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Review

Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)

  • Authors:
    • Qun Zhou
    • Jiangang Cao
    • Linxi Chen
  • View Affiliations / Copyright

    Affiliations: Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 1159-1169
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    Published online on: April 1, 2016
       https://doi.org/10.3892/ijmm.2016.2544
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Abstract

Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and pathological processes, and that it is associated with cardiovascular diseases (such as atherosclerosis, hypertension, heart failure and myocardial injury), diabetes with microvascular complications, ischemia reperfusion injury, tumors, pre-eclampsia, as well as others. The occurrence of these diseases is closely related to endothelial dysfunction and the local inflammatory response; however, the occurrence of oxidative stress is related to vascular injury, due to the excessive generation of reactive oxygen species (ROS) and can lead to vascular damage and a series of inflammatory reactions. Therefore, this review summarizes the association between apelin/APJ, oxidative stress and inflammation-related diseases. In addition, drugs targeting the apelin/APJ system are recommended, thus providing a novel therapeutic strategy for oxidative stress-related inflammatory diseases.
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1 

O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR and Nguyen T: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 136:355–360. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, et al: Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 251:471–476. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Xie F, Lv D and Chen L: ELABELA: A novel hormone in cardiac development acting as a new endogenous ligand for the APJ receptor. Acta Biochim Biophys Sin (Shanghai). 46:620–622. 2014. View Article : Google Scholar

4 

Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR and O'Dowd BF: Characterization of apelin, the ligand for the APJ receptor. J Neurochem. 74:34–41. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Saavedra JM, Correa FM, Seltzer A, Pinto JE, Viglione P and Tsutsumi K: Enhanced angiotensin converting enzyme binding in arteries from spontaneously hypertensive rats. J Hypertens. 10:1353–1359. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Choe W, Albright A, Sulcove J, Jaffer S, Hesselgesser J, Lavi E, Crino P and Kolson DL: Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells. J Neurovirol. 6(Suppl 1): S61–S69. 2000.PubMed/NCBI

7 

Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, et al: Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim Biophys Acta. 1452:25–35. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Pope GR, Roberts EM, Lolait SJ and O'Carroll AM: Central and peripheral apelin receptor distribution in the mouse: species differences with rat. Peptides. 33:139–148. 2012. View Article : Google Scholar :

9 

Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, et al: Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 84:1162–1172. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, Sugaya T, Matsuzaki H, Yamamoto R, Shiota N, et al: Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem. 279:26274–26279. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M and Ruskoaho H: Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 91:434–440. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Wang G, Anini Y, Wei W, Qi X, OCarroll AM, Mochizuki T, Wang HQ, Hellmich MR, Englander EW and Greeley GH Jr: Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion. Endocrinology. 145:1342–1348. 2004. View Article : Google Scholar

13 

Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C and Valet P: Apelin, diabetes, and obesity. Endocrine. 40:1–9. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Lv D, Li L, Lu Q, Li Y, Xie F, Li H, Cao J, Liu M, Wu D, He L and Chen LX: PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13. Clin Exp Pharmacol Physiol. In Press.

15 

Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, Bosch J and Fernandez M: Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. J Hepatol. 50:296–305. 2009. View Article : Google Scholar

16 

Adam F, Khatib AM, Lopez JJ, Vatier C, Turpin S, Muscat A, Soulet F, Aries A, Jardin I, Bobe R, et al: Apelin: an antithrombotic factor that inhibits platelet function. Blood. 127:908–920. 2016. View Article : Google Scholar

17 

Than A, Zhang X, Leow MK, Poh CL, Chong SK and Chen P: Apelin attenuates oxidative stress in human adipocytes. J Biol Chem. 289:3763–3774. 2014. View Article : Google Scholar :

18 

Foussal C, Lairez O, Calise D, Pathak A, Guilbeau-Frugier C, Valet P, Parini A and Kunduzova O: Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett. 584:2363–2370. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Li L, Li F, Li F, Mao X, Yang L, Huang H, Guo Y, Chen L and Li J: NOX4-derived reactive oxygen species drive apelin-13-induced vascular smooth muscle cell proliferation via the ERK pathway. Int J Pept Res Ther. 17:307–315. 2011. View Article : Google Scholar

20 

Katugampola SD, Maguire JJ, Matthewson SR and Davenport AP: [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol. 132:1255–1260. 2001. View Article : Google Scholar : PubMed/NCBI

21 

De Falco M, De Luca L, Onori N, Cavallotti I, Artigiano F, Esposito V, De Luca B, Laforgia V, Groeger AM and De Luca A: Apelin expression in normal human tissues. In Vivo. 16:333–336. 2002.PubMed/NCBI

