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Article

Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress

  • Authors:
    • Hidetoshi Fujita
    • Satoko Aratani
    • Ryouji Fujii
    • Yoshihisa Yamano
    • Naoko Yagishita
    • Natsumi Araya
    • Toshihiko Izumi
    • Kazuko Azakami
    • Daisuke Hasegawa
    • Kusuki Nishioka
    • Toshihiro Nakajima
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Science, Tokyo Medical University, Tokyo 160‑8402, Japan, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216‑8511, Japan
  • Pages: 1611-1618
    |
    Published online on: April 14, 2016
       https://doi.org/10.3892/ijmm.2016.2566
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Abstract

The nuclear factor-κB (NF-κB) transcription factor family members control various biological processes, such as apoptosis and proliferation. The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation. The accumulation of misfolded protein in the ER causes stress and ER stress-induced NF-κB activation to protect cells from apoptosis. In this study, we found a putative ER stress-response element (ERSE) on the promoter of mitochondrial ubiquitin ligase activator of NF-κB (MULAN), and that MULAN expression was upregulated by ER stress. MULAN specifically activated NF-κB dependent gene expression in an E3 ligase activity-dependent manner. The ectopic expression of MULAN induced the nuclear translocation of endogenous p65 and the degradation of IκB. Binding assay revealed that MULAN was associated with transforming growth factor β-activated kinase (TAK1). The knockdown of MULAN using siRNA inhibited the activation of NF-κB in the cells subjected to ER stress. The findings of our study indicate that MULAN is an E3 ligase that regulates NF-κB activation to protect cells from ER stress-induced apoptosis.
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1 

Karin M and Lin A: NF-kappaB at the crossroads of life and death. Nat Immunol. 3:221–227. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D and Maniatis T: Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 9:1586–1597. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Karin M and Ben-Neriah Y: Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol. 18:621–663. 2000. View Article : Google Scholar

4 

Chen ZJ: Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol. 7:758–765. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C and Chen ZJ: Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 103:351–361. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Chung JY, Park YC, Ye H and Wu H: All TRAFs are not created equal: Common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci. 115:679–688. 2002.PubMed/NCBI

7 

Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, et al: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 430:694–699. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L and Chen ZJ: TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 15:535–548. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Wang C, Deng L, Hong M, Akkaraju GR, Inoue J and Chen ZJ: TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 412:346–351. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z and Matsumoto K: The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. 398:252–256. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 13:1211–1233. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Sitia R and Braakman I: Quality control in the endoplasmic reticulum protein factory. Nature. 426:891–894. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Kopito RR: ER quality control: The cytoplasmic connection. Cell. 88:427–430. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Plemper RK and Wolf DH: Retrograde protein translocation: ERADication of secretory proteins in health and disease. Trends Biochem Sci. 24:266–270. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Hu MC, Gong HY, Lin GH, Hu SY, Chen MH, Huang SJ, Liao CF and Wu JL: XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Biochem Biophys Res Commun. 359:778–783. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, et al: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 17:2436–2449. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Li L, Shen Y, Ding Y, Liu Y, Su D and Liang X: Hrd1 participates in the regulation of collagen I synthesis in renal fibrosis. Mol Cell Biochem. 386:35–44. 2014. View Article : Google Scholar

18 

Bianchini E, Fanin M, Mamchaoui K, Betto R and Sandonà D: Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D. Hum Mol Genet. 23:3746–3758. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, et al: The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β. EMBO J. 34:1042–1055. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, et al: E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis. PLoS One. 5:e135902010. View Article : Google Scholar : PubMed/NCBI

21 

Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, doi T, Shimotohno K, Harada T, Nishida E, et al: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 22:3307–3318. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, Chanda SK, Batalov S and Joazeiro CA: Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One. 3:e14872008. View Article : Google Scholar : PubMed/NCBI

