Res. 54:127–138. 2013. View Article : Google Scholar

35 

Stefano GB, Snyder C and Kream RM: Mitochondria, chloroplasts in animal and plant cells: Significance of conformational matching. Med Sci Monit. 21:2073–2078. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Cruz S, Calado R, Serôdio J and Cartaxana P: Crawling leaves: Photosynthesis in sacoglossan sea slugs. J Exp Bot. 64:3999–4009. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Serôdio J, Cruz S, Cartaxana P and Calado R: Photophysiology of kleptoplasts: Photosynthetic use of light by chloroplasts living in animal cells. Philos Trans R Soc Lond B Biol Sci. 369:201302422014. View Article : Google Scholar : PubMed/NCBI

38 

de Vries J, Christa G and Gould SB: Plastid survival in the cytosol of animal cells. Trends Plant Sci. 19:347–350. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Pennisi E: Microbiology. Modern symbionts inside cells mimic organelle evolution. Science. 346:532–533. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Händeler K, Wägele H, Wahrmund U, Rüdinger M and Knoop V: Slugs' last meals: Molecular identification of sequestered chloroplasts from different algal origins in Sacoglossa (Opisthobranchia, Gastropoda). Mol Ecol Resour. 10:968–978. 2010. View Article : Google Scholar

41 

Stefano GB: Conformational matching: a possible evolutionary force in the evolvement of signal systems. CRC Handbook of Comparative Opioid and Related Neuropeptide Mechanisms. Stefano GB: CRC Press Inc; Boca Raton: pp. 271–277. 1986

42 

Kerney R, Kim E, Hangarter RP, Heiss AA, Bishop CD and Hall BK: Intracellular invasion of green algae in a salamander host. Proc Natl Acad Sci USA. 108:6497–6502. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Kao WC and Hunte C: The molecular evolution of the Qo motif. Genome Biol Evol. 6:1894–1910. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Renato M, Pateraki I, Boronat A and Azcón-Bieto J: Tomato fruit chromoplasts behave as respiratory bioenergetic organelles during ripening. Plant Physiol. 166:920–933. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Bailey-Serres J and Voesenek LA: Flooding stress: Acclimations and genetic diversity. Annu Rev Plant Biol. 59:313–339. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Gibbs DJ, Lee SC, Isa NM, Gramuglia S, Fukao T, Bassel GW, Correia CS, Corbineau F, Theodoulou FL, Bailey-Serres J and Holdsworth MJ: Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature. 479:415–418. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Xu K, Xu X, Fukao T, Canlas P, Maghirang-Rodriguez R, Heuer S, Ismail AM, Bailey-Serres J, Ronald PC and Mackill DJ: Sub1A is an ethylene-response-factor-like gene that confers submergence tolerance to rice. Nature. 442:705–708. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Fukao T, Yeung E and Bailey-Serres J: The submergence tolerance regulator SUB1A mediates crosstalk between submergence and drought tolerance in rice. Plant Cell. 23:412–427. 2011. View Article : Google Scholar : PubMed/NCBI

49 

van Dongen JT and Licausi F: Oxygen sensing and signaling. Annu Rev Plant Biol. 66:345–367. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Gibbs DJ, Conde JV, Berckhan S, Prasad G, Mendiondo GM and Holdsworth MJ: Group VII ethylene response factors coordinate oxygen and nitric oxide signal transduction and stress responses in plants. Plant Physiol. 169:23–31. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Kleine T and Leister D: Emerging functions of mammalian and plant mTERFs. Biochim Biophys Acta. 1847:786–797. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Maier UG, Zauner S, Woehle C, Bolte K, Hempel F, Allen JF and Martin WF: Massively convergent evolution for ribosomal protein gene content in plastid and mitochondrial genomes. Genome Biol Evol. 5:2318–2329. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Coates AR, Halls G and Hu Y: Novel classes of antibiotics or more of the same? Br J Pharmacol. 163:184–194. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS and Collins JJ: Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 5:192ra852013. View Article : Google Scholar : PubMed/NCBI

