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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2016 Volume 37 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Determining whether curcumin degradation/condensation is actually bioactivation (Review)

Jerzy Jankun, Marzena Wyganowska-Świątkowska, Katarzyna Dettlaff, Anna Jelińska, Anna Surdacka, Dorota Wątróbska-Świetlikowska, Ewa Skrzypczak-Jankun
Pages: 1151-1158
Published online on: 11 March 2016

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Review

Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)

Qun Zhou, Jiangang Cao, Linxi Chen
Pages: 1159-1169
Published online on: 01 April 2016

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Article Open Access

Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury

Sokjoong Chung, Seungsoo Rho, Gijin Kim, So-Ra Kim, Kwang-Hyun Baek, Myungseo Kang, Helen Lew
Pages: 1170-1180
Published online on: 17 March 2016

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Article Open Access

Prediction of the molecular mechanisms and potential therapeutic targets for diabetic nephropathy by bioinformatics methods

Wan-Ning Wang, Wen-Long Zhang, Guang-Yu Zhou, Fu-Zhe Ma, Tao Sun, Sen-Sen Su, Zhong-Gao Xu
Pages: 1181-1188
Published online on: 15 March 2016

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Article Open Access

High-mobility group box 1 impairs airway epithelial barrier function through the activation of the RAGE/ERK pathway

Wufeng Huang, Haijin Zhao, Hangming Dong, Yue Wu, Lihong Yao, Fei Zou, Shaoxi Cai
Pages: 1189-1198
Published online on: 24 March 2016

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Article Open Access

Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury

Weikun Jia, Zhao Jian, Jingwei Li, Lin Luo, Liang Zhao, Yang Zhou, Fuqin Tang, Yingbin Xiao
Pages: 1199-1208
Published online on: 22 March 2016

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Article Open Access

Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration

Saeyoung Park, Yoonyoung Choi, Namhee Jung, Yeonsil Yu, Kyung-Ha Ryu, Han Su Kim, Inho Jo, Byung-Ok Choi, Sung-Chul Jung
Pages: 1209-1220
Published online on: 22 March 2016

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Article Open Access

Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma

Ji-Hye Seo, Mi-Ae Bang, Gyeyeop Kim, Seung Sik Cho, Dae-Hun Park
Pages: 1221-1228
Published online on: 28 March 2016

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Article Open Access

Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway

Yue Guan, Zi-Jian Cui, Bei Sun, Li-Ping Han, Chun-Jun Li, Li-Ming Chen
Pages: 1229-1238
Published online on: 05 April 2016

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Article Open Access

Magnobovatol inhibits smooth muscle cell migration by suppressing PDGF-Rβ phosphorylation and inhibiting matrix metalloproteinase-2 expression

Hyreen Kang, Dong Hyeon Ahn, Jhang Ho Pak, Kyeong‑Hwa Seo, Nam-In Baek, Sung-Wuk Jang
Pages: 1239-1246
Published online on: 04 April 2016

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Article Open Access

Changes in small intestinal chromogranin A-immunoreactive cell densities in patients with irritable bowel syndrome after receiving dietary guidance

Tarek Mazzawi, Magdy El-Salhy
Pages: 1247-1253
Published online on: 11 March 2016

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Article Open Access

Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy

Li Zhang, Yang Yu, Xi Xia, Yang Ma, Xie-Wan Chen, Zhen-Hong Ni, Hong Wang
Pages: 1254-1262
Published online on: 09 March 2016

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Article Open Access

Abnormalities in the basement membrane structure promote basal keratinocytes in the epidermis of hypertrophic scars to adopt a proliferative phenotype

Shaowei Yang, Yexiao Sun, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
Pages: 1263-1273
Published online on: 08 March 2016

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Article Open Access

Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2

Qi Zeng, Xiaoan Tao, Fang Huang, Tong Wu, Juan Wang, Xiao Jiang, Zirong Kuang, Bin Cheng
Pages: 1274-1280
Published online on: 16 March 2016

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Article Open Access

Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3β/β-catenin signaling pathway

Ning Ge, Chao Liu, Guofeng Li, Lijun Xie, Qinzeng Zhang, Liping Li, Na Hao, Jianxin Zhang
Pages: 1281-1289
Published online on: 24 March 2016

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Article Open Access

The decreased expression of electron transfer flavoprotein β is associated with tubular cell apoptosis in diabetic nephropathy

Hua Wang, Haojun Zhang, Xiaohong Chen, Tingting Zhao, Qin Kong, Meihua Yan, Bingxuan Zhang, Sifan Sun, Hui-Yao Lan, Ning Li, Ping Li
Pages: 1290-1298
Published online on: 18 March 2016

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Article Open Access

Macrophage migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK pathways

Jinjin Cui, Fengyun Zhang, Yongshun Wang, Jingjin Liu, Xing Ming, Jingbo Hou, Bo Lv, Shaohong Fang, Bo Yu
Pages: 1299-1309
Published online on: 29 March 2016

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Article Open Access

A novel uPAg-KPI fusion protein inhibits the growth and invasion of human ovarian cancer cells in vitro