22 

Kleinz MJ and Davenport AP: Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul Pept. 118:119–125. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Li F, Li L, Qin X, Pan W, Feng F, Chen F, Zhu B, Liao D, Tanowitz H, Albanese C and Chen L: Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1. Front Biosci. 13:3786–3792. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D and Chen L: PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13. Acta Biochim Biophys Sin (Shanghai). 42:396–402. 2010. View Article : Google Scholar

25 

Mao XH, Tao S, Zhang XHui, Li F, Qin XP, Liao DF, Li LF and Chen LX: Apelin-13 promotes monocyte adhesion to human umbilical vein endothelial cell mediated by phosphatidylinositol 3-kinase signaling pathway. Prog Biochem Biophys. 38:1162–1170. 2011. View Article : Google Scholar

26 

Lu Y, Zhu X, Liang GX, Cui RR, Liu Y, Wu SS, Liang QH, Liu GY, Jiang Y, Liao XB, et al: Apelin-APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-κB/JNK signal pathway in human umbilical vein endothelial cells. Amino Acids. 43:2125–2136. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Lassègue B and Clempus RE: Vascular NAD(P)H oxidases: Specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol. 285:R277–R297. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Potdar S and Kavdia M: NO/peroxynitrite dynamics of high glucose-exposed HUVECs: Chemiluminescent measurement and computational model. Microvasc Res. 78:191–198. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Cohen RA and Tong X: Vascular oxidative stress: The common link in hypertensive and diabetic vascular disease. J Cardiovasc Pharmacol. 55:308–316. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Liang JH, Li YN, Qi JS and Jia XX: Peroxynitrite-induced protein nitration is responsible for renal mitochondrial damage in diabetic rat. J Endocrinol Invest. 33:140–146. 2010. View Article : Google Scholar

31 

Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L and Li J: Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation. Acta Biochim Biophys Sin (Shanghai). 45:875–881. 2013. View Article : Google Scholar

32 

Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, Yasuzaki H, Ishida J, Toya Y, Kiuchi Y, Hirawa N, et al: Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol. 171:1705–1712. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL and Quertermous T: Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol. 296:H1329–H1335. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Lv D, Li H and Chen L: Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 45:527–533. 2013. View Article : Google Scholar

35 

Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR and O'Dowd BF: Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology. 146:231–236. 2005. View Article : Google Scholar

36 

Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K and Fujimiya M: The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept. 99:87–92. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Japp AG, Cruden NL, Barnes G, van Gemeren N, Mathews J, Adamson J, Johnston NR, Denvir MA, Megson IL, Flapan AD and Newby DE: Acute cardiovascular effects of apelin in humans: Potential role in patients with chronic heart failure. Circulation. 121:1818–1827. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Dikalova AE, Góngora MC, Harrison DG, Lambeth JD, Dikalov S and Griendling KK: Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 299:H673–H679. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Ghiadoni L, Taddei S and Virdis A: Hypertension and endothelial dysfunction: Therapeutic approach. Curr Vasc Pharmacol. 10:42–60. 2012. View Article : Google Scholar

40 

Siddiquee K, Hampton J, Khan S, Zadory D, Gleaves L, Vaughan DE and Smith LH: Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production. J Hypertens. 29:724–731. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Sun X, Iida S, Yoshikawa A, Senbonmatsu R, Imanaka K, Maruyama K, Nishimura S, Inagami T and Senbonmatsu T: Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely. Hypertens Res. 34:701–706. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Ryu S, Ornoy A, Samuni A, Zangen S and Kohen R: Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: Inducing pancreatic damage and diabetes. Metabolism. 57:1253–1261. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Kitada M, Kume S, Imaizumi N and Koya D: Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes. 60:634–643. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Lee SH, Nam BY, Kang EW, Han SH, Li JJ, Kim H, Kim SH, Kwak SJ, Park JT, Chang TI, et al: Effects of an oral adsorbent on oxidative stress and fibronectin expression in experimental diabetic nephropathy. Nephrol Dial Transplant. 25:2134–2141. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Ha H, Yu MR, Choi YJ, Kitamura M and Lee HB: Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells. J Am Soc Nephrol. 13:894–902. 2002.PubMed/NCBI

46 

Morii T, Fujita H, Narita T, Shimotomai T, Fujishima H, Yoshioka N, Imai H, Kakei M and Ito S: Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy. J Diabetes Complications. 17:11–15. 2003. View Article : Google Scholar

