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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-2016 Volume 37 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)

George B. Stefano, Richard M. Kream
Pages: 547-555
Published online on: 28 January 2016

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Article Open Access

Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis

Magdy El-Salhy, Kazuo Umezawa
Pages: 556-564
Published online on: 05 February 2016

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Article Open Access

Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice Corrigendum in /10.3892/ijmm.2019.4091

Min Wu, Wenting Ai, Lin Chen, Sihai Zhao, Enqi Liu
Pages: 565-574
Published online on: 12 January 2016

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Article Open Access

Three-dimensional polyacrylamide gel-based DNA microarray method effectively identifies UDP-glucuronosyltransferase 1A1 gene polymorphisms for the correct diagnosis of Gilbert's syndrome

Jinyun Song, Mei Sun, Jiayan Li, Dongrui Zhou, Xuping Wu
Pages: 575-580
Published online on: 08 January 2016

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Article Open Access

The IL-24 gene protects human umbilical vein endothelial cells against H2O2-induced injury and may be useful as a treatment for cardiovascular disease

Zhaoxia Wang, Yang Wang, Yunfei Chen, Jiyuan Lv
Pages: 581-592
Published online on: 25 January 2016

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Article Open Access

Evolution of the protease-activated receptor family in vertebrates

Min Jin, Hai-Wei Yang, Ai-Lin Tao, Ji-Fu Wei
Pages: 593-602
Published online on: 22 January 2016

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Article Open Access

Safflower yellow B suppresses HepG2 cell injury induced by oxidative stress through the AKT/Nrf2 pathway

Zhongying Ma, Caixia Li, Yi Qiao, Chengtao Lu, Jiankang Li, Wei Song, Jin Sun, Xiaohu Zhai, Jing Niu, Qian Ren, Aidong Wen
Pages: 603-612
Published online on: 21 January 2016

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Article Open Access

Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription

Woo-Jae Park, So-Yeon Kim, Ye-Ryung Kim, Joo-Won Park
Pages: 613-622
Published online on: 20 January 2016

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Article Open Access

p120 catenin attenuates the angiotensin II-induced apoptosis of human umbilical vein endothelial cells by suppressing the mitochondrial pathway

Yan Zhang, Chenshuang Zou, Shuwen Yang, Jing Fu
Pages: 623-630
Published online on: 01 February 2016

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Article Open Access

Overexpression of uncoupling protein 2 inhibits the high glucose-induced apoptosis of human umbilical vein endothelial cells

Ying He, Zhou Luan, Xunan Fu, Xun Xu
Pages: 631-638
Published online on: 03 February 2016

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Article Open Access

Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway

Xue Wu, Longlong Yang, Zhao Zheng, Zhenzhen Li, Jihong Shi, Yan Li, Shichao Han, Jianxin Gao, Chaowu Tang, Linlin Su, Dahai Hu
Pages: 639-648
Published online on: 28 January 2016

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Article Open Access

The effects of Lycii Radicis Cortex on RANKL-induced osteoclast differentiation and activation in RAW 264.7 cells

Jae-Hyun Kim, Eun-Young Kim, Bina Lee, Ju-Hee Min, Dea-Uk Song, Jeong-Min Lim, Ji Whan Eom, Mijung Yeom, Hyuk-Sang Jung, Youngjoo Sohn
Pages: 649-658
Published online on: 01 February 2016

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Article Open Access

Effects of ketanserin on experimental colitis in mice and macrophage function

Junhua Xiao, Limei Shao, Jiaqing Shen, Weiliang Jiang, Yun Feng, Ping Zheng, Fei Liu
Pages: 659-668
Published online on: 10 February 2016

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Article Open Access

Effect of silencing HOXA5 gene expression using RNA interference on cell cycle and apoptosis in Jurkat cells

Hui-Ping Huang, Wen-Jun Liu, Qu-Lian Guo, Yong-Qi Bai
Pages: 669-678
Published online on: 04 February 2016

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Article Open Access

HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes

Fan Ouyang, He Huang, Mingyu Zhang, Mingxian Chen, Haobo Huang, Fang Huang, Shenghua Zhou
Pages: 679-689
Published online on: 29 January 2016

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Article Open Access

Pharmacokinetics and antitumor efficacy of DSPE-PEG2000 polymeric liposomes loaded with quercetin and temozolomide: Analysis of their effectiveness in enhancing the chemosensitization of drug-resistant glioma cells Corrigendum in /10.3892/ijmm.2025.5530

Jun Hu, Junjie Wang, Gang Wang, Zhongjun Yao, Xiaoqian Dang
Pages: 690-702
Published online on: 14 January 2016

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Article Open Access

Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice

Xin-Min Ding, Lei Pan, Yong Wang, Qin-Zhi Xu
Pages: 703-715
Published online on: 12 January 2016