Li-Ping Zhao, Tian-Min Xu, Mu-Jie Kan, Ye-Chen Xiao, Man-Hua Cui
Pages: 1310-1316
Published online on: 24 March 2016

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Article

Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis

Yongheng Bai, Hong Lu, Chengcheng Lin, Yaya Xu, Dannü Hu, Yong Liang, Weilong Hong, Bicheng Chen
Pages: 1317-1327
Published online on: 01 April 2016

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Article

Valsartan ameliorates podocyte loss in diabetic mice through the Notch pathway

Feng Gao, Min Yao, Yanping Cao, Shuxia Liu, Qingjuan Liu, Huijun Duan
Pages: 1328-1336
Published online on: 11 March 2016

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Article

The role and mechanisms of action of SIRT6 in the suppression of postoperative epidural scar formation

Xiaochen Fan, Junjie Chen, Da Shi, Jing Jia, Jia He, Liang Li, Tao Lei, Xuesong Chen
Pages: 1337-1344
Published online on: 11 March 2016

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Article

Optimization of a cationic liposome-based gene delivery system for the application of miR-145 in anticancer therapeutics

Jin Tao, Wei-Feng Ding, Xiao-Hang Che, Yi-Chen Chen, Fang Chen, Xiao-Dong Chen, Xiao-Lei Ye, Su-Bin Xiong
Pages: 1345-1354
Published online on: 17 March 2016

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Article

A robust biomarker of differential correlations improves the diagnosis of cytologically indeterminate thyroid cancers

Hugo Gomez-Rueda, Rebeca Palacios-Corona, Hugo Gutiérrez-Hermosillo, Victor Trevino
Pages: 1355-1362
Published online on: 18 March 2016

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Article

Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway

Jie Qin, Lin Wang, Ling Zheng, Xiaoyan Zhou, Yidi Zhang, Tingting Yang, Yanmin Zhou
Pages: 1363-1370
Published online on: 08 March 2016

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Article

Upregulation of miRNA-155 expression by OxLDL in dendritic cells involves JAK1/2 kinase and transcription factors YY1 and MYB

Hui Yan, Shuai Wang, Zhenwei Li, Wenting Zhao, Zhen Wang, Zewei Sun, Yanyun Pan, Jianhua Zhu
Pages: 1371-1378
Published online on: 11 March 2016

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Article

Icariin regulates systemic iron metabolism by increasing hepatic hepcidin expression through Stat3 and Smad1/5/8 signaling

Miao Zhang, Jing Liu, Wenli Guo, Xin Liu, Sijin Liu, Huijun Yin
Pages: 1379-1388
Published online on: 01 April 2016

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Article

Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study

Naishun Liao, Fan Pan, Yingchao Wang, Youshi Zheng, Bo Xu, Wenwei Chen, Yunzhen Gao, Zhixiong Cai, Xiaolong Liu, Jingfeng Liu
Pages: 1389-1396
Published online on: 15 March 2016

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Article

5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation

Woojung Lee, Goo Yoon, Min Cheol Kim, Hak Cheol Kwon, Gyu-Un Bae, Yong Kee Kim, Su-Nam Kim
Pages: 1397-1404
Published online on: 17 March 2016

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Article

Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1 Corrigendum in /10.3892/ijmm.2023.5315

Ying-Jie Yi, Xiu-Hong Jia, Jian-Yong Wang, You-Jie Li, Hong Wang, Shu-Yang Xie
Pages: 1405-1411
Published online on: 24 March 2016

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Article

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4+ T-cells

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Konstantina Tsogka, Maria Sounidaki, Ioannis Stefanidis
Pages: 1412-1420
Published online on: 01 April 2016

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Article

MicroRNA-214 acts as a potential oncogene in breast cancer by targeting the PTEN-PI3K/Akt signaling pathway

Fang Wang, Lin Li, Zhuo Chen, Mingzhi Zhu, Yuanting Gu
Pages: 1421-1428
Published online on: 07 March 2016

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Article

Vitamin E confers cytoprotective effects on cardiomyocytes under conditions of heat stress by increasing the expression of metallothionein

Xiaowu Wang, Wenpeng Dong, Binbin Yuan, Yongchao Yang, Dongpeng Yang, Xi Lin, Changfu Chen, Weida Zhang
Pages: 1429-1436
Published online on: 31 March 2016

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

DUSP26: Unveiling a critical molecular mediator and therapeutic target in developmental dysplasia of the hip‑associated secondary osteoarthritis

Enbo Wang, Haixiang Zhang, Dechao Wu, Sadik Ali, Xianglu Ji
Article Number: 105
Published online on: 26 February 2026

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Review Open Access

mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review)

Rongxiu Huo, Yanting Yang, Chengcheng Wei, Yang Yang, Danli Meng, Jinying Lin, Xinxiang Huang
Article Number: 104
Published online on: 25 February 2026

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Article Open Access

Bumetanide‑blocked SLC12A2 exerts a protective effect in experimental diabetic retinopathy