55 

Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CT, Lobritz MA, Braff D, Schwarz EG, et al: Antibiotics induce redox-related physiological alterations as part of their lethality. Proc Natl Acad Sci USA. 111:E2100–E2109. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Gray MW, Burger G and Lang BF: The origin and early evolution of mitochondria. Genome Biol. 2:reviews1018.1–reviews1018.5. 2001. View Article : Google Scholar

57 

Zimorski V, Ku C, Martin WF and Gould SB: Endosymbiotic theory for organelle origins. Curr Opin Microbiol. 22:38–48. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Powers JH: Antimicrobial drug development - the past, the present, and the future. Clin Microbiol Infect. 10(Suppl 4): 23–31. 2004. View Article : Google Scholar

59 

Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI, et al: Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet. 4:289–294. 1993. View Article : Google Scholar : PubMed/NCBI

60 

Desa D, Nichols MG and Jensen Smith H: The role of complex I in mitochondrial reactive oxygen species formation in cochlear sensory and supporting cells during ototoxic aminoglycoside exposure. Biophys J. 108:611a2015. View Article : Google Scholar

61 

Katsi V, Katsimichas T, Kallistratos MS, Tsekoura D, Makris T, Manolis AJ, Tousoulis D, Stefanadis C and Kallikazaros I: The association of Restless Legs Syndrome with hypertension and cardiovascular disease. Med Sci Monit. 20:654–659. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Stefano GB and Kream RM: Nitric oxide regulation of mitochondrial processes: Commonality in medical disorders. Ann Transplant. 20:402–407. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Jones CN, Miller C, Tenenbaum A, Spremulli LL and Saada A: Antibiotic effects on mitochondrial translation and in patients with mitochondrial translational defects. Mitochondrion. 9:429–437. 2009. View Article : Google Scholar : PubMed/NCBI

64 

Pacheu-Grau D, Gómez-Durán A, Iglesias E, López-Gallardo E, Montoya J and Ruiz-Pesini E: Mitochondrial antibiograms in personalized medicine. Hum Mol Genet. 22:1132–1139. 2013. View Article : Google Scholar

65 

Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, et al: Tetracyclines disturb mitochondrial function across eukaryotic models: A call for caution in biomedical research. Cell Rep. 10:1681–1691. 2015. View Article : Google Scholar

66 

Singh R, Sripada L and Singh R: Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell. Mitochondrion. 16:50–54. 2014. View Article : Google Scholar

67 

Stevens DL: The role of vancomycin in the treatment paradigm. Clin Infect Dis. 42(Suppl 1): S51–S57. 2006. View Article : Google Scholar

68 

Arimura Y, Yano T, Hirano M, Sakamoto Y, Egashira N and Oishi R: Mitochondrial superoxide production contributes to vancomycin-induced renal tubular cell apoptosis. Free Radic Biol Med. 52:1865–1873. 2012. View Article : Google Scholar : PubMed/NCBI

69 

Dieterich C, Puey A, Lin S, Swezey R, Furimsky A, Fairchild D, Mirsalis JC and Ng HH: Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates. Toxicol Sci. 107:258–269. 2009. View Article : Google Scholar :

70 

Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP and Sotgia F: Mitochondrial dysfunction in breast cancer cells prevents tumor growth: Understanding chemoprevention with metformin. Cell Cycle. 12:172–182. 2013. View Article : Google Scholar :

71 

Lamb R, Harrison H, Hulit J, Smith DL, Lisanti MP and Sotgia F: Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition. Oncotarget. 5:11029–11037. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Lamb R, Fiorillo M, Chadwick A, Ozsvari B, Reeves KJ, Smith DL, Clarke RB, Howell SJ, Cappello AR, Martinez-Outschoorn UE, et al: Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. Oncotarget. 6:14005–14025. 2015. View Article : Google Scholar : PubMed/NCBI