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Article Open Access

Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c

Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Jing Wang, Cao Chen, Li-Na Chen, Yan Lv, Qi Shi, Xiao-Ping Dong
Pages: 716-726
Published online on: 25 January 2016

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Article Open Access

A novel mutation in the SCN5A gene contributes to arrhythmogenic characteristics of early repolarization syndrome

Qi Guo, Lan Ren, Xuhua Chen, Cuihong Hou, Jianmin Chu, Jielin Pu, Shu Zhang
Pages: 727-733
Published online on: 26 January 2016

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Article Open Access

Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Pages: 734-742
Published online on: 29 January 2016

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Article

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity

Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho
Pages: 743-754
Published online on: 29 January 2016

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Article

Role of the Wnt/β-catenin signaling pathway in the response of chondrocytes to mechanical loading

Qiannan Niu, Feifei Li, Liang Zhang, Xinyuan Xu, Yucong Liu, Jie Gao, Xue Feng
Pages: 755-762
Published online on: 22 January 2016

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Article

ATP-sensitive K+ channels contribute to the protective effects of exogenous hydrogen sulfide against high glucose-induced injury in H9c2 cardiac cells

Weijie Liang, Jingfu Chen, Liqiu Mo, Xiao Ke, Wenzhu Zhang, Dongdan Zheng, Wanying Pan, Shaoyun Wu, Jianqiang Feng, Mingcai Song, Xinxue Liao
Pages: 763-772
Published online on: 25 January 2016

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Article

Lipoxin A4 exerts protective effects against experimental acute liver failure by inhibiting the NF-κB pathway

Xueqiang Jiang, Zhihao Li, Shengfang Jiang, Xuefei Tong, Xiaojing Zou, Wan Wang, Zhengang Zhang, Liang Wu, Deying Tian
Pages: 773-780
Published online on: 05 February 2016

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Article

Ginsenoside Rg1 exerts a protective effect against Aβ25-35-induced toxicity in primary cultured rat cortical neurons through the NF-κB/NO pathway

Jiaying Wu, Hongyu Yang, Qingwei Zhao, Xingguo Zhang, Yijia Lou
Pages: 781-788
Published online on: 08 February 2016

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Article

Signaling pathways involved in the effects of HMGB1 on mesenchymal stem cell migration and osteoblastic differentiation

Feng Lin, Wei Zhang, Deting Xue, Ting Zhu, Jin Li, Erman Chen, Xueyu Yao, Zhijun Pan
Pages: 789-797
Published online on: 03 February 2016

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Article

Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway

Eun-Ok Choi, Jin-Woo Jeong, Cheol Park, Su Hyun Hong, Gi-Young Kim, Hye-Jin Hwang, Eun-Ju Cho, Yung Hyun Choi
Pages: 798-806
Published online on: 20 January 2016

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Article

The influence of the WWOX gene on the regulation of biological processes during endometrial carcinogenesis

E. Płuciennik, M. Nowakowska, M. Gałdyszyńska, M. Popęda, A. K. Bednarek
Pages: 807-815
Published online on: 27 January 2016

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Article

AMPK and SREBP-1c mediate the anti-adipogenic effect of β-hydroxyisovalerylshikonin

Jong-Hyeok Ha, Jaewoong Jang, Sang-In Chung, Yoosik Yoon
Pages: 816-824
Published online on: 08 February 2016

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Article

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma Corrigendum in /10.3892/ijmm.2022.5193

Xin Liu, Shuda Chen, Jianfeng Tu, Wenwei Cai, Qiuran Xu
Pages: 825-835
Published online on: 05 February 2016

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Article

Synthesized peptide 710-725 from HCV subtype 1a E2 glycoprotein blocks HCV infection through competitive binding of CD81

Xiaojing Liu, Na Chen, Shumei Lin, Min Liu
Pages: 836-842
Published online on: 19 January 2016

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Article

Amygdalin blocks the in vitro adhesion and invasion of renal cell carcinoma cells by an integrin-dependent mechanism

Eva Juengel, Masud Afschar, Jasmina Makarević, Jochen Rutz, Igor Tsaur, Jens Mani, Karen Nelson, Axel Haferkamp, Roman A. Blaheta
Pages: 843-850
Published online on: 08 January 2016

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Article

Downregulation of microRNA-218 relieves neuropathic pain by regulating suppressor of cytokine signaling 3

Longyun Li, Guoqing Zhao
Pages: 851-858
Published online on: 12 January 2016

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Article

Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway

Huanxin Xie, Yongbin Jing, Jingjun Xia, Xintao Wang, Changcheng You, Jinglong Yan
Pages: 859-864
Published online on: 27 January 2016

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Article Open Access

Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Article Open Access

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Review Open Access

Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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