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International Journal of Molecular Medicine
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Article

5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation

  • Authors:
    • Woojung Lee
    • Goo Yoon
    • Min Cheol Kim
    • Hak Cheol Kwon
    • Gyu-Un Bae
    • Yong Kee Kim
    • Su-Nam Kim
  • View Affiliations / Copyright

    Affiliations: Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, Gangwon-do 210-340, Republic of Korea, College of Pharmacy, Mokpo National University, Muan, Jeonnam 534‑729, Republic of Korea, College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea
  • Pages: 1397-1404
    |
    Published online on: March 17, 2016
       https://doi.org/10.3892/ijmm.2016.2531
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Abstract

In the present study, we demonstrate that 5,7-dihydroxy-6-geranylflavanone (DGF) isolated from Amorpha fruticosa (A. fruticosa) is a novel peroxisome proliferator-activated receptor (PPAR)α/γ dual agonist which may be used to improve insulin sensitivity. The extract from A. fruticosa increased the transcriptional activity of both PPARα and PPARγ which was, in part, driven by the active ingredient DGF. Treatment with DGF markedly enhanced the adipogenesis of 3T3-L1 preadipocytes, which was comparable to the effect of the PPARγ agonist, troglitazone. In addition, DGF was found to enhance fatty acid oxidation and glucose utilization through the dual activation of PPARα/γ. In addition treatment with DGF led to an improvement in insulin sensitivity, resulting in enhanced glucose uptake in muscle cells. The findings of our study data suggest that DGF may be used as potential therapeutic agent in the treatment of type 2 diabetes and related metabolic disorders by enhancing glucose and lipid metabolism.
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Copy and paste a formatted citation
Spandidos Publications style
Lee W, Yoon G, Kim MC, Kwon HC, Bae G, Kim YK and Kim S: 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation. Int J Mol Med 37: 1397-1404, 2016.
APA
Lee, W., Yoon, G., Kim, M.C., Kwon, H.C., Bae, G., Kim, Y.K., & Kim, S. (2016). 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation. International Journal of Molecular Medicine, 37, 1397-1404. https://doi.org/10.3892/ijmm.2016.2531
MLA
Lee, W., Yoon, G., Kim, M. C., Kwon, H. C., Bae, G., Kim, Y. K., Kim, S."5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation". International Journal of Molecular Medicine 37.5 (2016): 1397-1404.
Chicago
Lee, W., Yoon, G., Kim, M. C., Kwon, H. C., Bae, G., Kim, Y. K., Kim, S."5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation". International Journal of Molecular Medicine 37, no. 5 (2016): 1397-1404. https://doi.org/10.3892/ijmm.2016.2531
Copy and paste a formatted citation
x
Spandidos Publications style
Lee W, Yoon G, Kim MC, Kwon HC, Bae G, Kim YK and Kim S: 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation. Int J Mol Med 37: 1397-1404, 2016.
APA
Lee, W., Yoon, G., Kim, M.C., Kwon, H.C., Bae, G., Kim, Y.K., & Kim, S. (2016). 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation. International Journal of Molecular Medicine, 37, 1397-1404. https://doi.org/10.3892/ijmm.2016.2531
MLA
Lee, W., Yoon, G., Kim, M. C., Kwon, H. C., Bae, G., Kim, Y. K., Kim, S."5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation". International Journal of Molecular Medicine 37.5 (2016): 1397-1404.
Chicago
Lee, W., Yoon, G., Kim, M. C., Kwon, H. C., Bae, G., Kim, Y. K., Kim, S."5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation". International Journal of Molecular Medicine 37, no. 5 (2016): 1397-1404. https://doi.org/10.3892/ijmm.2016.2531
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