73 

Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA and Sachidanandam R: Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Res. 43:2177–2187. 2015. View Article : Google Scholar : PubMed/NCBI

74 

Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez-Outschoorn UE, Sotgia F and Lisanti MP: Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease. Oncotarget. 6:4569–4584. 2015. View Article : Google Scholar : PubMed/NCBI

75 

Leeman MF, Curran S and Murray GI: The structure, regulation, and function of human matrix metalloproteinase-13. Crit Rev Biochem Mol Biol. 37:149–166. 2002. View Article : Google Scholar : PubMed/NCBI

76 

Li CH, Cheng YW, Liao PL, Yang YT and Kang JJ: Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 116:140–150. 2010. View Article : Google Scholar : PubMed/NCBI

77 

Abouesh A, Stone C and Hobbs WR: Antimicrobial-induced mania (antibiomania): A review of spontaneous reports. J Clin Psychopharmacol. 22:71–81. 2002. View Article : Google Scholar : PubMed/NCBI

78 

Ben-Chetrit E, Rothstein N and Munter G: Ciprofloxacin-induced psychosis. Antimicrob Agents Chemother. 57:40792013. View Article : Google Scholar : PubMed/NCBI

79 

Mulhall JP and Bergmann LS: Ciprofloxacin-induced acute psychosis. Urology. 46:102–103. 1995. View Article : Google Scholar : PubMed/NCBI

80 

Reeves RR: Ciprofloxacin-induced psychosis. Ann Pharmacother. 26:930–931. 1992.PubMed/NCBI

81 

Koul S, Bhan-Kotwal S, Jenkins HS and Carmaciu CD: Organic psychosis induced by ofloxacin and metronidazole. Br J Hosp Med (Lond). 70:236–237. 2009. View Article : Google Scholar

82 

Dinca EB, Skinner A, Dinca RV and Tudose C: The dangers of gastritis: A case of clarithromycin-associated brief psychotic episode. J Nerv Ment Dis. 203:149–151. 2015. View Article : Google Scholar : PubMed/NCBI

83 

Jiménez-Pulido I, Navarro-Ruiz A, Sendra P, Martínez-Ramírez M, Garcia-Motos C and Montesinos-Ros A: Hallucinations with therapeutic doses of clarithromycin. Int J Clin Pharmacol Ther. 40:20–22. 2002. View Article : Google Scholar : PubMed/NCBI

84 

Korde AS and Maragos WF: Identification of an N-methyl-D-aspartate receptor in isolated nervous system mitochondria. J Biol Chem. 287:35192–35200. 2012. View Article : Google Scholar : PubMed/NCBI

85 

Schmuck G, Schürmann A and Schlüter G: Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model. Antimicrob Agents Chemother. 42:1831–1836. 1998.PubMed/NCBI

86 

Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK and Bowie D: Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun. 5:31682014. View Article : Google Scholar : PubMed/NCBI

87 

Kawakami J, Yamamoto K, Asanuma A, Yanagisawa K, Sawada Y and Iga T: Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: Correlation with convulsive potency in vivo. Toxicol Appl Pharmacol. 145:246–254. 1997. View Article : Google Scholar : PubMed/NCBI

88 

Zhang HYMB, McPherson BC, Liu H, Baman TS, Rock P and Yao Z: H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardio-myocytes. Am J Physiol Heart Circ Physiol. 282:H1395–H1403. 2002. View Article : Google Scholar : PubMed/NCBI

89 

Grill MF and Maganti RK: Neurotoxic effects associated with antibiotic use: Management considerations. Br J Clin Pharmacol. 72:381–393. 2011. View Article : Google Scholar : PubMed/NCBI

90 

Stuhec M: Trimethoprim-sulfamethoxazole-related hallucinations. Gen Hosp Psychiatry. 36:230.e237–e238. 2014. View Article : Google Scholar

91 

Weis S, Karagülle D, Kornhuber J and Bayerlein K: Cotrimoxazole-induced psychosis: A case report and review of literature. Pharmacopsychiatry. 39:236–237. 2006. View Article : Google Scholar : PubMed/NCBI

