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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2016 Volume 37 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Molecular mechanisms of cell death in intervertebral disc degeneration (Review)

Fan Zhang, Xueling Zhao, Hongxing Shen, Caiguo Zhang
Pages: 1439-1448
Published online on: 21 April 2016

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Article Open Access

An examination of the regulatory mechanism of Pxdn mutation-induced eye disorders using microarray analysis

Yang Yang, Yiqiao Xing, Chaoqun Liang, Liya Hu, Fei Xu, Qi Mei
Pages: 1449-1456
Published online on: 20 April 2016

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Article Open Access

Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats

Magdy El-Salhy, Kazuo Umezawa
Pages: 1457-1464
Published online on: 12 April 2016

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Article Open Access

Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells

Xiu-Yun Li, Lun Wu, Sheng-Wei Li, Wen-Bo Zhou, Meng-Yuan Wang, Guo-Qing Zuo, Chang-An Liu, Xiong Ding
Pages: 1465-1474
Published online on: 12 April 2016

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Article Open Access

Estrogen enhances the bone regeneration potential of periodontal ligament stem cells derived from osteoporotic rats and seeded on nano-hydroxyapatite/collagen/poly(L-lactide)

Ling-Ling E, Wen-Huan Xu, Lin Feng, Yi Liu, Dong-Qing Cai, Ning Wen, Wen-Jie Zheng
Pages: 1475-1486
Published online on: 12 April 2016

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Article Open Access

Analysis of SLC4A11, ZEB1, LOXHD1, COL8A2 and TCF4 gene sequences in a multi-generational family with late-onset Fuchs corneal dystrophy

Hui Tang, Wen Zhang, Xin-Min Yan, Lin-Ping Wang, Hong Dong, Tao Shou, Huo Lei, Qiang Guo
Pages: 1487-1500
Published online on: 20 April 2016

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Article Open Access

Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats Corrigendum in /10.3892/ijmm.2021.5067

Minchun Chen, Mingming Wang, Qiong Yang, Min Wang, Zhipeng Wang, Yanrong Zhu, Yikai Zhang, Chao Wang, Yanyan Jia, Yuwen Li, Aidong Wen
Pages: 1501-1510
Published online on: 20 April 2016

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Article Open Access

Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system

Yue Zhao, Hong Cao, Yindi Song, Yue Feng, Xiaoxue Ding, Mingjie Pang, Yunmei Zhang, Hong Zhang, Jiahuan Ding, Xueshan Xia
Pages: 1511-1520
Published online on: 14 April 2016

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Article Open Access

293 cells express both epithelial as well as mesenchymal cell adhesion molecules

Masakazu Inada, Genya Izawa, Wakako Kobayashi, Masayuki Ozawa
Pages: 1521-1527
Published online on: 18 April 2016

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Article Open Access

Whole-exome sequencing identifies a novel homozygous frameshift mutation in the PROM1 gene as a causative mutation in two patients with sporadic retinitis pigmentosa

Sanmei Liu, Lan Xie, Jun Yue, Tao Ma, Chunyan Peng, Biyuan Qiu, Zhenglin Yang, Jiyun Yang
Pages: 1528-1534
Published online on: 08 April 2016

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Article Open Access

Tumor-associated fibroblasts promote the proliferation and decrease the doxorubicin sensitivity of liposarcoma cells

Kamran Harati, Adrien Daigeler, Tobias Hirsch, Frank Jacobsen, Björn Behr, Christoph Wallner, Marcus Lehnhardt, Mustafa Becerikli
Pages: 1535-1541
Published online on: 11 April 2016

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Article Open Access

Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism

Zhenzhong Wang, Ai Guo, Lifeng Ma, Haomiao Yu, Liang Zhang, Hai Meng, Yinpeng Cui, Fei Yu, Bo Yang
Pages: 1542-1550
Published online on: 14 April 2016

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Article Open Access

High expression of DDX20 enhances the proliferation and metastatic potential of prostate cancer cells through the NF-κB pathway

Weiguo Chen, Peng Zhou, Xiaowei Li
Pages: 1551-1557
Published online on: 25 April 2016

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Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase

Song-Tao Tang, Huan Su, Qiu Zhang, Hai-Qin Tang, Chang-Jiang Wang, Qing Zhou, Wei Wei, Hua-Qing Zhu, Yuan Wang
Pages: 1558-1566
Published online on: 26 April 2016

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Article Open Access

Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro

Yue Wang, Jiatian Cao, Yuqi Fan, Yushui Xie, Zuojun Xu, Zhaofang Yin, Lin Gao, Changqian Wang
Pages: 1567-1575
Published online on: 26 April 2016

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Article Open Access

Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer

Chen Chen, Hong Shen, Li-Guo Zhang, Jian Liu, Xiao-Ge Cao, An-Liang Yao, Shao-San Kang, Wei-Xing Gao, Hui Han, Feng-Hong Cao, Zhi-Guo Li
Pages: 1576-1586
Published online on: 26 April 2016

