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Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism

  • Authors:
    • Zhenzhong Wang
    • Ai Guo
    • Lifeng Ma
    • Haomiao Yu
    • Liang Zhang
    • Hai Meng
    • Yinpeng Cui
    • Fei Yu
    • Bo Yang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Surgery, Medical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1542-1550
    |
    Published online on: April 14, 2016
       https://doi.org/10.3892/ijmm.2016.2567
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Abstract

Osteoarthritis (OA) is a common chronic inflammatory disease, characterized by cartilage degradation. The aberrant expression of matrix metalloproteinase-13 (MMP-13) plays a vital role in the pathogenesis of OA. The anti‑inflammatory property of docosahexenoic acid (DHA) was previously revealed and showed that DHA retards the progress of many types of inflammatory disease. To evaluate the prophylactic function of DHA in OA, the effect of DHA on cartilage degeneration was assessed in interleukin‑1β (IL‑1β) stimulated human chondrosarcoma SW1353 cells or a rat model of adjuvant‑induced arthritis (AIA). The safe concentration range (0‑50 µg/ml in vitro) of DHA was determined by flow cytometry and MTT assay. The inhibitory effects of DHA on MMP‑13 mRNA and protein expression were confirmed by RT‑qPCR, ELISA and western blotting. Furthermore, findings of an in vivo study showed that DHA can increase the thickness of articular cartilage and decrease MMP‑13 expression in cartilage matrix in a rat AIA model. We also revealed the mechanism by which DHA ameliorates cartilage degeneration from OA. The DHA-mediated inhibition of MMP‑13 expression was partially attributed to the inactivation of the p38 mitogen‑activated protein kinases pathway by suppressing p‑p38 in IL-1β-stimulated SW1353 cells and a rat AIA model. Our findings suggested that DHA is a promising therapeutic agent that may be used for the prevention and treatment of OA.
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1 

Moyer RF, Ratneswaran A, Beier F and Birmingham TB: Osteoarthritis year in review 2014: mechanics - basic and clinical studies in osteoarthritis. Osteoarthritis Cartilage. 22:1989–2002. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Fibel KH, Hillstrom HJ and Halpern BC: State-of-the-Art management of knee osteoarthritis. World J Clin Cases. 3:89–101. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Troeberg L and Nagase H: Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 1824:133–145. 2012. View Article : Google Scholar

4 

Takaishi H, Kimura T, Dalal S, Okada Y and D'Armiento J: Joint diseases and matrix metalloproteinases: A role for MMP-13. Curr Pharm Biotechnol. 9:47–54. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Mabey T and Honsawek S: Cytokines as biochemical markers for knee osteoarthritis. World J Orthop. 6:95–105. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar

7 

Goldring MB and Otero M: Inflammation in osteoarthritis. Curr Opin Rheumatol. 23:471–478. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Garvican ER, Vaughan-Thomas A, Redmond C, Gabriel N and Clegg PD: MMP-mediated collagen breakdown induced by activated protein C in equine cartilage is reduced by corticosteroids. J Orthop Res. 28:370–378. 2010.

9 

Houard X, Goldring MB and Berenbaum F: Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep. 15(375)2013. View Article : Google Scholar : PubMed/NCBI

10 

Shi J, Schmitt-Talbot E, DiMattia DA and Dullea RG: The differential effects of IL-1 and TNF-alpha on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells. Inflamm Res. 53:377–389. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Gebauer M, Saas J, Sohler F, Haag J, Soder S, Pieper M, Bartnik E, Beninga J, Zimmer R and Aigner T: Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta. Osteoarthritis Cartilage. 13:697–708. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Tetsunaga T, Nishida K, Furumatsu T, Naruse K, Hirohata S, Yoshida A, Saito T and Ozaki T: Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells. Osteoarthritis Cartilage. 19:222–232. 2011. View Article : Google Scholar

13 

Tabbaa M, Golubic M, Roizen MF and Bernstein AM: Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. Nutrients. 5:3299–3310. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Raphael W and Sordillo LM: Dietary polyunsaturated fatty acids and inflammation: The role of phospholipid biosynthesis. Int J Mol Sci. 14:21167–21188. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Caplan MS and Jilling T: The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. Lipids. 36:1053–1057. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, et al: Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage. 20:382–387. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ishijima M, Kaneko H and Kaneko K: The evolving role of biomarkers for osteoarthritis. Ther Adv Musculoskelet Dis. 6:144–153. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Calder PC: Polyunsaturated fatty acids, inflammation, and immunity. Lipids. 36:1007–1024. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Zainal Z, Longman AJ, Hurst S, Duggan K, Caterson B, Hughes CE and Harwood JL: Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis Cartilage. 17:896–905. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Schmitt D, Tran N, Peach J, Bauter M and Marone P: Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. Food Chem Toxicol. 50:3567–3576. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Shahrara S, Proudfoot AE, Woods JM, Ruth JH, Amin MA, Park CC, Haas CS, Pope RM, Haines GK, Zha YY, et al: Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum. 52:1907–1919. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Iannitti T, Elhensheri M, Bingöl AO and Palmieri B: Preliminary histopathological study of intra-articular injection of a novel highly cross-linked hyaluronic acid in a rabbit model of knee osteoarthritis. J Mol Histol. 44:191–201. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Saklatvala J: Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets. 8:305–313. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Gao SC, Yin HB, Liu HX and Sui YH: Research progress on MAPK signal pathway in the pathogenesis of osteoarthritis. Zhongguo Gu Shang. 27:441–444. 2014.In Chinese. PubMed/NCBI