92 

Lee KY, Huang CH, Tang HJ, Yang CJ, Ko WC, Chen YH, Lee YC and Hung CC: Acute psychosis related to use of trimethoprim/sulfamethoxazole in the treatment of HIV-infected patients with Pneumocystis jirovecii pneumonia: A multicentre, retrospective study. J Antimicrob Chemother. 67:2749–2754. 2012. View Article : Google Scholar : PubMed/NCBI

93 

Quandt-Herrera P, Suarez-Jesus J and Yelmo-Cruz S: Antibiomania: Secondary mania associated with ceftazidime. J Clin Psychopharmacol. 35:619–621. 2015. View Article : Google Scholar : PubMed/NCBI

94 

Landais A, Marty N, Bessis D, Pages M and Blard JM: Hoigne syndrome following an intravenous injection of ceftriaxone: A case report. Rev Med Interne. 35:199–201. 2014.In French. View Article : Google Scholar

95 

Stefano GB, Kim C, Mantione K, Casares F and Kream RM: Targeting mitochondrial biogenesis for promoting health. Med Sci Monit. 18:SC1–SC3. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Michel TM, Pülschen D and Thome J: The role of oxidative stress in depressive disorders. Curr Pharm Des. 18:5890–5899. 2012. View Article : Google Scholar : PubMed/NCBI

97 

Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T and Fiskum G: Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling. J Psychiatr Res. 46:95–104. 2012. View Article : Google Scholar

98 

Tobe EH: Mitochondrial dysfunction, oxidative stress, and major depressive disorder. Neuropsychiatr Dis Treat. 9:567–573. 2013. View Article : Google Scholar : PubMed/NCBI

99 

Hovatta I, Juhila J and Donner J: Oxidative stress in anxiety and comorbid disorders. Neurosci Res. 68:261–275. 2010. View Article : Google Scholar : PubMed/NCBI

100 

Andreazza AC: Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders. Mol Biosyst. 8:2503–2512. 2012. View Article : Google Scholar : PubMed/NCBI

101 

Gigante AD, Andreazza AC, Lafer B, Yatham LN, Beasley CL and Young LT: Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett. 505:47–51. 2011. View Article : Google Scholar : PubMed/NCBI

102 

Rossignol DA and Frye RE: A review of research trends in physiological abnormalities in autism spectrum disorders: Immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry. 17:389–401. 2012. View Article : Google Scholar :

103 

Mehta SL, Kumari S, Mendelev N and Li PA: Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia. BMC Neurosci. 13:792012. View Article : Google Scholar : PubMed/NCBI

104 

Badjatia N, Seres D, Carpenter A, Schmidt JM, Lee K, Mayer SA, Claassen J, Connolly ES and Elkind MS: Free fatty acids and delayed cerebral ischemia after subarachnoid hemorrhage. Stroke. 43:691–696. 2012. View Article : Google Scholar : PubMed/NCBI

105 

Chen G, Jing CH, Liu PP, Ruan D and Wang L: Induction of autophagic cell death in the rat brain caused by iron. Am J Med Sci. 345:369–374. 2013. View Article : Google Scholar

106 

McCracken E, Valeriani V, Simpson C, Jover T, McCulloch J and Dewar D: The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes. J Cereb Blood Flow Metab. 20:1529–1536. 2000. View Article : Google Scholar : PubMed/NCBI

107 

Cui J, Holmes EH, Greene TG and Liu PK: Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J. 14:955–967. 2000.PubMed/NCBI

108 

Panov A, Dikalov S, Shalbuyeva N, Hemendinger R, Greenamyre JT and Rosenfeld J: Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice. Am J Physiol Cell Physiol. 292:C708–C718. 2007. View Article : Google Scholar