47 

Day RT, Cavaglieri RC and Feliers D: Apelin retards the progression of diabetic nephropathy. Am J Physiol Renal Physiol. 304:F788–F800. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Nishida M, Okumura Y, Oka T, Toiyama K, Ozawa S, Itoi T and Hamaoka K: The role of apelin on the alleviative effect of Angiotensin receptor blocker in unilateral ureteral obstruction-induced renal fibrosis. Nephron Extra. 2:39–47. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Cameron NE and Cotter MA: Pro-inflammatory mechanisms in diabetic neuropathy: Focus on the nuclear factor kappa B pathway. Curr Drug Targets. 9:60–67. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Ganesh Yerra V, Negi G, Sharma SS and Kumar A: Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy. Redox Biol. 1:394–397. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Zeng XJ, Yu SP, Zhang L and Wei L: Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. 316:1773–1783. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Simó R, Carrasco E, García-Ramírez M and Hernández C: Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Curr Diabetes Rev. 2:71–98. 2006. View Article : Google Scholar

53 

Tao Y, Lu Q, Jiang YR, Qian J, Wang JY, Gao L and Jonas JB: Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 51:4237–4242. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Lu Q, Feng J and Jiang YR: The role of apelin in the retina of diabetic rats. PLoS One. 8:e697032013. View Article : Google Scholar : PubMed/NCBI

55 

Saint-Geniez M, Masri B, Malecaze F, Knibiehler B and Audigier Y: Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev. 110:183–186. 2002. View Article : Google Scholar

56 

Cain K, Bratton SB and Cohen GM: The Apaf-1 apoptosome: A large caspase-activating complex. Biochimie. 84:203–214. 2002. View Article : Google Scholar : PubMed/NCBI

57 

Matsushita H, Morishita R, Nata T, Aoki M, Nakagami H, Taniyama Y, Yamamoto K, Higaki J, Yasufumi K and Ogihara T: Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: In vivo evidence of the importance of NF-kappaB in endothelial cell regulation. Circ Res. 86:974–981. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Di Stilo A, Chegaev K, Lazzarato L, Fruttero R, Gasco A, Rastaldo R and Cappello S: Effects of nitric oxide donor antioxidants containing the phenol vitamin E substructure and a furoxan moiety on ischemia/reperfusion injury. Arzneimittelforschung. 59:111–116. 2009.PubMed/NCBI

59 

Rastaldo R, Cappello S, Folino A, Di Stilo A, Chegaev K, Tritto I, Pagliaro P and Losano G: Low concentrations of an nitric oxide-donor combined with a liposoluble antioxidant compound enhance protection against reperfusion injury in isolated rat hearts. J Physiol Pharmacol. 61:21–27. 2010.PubMed/NCBI

60 

Chen Z, Li T and Zhang B: Morphine postconditioning protects against reperfusion injury in the isolated rat hearts. J Surg Res. 145:287–294. 2008. View Article : Google Scholar

61 

Zeng XJ, Zhang LK, Wang HX, Lu LQ, Ma LQ and Tang CS: Apelin protects heart against ischemia/reperfusion injury in rat. Peptides. 30:1144–1152. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Simpkin JC, Yellon DM, Davidson SM, Lim SY, Wynne AM and Smith CC: Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury. Basic Res Cardiol. 102:518–528. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Sorli SC, Le Gonidec S, Knibiehler B and Audigier Y: Apelin is a potent activator of tumour neoangiogenesis. Oncogene. 26:7692–7699. 2007. View Article : Google Scholar : PubMed/NCBI

64 

Han S, Wang G, Qi X, Lee HM, Englander EW and Greeley GH Jr: A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Am J Physiol Regul Integr Comp Physiol. 294:R1832–R1839. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Liu J and Wang Z: Increased oxidative stress as a selective anticancer therapy. Oxid Med Cell Longev. 2015:2943032015. View Article : Google Scholar : PubMed/NCBI

66 

Sawicka E, Lisowska A, Kowal P and Długosz A: The role of oxidative stress in bladder cancer. Postepy Hig Med Dosw (Online). 69:744–752. 2015.In Polish. View Article : Google Scholar

67 

Raina K, Tyagi A, Kumar D, Agarwal R and Agarwal C: Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells. Food Chem Toxicol. 61:187–195. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Tong L, Chuang CC, Wu S and Zuo L: Reactive oxygen species in redox cancer therapy. Cancer Lett. 367:18–25. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Shipitsin M and Polyak K: The cancer stem cell hypothesis: In search of definitions, markers, and relevance. Lab Invest. 88:459–463. 2008. View Article : Google Scholar : PubMed/NCBI