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Article Open Access

MicroRNA-130b promotes cell proliferation and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma cells

Jian-Jun Gu, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wang
Pages: 1587-1593
Published online on: 27 April 2016

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Article

Clinical implications of the growth-suppressive effects of chlorhexidine at low and high concentrations on human gingival fibroblasts and changes in morphology

Marzena Wyganowska-Swiatkowska, Malgorzata Kotwicka, Paulina Urbaniak, Agnieszka Nowak, Ewa Skrzypczak-Jankun, Jerzy Jankun
Pages: 1594-1600
Published online on: 07 April 2016

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Article

Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues Expression of Concern in /10.3892/ijmm.2025.5627 Retraction in /10.3892/ijmm.2025.5700

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Pages: 1601-1610
Published online on: 11 April 2016

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Article

Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress

Hidetoshi Fujita, Satoko Aratani, Ryouji Fujii, Yoshihisa Yamano, Naoko Yagishita, Natsumi Araya, Toshihiko Izumi, Kazuko Azakami, Daisuke Hasegawa, Kusuki Nishioka, Toshihiro Nakajima
Pages: 1611-1618
Published online on: 14 April 2016

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Article

A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells

Qingqing Chu, Zhi-Hong Chi, Xiuli Zhang, Dan Liang, Xuemei Wang, Yue Zhao, Li Zhang, Ping Zhang
Pages: 1619-1626
Published online on: 25 April 2016

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Article

miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma

Ting-Gang Fu, Ling Wang, Wei Li, Jian-Zhong Li, Jian Li
Pages: 1627-1635
Published online on: 13 April 2016

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Article

miR-133a enhances the sensitivity of Hep-2 cells and vincristine-resistant Hep-2v cells to cisplatin by downregulating ATP7B expression

Xurui Wang, Wei Zhu, Xiaodong Zhao, Ping Wang
Pages: 1636-1642
Published online on: 20 April 2016

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Article

MicroRNA-101 inhibits cell proliferation and induces apoptosis by targeting EYA1 in breast cancer

Haitao Guan, Zhijun Dai, Yuguang Ma, Zhongwei Wang, Xiaoxu Liu, Xijing Wang
Pages: 1643-1651
Published online on: 11 April 2016

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Article

Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway

Yi Ma, Xun Gong, Yingli Mo, Saizhu Wu
Pages: 1652-1660
Published online on: 11 April 2016

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Article

Hydrogen sulfide protects H9c2 cardiac cells against doxorubicin-induced cytotoxicity through the PI3K/Akt/FoxO3a pathway

Mi-Hua Liu, Yuan Zhang, Jun He, Tian-Ping Tan, Shao-Jian Wu, Dong-Ming Guo, Hui He, Juan Peng, Zhi-Han Tang, Zhi-Sheng Jiang
Pages: 1661-1668
Published online on: 14 April 2016

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Article

Plumbagin exerts protective effects in nucleus pulposus cells by attenuating hydrogen peroxide-induced oxidative stress, inflammation and apoptosis through NF-κB and Nrf-2

Hui Chu, Hang Yu, Ding Ren, Kejun Zhu, Hong Huang
Pages: 1669-1676
Published online on: 14 April 2016

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Article

Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression

Han Xu, Long Jin, Yan Chen, Junzhi Li
Pages: 1677-1685
Published online on: 12 April 2016

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Article

Valproic acid enhances the antileukemic effect of cytarabine by triggering cell apoptosis

Nan Liu, Chen Wang, Libing Wang, Lei Gao, Hui Cheng, Gusheng Tang, Xiaoxia Hu, Jianmin Wang
Pages: 1686-1696
Published online on: 08 April 2016

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Article

Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway

Rongfeng Zhu, Jianjun Zheng, Lizhen Chen, Bin Gu, Shengli Huang
Pages: 1697-1705
Published online on: 11 April 2016

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Article

Effects of nitrogen on the apoptosis of and changes in gene expression in human lymphoma U937 cells exposed to argon-based cold atmospheric pressure plasma

Yoshiaki Tabuchi, Hidefumi Uchiyama, Qing-Li Zhao, Tatsuya Yunoki, Gabor Andocs, Nobuyuki Nojima, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Takashi Kondo
Pages: 1706-1714
Published online on: 25 April 2016

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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Review Open Access

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Review Open Access

Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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Review Open Access

The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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Article Open Access

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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Article Open Access

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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Article Open Access

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Article Open Access

Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Review Open Access

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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Review Open Access

CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

Li-Hua Guo, Yu Cao, Run-Tao Zhuang, Yan Han, Jun Li
Article Number: 106
Published online on: 02 March 2026

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June-2026 Volume 57 Issue 6

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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