109 

Hansson MJ, Månsson R, Morota S, Uchino H, Kallur T, Sumi T, Ishii N, Shimazu M, Keep MF, Jegorov A and Elmér E: Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition. Free Radic Biol Med. 45:284–294. 2008. View Article : Google Scholar : PubMed/NCBI

110 

Opii WO, Nukala VN, Sultana R, Pandya JD, Day KM, Merchant ML, Klein JB, Sullivan PG and Butterfield DA: Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. J Neurotrauma. 24:772–789. 2007. View Article : Google Scholar : PubMed/NCBI

111 

Lemasters JJ, Theruvath TP, Zhong Z and Nieminen AL: Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. 1787:1395–1401. 2009. View Article : Google Scholar : PubMed/NCBI

112 

Rasola A, Sciacovelli M, Pantic B and Bernardi P: Signal transduction to the permeability transition pore. FEBS Lett. 584:1989–1996. 2010. View Article : Google Scholar : PubMed/NCBI

113 

Esch T, Stefano GB, Fricchione GL and Benson H: The role of stress in neurodegenerative diseases and mental disorders. Neuro Endocrinol Lett. 23:199–208. 2002.PubMed/NCBI

114 

Halliwell B: Oxidative stress and neurodegeneration: Where are we now? J Neurochem. 97:1634–1658. 2006. View Article : Google Scholar : PubMed/NCBI

115 

Tsaluchidu S, Cocchi M, Tonello L and Puri BK: Fatty acids and oxidative stress in psychiatric disorders. BMC Psychiatry. 8(Suppl 1): S52008. View Article : Google Scholar : PubMed/NCBI

116 

Masood A, Nadeem A, Mustafa SJ and O'Donnell JM: Reversal of oxidative stress-induced anxiety by inhibition of phosphodi-esterase-2 in mice. J Pharmacol Exp Ther. 326:369–379. 2008. View Article : Google Scholar : PubMed/NCBI

117 

Arranz MJ and de Leon J: Pharmacogenetics and pharmacoge-nomics of schizophrenia: A review of last decade of research. Mol Psychiatry. 12:707–747. 2007. View Article : Google Scholar : PubMed/NCBI

118 

Bouayed J, Rammal H, Younos C and Soulimani R: Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice. Eur J Pharmacol. 564:146–149. 2007. View Article : Google Scholar : PubMed/NCBI

119 

Bouayed J, Rammal H and Soulimani R: Oxidative stress and anxiety: Relationship and cellular pathways. Oxid Med Cell Longev. 2:63–67. 2009. View Article : Google Scholar :

120 

Marazziti D, Baroni S, Picchetti M, Landi P, Silvestri S, Vatteroni E and Catena Dell'Osso M: Psychiatric disorders and mitochondrial dysfunctions. Eur Rev Med Pharmacol Sci. 16:270–275. 2012.PubMed/NCBI

121 

Ng F, Berk M, Dean O and Bush AI: Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications. Int J Neuropsychopharmacol. 11:851–876. 2008. View Article : Google Scholar : PubMed/NCBI

122 

Kunz M, Gama CS, Andreazza AC, Salvador M, Ceresér KM, Gomes FA, Belmonte-de-Abreu PS, Berk M and Kapczinski F: Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 32:167–1681. 2008. View Article : Google Scholar

123 

Wass CE and Andreazza A: The Redox Brain and Nitric Oxide: Implications for Psychiatric Illness. J Pharmacol Clin Toxicol. 1:1008–1009. 2013.

124 

Gubert C, Stertz L, Pfaffenseller B, Panizzutti BS, Rezin GT, Massuda R, Streck EL, Gama CS, Kapczinski F and Kunz M: Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects. J Psychiatr Res. 47:1396–1402. 2013. View Article : Google Scholar : PubMed/NCBI

125 

Emiliani FE, Sedlak TW and Sawa A: Oxidative stress and schizophrenia: recent breakthroughs from an old story. 27:185–190. 2014.