Yuting Zhang, Xiuli Wang, Qinyue Xie, Yue Huang, Dongjia Huang, Ziqing Liu, Tong Xu, Man Ni, Hongwei Yang
Article Number: 103
Published online on: 25 February 2026

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Article Open Access

Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 102
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] A novel role for Livin in the response to ultraviolet B radiation and pterygium development

Shuang-Qing Wu, Qi-Bin Xu, Wen-Yan Sheng, Lin-Ya Su, Li-Wei Zhu
Article Number: 101
Published online on: 24 February 2026

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Article Open Access

Endothelial UNC5B regulates blood‑retinal barrier homeostasis

Yujia Yao, Suyu Wang, Jiajun Li, Qianzi Jin, Ziyi Chen, Qin Jiang, Keran Li
Article Number: 100
Published online on: 20 February 2026

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Review Open Access

Metabolic hubs in reproduction: The regulatory network of lipid droplets in gamete and embryo physiology (Review)

Liuzhu Pan, Zongzhuang Wen, Yi Jin
Article Number: 99
Published online on: 17 February 2026

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Review Open Access

The role and mechanism of IL‑35 in myasthenia gravis (Review)

Jing Mao, Lin-Ming Zhang, Yan-Lin Zhu, Shu-Ji Gao, Ming-Wei Liu
Article Number: 98
Published online on: 17 February 2026

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Article Open Access

miRNA‑378a‑5p attenuates the development of abdominal aortic aneurysm via ABLIM1‑MKL1 signaling pathways

Jing Wang, Yujia Zou, Yani Wang, Zheming Yang, Daoshen Liu, Xiaolin Su, Haixu Song, Kai Xu, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 97
Published online on: 16 February 2026

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Review Open Access

Dysregulated post‑translational modifications in granulosa cells drive ovarian dysfunction and potential infertility applications (Review)

Yufei Zhong, Yunfei Zou, Zhuoyuan Yang, Junjun Wang, Zezheng Pan, Jiugeng Feng
Article Number: 96
Published online on: 16 February 2026

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Review Open Access

Microglia‑mediated neuroinflammation in intracerebral hemorrhage: Pathological mechanisms and implications for therapeutic development (Review)

Xuehui Fan, Changzhi Pu, Luyi Zhong, Oucheng Wang, Binyi Zhao, Dongyi Liao, Xue Bai, Guiquan Chen, Guoqiang Yang
Article Number: 95
Published online on: 16 February 2026

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Correction Open Access

[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs

Qing-Yong Chen, Li-Qun Xu, De-Min Jiao, Qing-Hua Yao, Yan-Yi Wang, Hui-Zhen Hu, Yu-Quan Wu, Jia Song, Jie Yan, Li-Jun Wu
Article Number: 94
Published online on: 12 February 2026

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Article Open Access

Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2

Caizi Li, Xinglinzi Tang, Xiaoru Luo, Xin Lai, Jing Yang, Zheng Xu, Gulizeba Muhetaer, Yizi Xie, Xiufang Huang, Hang Li
Article Number: 93
Published online on: 10 February 2026

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Review Open Access

Helicobacter pylori and hyperglycemia fuel gastric cancer glycolysis: Mechanisms and targeted intervention (Review)

Youjia Liu, Fang Wang, Ya Deng, Yanxia Hu, Feihong Shu, Jie Yu, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Qian Du, Jingyu Xu, Rui Xie
Article Number: 92
Published online on: 09 February 2026

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Review Open Access

Targeting the gut‑bone axis through exercise: A novel approach to osteoporosis prevention and treatment (Review)

Jingjing Wu, Siqi Zhang, Junjie Wu, Yuhang Luan, Xingchen Yao, Boyan Xu, Yiting Wang, Yingyue Sheng, Yuzheng Xue, Yilin Ren
Article Number: 91
Published online on: 09 February 2026

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Review Open Access

Chorus line in oral squamous cell carcinoma: How stromal and immune players orchestrate tumor progression (Review)

Eliano Cascardi, Mario Della Mura, Nicoletta Sgarro, Silvia Minei, Gerardo Cazzato, Eugenio Maiorano, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Fábio França Vieira E Silva, Eleonora Lo Muzio, Mario Dioguardi, Andrea Ballini
Article Number: 90
Published online on: 09 February 2026

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Correction Open Access

[Corrigendum] Hsa_circularRNA_0079201 suppresses chondrocyte proliferation and endochondral ossification by regulating the microRNA‑140‑3p/SMAD2 signaling pathway in idiopathic short stature 

Xijuan Liu, Chen Yan, Xueqiang Deng, Jingyu Jia
Article Number: 89
Published online on: 09 February 2026

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Review Open Access

Post‑translational modifications in diabetic kidney disease (Review)

Mengfei He, Zihang Wang, Zhuang Miao, Yu Zhao, Lingling Wei, Lijie Zhang, Ruili Yin, Yan Wang, Longyan Yang
Article Number: 88
Published online on: 09 February 2026

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Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Review Open Access

Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Article Open Access

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Review Open Access

Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Review Open Access

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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Review Open Access

IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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