70 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

71 

Shi X, Zhang Y, Zheng J and Pan J: Reactive oxygen species in cancer stem cells. Antioxid Redox Signal. 16:1215–1228. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Gu Q, Zhai L, Feng X, Chen J, Miao Z, Ren L, Qian X, Yu J, Li Y, Xu X, et al: Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway. Neurochem Int. 63:535–540. 2013. View Article : Google Scholar : PubMed/NCBI

73 

Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, Nowill AE, Leslie NR, Cardoso AA and Barata JT: PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 3762–3774. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Min KJ, Lee JT, Joe EH and Kwon TK: An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism. Cell Signal. 23:1505–1513. 2011. View Article : Google Scholar : PubMed/NCBI

75 

Khaksari M, Aboutaleb N, Nasirinezhad F, Vakili A and Madjd Z: Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia. J Mol Neurosci. 48:201–208. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Bao HJ, Zhang L, Han WC and Dai DK: Apelin-13 attenuates traumatic brain injury-induced damage by suppressing autophagy. Neurochem Res. 40:89–97. 2015. View Article : Google Scholar

77 

Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y and Maeda S: Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis. PLoS One. 6:e239682011. View Article : Google Scholar : PubMed/NCBI

78 

Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R and Takakura N: Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J. 27:522–534. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Inuzuka H, Nishizawa H, Inagaki A, Suzuki M, Ota S, Miyamura H, Miyazaki J, Sekiya T, Kurahashi H and Udagawa Y: Decreased expression of apelin in placentas from severe pre-eclampsia patients. Hypertens Pregnancy. 32:410–421. 2013. View Article : Google Scholar : PubMed/NCBI

80 

Bortoff KD, Qiu C, Runyon S, Williams MA and Maitra R: Decreased maternal plasma apelin concentrations in preeclampsia. Hypertens Pregnancy. 31:398–404. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Furuya M, Okuda M, Usui H, Takenouchi T, Kami D, Nozawa A, Shozu M, Umezawa A, Takahashi T and Aoki I: Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension. Int J Gynecol Pathol. 31:227–235. 2012. View Article : Google Scholar : PubMed/NCBI

82 

Vatish M, Randeva HS and Grammatopoulos DK: Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med. 12:223–233. 2006. View Article : Google Scholar : PubMed/NCBI

83 

Han S, Wang G, Qi X, Englander EW and Greeley GH Jr: Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression. Am J Physiol Gastrointest Liver Physiol. 295:G1068–G1078. 2008. View Article : Google Scholar : PubMed/NCBI

84 

Cai X, Chen X, Wang X, Xu C, Guo Q, Zhu L, Zhu S and Xu J: Pre-protective effect of lipoic acid on injury induced by H2O2 in IPEC-J2 cells. Mol Cell Biochem. 378:73–81. 2013. View Article : Google Scholar : PubMed/NCBI

85 

Baregamian N, Song J, Jeschke MG, Evers BM and Chung DH: IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis. J Surg Res. 136:31–37. 2006. View Article : Google Scholar : PubMed/NCBI

86 

Gad GI, Ismail RI, El-Masry SA and Gouda HR: Serum apelin in early-onset neonatal sepsis: Is it diagnostic? J Neonatal Perinatal Med. 7:207–212. 2014.PubMed/NCBI

87 

Lesur O, Roussy JF, Chagnon F, Gallo-Payet N, Dumaine R, Sarret P, Chraibi A, Chouinard L and Hogue B: Proven infection-related sepsis induces a differential stress response early after ICU admission. Crit Care. 14:R1312010. View Article : Google Scholar : PubMed/NCBI

88 

Pan CS, Teng X, Zhang J, Cai Y, Zhao J, Wu W, Wang X, Tang CS and Qi YF: Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 16:609–617. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Mertens K, Lowes DA, Webster NR, Talib J, Hall L, Davies MJ, Beattie JH and Galley HF: Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation. Br J Anaesth. 114:990–999. 2015. View Article : Google Scholar : PubMed/NCBI

90 

Bar-Or D, Carrick MM, Mains CW, Rael LT, Slone D and Brody EN: Sepsis, oxidative stress, and hypoxia: Are there clues to better treatment? Redox Rep. 20:193–197. 2015. View Article : Google Scholar : PubMed/NCBI

91 

Rastaldo R, Cappello S, Folino A and Losano G: Effect of apelin-apelin receptor system in postischaemic myocardial protection: a pharmacological postconditioning tool? Antioxid Redox Signal. 14:909–922. 2011. View Article : Google Scholar

92 

Azizi Y, Faghihi M, Imani A, Roghani M and Nazari A: Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction. Peptides. 46:76–82. 2013. View Article : Google Scholar : PubMed/NCBI