126 

Andreazza AC, Kauer-Sant'anna M, Frey BN, Bond DJ, Kapczinski F, Young LT and Yatham LN: Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord. 111:135–144. 2008. View Article : Google Scholar : PubMed/NCBI

127 

Scola G, Kim HK, Young LT and Andreazza AC: A fresh look at complex I in microarray data: Clues to understanding disease-specific mitochondrial alterations in bipolar disorder. Biol Psychiatry. 73:e4–e5. 2013. View Article : Google Scholar

128 

Boess FG, Hendrix M, van der Staay FJ, Erb C, Schreiber R, van Staveren W, de Vente J, Prickaerts J, Blokland A and Koenig G: Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology. 47:1081–1092. 2004. View Article : Google Scholar : PubMed/NCBI

129 

Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R and Hofmann F: Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur J Neurosci. 20:3498–3506. 2004. View Article : Google Scholar : PubMed/NCBI

130 

Wang X, Pinto-Duarte A, Sejnowski TJ and Behrens MM: How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia. Antioxid Redox Signal. 18:1444–1462. 2013. View Article : Google Scholar :

131 

Gu F, Chauhan V, Kaur K, Brown WT, LaFauci G, Wegiel J and Chauhan A: Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism. Transl Psychiatry. 3:e2992013. View Article : Google Scholar : PubMed/NCBI

132 

Ptacek R, Stefano GB, Weissenberger S, et al: ADHD and eating disorders: risks and co-Morbidities. J Neuropsychiatric Dis Treat. In press.

133 

Ming X, Brimacombe M, Malek JH, Jani N and Wagner GC: Autism spectrum disorders and identified toxic land fills: Co-occurrence across States. Environ Health Insights. 2:55–59. 2008.PubMed/NCBI

134 

Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N and James SJ: Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry. 3:e2732013. View Article : Google Scholar : PubMed/NCBI

135 

Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE and James SJ: Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry. 2:e1342012. View Article : Google Scholar : PubMed/NCBI

136 

Kulak A, Steullet P, Cabungcal JH, Werge T, Ingason A, Cuenod M and Do KQ: Redox dysregulation in the pathophysiology of schizophrenia and bipolar disorder: Insights from animal models. Antioxid Redox Signal. 18:1428–1443. 2013. View Article : Google Scholar

137 

Kream RM and Stefano GB: De novo biosynthesis of morphine in animal cells: An evidence-based model. Med Sci Monit. 12:RA207–RA219. 2006.PubMed/NCBI

138 

Kream RM, Sheehan M, Cadet P, Mantione KJ, Zhu W, Casares F and Stefano GB: Persistence of evolutionary memory: Primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling. Med Sci Monit. 13:SC5–SC6. 2007.PubMed/NCBI

139 

Stefano GB, Mantione KJ, Capellan L, Casares FM, Challenger S, Ramin R, Samuel JM, Snyder C and Kream RM: Morphine stimulates nitric oxide release in human mitochondria. J Bioenerg Biomembr. 47:409–417. 2015. View Article : Google Scholar : PubMed/NCBI

140 

Kream RM, Stefano GB and Rtacek R: Psychiatric implications of endogenous morphine: up-to-date review. Folia Biol (Praha). 56:231–241. 2010.

141 

Kream RM, Mantione KJ, Sheehan M and Stefano GB: Morphine's chemical messenger status in animals. Activitas Nerv Super Rediviva. 51:153–161. 2009.

142 

Mantione KJ, Cadet P, Zhu W, Kream RM, Sheehan M, Fricchione GL, Goumon Y, Esch T and Stefano GB: Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addict Biol. 13:118–123. 2008. View Article : Google Scholar

143 

Stefano GB, Cadet P, Kream RM and Zhu W: The presence of endogenous morphine signaling in animals. Neurochem Res. 33:1933–1939. 2008. View Article : Google Scholar : PubMed/NCBI

144 

Stefano GB, Ptacek R, Kuzelova H and Kream RM: Endogenous morphine: Up-to-date review 2011. Folia Biologica. J Cell Mol Biol. 58:49–56. 2012.