23 

Zemirli N, Pourcelot M, Ambroise G, Hatchi E, Vazquez A and Arnoult D: Mitochondrial hyperfusion promotes NF-κB activation via the mitochondrial E3 ligase MULAN. FEBS J. 281:3095–3112. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A and Nakajima T: Antithetic effects of MBD2a on gene regulation. Mol Cell Biol. 23:2645–2657. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J and Montminy MR: The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 86:465–474. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD and Montminy M: RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 90:1107–1112. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Fujita H, Ohshima T, Oishi T, Aratani S, Fujii R, Fukamizu A and Nakajima T: Relevance of nuclear localization and functions of RNA helicase. A Int J Mol Med. 15:555–560. 2005.

28 

Hoffmann A and Baltimore D: Circuitry of nuclear factor kappaB signaling. Immunol Rev. 210:171–186. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Roy B and Lee AS: The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex. Nucleic Acids Res. 27:1437–1443. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Yoshida H, Haze K, Yanagi H, Yura T and Mori K: Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem. 273:33741–33749. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M and Mori K: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol. 20:6755–6767. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Lee TH, Shank J, Cusson N and Kelliher MA: The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiqui-tination of Rip1 by Traf2. J Biol Chem. 279:33185–33191. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Legler DF, Micheau O, Doucey MA, Tschopp J and Bron C: Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 18:655–664. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Chen IT, Hsu PH, Hsu WC, Chen NJ and Tseng PH: Polyubiquitination of transforming growth factor β-activated kinase 1 (TAK1) atlysine 562 residue regulates TLR4-mediated JNK and p38 MAPK activation. Sci Rep. 5:123002015. View Article : Google Scholar

35 

Ajibade AA, Wang HY and Wang RF: Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol. 34:307–316. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, et al: Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis. J Biol Chem. 281:2631–2638. 2006. View Article : Google Scholar

37 

Hu P, Han Z, Couvillon AD, Kaufman RJ and Exton JH: Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and downregulation of TRAF2 expression. Mol Cell Biol. 26:3071–3084. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Leonardi A, Vito P, Mauro C, Pacifico F, Ulianich L, Consiglio E, Formisano S and Di Jeso B: Endoplasmic reticulum stress causes thyroglobulin retention in this organelle and triggers activation of nuclear factor-kappa B via tumor necrosis factor receptor-associated factor 2. Endocrinology. 143:2169–2177. 2002.PubMed/NCBI

39 

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron D: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 287:664–666. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nishioka K, et al: Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress. Int J Mol Med 37: 1611-1618, 2016.
APA
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N. ... Nakajima, T. (2016). Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress. International Journal of Molecular Medicine, 37, 1611-1618. https://doi.org/10.3892/ijmm.2016.2566
MLA
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N., Izumi, T., Azakami, K., Hasegawa, D., Nishioka, K., Nakajima, T."Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress". International Journal of Molecular Medicine 37.6 (2016): 1611-1618.
Chicago
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N., Izumi, T., Azakami, K., Hasegawa, D., Nishioka, K., Nakajima, T."Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress". International Journal of Molecular Medicine 37, no. 6 (2016): 1611-1618. https://doi.org/10.3892/ijmm.2016.2566
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nishioka K, et al: Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress. Int J Mol Med 37: 1611-1618, 2016.
APA
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N. ... Nakajima, T. (2016). Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress. International Journal of Molecular Medicine, 37, 1611-1618. https://doi.org/10.3892/ijmm.2016.2566
MLA
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N., Izumi, T., Azakami, K., Hasegawa, D., Nishioka, K., Nakajima, T."Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress". International Journal of Molecular Medicine 37.6 (2016): 1611-1618.
Chicago
Fujita, H., Aratani, S., Fujii, R., Yamano, Y., Yagishita, N., Araya, N., Izumi, T., Azakami, K., Hasegawa, D., Nishioka, K., Nakajima, T."Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress". International Journal of Molecular Medicine 37, no. 6 (2016): 1611-1618. https://doi.org/10.3892/ijmm.2016.2566
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