93 

Chen XY, Liu XM, Feng LL and Tang CS: Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 30:131–135. 2008.In Chinese. PubMed/NCBI

94 

Cao J, Li H and Chen L: Targeting drugs to APJ receptor: The prospect of treatment of hypertension and other cardiovascular diseases. Curr Drug Targets. 16:148–155. 2015. View Article : Google Scholar

95 

Iturrioz X, Alvear-Perez R, De Mota N, Franchet C, Guillier F, Leroux V, Dabire H, Le Jouan M, Chabane H, Gerbier R, et al: Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB J. 24:1506–1517. 2010. View Article : Google Scholar

96 

Khan P, Maloney PR, Hedrick M, Gosalia P, Milewski M, Li L, Roth GP, Sergienko E, Suyama E, Sugarman E, et al: Functional Agonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program [Internet]. Last Update. Dec 12–2011

97 

Mendez M: Renin release: Role of SNAREs. Am J Physiol Regul Integr Comp Physiol. 307:R484–R486. 2014. View Article : Google Scholar : PubMed/NCBI

98 

Maloney PR, Khan P, Hedrick M, Gosalia P, Milewski M, Li L, Roth GP, Sergienko E, Suyama E, Sugarman E, et al: Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitro-benzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 22:6656–6660. 2012. View Article : Google Scholar : PubMed/NCBI

99 

Zhou N, Fang J, Acheampong E, Mukhtar M and Pomerantz RJ: Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 312:196–203. 2003. View Article : Google Scholar : PubMed/NCBI

100 

Zhang Y, Maitra R, Harris DL, Dhungana S, Snyder R and Runyon SP: Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure-activity. Bioorg Med Chem. 22:2992–2997. 2014. View Article : Google Scholar : PubMed/NCBI

101 

Jin G, Yang P, Gong Y, Fan X, Tang J and Lin J: Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats. Zhongguo Zhong Yao Za Zhi. 34:3263–3267. 2009.In Chinese.

102 

Wu D, He L and Chen L: Apelin/APJ system: A promising therapy target for hypertension. Mol Biol Rep. 41:6691–6703. 2014. View Article : Google Scholar : PubMed/NCBI

103 

El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D and Llorens-Cortes C: Functional dissociation of apelin receptor signaling and endocytosis: Implications for the effects of apelin on arterial blood pressure. J Neurochem. 90:1290–1301. 2004. View Article : Google Scholar : PubMed/NCBI

104 

Zhang BH, Wang W, Wang H, Yin J and Zeng XJ: Promoting effects of the adipokine, apelin, on diabetic nephropathy. PLoS One. 8:e604572013. View Article : Google Scholar : PubMed/NCBI

105 

Chen H, Wan D, Wang L, Peng A, Xiao H, Petersen RB, Liu C, Zheng L and Huang K: Apelin protects against acute renal injury by inhibiting TGF-β1. Biochim Biophys Acta. 1852:1278–1287. 2015. View Article : Google Scholar : PubMed/NCBI

106 

Yang Y, Zhang X, Cui H, Zhang C, Zhu C and Li L: Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways. Neurosci Lett. 568:44–49. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Xin Q, Cheng B, Pan Y, Liu H, Yang C, Chen J and Bai B: Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation. Peptides. 63:55–62. 2015. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Q, Cao J and Chen L: Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review). Int J Mol Med 37: 1159-1169, 2016.
APA
Zhou, Q., Cao, J., & Chen, L. (2016). Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review). International Journal of Molecular Medicine, 37, 1159-1169. https://doi.org/10.3892/ijmm.2016.2544
MLA
Zhou, Q., Cao, J., Chen, L."Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)". International Journal of Molecular Medicine 37.5 (2016): 1159-1169.
Chicago
Zhou, Q., Cao, J., Chen, L."Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)". International Journal of Molecular Medicine 37, no. 5 (2016): 1159-1169. https://doi.org/10.3892/ijmm.2016.2544
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Q, Cao J and Chen L: Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review). Int J Mol Med 37: 1159-1169, 2016.
APA
Zhou, Q., Cao, J., & Chen, L. (2016). Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review). International Journal of Molecular Medicine, 37, 1159-1169. https://doi.org/10.3892/ijmm.2016.2544
MLA
Zhou, Q., Cao, J., Chen, L."Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)". International Journal of Molecular Medicine 37.5 (2016): 1159-1169.
Chicago
Zhou, Q., Cao, J., Chen, L."Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)". International Journal of Molecular Medicine 37, no. 5 (2016): 1159-1169. https://doi.org/10.3892/ijmm.2016.2544
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