145 

Stefano GB and Scharrer B: Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol. 4:57–67. 1994. View Article : Google Scholar : PubMed/NCBI

146 

Stefano GB: The evolvement of signal systems: Conformational matching a determining force stabilizing families of signal molecules. Comp Biochem Physiol C. 90:287–294. 1988. View Article : Google Scholar : PubMed/NCBI

147 

Stefano GB: Stereospecificity as a determining force stabilizing families of signal molecules within the context of evolution. Comparative Aspects of Neuropeptide Function. Stefano GB and Florey E: University of Manchester Press; Manchester: pp. 14–28. 1991

148 

Otten AB and Smeets HJ: Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing. Hum Reprod Update. 21:671–689. 2015. View Article : Google Scholar : PubMed/NCBI

149 

Hedges SB, Chen H, Kumar S, Wang DY, Thompson AS and Watanabe H: A genomic timescale for the origin of eukaryotes. BMC Evol Biol. 1:42001. View Article : Google Scholar : PubMed/NCBI

150 

Xavier JM, Rodrigues CM and Solá S: Mitochondria: Major Regulators of Neural Development. Neuroscientist. May 6–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

151 

Dinan TG, Stilling RM, Stanton C and Cryan JF: Collective unconscious: How gut microbes shape human behavior. J Psychiatr Res. 63:1–9. 2015. View Article : Google Scholar : PubMed/NCBI

152 

Wood JP: Communication between the minibrain in gut and enteric immune system. News Physiol Sci (NIPS). 6:64–69. 1991.

153 

Snyder C, Kream RM, Ptacek R and Stefano GB: Mitochondria, microbiome and their potential psychiatric modulation. Autism Open Access. In press.

154 

Lackner JM, Ma CX, Keefer L, Brenner DM, Gudleski GD, Satchidanand N, Firth R, Sitrin MD, Katz L, Krasner SS, et al: Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 11:1147–1157. 2013. View Article : Google Scholar : PubMed/NCBI

155 

Guinane CM and Cotter PD: Role of the gut microbiota in health and chronic gastrointestinal disease: Understanding a hidden metabolic organ. Therap Adv Gastroenterol. 6:295–308. 2013. View Article : Google Scholar : PubMed/NCBI

156 

Peterson CT, Sharma V, Elmén L and Peterson SN: Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clin Exp Immunol. 179:363–377. 2015. View Article : Google Scholar

157 

Stefano GB, Bilfinger TV and Fricchione GL: The immune-neuro-link and the macrophage: Postcardiotomy delirium, HIV-associated dementia and psychiatry. Prog Neurobiol. 42:475–488. 1994. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Stefano GB and Kream RM: Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review). Int J Mol Med 37: 547-555, 2016.
APA
Stefano, G.B., & Kream, R.M. (2016). Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review). International Journal of Molecular Medicine, 37, 547-555. https://doi.org/10.3892/ijmm.2016.2471
MLA
Stefano, G. B., Kream, R. M."Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)". International Journal of Molecular Medicine 37.3 (2016): 547-555.
Chicago
Stefano, G. B., Kream, R. M."Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)". International Journal of Molecular Medicine 37, no. 3 (2016): 547-555. https://doi.org/10.3892/ijmm.2016.2471
Copy and paste a formatted citation
x
Spandidos Publications style
Stefano GB and Kream RM: Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review). Int J Mol Med 37: 547-555, 2016.
APA
Stefano, G.B., & Kream, R.M. (2016). Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review). International Journal of Molecular Medicine, 37, 547-555. https://doi.org/10.3892/ijmm.2016.2471
MLA
Stefano, G. B., Kream, R. M."Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)". International Journal of Molecular Medicine 37.3 (2016): 547-555.
Chicago
Stefano, G. B., Kream, R. M."Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)". International Journal of Molecular Medicine 37, no. 3 (2016): 547-555. https://doi.org/10.3892/ijmm.2016.2471
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