25 

Amir M, Somakala K and Ali S: p38 MAP kinase inhibitors as anti inflammatory agents. Mini Rev Med Chem. 13:2082–2096. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Okubo M and Okada Y: Destruction of the articular cartilage in osteoarthritis. Clin Calcium. 23:1705–1713. 2013.In Japanese. PubMed/NCBI

27 

Malemud CJ: Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci. 11:1696–1701. 2006. View Article : Google Scholar

28 

Liu-Bryan R: Synovium and the innate inflammatory network in osteoarthritis progression. Curr Rheumatol Rep. 15(323)2013. View Article : Google Scholar : PubMed/NCBI

29 

Fernandes JC, Martel-Pelletier J and Pelletier JP: The role of cytokines in osteoarthritis pathophysiology. Biorheology. 39:237–246. 2002.PubMed/NCBI

30 

Fernandes JC, Martel-Pelletier J, Lascau-Coman V, Moldovan F, Jovanovic D, Raynauld JP and Pelletier JP: Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: An immunohistochemical study. J Rheumatol. 25:1585–1594. 1998.PubMed/NCBI

31 

Mudgett JS, Hutchinson NI, Chartrain NA, Forsyth AJ, McDonnell J, Singer II, Bayne EK, Flanagan J, Kawka D, Shen CF, et al: Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 41:110–121. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, López-Otín C and Krane SM: Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endo-chondral ossification. Proc Natl Acad Sci USA. 101:17192–17197. 2004. View Article : Google Scholar

33 

Xue B, Yang Z, Wang X and Shi H: Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One. 7:e459902012. View Article : Google Scholar : PubMed/NCBI

34 

Caughey GE, Mantzioris E, Gibson RA, Cleland LG and James MJ: The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 63:116–122. 1996.PubMed/NCBI

35 

Trebble TM, Wootton SA, Miles EA, Mullee M, Arden NK, Ballinger AB, Stroud MA, Burdge GC and Calder PC: Prostaglandin E2 production and T cell function after fish-oil supplementation: Response to antioxidant cosupplementation. Am J Clin Nutr. 78:376–382. 2003.PubMed/NCBI

36 

Olson MV, Liu YC, Dangi B, Paul Zimmer J, Salem N Jr and Nauroth JM: Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. Inflamm Res. 62:1003–1013. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Sydenham E, Dangour AD and Lim WS: Omega 3 fatty acid for the prevention of cognitive decline and dementia. Cochrane Database Syst Rev. 6:CD0053792012.PubMed/NCBI

38 

Schulzke SM, Patole S and Simmer K: Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev. 1:CD0003752008.PubMed/NCBI

39 

Geng Y, Valbracht J and Lotz M: Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chon-drocytes. J Clin Invest. 98:2425–2430. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Mengshol JA, Vincenti MP, Coon CI, Barchowsky A and Brinckerhoff CE: Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: Differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 43:801–811. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Marcu KB, Otero M, Olivotto E, Borzi RM and Goldring MB: NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets. 11:599–613. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Guo A, Ma L, Yu H, Zhang L, Meng H, Cui Y, Yu F and Yang B: Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism. Int J Mol Med 37: 1542-1550, 2016.
APA
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H. ... Yang, B. (2016). Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism. International Journal of Molecular Medicine, 37, 1542-1550. https://doi.org/10.3892/ijmm.2016.2567
MLA
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H., Cui, Y., Yu, F., Yang, B."Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism". International Journal of Molecular Medicine 37.6 (2016): 1542-1550.
Chicago
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H., Cui, Y., Yu, F., Yang, B."Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism". International Journal of Molecular Medicine 37, no. 6 (2016): 1542-1550. https://doi.org/10.3892/ijmm.2016.2567
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Guo A, Ma L, Yu H, Zhang L, Meng H, Cui Y, Yu F and Yang B: Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism. Int J Mol Med 37: 1542-1550, 2016.
APA
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H. ... Yang, B. (2016). Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism. International Journal of Molecular Medicine, 37, 1542-1550. https://doi.org/10.3892/ijmm.2016.2567
MLA
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H., Cui, Y., Yu, F., Yang, B."Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism". International Journal of Molecular Medicine 37.6 (2016): 1542-1550.
Chicago
Wang, Z., Guo, A., Ma, L., Yu, H., Zhang, L., Meng, H., Cui, Y., Yu, F., Yang, B."Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism". International Journal of Molecular Medicine 37, no. 6 (2016): 1542-1550. https://doi.org/10.3892/ijmm.2016.2567
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